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Biochemical Pharmacology, ISSN 0006-2952, 07/2012, Volume 84, Issue 1, pp. 68 - 75
The prostacyclin analogues, iloprost and treprostinil are extensively used in treating pulmonary hypertension. Their binding profile and corresponding... 
Cyclic AMP | Prostacyclin analogues | Prostanoid receptors | Radioligand binding | Calcium influx
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 03/2011, Volume 654, Issue 3, p. 258
Prostanoid IP receptors coupled to Gs are thought to be the primary target for prostacyclin (PGI.sub.2) analogues. However, these agents also activate... 
Dilatation | Heterocyclic compounds | Blood vessels
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 07/2012, Volume 84, Issue 1, p. 68
Differential activation of human prostanoid receptors expressed in cells: EC.sub.50 values for prostacyclin analogues treprostinil or iloprost in stimulating... 
Medical colleges | Heterocyclic compounds | Prostacyclin
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 2011, Volume 654, Issue 3, pp. 258 - 265
Prostanoid IP receptors coupled to Gs are thought to be the primary target for prostacyclin (PGI ) analogues. However, these agents also activate prostanoid EP... 
Prostanoid IP receptor | G i/o, rat tail artery | Prostanoid EP 3 receptor | PGI 2 analogue | Prostanoid EP 4 receptor
Journal Article
European Journal of Pharmaceutics and Biopharmaceutics, ISSN 0939-6411, 09/2019, Volume 142, pp. 377 - 386
Poly(glycerol adipate) (PGA) is a biodegradable, biocompatible, polymer with a great deal of potential in the field of drug delivery. Active drug molecules can... 
Breakdown | Polyester | Biodegradable | Enzymatic degradation | Poly(glycerol adipate) | Polymer modification | Glycerin | Drugs | Enzymes | Drug delivery systems | Analysis | Pharmacy | Glycerol | Polymer industry | Polymers | Vehicles | Index Medicus
Journal Article
Journal Article
Journal Article
Circulation Research, ISSN 0009-7330, 08/2007, Volume 101, Issue 5, pp. 436 - 438
Journal Article
Drug, Healthcare and Patient Safety, ISSN 1179-1365, 01/2019, Volume 11, pp. 55 - 64
Selexipag is a compound that was designed to overcome the issues associated with oral administration of prostanoid compounds, beraprost and treprostinil in the... 
Heart failure | Hypertension | Disease | Cytokines | Mortality | Physiology | Thyroid gland | Growth factors | haemodynamic | Selexipag | prostanoid | pulmonary arterial hypertension | mortality/morbidity | prognosis | averse events
Journal Article
Cardiovascular Research, ISSN 0008-6363, 11/2006, Volume 72, Issue 2, p. 220
Sepsis is an infection-induced inflammatory syndrome responsible for [approximately equal to]10% of all deaths worldwide. While pathophysiological mechanisms... 
Catecholamines | Mitochondrial DNA
Journal Article
Circulation, ISSN 0009-7322, 08/2014, Volume 130, Issue 6, pp. 496 - 507
BACKGROUND—Pulmonary hypertension (PH) is a life-threatening disorder characterized by increased pulmonary artery pressure, remodeling of the pulmonary... 
Phosphodiesterase inhibitor | Cyclic nucleotide | Natriuretic peptide | Nitric oxide | Pulmonary hypertension | SURVIVAL | nitric oxide | CARDIAC & CARDIOVASCULAR SYSTEMS | ATRIAL-NATRIURETIC-PEPTIDE | pulmonary hypertension | NITRIC-OXIDE SYNTHASE | PROSTACYCLIN | natriuretic peptide | DIFFERENTIAL REGULATION | RESPONSES | THERAPY | RIGHT HEART-FAILURE | phosphodiesterase inhibitor | ARTERIAL-HYPERTENSION | PERIPHERAL VASCULAR DISEASE | cyclic nucleotide | EXPRESSION | Cyclic Nucleotide Phosphodiesterases, Type 2 - antagonists & inhibitors | Phosphodiesterase Inhibitors - therapeutic use | Triazines - pharmacology | Cyclic GMP - physiology | Triazines - therapeutic use | Humans | Mice, Inbred C57BL | Cells, Cultured | Phosphodiesterase Inhibitors - pharmacology | Rats | Male | Imidazoles - pharmacology | Rats, Sprague-Dawley | Mice, Knockout | Cyclic AMP - physiology | Animals | Signal Transduction - drug effects | Signal Transduction - physiology | Hypertension, Pulmonary - drug therapy | Mice | Imidazoles - therapeutic use | Cyclic Nucleotide Phosphodiesterases, Type 2 - physiology | Hypertension, Pulmonary - enzymology | Care and treatment | Usage | Treprostinil | Diagnosis | Phosphodiesterases | Health aspects | Index Medicus | Abridged Index Medicus | vasodilatation | endothelium | hypoxia | prostacyclin | cGMP | phosphodiesterase | cAMP
Journal Article
Nature, ISSN 0028-0836, 02/2004, Volume 427, Issue 6977, pp. 853 - 858
Journal Article
Journal Article
Cardiovascular Research, ISSN 0008-6363, 01/2006, Volume 69, Issue 1, p. 107
We investigated the role of the inward rectifier potassium (K.sub.IR) channel and the cyclic AMP-dependent pathway in mediating vasorelaxation induced by the... 
Prostanoids
Journal Article
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