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Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 4/2012, Volume 109, Issue 15, pp. 5803 - 5808
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 04/2012, Volume 109, Issue 15, p. 5803
Transactive response DNA-binding (TDP-43) protein is the dominant disease protein in amyotrophic lateral sclerosis (ALS) and a subgroup of frontotemporal lobar... 
Proteins | Neurons | Stem cells | Mutation | Binding sites
Journal Article
Science Translational Medicine, ISSN 1946-6234, 06/2013, Volume 5, Issue 188, pp. 188le2 - 188le2
Egawa et al. recently showed the value of patient-specific induced pluripotent stem cells (iPSCs) for modeling amyotrophic lateral sclerosis in vitro. Their... 
MEDICINE, RESEARCH & EXPERIMENTAL | CELL BIOLOGY | Drug Evaluation, Preclinical - methods | Amyotrophic Lateral Sclerosis - pathology | Induced Pluripotent Stem Cells - cytology | Humans | Motor Neurons - cytology
Journal Article
ISSN 0036-8075, 08/2013
DNA methylation is implicated in mammalian brain development and plasticity underlying learning and memory. We report the genome-wide composition, patterning,... 
Learning | Memòria | DNA | Memory | Aprenentatge | ADN
Journal Article
Science translational medicine, ISSN 1946-6234, 6/2013, Volume 5, Issue 188, pp. 188le2 - 188le2
Egawa et al. recently showed the value of patient-specific induced pluripotent stem cells (iPSCs) for modeling amyotrophic lateral sclerosis in vitro. Their... 
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 02/2010, Volume 30, Issue 7, pp. 2623 - 2635
Synaptic activity promotes resistance to diverse apoptotic insults, the mechanism behind which is incompletely understood. We show here that a coordinated... 
NEURONAL APOPTOSIS | NMDA-RECEPTOR | SIGNALING PATHWAYS | NEURODEGENERATIVE DISORDERS | ALZHEIMERS-DISEASE | RAT-BRAIN | NEUROSCIENCES | D-ASPARTATE ANTAGONISTS | BH3-ONLY PROTEIN PUMA | CELL-DEATH | PERMEABILITY TRANSITION | Caspase 9 - metabolism | Apoptosis - drug effects | Embryo, Mammalian | Male | Green Fluorescent Proteins - genetics | Tacrolimus - analogs & derivatives | Cerebral Cortex - cytology | Dose-Response Relationship, Drug | Neural Inhibition - physiology | Neuroprotective Agents - pharmacology | Transfection - methods | Time Factors | Apoptosis Regulatory Proteins - deficiency | Tumor Suppressor Proteins - deficiency | Neurons - physiology | Tacrolimus - pharmacology | Potassium Channel Blockers | Neurons - drug effects | 4-Aminopyridine - pharmacology | Animals, Newborn | Synapses - drug effects | Tumor Suppressor Proteins - metabolism | Synapses - physiology | Cytochromes c - metabolism | Mice, Inbred C57BL | Cells, Cultured | Enzyme Inhibitors - pharmacology | Tumor Suppressor Protein p53 - metabolism | Bicuculline - pharmacology | Mutation - genetics | Tumor Suppressor Protein p53 - deficiency | Apoptosis Regulatory Proteins - metabolism | Apoptotic Protease-Activating Factor 1 - metabolism | GABA Antagonists - pharmacology | Up-Regulation - drug effects | Animals | Analysis of Variance | Signal Transduction - drug effects | Signal Transduction - physiology | Mice | Apoptosis - physiology | Dizocilpine Maleate - pharmacology | Neural Inhibition - drug effects | Drug Combinations | Staurosporine - pharmacology
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 05/2012, Volume 32, Issue 20, pp. 6995 - 7000
Underexpression of the transcriptional coactivator PGC-1 alpha is causally linked to certain neurodegenerative disorders, including Huntington's Disease (HD).... 
ACTIVATION | PROTEIN | MOUSE MODEL | MUTANT-HUNTINGTIN | NEURODEGENERATION | HUNTINGTONS-DISEASE | EXPRESSION | CONTRIBUTES | NEUROSCIENCES | AMYLOID-BETA PRODUCTION | CELL-DEATH | RNA-Binding Proteins - genetics | Receptors, N-Methyl-D-Aspartate - metabolism | Male | Corpus Striatum - metabolism | Gene Knockdown Techniques - methods | Cerebral Cortex - metabolism | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha | Neurons - physiology | Female | Neurons - metabolism | Cell Death - drug effects | Cerebral Cortex - drug effects | Nuclear Proteins - genetics | Huntington Disease - physiopathology | Disease Models, Animal | Transcription Factors - physiology | RNA-Binding Proteins - physiology | Cells, Cultured | Rats | Nuclear Proteins - metabolism | Transcription Factors - genetics | Membrane Potentials - physiology | Huntington Disease - metabolism | Nerve Tissue Proteins - genetics | Rats, Sprague-Dawley | Nerve Tissue Proteins - metabolism | Transcription Factors - metabolism | Huntingtin Protein | Animals | Cell Death - physiology | Corpus Striatum - drug effects | Corpus Striatum - physiology | Huntington Disease - genetics | Cerebral Cortex - physiology | RNA-Binding Proteins - metabolism | N-Methylaspartate - toxicity | Neurones | Neurodegenerative diseases | Huntington's chorea | Regulació genètica | Neurons | Corea de Huntington | Malalties neurodegeneratives | Genetic regulation | Brief Communications
Journal Article
Journal Article
ISSN 1523-0864, 03/2010
Transcriptional coactivators and corepressors often have multiple targets and can have opposing actions on transcription and downstream physiological events.... 
Neurones | Neurodegenerative diseases | Huntington's chorea | Regulació genètica | Neurons | Corea de Huntington | Malalties neurodegeneratives | Genetic regulation
Journal Article
ISSN 0270-6474, 02/2010
Synaptic activity promotes resistance to diverse apoptotic insults, the mechanism behind which is incompletely understood. We show here that a coordinated... 
Sinapsi | Apoptosi | Neurones | Regulació genètica | Neurons | Genetic regulation | Synapses | Apoptosis
Journal Article
2013
The transcriptional coactivator PPARgamma coactivator 1alpha (PGC-1α) is a regulator of mitochondrial biogenesis and function and is decreased in the striatum... 
Huntington’s Disease | NMDA | PGC-1a | excitotoxicity
Dissertation
Journal Article