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infectious diseases (20) 20
humans (14) 14
index medicus (13) 13
pregnancy (13) 13
immunology (11) 11
hiv (10) 10
aids/hiv (9) 9
drug therapy (8) 8
female (8) 8
hiv infections - drug therapy (8) 8
research (8) 8
therapy (8) 8
antiviral agents (7) 7
hiv infection (7) 7
hiv infections - transmission (7) 7
highly active antiretroviral therapy (6) 6
human immunodeficiency virus--hiv (6) 6
infectious disease transmission, vertical - prevention & control (6) 6
anti-hiv agents - therapeutic use (5) 5
antiretroviral therapy (5) 5
efavirenz (5) 5
health aspects (5) 5
infection (5) 5
prevention (5) 5
public aspects of medicine (5) 5
to-child transmission (5) 5
virology (5) 5
dolutegravir (4) 4
drugs (4) 4
hiv infections - prevention & control (4) 4
human-immunodeficiency-virus (4) 4
infant, newborn (4) 4
medicine, general & internal (4) 4
pharmaceutical industry (4) 4
pregnant women (4) 4
public health (4) 4
tenofovir (4) 4
acquired immune deficiency syndrome--aids (3) 3
article (3) 3
care and treatment (3) 3
clinical trials (3) 3
disease transmission (3) 3
dosage and administration (3) 3
drug administration schedule (3) 3
hiv-infected women (3) 3
lamivudine (3) 3
pregnancy complications, infectious - prevention & control (3) 3
risk factors (3) 3
safety (3) 3
usage (3) 3
women (3) 3
active antiretroviral therapy (2) 2
adults (2) 2
analysis (2) 2
anti-hiv agents - administration & dosage (2) 2
anti-retroviral agents - administration & dosage (2) 2
anti-retroviral agents - therapeutic use (2) 2
antiretroviral drugs (2) 2
antiretroviral therapy, highly active (2) 2
birth defects (2) 2
birth outcomes (2) 2
breast feeding (2) 2
children (2) 2
commentary (2) 2
diagnosis (2) 2
drug dosages (2) 2
drug resistance (2) 2
edited by charles w. flexner, willem d.f. venter, and polly clayden (2) 2
guidelines as topic (2) 2
hepatitis-c-virus (2) 2
hiv infections - immunology (2) 2
hiv-1 infection (2) 2
inclusion (2) 2
infants (2) 2
low-birth-weight (2) 2
maternal-infant transmission (2) 2
mortality (2) 2
naive patients (2) 2
nevirapine - administration & dosage (2) 2
optimized antiretroviral therapy (2) 2
outcomes (2) 2
pediatrics (2) 2
practice guidelines (2) 2
pregnancy and breast feeding (2) 2
prevent perinatal transmission (2) 2
reverse transcriptase inhibitors - administration & dosage (2) 2
stavudine (2) 2
surveillance (2) 2
tenofovir alafenamide (2) 2
tenofovir disoproxil fumarate (2) 2
towards a universal antiretroviral regimen (2) 2
towards a universal antiretroviral regimen: edited by charles w. flexner, willem d.f. venter, and polly clayden (2) 2
treatment outcome (2) 2
vertical hiv transmission (2) 2
viral load (2) 2
womens health (2) 2
1st trimester (1) 1
3rd trimester (1) 1
abnormalities, drug-induced - classification (1) 1
abridged index medicus (1) 1
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1. Full Text When could new antiretrovirals be recommended for national treatment programmes in low-income and middle-income countries: Results of a WHO Think Tank
by Vitoria, Marco and Ford, Nathan and Clayden, Polly and Pozniak, Anton L and Hill, Andrew M
Current Opinion in HIV and AIDS, ISSN 1746-630X, 07/2017, Volume 12, Issue 4, pp. 414 - 422
Purpose of review To discuss barriers and opportunities for the introduction of new antiretrovirals into national treatment programmes in low-income and... 
drug-drug interactions | HIV-TB coinfection | pregnant women | antiretroviral treatment | INFECTIOUS DISEASES | THERAPY | PHARMACOKINETICS | SAFETY | DOLUTEGRAVIR | IMMUNOLOGY | HIV-1 INFECTION | Pregnancy | Anti-HIV Agents - supply & distribution | Drug Interactions | Humans | Anti-HIV Agents - therapeutic use | Female | HIV Infections - drug therapy | Developing Countries | HIV–TB coinfection | TOWARDS A UNIVERSAL ANTIRETROVIRAL REGIMEN | Edited by Charles W. Flexner, Willem D.F. Venter, and Polly Clayden | drug–drug interactions
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2. Full Text The ADVANCE study: A groundbreaking trial to evaluate a candidate universal antiretroviral regimen
by Venter, Willem D.F and Clayden, Polly and Serenata, Celicia and OPTIMIZE Consortium
Current Opinion in HIV and AIDS, ISSN 1746-630X, 07/2017, Volume 12, Issue 4, pp. 351 - 354
Purpose of review Current WHO-recommended first-line therapy in low-income and middle-income countries has been very successful in saving millions of lives but... 
tenofovir alafenamide | dolutegravir | antiretrovirals | first-line | WHO | INFECTIOUS DISEASES | IMMUNOLOGY | Tenofovir - therapeutic use | Adenine - therapeutic use | Humans | Anti-HIV Agents - therapeutic use | HIV Infections - drug therapy | Drug Combinations | Randomized Controlled Trials as Topic | Index Medicus | AIDS/HIV | Edited by Charles W. Flexner, Willem D.F. Venter, and Polly Clayden | TOWARDS A UNIVERSAL ANTIRETROVIRAL REGIMEN
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3. Full Text Dolutegravir plus Two Different Prodrugs of Tenofovir to Treat HIV
by Venter, Willem D.F and Moorhouse, Michelle and Sokhela, Simiso and Fairlie, Lee and Mashabane, Nkuli and Masenya, Masebole and Serenata, Celicia and Akpomiemie, Godspower and Qavi, Ambar and Chandiwana, Nomathemba and Norris, Shane and Chersich, Matthew and Clayden, Polly and Abrams, Elaine and Arulappan, Natasha and Vos, Alinda and McCann, Kaitlyn and Simmons, Bryony and Hill, Andrew
The New England Journal of Medicine, ISSN 0028-4793, 08/2019, Volume 381, Issue 9, pp. 803 - 815
Treatment of HIV-1 infection in sub-Saharan Africa has many challenges. In this report, the safety and efficacy of three different regimens are assessed in... 
RISKS | MEDICINE, GENERAL & INTERNAL | OBESITY | EFFICACY | RECOMMENDATIONS | PROGRAMS | GUIDELINES | EFAVIRENZ | ADULTS | ANTIRETROVIRAL THERAPY | INFECTION | Treatment outcome | Drug therapy | HIV infection | Analysis
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4. Full Text Paediatric overview, IAS 2009
by Clayden, Polly
Southern African Journal of HIV Medicine, ISSN 1608-9693, 12/2009, Volume 10, Issue 4, p. 91
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5. Full Text The transition to dolutegravir and other new antiretrovirals in low-income and middle-income countries: what are the issues?
by Vitoria, Marco and Hill, Andrew and Ford, Nathan and Doherty, Meg and Clayden, Polly and Venter, Francois and Ripin, David and Flexner, Charles and Domanico, Paul L
AIDS, ISSN 0269-9370, 07/2018, Volume 32, Issue 12, pp. 1551 - 1561
There are currently approximately 16 million people taking NNRTI-based first-line treatment in low-income and middle-income countries. Most of these patients... 
Tenofovir | Nucleoside analogues | Lamivudine | Drug resistance | Efavirenz | Zidovudine | Dolutegravir | INFECTIOUS DISEASES | zidovudine | ONCE-DAILY DOLUTEGRAVIR | tenofovir | NON-INFERIORITY TRIAL | INITIAL TREATMENT | OPEN-LABEL | dolutegravir | DRUG-RESISTANCE | IMMUNOLOGY | TENOFOVIR ALAFENAMIDE | PHASE 3B | VIROLOGY | NAIVE PATIENTS | nucleoside analogues | DOUBLE-BLIND | drug resistance | HIV-1 INFECTION | efavirenz | lamivudine | Antiviral agents | Analysis | Clinical trials | Economic aspects | Dosage and administration | Research
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6. Full Text Editorial introductions
by Flexner, Charles W and Francois Venter, Willem Daniel and Clayden, Polly
Current Opinion in HIV and AIDS, ISSN 1746-630X, 07/2017, Volume 12, Issue 4, pp. v - vi
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7. Full Text Towards a Universal Antiretroviral Regimen: Special Considerations of Pregnancy and Breast Feeding
by Slogrove, Amy L and Clayden, Polly and Abrams, Elaine J
Current opinion in HIV and AIDS, ISSN 1746-630X, 7/2017, Volume 12, Issue 4, pp. 359 - 368
vertical HIV transmission | HIV | optimized antiretroviral therapy | pregnancy and breast feeding
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8. Full Text Analysis of Pharmacovigilance Databases for Dolutegravir Safety in Pregnancy
by van De Ven, Nikolien S and Pozniak, Anton L and Levi, Jacob A and Clayden, Polly and Garratt, Anna and Redd, Christopher and Mofenson, Lynne M and Hill, Andrew
Clinical Infectious Diseases, ISSN 1058-4838, 10/2019
Abstract Background The Botswana Tsepamo study reported neural tube defects (NTDs) in 4 of 426 (0.94%) infants of women receiving preconception dolutegravir... 
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9. Full Text Paediatric overview, IAS2009
by Clayden, Polly
Southern African Journal of HIV Medicine, ISSN 1608-9693, 12/2009, Volume 10, Issue 4, p. 91
A wealth of paediatric data was presented at IAS 2009. Also preceding the conference was the 1st International Workshop on HIV Pediatrics, which looks as if it... 
Highly active antiretroviral therapy | Care and treatment | Usage | Distribution | Practice guidelines (Medicine) | HIV infection in children | Diagnosis | Research | Health aspects
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10. Full Text Paediatric overview, IAS2009
by Clayden, Polly
Southern African Journal of HIV Medicine, ISSN 1608-9693, 12/2009, Issue 36, pp. 91 - 96
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11. Full Text Inclusion of pregnant women in antiretroviral drug research: what is needed to move forwards?
by Fairlie, Lee and Waitt, Catriona and Lockman, Shahin and Moorhouse, Michelle and Abrams, Elaine J and Clayden, Polly and Boffito, Marta and Khoo, Saye and Rees, Helen and Cournil, Amandine and Venter, Willem Francois and Serenata, Celicia and Chersich, Matthew
Journal of the International AIDS Society, ISSN 1758-2652, 09/2019, Volume 22, Issue 9, pp. 1 - n/a
Introduction To adequately ascertain drug safety and efficacy, drug trials need to include participants from all groups likely to receive the medication... 
antiretroviral | drug dosing | HIV | pregnancy | teratogen | maternal health | child health | dolutegravir | birth defects | INFECTIOUS DISEASES | IN-UTERO EXPOSURE | SAFETY | IMMUNOLOGY | BIRTH OUTCOMES | HIV-INFECTED WOMEN | NEVIRAPINE PHARMACOKINETICS | THERAPY | 3RD TRIMESTER | CLINICAL-TRIALS | EFAVIRENZ | 1ST TRIMESTER | Prevention | Drugs | Pregnancy | Highly active antiretroviral therapy | Pregnant women | Birth defects | HIV (Viruses) | Efavirenz | Drug approval | Task forces | Breastfeeding & lactation | Fetuses | Clinical trials | Research | International organizations | Prescription drugs | Researchers | Surveillance | Womens health | Human immunodeficiency virus--HIV | Pharmaceutical industry | Drug dosages | Public health
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12. Full Text Starting infants on antiretroviral therapy
by Clayden, Polly
Southern African Journal of HIV Medicine, ISSN 1608-9693, 03/2009, Volume 9, Issue 4, p. 25
The most effective way to combat paediatric HIV infection is through good management of maternal health and prevention of mother-to-child transmission (PMTCT).... 
Infection | Highly active antiretroviral therapy | Pediatrics | Antiviral agents | Disease transmission | HIV (Viruses) | Drug therapy | Health aspects | HIV infection
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13. Full Text The Virus, Vitamins & Vegetables : The South African HIV / AIDS Mystery, Kerry Cullinan and Anso Thorn (Eds.) : book review
by Clayden, Polly
Southern African Journal of HIV Medicine, ISSN 2078-6751, 10/2009, Volume 10, Issue 3, p. 48
Political power and bad science is never a good combination. The Virus, Vitamins & Vegetables is a collection of essays that takes a look at the baffling... 
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14. Full Text Toward a universal antiretroviral regimen: special considerations of pregnancy and breast feeding
by Slogrove, Amy L and Clayden, Polly and Abrams, Elaine J
Current Opinion in HIV and AIDS, ISSN 1746-630X, 04/2017, Volume 12, Issue 4, pp. 359 - 368
PURPOSE OF REVIEWAs optimized antiretroviral therapy (ART) regimens are prepared for introduction in low-income and middle-income countries (LMIC), we consider... 
vertical HIV transmission | HIV | optimized antiretroviral therapy | pregnancy and breast feeding | SOUTH-AFRICA | IN-UTERO | INFECTIOUS DISEASES | EXPOSED UNINFECTED INFANTS | IMMUNOLOGY | RALTEGRAVIR PHARMACOKINETICS | BIRTH OUTCOMES | HIV-INFECTED WOMEN | TENOFOVIR DISOPROXIL FUMARATE | THERAPY | GROWTH OUTCOMES | TO-CHILD TRANSMISSION | Dose-Response Relationship, Drug | Pregnancy | HIV Infections - prevention & control | Humans | Breast Feeding | Anti-HIV Agents - therapeutic use | Female | HIV Infections - transmission | Clinical Trials as Topic | Pregnancy Complications, Infectious | Infectious Disease Transmission, Vertical - prevention & control
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15. Full Text Optimizing responses to drug safety signals in pregnancy: the example of dolutegravir and neural tube defects
by Mofenson, Lynne M and Pozniak, Anton L and Wambui, Jacque and Raizes, Elliot and Ciaranello, Andrea and Clayden, Polly and Ehrenkranz, Peter and Fakoya, Ade and Hill, Andrew and Khoo, Saye and Mahaka, Imelda and Modi, Surbhi and Moore, Cynthia and Phillips, Andrew and Siberry, George and Sikwese, Kenly and Thorne, Claire and Watts, Heather D and Doherty, Meg and Ford, Nathan P
Journal of the International AIDS Society, ISSN 1758-2652, 07/2019, Volume 22, Issue 7, pp. e25352 - n/a
Introduction The unexpected identification of a neural tube defect (NTD) safety signal with preconception dolutegravir (DTG) exposure in the Botswana Tsepamo... 
treatment | health systems | ARV | periconception | neural tube defects | pharmacovigilance | women | INFECTIOUS DISEASES | INCLUSION | IMMUNOLOGY | Regulatory agencies | Funding | Girls | Studies | Pregnancy | Surveillance | Womens health | Human immunodeficiency virus--HIV | Collaboration | Data collection | Pharmaceutical industry | Product safety | Drug therapy | Public health
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16. Full Text Why a universal antiretroviral regimen?
by Flexner, CW and Clayden, P and Venter, WDF
CURRENT OPINION IN HIV AND AIDS, ISSN 1746-630X, 07/2017, Volume 12, Issue 4, pp. 315 - 317
INFECTIOUS DISEASES | THERAPY | IMMUNOLOGY | Antiretroviral Therapy, Highly Active | HIV Infections | Anti-Retroviral Agents - therapeutic use | Global Health | Humans
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17. Full Text SAFETY OF ANTIRETROVIRALS IN PREGNANCY
by Clayden, P
SOUTHERN AFRICAN JOURNAL OF HIV MEDICINE, ISSN 1608-9693, 2009, Volume 10, Issue 33, pp. 15 - 18
Highly active antiretroviral therapy (HAART) of three or more drugs is used extensively in industrialised countries for pregnant women with HIV, both to treat... 
HIV-INFECTED WOMEN | INFECTIOUS DISEASES | UNITED-KINGDOM | THERAPY | IRELAND | VIROLOGY | INFANTS | DISEASE | PREVENTION | OUTCOMES | TO-CHILD TRANSMISSION | NEVIRAPINE | Drugs | Women | Antiviral agents | Safety and security measures | Infants | Research | Prevention | Pregnancy | Infection | Highly active antiretroviral therapy | Disease transmission | Pregnant women | Poisoning | Health aspects
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18. Full Text British HIV Association guidelines for the management of HIV infection in pregnant women 2012 (2014 interim review)
by de Ruiter, A and Taylor, GP and Clayden, P and Dhar, J and Gandhi, K and Gilleece, Y and Harding, K and Hay, P and Kennedy, J and Low-Beer, N and Lyall, H and Palfreeman, A and O'Shea, S and Tookey, P and Tosswill, J and Welch, S and Wilkins, E and British HIV Association
HIV Medicine, ISSN 1464-2662, 09/2014, Volume 15, Issue 4, pp. 1 - 77
SINGLE-DOSE NEVIRAPINE | INFECTIOUS DISEASES | SEXUALLY-TRANSMITTED-DISEASES | LOW-BIRTH-WEIGHT | FEMALE GENITAL-TRACT | ACTIVE ANTIRETROVIRAL THERAPY | HEPATITIS-C-VIRUS | PREVENT PERINATAL TRANSMISSION | HUMAN-IMMUNODEFICIENCY-VIRUS | TO-CHILD TRANSMISSION | MATERNAL-INFANT TRANSMISSION | Prevalence | Infant Formula | Pregnancy Complications, Infectious - epidemiology | AIDS-Related Opportunistic Infections - immunology | Humans | Maternal Health Services | Male | Pregnancy Complications, Infectious - immunology | Anti-HIV Agents - administration & dosage | Antiretroviral Therapy, Highly Active | Pregnancy | HIV Infections - immunology | AIDS-Related Opportunistic Infections - prevention & control | Delivery, Obstetric - methods | Societies, Medical | Pregnancy Complications, Infectious - drug therapy | Adult | Female | HIV Infections - drug therapy | HIV Infections - transmission | Post-Exposure Prophylaxis - utilization | Infectious Disease Transmission, Vertical - prevention & control | United Kingdom - epidemiology | Infant, Newborn | HIV (Viruses) | Pregnant women | HIV infection
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19. Full Text Paediatric European Network for Treatment of AIDS Treatment Guideline 2016 update: antiretroviral therapy recommended for all children living with HIV
by Foster, C and Bamford, A and Turkova, A and Welch, S and Klein, N and Burger, D.M and et al and PENTA Guidelines Writing Grp and PENTA Steering Comm and PENTA Guidelines Writing Group and PENTA steering committee and the PENTA Guidelines Writing Group and PENTA steering committee
Hiv Medicine, ISSN 1464-2662, 2017, Volume 18, Issue 2, pp. 133 - 134
INFECTIOUS DISEASES | INITIATION | Highly active antiretroviral therapy | Pediatrics | AIDS treatment | Practice guidelines (Medicine) | HIV patients | HIV (Viruses) | Drug therapy | Children | Acquired immune deficiency syndrome--AIDS | Antiretroviral agents | Human immunodeficiency virus--HIV | Antiretroviral therapy | Letter to the Editor
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20. Full Text HIV-1 viral load assays for resource-limited settings
by Fiscus, Susan A and Cheng, Ben and Crowe, Suzanne M and Demeter, Lisa and Jennings, Cheryl and Miller, Veronica and Respess, Richard and Stevens, Wendy and Balakrishnan, Pachamuthu and Branson, Bernie and Burgess, Deborah and Cabruja, Isabel and Clayden, Polly and Condliffe, Kate and Corrigan, Gary and De Baar, Michel and Downing, Robert and Ekong, Ernest and Fox, Larry and Gonsalves, Gregg and Guarinieri, Mauro and Guillerm, Martine and Hellmann, Nick and Kaplan, Jon and Lee, Helen and Lloyd, Robert and Major, Carol and Margherio, Lynn and Martinez-Picardo, Javier and Newman, Daniel and Peter, Trevor and Rayfield, Mark and Ridzon, Renee and De Wit, Tobias Rinke and Safrit, Jeff and Spacek, Lisa and Spira, Tom and Tamura, Kenji and Ussery, Michael and Valentine, Fred and Varnier, Oliviero and Ziermann, Rainer and Forum Collaborative HIV Res Altern and Forum for Collaborative HIV Research Alternative Viral Load Assay Working Group and and the Forum for Collaborative HIV Research Alternative Viral Load Assay Working Group
PLoS Medicine, ISSN 1549-1277, 10/2006, Volume 3, Issue 10, pp. 1743 - 1750
The authors discuss studies on the low-cost viral load assays that are currently available and their potential for use in resource-limited settings. 
REAL-TIME PCR | MEDICINE, GENERAL & INTERNAL | POLYMERASE-CHAIN-REACTION | REVERSE-TRANSCRIPTASE ACTIVITY | HEAT-DENATURED PLASMA | P24 ANTIGEN-ASSAY | TYPE-1 SUBTYPE-C | FILTER-PAPER | HUMAN-IMMUNODEFICIENCY-VIRUS | TO-CHILD TRANSMISSION | DRIED BLOOD SPOTS | Reagent Kits, Diagnostic - economics | Humans | RNA, Viral - blood | Developed Countries - economics | HIV Infections - enzymology | Polymerase Chain Reaction - economics | Viral Load | Polymerase Chain Reaction - methods | HIV Infections - immunology | Specimen Handling | HIV Infections - diagnosis | Sensitivity and Specificity | Female | HIV Infections - transmission | HIV Core Protein p24 - blood | Infant, Newborn | Anti-Retroviral Agents - therapeutic use | Developing Countries - economics | Maternal-Fetal Exchange | HIV Infections - virology | Treatment Outcome | HIV-1 - genetics | Pregnancy | HIV-1 - immunology | HIV Reverse Transcriptase - blood | HIV-1 - enzymology | Enzyme-Linked Immunosorbent Assay - economics | Prevention | Antiviral agents | Care and treatment | Dosage and administration | Research | HIV infection | Public Health | Research in Translation | HIV | Medicine in Developing Countries | Infectious Diseases | AIDS | Resource allocation and rationing | Health Policy | Epidemiology | Science Policy | HIV Infection
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