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1. Full Text Epigenetic Roles of MLL Oncoproteins Are Dependent on NF-κB
by Kuo, Hsu-Ping and Wang, Zhong and Lee, Dung-Fang and Iwasaki, Masayuki and Duque-Afonso, Jesus and Wong, Stephen H.K and Lin, Chiou-Hong and Figueroa, Maria E and Su, Jie and Lemischka, Ihor R and Cleary, Michael L
Cancer Cell, ISSN 1535-6108, 10/2013, Volume 24, Issue 4, pp. 423 - 437
MLL fusion proteins in leukemia induce aberrant transcriptional elongation and associated chromatin perturbations; however, the upstream signaling pathways and... 
GENE-EXPRESSION SIGNATURE | H3K79 METHYLATION | STEM-CELLS | ONCOLOGY | ACUTE LYMPHOBLASTIC-LEUKEMIA | TRANSCRIPTION ELONGATION | EMBRYONIC STEM | ACUTE MYELOID-LEUKEMIA | MIXED-LINEAGE LEUKEMIA | MLL-AF9-INDUCED LEUKEMOGENESIS | P-TEFB | CELL BIOLOGY | Chromatin - metabolism | Promoter Regions, Genetic | Myeloid-Lymphoid Leukemia Protein - metabolism | Prognosis | Signal Transduction | Cell Survival | Histone-Lysine N-Methyltransferase | Epigenesis, Genetic | Genomics | Humans | NF-kappa B - metabolism | Leukemia - metabolism | Gene Expression Regulation, Leukemic | Dose-Response Relationship, Drug | Animals | I-kappa B Kinase - metabolism | Myeloid-Lymphoid Leukemia Protein - physiology | Time Factors | Transcription Factor RelA - metabolism | Cell Line, Tumor | Transcription, Genetic | Mice | Leukemia - genetics | HOX | NF-κB | leukemia | MLL | MEIS
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2. Full Text A Randomized and Blinded Multicenter Trial of High-Dose Fluconazole plus Placebo versus Fluconazole plus Amphotericin B as Therapy for Candidemia and Its Consequences in Nonneutropenic Subjects
by John H. Rex and Peter G. Pappas and Adolf W. Karchmer and Jack Sobel and John E. Edwards and Susan Hadley and Corstiaan Brass and Jose A. Vazquez and Stanley W. Chapman and Harold W. Horowitz and Marcus Zervos and David McKinsey and Jeannette Lee and Timothy Babinchak and Robert W. Bradsher and John D. Cleary and David M. Cohen and Larry Danziger and Mitchell Goldman and Jesse Goodman and Eileen Hilton and Newton E. Hyslop and Daniel H. Kett and Jon Lutz and Robert H. Rubin and W. Michael Scheld and Mindy Schuster and Bryan Simmons and David K. Stein and Ronald G. Washburn and Linda Mautner and Teng-Chiao Chu and Helene Panzer and Rebecca B. Rosenstein and Jenia Booth and Natl Inst Allergy Infectious Dis M and National Institute of Allergy and Infectious Diseases Mycoses Study Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group
Clinical Infectious Diseases, ISSN 1058-4838, 5/2003, Volume 36, Issue 10, pp. 1221 - 1228
A randomized, blinded, multicenter trial was conducted to compare fluconazole (800 mg per day) plus placebo with fluconazole plus amphotericin B (AmB)... 
Antifungals | Logistic regression | Infectious diseases | Major Articles | Placebos | Cultural groups | Infections | Candidemia | Dosage | Blood | Catheters | CANDIDIASIS | INFECTIOUS DISEASES | MICROBIOLOGY | INFECTIONS | IMMUNOLOGY | CLINICAL-TRIALS | Fungemia - physiopathology | Antifungal Agents - adverse effects | Catheterization | Double-Blind Method | Candidiasis - physiopathology | Humans | Middle Aged | Fluconazole - adverse effects | Male | Treatment Outcome | Fluconazole - therapeutic use | Antifungal Agents - therapeutic use | Amphotericin B - adverse effects | Neutropenia - etiology | Candidiasis - drug therapy | Fungemia - drug therapy | Adult | Female | Candida - drug effects | Amphotericin B - therapeutic use | Drug Therapy, Combination | Evaluation | Candidiasis | Dosage and administration | Amphotericin B | Fluconazole | Drug therapy
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3. Full Text NFκB signaling in alveolar rhabdomyosarcoma
by Cleary, Megan M and Mansoor, Atiya and Settelmeyer, Teagan and Ijiri, Yuichi and Ladner, Katherine J and Svalina, Matthew N and Rubin, Brian P and Guttridge, Denis C and Keller, Charles
DMM Disease Models and Mechanisms, ISSN 1754-8403, 09/2017, Volume 10, Issue 9, pp. 1109 - 1115
Alveolar rhabdomyosarcoma (aRMS) is a pediatric soft tissue cancer commonly associated with a chromosomal translocation that leads to the expression of a... 
IKKβ | NFκB | Rhabdomyosarcoma | Cancer | CHILDHOOD RHABDOMYOSARCOMA | ACTIVATION | TISSUE SARCOMA COMMITTEE | CYCLIN D1 | PHOSPHORYLATION | PATHOLOGY | CHILDRENS ONCOLOGY GROUP | CELL BIOLOGY | IKK beta | PATHWAY | SKELETAL MYOGENESIS | MICE | NF kappa B | PANCREATIC-CANCER CELLS | Humans | NF-kappa B - metabolism | Mice, SCID | Allografts - drug effects | Genetic Complementation Test | Peptides - pharmacology | Proto-Oncogene Proteins c-bcl-2 - metabolism | Phenotype | Animals | I-kappa B Kinase - metabolism | Rhabdomyosarcoma, Alveolar - metabolism | Signal Transduction - drug effects | Gene Deletion | Dogs | Cell Line, Tumor | Female | Rhabdomyosarcoma, Alveolar - pathology | Cell Proliferation - drug effects | 304
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4. Full Text In pursuit of control and elimination: Update on hepatitis A and B epidemiology and prevention strategies
by Chi, Victoria and Cleary, Shannon and Bocchini, Joseph A
Current Opinion in Pediatrics, ISSN 1040-8703, 2018, Volume 30, Issue 5, pp. 689 - 697
Purpose of review This review describes the impact of recommendations for routine immunization of infants and children against hepatitis A and hepatitis B, the... 
Vaccine | Hepatitis A | Hepatitis B | UNITED-STATES | VIRUS-INFECTION | PERINATAL TRANSMISSION | hepatitis A | hepatitis B | COMMUNITY-WIDE OUTBREAK | ADULT-POPULATIONS | IMMUNIZATION | vaccine | IMPACT | ADOLESCENTS | PEDIATRICS | VACCINATION COVERAGE | SEMIDRIED TOMATOES | Prevention | Pediatrics | Vaccination | Management | Methods
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5. Full Text Progress toward the Total Synthesis of N‑Methylwelwitindolinone B Isothiocyanate
by Cleary, Leah and Pitzen, Jennifer and Brailsford, John A and Shea, Kenneth J
Organic Letters, ISSN 1523-7060, 09/2014, Volume 16, Issue 17, pp. 4460 - 4463
Progress toward the welwitindolinone alkaloid N-methylwelwitindolinone B isothiocyanate is reported. A key reaction to synthesize the [4.3.1] bicycle embedded... 
CONSTRUCTION | ESTERS | CHEMISTRY | CHEMISTRY, ORGANIC | WELWISTATIN | FISCHERINDOLES | EFFICIENT | C ISOTHIOCYANATE | OXIDIZED WELWITINDOLINONES | ALKALOIDS | SKELETON | Molecular Structure | Indole Alkaloids - chemical synthesis | Indole Alkaloids - chemistry | Cyanobacteria - chemistry
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6. Full Text Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth
by Baell, Jonathan B and Leaver, David J and Hermans, Stefan J and Kelly, Gemma L and Brennan, Margs S and Downer, Natalie L and Nguyen, Nghi and Wichmann, Johannes and McRae, Helen M and Yang, Yuqing and Cleary, Ben and Lagiakos, H. Rachel and Mieruszynski, Stephen and Pacini, Guido and Vanyai, Hannah K and Bergamasco, Maria I and May, Rose E and Davey, Bethany K and Morgan, Kimberly J and Sealey, Andrew J and Wang, Beinan and Zamudio, Natasha and Wilcox, Stephen and Garnham, Alexandra L and Sheikh, Bilal N and Aubrey, Brandon J and Doggett, Karen and Chung, Matthew C and de Silva, Melanie and Bentley, John and Pilling, Pat and Hattarki, Meghan and Dolezal, Olan and Dennis, Matthew L and Falk, Hendrik and Ren, Bin and Charman, Susan A and White, Karen L and Rautela, Jai and Newbold, Andrea and Hawkins, Edwin D and Johnstone, Ricky W and Huntington, Nicholas D and Peat, Thomas S and Heath, Joan K and Strasser, Andreas and Parker, Michael W and Smyth, Gordon K and Street, Ian P and Monahan, Brendon J and Voss, Anne K and Thomas, Tim
Nature, ISSN 0028-0836, 08/2018, Volume 560, Issue 7717, pp. 253 - 257
Acetylation of histones by lysine acetyltransferases (KATs) is essential for chromatin organization and function(1). Among the genes coding for the MYST family... 
MAINTENANCE | PROTEIN | RAS | MULTIDISCIPLINARY SCIENCES | HEMATOPOIETIC STEM-CELLS | GENE-EXPRESSION | MOZ | CYCLE PROGRESSION | P16(INK4A) | FAMILY | P53 | Histone Acetyltransferases - deficiency | Histones - chemistry | Cellular Senescence - drug effects | Histone Acetyltransferases - genetics | Male | Benzenesulfonates - therapeutic use | Benzenesulfonates - pharmacology | Lymphoma - drug therapy | Fibroblasts | Lymphoma - enzymology | Lymphoma - pathology | Lysine - metabolism | Gene Expression Regulation, Neoplastic - drug effects | Hydrazines - pharmacology | Hydrazines - therapeutic use | Mice, Inbred C57BL | Cells, Cultured | Lymphoma - genetics | Models, Molecular | Sulfonamides - pharmacology | Acetylation - drug effects | Animals | Sulfonamides - therapeutic use | Histone Acetyltransferases - antagonists & inhibitors | Cell Proliferation - drug effects | Mice | Drug Development | Histones - metabolism | Lysine - chemistry | Analysis | Transferases | Oncology, Experimental | Histones | Physiological aspects | Acetylation | Research | Gene expression | Tumors | Cancer | Chromatin | Senescence | Transcription | Leukemia | DNA damage | Hepatocellular carcinoma | Myc protein | Drug development | Proteins | Cell cycle | Coenzyme A | Cyclin-dependent kinase inhibitors | Deoxyribonucleic acid--DNA | Zebrafish | INK4 protein | Bioavailability | Lymphoma | Suppressors | Chromosome translocations | Inhibitors | Lysine | Stem cells | Lymphomas | Kinetics
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7. Full Text Inhibition of precursor B-cell malignancy progression by toll-like receptor ligand-induced immune responses
by Fidanza, M and Seif, A.E and Demicco, A and Rolf, N and Jo, S and Yin, B and Li, Y and Barrett, D.M and Duque-Afonso, J and Cleary, M.L and Bassing, C.H and Grupp, S.A and Reid, G.S.D
Leukemia, ISSN 0887-6924, 10/2016, Volume 30, Issue 10, pp. 2116 - 2119
EVOLUTION | ONCOLOGY | ACUTE LYMPHOBLASTIC-LEUKEMIA | INFECTION | BIRTH | HEMATOLOGY | MU-RET MOUSE | CHILDREN | Genetically modified mice | Pediatrics | Care and treatment | Immune response | Analysis | Acute lymphocytic leukemia | Management | B cells | Research
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8. Full Text Voriconazole versus a regimen of amphotericin B followed by fluconazole for candidaemia in non-neutropenic patients: a randomised non-inferiority trial
by Kullberg, BJ and Sobel, JD and Ruhnke, M and Pappas, PG and Viscoli, C and Rex, JH and Cleary, JD and Rubinstein, E and Church, LWP and Brown, JM and Schlamm, HT and Oborska, IT and Hilton, F and Hodges, MR
The Lancet, ISSN 0140-6736, 2005, Volume 366, Issue 9495, pp. 1435 - 1442
Voriconazole has proven efficacy against invasive aspergillosis and oesophageal candidiasis. This multicentre, randomised, non-inferiority study compared... 
MULTICENTER TRIAL | MEDICINE, GENERAL & INTERNAL | INVASIVE ASPERGILLOSIS | INTERNATIONAL SURVEILLANCE | CANDIDEMIA | THERAPY | IN-VITRO ACTIVITIES | CANDIDIASIS | AGENTS | BLOOD-STREAM INFECTIONS | FUNGAL-INFECTIONS | Triazoles - adverse effects | Antifungal Agents - adverse effects | Humans | Middle Aged | Fluconazole - adverse effects | Male | Fluconazole - therapeutic use | Antifungal Agents - therapeutic use | Candidiasis - drug therapy | Voriconazole | Aged, 80 and over | Adult | Female | Drug Therapy, Combination | Triazoles - therapeutic use | Candidiasis - mortality | Treatment Outcome | Amphotericin B - adverse effects | Candidiasis - classification | Pyrimidines - therapeutic use | Adolescent | Pyrimidines - adverse effects | Aged | Amphotericin B - therapeutic use | APACHE | Evaluation | Candidiasis | Dosage and administration | Amphotericin B | Fluconazole | Drug therapy | Research | Comparative analysis | Fungi | Prescription drugs | Infections | Medical treatment | Blood | Pharmaceuticals
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9. Full Text Estrogen alters thresholds for B cell apoptosis and activation
by Grimaldi, Christine M and Cleary, James and Selma Dagtas, A and Moussai, Dariush and Diamond, Betty
Journal of Clinical Investigation, ISSN 0021-9738, 2002, Volume 109, Issue 12, pp. 1625 - 1633
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10. Full Text The Nuclear Factor-κB RelA Transcription Factor Is Constitutively Activated in Human Pancreatic Adenocarcinoma Cells
by Weixin Wang and James L. Abbruzzese and Douglas B. Evans and Lillie Larry and Karen R. Cleary and Paul J. Chiao
Clinical Cancer Research, ISSN 1078-0432, 01/1999, Volume 5, Issue 1, pp. 119 - 127
Pancreatic adenocarcinoma is a leading cause of adult cancer mortality in the United States. Recent studies have revealed that point mutation of the K- ras... 
TRANSFORMATION | PREOPERATIVE CHEMORADIATION | KINASE COMPLEX | ONCOGENE | ONCOLOGY | INDUCED APOPTOSIS | RAS | PHOSPHORYLATION | ALPHA | EXPRESSION | CANCER | Immunohistochemistry | Amino Acid Sequence | Cricetinae | Pancreatic Neoplasms - metabolism | DNA, Neoplasm - metabolism | Humans | Gene Expression Regulation, Neoplastic | Molecular Sequence Data | Transcription Factor RelA | NF-kappa B - metabolism | Pancreatic Neoplasms - genetics | Point Mutation | Adenocarcinoma - metabolism | Animals | Mesocricetus | Adult | Adenocarcinoma - genetics | Tumor Cells, Cultured | Genes, ras
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11. Full Text Estrogen alters thresholds for B cell apoptosis and activation
by Grimaldi, CM and Cleary, J and Dagtas, AS and Moussai, D and Diamond, B
JOURNAL OF CLINICAL INVESTIGATION, ISSN 0021-9738, 06/2002, Volume 109, Issue 12, pp. 1625 - 1633
Estrogen is thought to contribute to the increased frequency of autoimmune disorders occurring in females, but a molecular basis for its effects on... 
BCL-2 TRANSGENE | MEDICINE, RESEARCH & EXPERIMENTAL | INHIBITS APOPTOSIS | SYSTEMIC LUPUS-ERYTHEMATOSUS | BONE-MARROW | NEGATIVE SELECTION | SEX STEROID REGULATION | GERMINAL CENTER | AUTOIMMUNE-DISEASE | RECEPTOR-ALPHA | CUTTING EDGE
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12. Full Text Observational Prospective Natural History of Patients with Sanfilippo Syndrome Type B
by Whitley, Chester B and Cleary, Maureen and Eugen Mengel, Karl and Harmatz, Paul and Shapiro, Elsa and Nestrasil, Igor and Haslett, Patrick and Whiteman, David and Alexanderian, David
The Journal of Pediatrics, ISSN 0022-3476, 06/2018, Volume 197, pp. 198 - 206.e2
To evaluate the natural course of disease progression in patients with Sanfilippo syndrome type B (mucopolysaccharidosis type IIIB), identify potential end... 
disease progression | biomarkers | prospective study | mucopolysaccharidosis type III B | DIAGNOSTIC-TEST | HETEROGENEITY | MUCOPOLYSACCHARIDOSIS TYPE IIIB | THERAPY | CLINICAL-TRIAL | QUANTIFICATION | PHENOTYPE | PEDIATRICS | CEREBROSPINAL-FLUID | GLYCOSAMINOGLYCAN | CHILDREN | Biomarkers - metabolism | Neurodevelopmental Disorders - epidemiology | Brain - diagnostic imaging | Prospective Studies | Humans | Child, Preschool | Infant | Male | Heparitin Sulfate - metabolism | Disease Progression | Mucopolysaccharidosis III - complications | Young Adult | Magnetic Resonance Imaging | Mucopolysaccharidosis III - diagnosis | Cerebrospinal Fluid - metabolism | Adolescent | Adult | Female | Child | Glycosaminoglycans - urine | Longitudinal Studies | Neurodevelopmental Disorders - etiology | Enzymes | Development and progression | Nervous system diseases | Infants | Child development | Sulfates
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13. Full Text Prolactin modulates the naive B cell repertoire
by Peeva, Elena and Michael, Daniel and Cleary, James and Rice, Jeffrey and Chen, Xian and Diamond, Betty
Journal of Clinical Investigation, ISSN 0021-9738, 01/2003, Volume 111, Issue 2, pp. 275 - 283
Prolactin is a peptide hormone produced by the anterior pituitary gland that is critical in lactation. Prolactin can also be produced by lymphocytes, and both... 
MEDICINE, RESEARCH & EXPERIMENTAL | SYSTEMIC-LUPUS-ERYTHEMATOSUS | SEX-HORMONES | HYPERPROLACTINEMIA | BROMOCRIPTINE | TOLERANCE | LYMPHOID-CELLS | AUTOIMMUNE-DISEASE | EXPRESSION | DISEASE-ACTIVITY | LYMPHOCYTES
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14. Full Text E2A-PBX1 remodels oncogenic signaling networks in B-cell precursor acute lymphoid leukemia
by Duque-Afonso, Jesús and Lin, Chiou-Hong and Han, Kyuho and Wei, Michael C and Feng, Jue and Kurzer, Jason H and Schneidawind, Corina and Wong, Stephen Hon-Kit and Bassik, Michael C and Cleary, Michael L
Cancer Research, ISSN 0008-5472, 12/2016, Volume 76, Issue 23, pp. 6937 - 6949
There is limited understanding of how signaling pathways are altered by oncogenic fusion transcription factors that drive leukemogenesis. To address this, we... 
KINASE INHIBITOR DASATINIB | ACTIVATION | SYK | ONCOLOGY | TYROSINE KINASE | ACUTE LYMPHOBLASTIC-LEUKEMIA | DISEASE | CHRONIC LYMPHOCYTIC-LEUKEMIA | MICE | ZAP-70 EXPRESSION | LCK GENE | Gene Expression | Oncogene Proteins, Fusion - metabolism | Signal Transduction | Homeodomain Proteins - metabolism | Humans | Mice, Transgenic | Homeodomain Proteins - genetics | Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics | Precursor Cell Lymphoblastic Leukemia-Lymphoma - metabolism | Animals | Oncogene Proteins, Fusion - genetics | Mice | B-Lymphocytes - metabolism | pre-BCR | signaling pathways | Acute lymphoblastic leukemia | genetic interactions | E2A-PBX1
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