NATURE COMMUNICATIONS, ISSN 2041-1723, 11/2019, Volume 10, Issue 1, pp. 1 - 9
The director field adopted by a confined liquid crystal is controlled by a balance between the externally imposed interactions and the liquid's internal...
TRANSITION | ENERGY | ALIGNMENT | MEMORY | FIELD | MULTIDISCIPLINARY SCIENCES | NEMATIC LIQUID-CRYSTALS | Deformation resistance | Crystals | Elasticity | Optoelectronic devices | Elastic properties | Liquid crystals | Anchoring
TRANSITION | ENERGY | ALIGNMENT | MEMORY | FIELD | MULTIDISCIPLINARY SCIENCES | NEMATIC LIQUID-CRYSTALS | Deformation resistance | Crystals | Elasticity | Optoelectronic devices | Elastic properties | Liquid crystals | Anchoring
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 11/2009, Volume 119, Issue 11, pp. 3408 - 3419
Smad4 is a central mediator of TGF-beta signaling, and its expression is downregulated or lost at the malignant stage in several cancer types. In this study,...
MEDICINE, RESEARCH & EXPERIMENTAL | TGF-BETA | EPITHELIAL-CELLS | SIGNALING PATHWAY | SQUAMOUS-CELL CARCINOMA | TUMOR-SUPPRESSOR GENE | SKIN | FANCONI ANEMIA/BRCA PATHWAY | KNOCKOUT MICE | EXPRESSION | T-CELLS | Rad51 Recombinase - metabolism | Carcinoma, Squamous Cell - genetics | Carcinoma, Squamous Cell - pathology | Down-Regulation | Humans | Mice, Inbred C57BL | Head and Neck Neoplasms - physiopathology | DNA Repair - genetics | Carcinoma, Squamous Cell - physiopathology | Smad4 Protein - metabolism | Head and Neck Neoplasms - pathology | Mice, Knockout | Fanconi Anemia Complementation Group Proteins - metabolism | Animals | Smad4 Protein - genetics | Gene Deletion | Inflammation - genetics | Head and Neck Neoplasms - genetics | Mice | Genes, BRCA1 | Genomic Instability - genetics | Inflammation - physiopathology | Usage | Care and treatment | Animal models in research | Physiological aspects | Head and neck cancer | Genetic aspects | Inflammation | Research | Transforming growth factors | Risk factors
MEDICINE, RESEARCH & EXPERIMENTAL | TGF-BETA | EPITHELIAL-CELLS | SIGNALING PATHWAY | SQUAMOUS-CELL CARCINOMA | TUMOR-SUPPRESSOR GENE | SKIN | FANCONI ANEMIA/BRCA PATHWAY | KNOCKOUT MICE | EXPRESSION | T-CELLS | Rad51 Recombinase - metabolism | Carcinoma, Squamous Cell - genetics | Carcinoma, Squamous Cell - pathology | Down-Regulation | Humans | Mice, Inbred C57BL | Head and Neck Neoplasms - physiopathology | DNA Repair - genetics | Carcinoma, Squamous Cell - physiopathology | Smad4 Protein - metabolism | Head and Neck Neoplasms - pathology | Mice, Knockout | Fanconi Anemia Complementation Group Proteins - metabolism | Animals | Smad4 Protein - genetics | Gene Deletion | Inflammation - genetics | Head and Neck Neoplasms - genetics | Mice | Genes, BRCA1 | Genomic Instability - genetics | Inflammation - physiopathology | Usage | Care and treatment | Animal models in research | Physiological aspects | Head and neck cancer | Genetic aspects | Inflammation | Research | Transforming growth factors | Risk factors
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 9/2015, Volume 112, Issue 35, pp. 10995 - 11000
Melanoma is difficult to treat once it becomes metastatic. However, the precise ancestral relationship between primary tumors and their metastases is not well...
Genetics | Melanoma | Metastasis | LYMPH-NODE DISSECTION | CELLS | MULTIDISCIPLINARY SCIENCES | PANCREATIC-CANCER | melanoma | BETA-CATENIN | genetics | EVOLUTION | INHIBITION | metastasis | SOMATIC POINT MUTATIONS | MM THICK MELANOMAS | CLINICAL-IMPLICATIONS | PROGRESSION | Neoplasm Metastasis | Melanoma - pathology | Phylogeny | Melanoma - genetics | Humans | Genetic aspects | Observations | Biological Sciences
Genetics | Melanoma | Metastasis | LYMPH-NODE DISSECTION | CELLS | MULTIDISCIPLINARY SCIENCES | PANCREATIC-CANCER | melanoma | BETA-CATENIN | genetics | EVOLUTION | INHIBITION | metastasis | SOMATIC POINT MUTATIONS | MM THICK MELANOMAS | CLINICAL-IMPLICATIONS | PROGRESSION | Neoplasm Metastasis | Melanoma - pathology | Phylogeny | Melanoma - genetics | Humans | Genetic aspects | Observations | Biological Sciences
Journal Article
Developmental Dynamics, ISSN 1058-8388, 11/2017, Volume 246, Issue 11, pp. 779 - 801
Background: Austrofundulus limnaeus is an annual killifish from the Maracaibo basin of Venezuela. Annual killifishes are unique among vertebrates in their...
mid‐blastula transition | diapause | emerging model organism | embryo | development | mid-blastula transition | ZYGOTIC TRANSITION | ANNUAL FISHES | ANATOMY & MORPHOLOGY | DEVELOPMENTAL BIOLOGY | EGGS | Fundulidae - growth & development | Animals | Developmental Biology - methods | Embryo, Nonmammalian | Killifishes - embryology | Models, Animal | Killifishes - growth & development | Gene-Environment Interaction | Fundulidae - embryology | Biological research | Embryonic development | Developmental biology | Analysis | Environmental aspects | Study and teaching | Biology, Experimental | Dormancy | Vertebrates | Embryogenesis | Developmental stages | Laboratories | Biological evolution | Diapause | Genomes | Biology | Fecundity | Embryos
mid‐blastula transition | diapause | emerging model organism | embryo | development | mid-blastula transition | ZYGOTIC TRANSITION | ANNUAL FISHES | ANATOMY & MORPHOLOGY | DEVELOPMENTAL BIOLOGY | EGGS | Fundulidae - growth & development | Animals | Developmental Biology - methods | Embryo, Nonmammalian | Killifishes - embryology | Models, Animal | Killifishes - growth & development | Gene-Environment Interaction | Fundulidae - embryology | Biological research | Embryonic development | Developmental biology | Analysis | Environmental aspects | Study and teaching | Biology, Experimental | Dormancy | Vertebrates | Embryogenesis | Developmental stages | Laboratories | Biological evolution | Diapause | Genomes | Biology | Fecundity | Embryos
Journal Article
STEM CELLS, ISSN 1066-5099, 04/2011, Volume 29, Issue 4, pp. 725 - 735
Tissue‐resident mesenchymal stem cells (MSCs) are important regulators of tissue repair or regeneration, fibrosis, inflammation, angiogenesis, and tumor...
Resident lung mesenchymal stem cells | Pulmonary fibrosis | Pulmonary hypertension | Stem cells | PROGENITOR CELLS | POPULATION | BONE-MARROW | INJURY | ADULT-MOUSE LUNG | CELL & TISSUE ENGINEERING | CELL BIOLOGY | ONCOLOGY | MARROW-DERIVED CELLS | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | MICE | ALLOGRAFTS | HEMATOLOGY | EXPRESSION | INDUCED PULMONARY-HYPERTENSION | Cell Proliferation | Mice, Inbred C57BL | Familial Primary Pulmonary Hypertension | Pulmonary Fibrosis - pathology | Bleomycin - adverse effects | Animals | T-Lymphocytes - cytology | Mesenchymal Stem Cells - cytology | Mesenchymal Stem Cells - drug effects | Polymerase Chain Reaction | Pulmonary Fibrosis - chemically induced | Bleomycin - pharmacology | Lung Injury | Mice | Hypertension, Pulmonary - pathology
Resident lung mesenchymal stem cells | Pulmonary fibrosis | Pulmonary hypertension | Stem cells | PROGENITOR CELLS | POPULATION | BONE-MARROW | INJURY | ADULT-MOUSE LUNG | CELL & TISSUE ENGINEERING | CELL BIOLOGY | ONCOLOGY | MARROW-DERIVED CELLS | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | MICE | ALLOGRAFTS | HEMATOLOGY | EXPRESSION | INDUCED PULMONARY-HYPERTENSION | Cell Proliferation | Mice, Inbred C57BL | Familial Primary Pulmonary Hypertension | Pulmonary Fibrosis - pathology | Bleomycin - adverse effects | Animals | T-Lymphocytes - cytology | Mesenchymal Stem Cells - cytology | Mesenchymal Stem Cells - drug effects | Polymerase Chain Reaction | Pulmonary Fibrosis - chemically induced | Bleomycin - pharmacology | Lung Injury | Mice | Hypertension, Pulmonary - pathology
Journal Article
The European Physical Journal C, ISSN 1434-6044, 10/2012, Volume 72, Issue 10, pp. 1 - 29
The discovery that the number of physically consistent string vacua is on the order of 10500 has prompted several statistical studies of string phenomenology....
Measurement Science and Instrumentation | Nuclear Physics, Heavy Ions, Hadrons | Nuclear Energy | Quantum Field Theories, String Theory | Physics | Astronomy, Astrophysics and Cosmology | Elementary Particles, Quantum Field Theory | STRING MODELS | MSSM | ABELIAN FLAT DIRECTIONS | SEARCH | STANDARD-LIKE MODEL | CONSTRUCTION | VACUA | PHYSICS, PARTICLES & FIELDS | Toy industry | Investigations | Phenomenology | Supersymmetry | Strings
Measurement Science and Instrumentation | Nuclear Physics, Heavy Ions, Hadrons | Nuclear Energy | Quantum Field Theories, String Theory | Physics | Astronomy, Astrophysics and Cosmology | Elementary Particles, Quantum Field Theory | STRING MODELS | MSSM | ABELIAN FLAT DIRECTIONS | SEARCH | STANDARD-LIKE MODEL | CONSTRUCTION | VACUA | PHYSICS, PARTICLES & FIELDS | Toy industry | Investigations | Phenomenology | Supersymmetry | Strings
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2005, Volume 102, Issue 29, pp. 10058 - 10063
The UV components of sunlight (UVA and UVB) are implicated in the etiology of human skin cancer. The underlying mechanism of action for UVB carcinogenicity is...
Biological Sciences | Exons | DNA | Genomics | DNA damage | Cephalopelvic disproportion | Fibroblasts | Irradiation | Genomes | Lesions | Radiation dosage | NORMAL HUMAN-SKIN | EXCISION-REPAIR | CYCLOBUTANE PYRIMIDINE DIMERS | SIMULATED SUNLIGHT | CELLULAR-DNA | BIPYRIMIDINE PHOTOPRODUCTS | MULTIDISCIPLINARY SCIENCES | SINGLET OXYGEN | WAVELENGTH DEPENDENCE | ULTRAVIOLET-RADIATION | MAMMALIAN-CELLS | Humans | Cells, Cultured | Immunoblotting | Chromatography, High Pressure Liquid | Genes, p53 - genetics | Polymerase Chain Reaction - methods | Pyrimidine Dimers - radiation effects | Ultraviolet Rays | Genes, p53 - radiation effects | Mass Spectrometry | DNA Repair Enzymes - metabolism | DNA Damage - genetics | Genome, Human | Dose-Response Relationship, Radiation | Ultraviolet radiation | Causes of | Sunshine | Research | Health aspects | Skin cancer
Biological Sciences | Exons | DNA | Genomics | DNA damage | Cephalopelvic disproportion | Fibroblasts | Irradiation | Genomes | Lesions | Radiation dosage | NORMAL HUMAN-SKIN | EXCISION-REPAIR | CYCLOBUTANE PYRIMIDINE DIMERS | SIMULATED SUNLIGHT | CELLULAR-DNA | BIPYRIMIDINE PHOTOPRODUCTS | MULTIDISCIPLINARY SCIENCES | SINGLET OXYGEN | WAVELENGTH DEPENDENCE | ULTRAVIOLET-RADIATION | MAMMALIAN-CELLS | Humans | Cells, Cultured | Immunoblotting | Chromatography, High Pressure Liquid | Genes, p53 - genetics | Polymerase Chain Reaction - methods | Pyrimidine Dimers - radiation effects | Ultraviolet Rays | Genes, p53 - radiation effects | Mass Spectrometry | DNA Repair Enzymes - metabolism | DNA Damage - genetics | Genome, Human | Dose-Response Relationship, Radiation | Ultraviolet radiation | Causes of | Sunshine | Research | Health aspects | Skin cancer
Journal Article
2005, ISBN 9780851998633, xv, 221
Book
Developmental Dynamics, ISSN 1058-8388, 11/2017, Volume 246, Issue 11, pp. 779 - 801
Journal Article
Oncogene, ISSN 0950-9232, 02/2016, Volume 35, Issue 5, pp. 577 - 586
Non-small-cell lung cancer (NSCLC) is a common malignancy with a poor prognosis. Despite progress targeting oncogenic drivers, there are no therapies targeting...
STEM-CELLS | ACTIVATION | ADENOCARCINOMA | BIOCHEMISTRY & MOLECULAR BIOLOGY | MOUSE | PTEN | BASAL-CELLS | CELL BIOLOGY | REPAIR | DISRUPTION | ONCOLOGY | GENETICS & HEREDITY | SQUAMOUS-CELL CARCINOMA | EXPRESSION | Carcinoma, Non-Small-Cell Lung - pathology | Lung Neoplasms - genetics | Lung Neoplasms - drug therapy | Carcinoma, Non-Small-Cell Lung - genetics | Humans | Lung Neoplasms - metabolism | Carcinoma, Non-Small-Cell Lung - metabolism | Lung Neoplasms - pathology | Smad4 Protein - metabolism | Gene Knockdown Techniques | Topoisomerase Inhibitors - pharmacology | Animals | Smad4 Protein - genetics | DNA Repair | Mice | Smad4 Protein - deficiency | Carcinoma, Non-Small-Cell Lung - drug therapy | Transcription factors | Oncology, Experimental | Genetic research | Development and progression | Genetic aspects | Research | Lung cancer, Non-small cell | Drug resistance | Health aspects | Cancer | Genotype & phenotype | Gene expression | DNA repair | Lung cancer | DNA damage | lung cancer | TGFβ | genotoxic stress | Smad4 | chemosensitivity
STEM-CELLS | ACTIVATION | ADENOCARCINOMA | BIOCHEMISTRY & MOLECULAR BIOLOGY | MOUSE | PTEN | BASAL-CELLS | CELL BIOLOGY | REPAIR | DISRUPTION | ONCOLOGY | GENETICS & HEREDITY | SQUAMOUS-CELL CARCINOMA | EXPRESSION | Carcinoma, Non-Small-Cell Lung - pathology | Lung Neoplasms - genetics | Lung Neoplasms - drug therapy | Carcinoma, Non-Small-Cell Lung - genetics | Humans | Lung Neoplasms - metabolism | Carcinoma, Non-Small-Cell Lung - metabolism | Lung Neoplasms - pathology | Smad4 Protein - metabolism | Gene Knockdown Techniques | Topoisomerase Inhibitors - pharmacology | Animals | Smad4 Protein - genetics | DNA Repair | Mice | Smad4 Protein - deficiency | Carcinoma, Non-Small-Cell Lung - drug therapy | Transcription factors | Oncology, Experimental | Genetic research | Development and progression | Genetic aspects | Research | Lung cancer, Non-small cell | Drug resistance | Health aspects | Cancer | Genotype & phenotype | Gene expression | DNA repair | Lung cancer | DNA damage | lung cancer | TGFβ | genotoxic stress | Smad4 | chemosensitivity
Journal Article
Molecular Carcinogenesis, ISSN 0899-1987, 10/2014, Volume 53, Issue 10, pp. 841 - 846
Lung adenocarcinoma (AdC) and lung squamous cell carcinoma (SCC) are the most common non‐small cell lung cancer (NSCLC) subtypes, however, most genetic mouse...
adenocarcinoma | Kras | non‐small cell lung cancer | squamous cell carcinoma | Adenocarcinoma | Squamous cell carcinoma | Non-small cell lung cancer | non-small cell lung cancer | MUTANT | BIOCHEMISTRY & MOLECULAR BIOLOGY | TUMOR-SUPPRESSOR GENE | CANCER | INACTIVATION | ORIGIN | ONCOLOGY | BRONCHIOALVEOLAR STEM-CELLS | MOUSE MODEL | II RECEPTOR | CARCINOMA | Lung Neoplasms - genetics | Neoplasms, Basal Cell - metabolism | PTEN Phosphohydrolase - genetics | PTEN Phosphohydrolase - deficiency | Carcinoma, Squamous Cell - genetics | Carcinoma, Squamous Cell - metabolism | Humans | Lung Neoplasms - metabolism | Mice, Inbred C57BL | Mice, Transgenic | Mutation, Missense | Neoplasms, Basal Cell - genetics | Animals | Gene Deletion | Mice | Proto-Oncogene Proteins p21(ras) - metabolism | Lung cancer, Non-small cell | Lung cancer | Tumorigenesis | Index Medicus
adenocarcinoma | Kras | non‐small cell lung cancer | squamous cell carcinoma | Adenocarcinoma | Squamous cell carcinoma | Non-small cell lung cancer | non-small cell lung cancer | MUTANT | BIOCHEMISTRY & MOLECULAR BIOLOGY | TUMOR-SUPPRESSOR GENE | CANCER | INACTIVATION | ORIGIN | ONCOLOGY | BRONCHIOALVEOLAR STEM-CELLS | MOUSE MODEL | II RECEPTOR | CARCINOMA | Lung Neoplasms - genetics | Neoplasms, Basal Cell - metabolism | PTEN Phosphohydrolase - genetics | PTEN Phosphohydrolase - deficiency | Carcinoma, Squamous Cell - genetics | Carcinoma, Squamous Cell - metabolism | Humans | Lung Neoplasms - metabolism | Mice, Inbred C57BL | Mice, Transgenic | Mutation, Missense | Neoplasms, Basal Cell - genetics | Animals | Gene Deletion | Mice | Proto-Oncogene Proteins p21(ras) - metabolism | Lung cancer, Non-small cell | Lung cancer | Tumorigenesis | Index Medicus
Journal Article
Physical Review E - Statistical, Nonlinear, and Soft Matter Physics, ISSN 1539-3755, 10/2012, Volume 86, Issue 4, p. 041707
A theoretical analysis is presented of a nematic liquid crystal confined between substrates patterned with squares that promote vertical and planar alignment....
STATES | SELF-ASSEMBLED MONOLAYERS | FILMS | CHEMICAL NANOPATTERNS | PHYSICS, FLUIDS & PLASMAS | SURFACE | POLAR ALIGNMENT | AZIMUTHAL | PHYSICS, MATHEMATICAL | Physics - Soft Condensed Matter
STATES | SELF-ASSEMBLED MONOLAYERS | FILMS | CHEMICAL NANOPATTERNS | PHYSICS, FLUIDS & PLASMAS | SURFACE | POLAR ALIGNMENT | AZIMUTHAL | PHYSICS, MATHEMATICAL | Physics - Soft Condensed Matter
Journal Article
Physical Review E - Statistical, Nonlinear, and Soft Matter Physics, ISSN 1539-3755, 10/2015, Volume 92, Issue 4, p. 042501
Due to elastic anisotropy, two-dimensional patterning of substrates can promote weak azimuthal alignment of adjacent nematic liquid crystals. Here we consider...
MICROPATTERNED SURFACE | ELASTICITY | TRANSITION | PATTERNED ALIGNMENT | CONTACT | DESIGN | SELF-ASSEMBLED-MONOLAYERS | BISTABILITY | PHYSICS, FLUIDS & PLASMAS | POLYMER | PLANAR | PHYSICS, MATHEMATICAL | Physics - Soft Condensed Matter
MICROPATTERNED SURFACE | ELASTICITY | TRANSITION | PATTERNED ALIGNMENT | CONTACT | DESIGN | SELF-ASSEMBLED-MONOLAYERS | BISTABILITY | PHYSICS, FLUIDS & PLASMAS | POLYMER | PLANAR | PHYSICS, MATHEMATICAL | Physics - Soft Condensed Matter
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 04/2012, Volume 18, Issue 8, pp. 2173 - 2183
Purpose: Lung adenocarcinoma and lung squamous cell carcinoma (SCC) are the most common non-small cell lung cancer (NSCLC) subtypes. This study was designed to...
DEFECTIVE EXPRESSION | HEAD | STEM-CELLS | TGF-BETA | METASTASIS | ONCOLOGY | HISTOLOGICAL TYPES | MICE | CANCER | MOUSE MODELS | BASAL-CELLS | Receptors, Transforming Growth Factor beta - genetics | Adenocarcinoma - pathology | Adenocarcinoma of Lung | Lung Neoplasms - mortality | Carcinoma, Squamous Cell - metabolism | Carcinoma, Squamous Cell - pathology | Humans | Lung Neoplasms - metabolism | Gene Expression Regulation, Neoplastic | Lung Neoplasms - pathology | Male | Adenocarcinoma - metabolism | Carcinoma, Squamous Cell - mortality | Receptor, Transforming Growth Factor-beta Type II | RNA Interference | Female | Protein-Serine-Threonine Kinases - metabolism | Carcinoma, Non-Small-Cell Lung - pathology | Neoplasm Invasiveness | RNA, Messenger - genetics | Carcinoma, Non-Small-Cell Lung - metabolism | Protein-Serine-Threonine Kinases - genetics | Mice, Transgenic | Carcinoma, Non-Small-Cell Lung - mortality | Animals | Receptors, Transforming Growth Factor beta - metabolism | Cell Line, Tumor | Mice | RNA, Small Interfering | Adenocarcinoma - mortality | Cell Movement | TGFβ | tumor progression | mouse model | lung squamous cell carcinoma | lung adenocarcinoma
DEFECTIVE EXPRESSION | HEAD | STEM-CELLS | TGF-BETA | METASTASIS | ONCOLOGY | HISTOLOGICAL TYPES | MICE | CANCER | MOUSE MODELS | BASAL-CELLS | Receptors, Transforming Growth Factor beta - genetics | Adenocarcinoma - pathology | Adenocarcinoma of Lung | Lung Neoplasms - mortality | Carcinoma, Squamous Cell - metabolism | Carcinoma, Squamous Cell - pathology | Humans | Lung Neoplasms - metabolism | Gene Expression Regulation, Neoplastic | Lung Neoplasms - pathology | Male | Adenocarcinoma - metabolism | Carcinoma, Squamous Cell - mortality | Receptor, Transforming Growth Factor-beta Type II | RNA Interference | Female | Protein-Serine-Threonine Kinases - metabolism | Carcinoma, Non-Small-Cell Lung - pathology | Neoplasm Invasiveness | RNA, Messenger - genetics | Carcinoma, Non-Small-Cell Lung - metabolism | Protein-Serine-Threonine Kinases - genetics | Mice, Transgenic | Carcinoma, Non-Small-Cell Lung - mortality | Animals | Receptors, Transforming Growth Factor beta - metabolism | Cell Line, Tumor | Mice | RNA, Small Interfering | Adenocarcinoma - mortality | Cell Movement | TGFβ | tumor progression | mouse model | lung squamous cell carcinoma | lung adenocarcinoma
Journal Article
International Journal of Modern Physics A, ISSN 0217-751X, 10/2011, Volume 26, Issue 25, pp. 4451 - 4473
Using Baylor University's C++ software for construction of weakly coupled free fermionic heterotic string models, called the FF Framework, we explicitly...
ten-dimensional | string vacuum landscape | redundancies | free fermionic | String phenomenology | MSSM | SEARCH | STANDARD-LIKE MODEL | CLASSIFICATION | PHYSICS, NUCLEAR | tendimensional | ABELIAN FLAT DIRECTIONS | VACUA | PHYSICS, PARTICLES & FIELDS | Layoffs
ten-dimensional | string vacuum landscape | redundancies | free fermionic | String phenomenology | MSSM | SEARCH | STANDARD-LIKE MODEL | CLASSIFICATION | PHYSICS, NUCLEAR | tendimensional | ABELIAN FLAT DIRECTIONS | VACUA | PHYSICS, PARTICLES & FIELDS | Layoffs
Journal Article