Oncogene, ISSN 0950-9232, 01/2014, Volume 33, Issue 5, pp. 556 - 566
Retinoblastoma (Rb) protein is a tumor suppressor that is dysregulated in a majority of human cancers. Rb functions to inhibit cell cycle progression in part...
Metabolism | Cancer | Glutamine | Retinoblastoma Protein | Tumor Suppressor | retinoblastoma protein | APOPTOSIS | PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | G CONTROL | tumor suppressor | CELL-PROLIFERATION | FACTOR-I | glutamine | CELL BIOLOGY | GLYCOLYSIS | INHIBITION | ONCOLOGY | GENETICS & HEREDITY | metabolism | cancer | GROWTH-FACTOR | ENERGY-METABOLISM | Cell Proliferation | Reactive Oxygen Species - metabolism | Glutamate-Cysteine Ligase - biosynthesis | Minor Histocompatibility Antigens | Glutamine - metabolism | Retinoblastoma-Like Protein p107 - genetics | Adenosine Triphosphate - biosynthesis | Oxygen - metabolism | Glutathione - biosynthesis | RNA Interference | Retinoblastoma-Like Protein p130 - metabolism | Fibroblasts | Biological Transport - genetics | Amino Acid Transport System ASC - genetics | Ketoglutaric Acids - metabolism | Glutaminase - biosynthesis | Promoter Regions, Genetic | Retinoblastoma-Like Protein p107 - metabolism | Retinoblastoma Protein - metabolism | Cells, Cultured | Amino Acid Transport System ASC - metabolism | Glutaminase - metabolism | Mice, Knockout | Animals | E2F3 Transcription Factor - biosynthesis | Cell Cycle | Retinoblastoma Protein - genetics | E2F3 Transcription Factor - metabolism | Mice | RNA, Small Interfering | Retinoblastoma-Like Protein p130 - genetics | Amino Acid Transport System ASC - biosynthesis | Glutaminase - genetics | Oncology, Experimental | Physiological aspects | Genetic research | Tumor suppressor genes | Genetic aspects | Research | Studies | Oncology | Tumors
Metabolism | Cancer | Glutamine | Retinoblastoma Protein | Tumor Suppressor | retinoblastoma protein | APOPTOSIS | PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | G CONTROL | tumor suppressor | CELL-PROLIFERATION | FACTOR-I | glutamine | CELL BIOLOGY | GLYCOLYSIS | INHIBITION | ONCOLOGY | GENETICS & HEREDITY | metabolism | cancer | GROWTH-FACTOR | ENERGY-METABOLISM | Cell Proliferation | Reactive Oxygen Species - metabolism | Glutamate-Cysteine Ligase - biosynthesis | Minor Histocompatibility Antigens | Glutamine - metabolism | Retinoblastoma-Like Protein p107 - genetics | Adenosine Triphosphate - biosynthesis | Oxygen - metabolism | Glutathione - biosynthesis | RNA Interference | Retinoblastoma-Like Protein p130 - metabolism | Fibroblasts | Biological Transport - genetics | Amino Acid Transport System ASC - genetics | Ketoglutaric Acids - metabolism | Glutaminase - biosynthesis | Promoter Regions, Genetic | Retinoblastoma-Like Protein p107 - metabolism | Retinoblastoma Protein - metabolism | Cells, Cultured | Amino Acid Transport System ASC - metabolism | Glutaminase - metabolism | Mice, Knockout | Animals | E2F3 Transcription Factor - biosynthesis | Cell Cycle | Retinoblastoma Protein - genetics | E2F3 Transcription Factor - metabolism | Mice | RNA, Small Interfering | Retinoblastoma-Like Protein p130 - genetics | Amino Acid Transport System ASC - biosynthesis | Glutaminase - genetics | Oncology, Experimental | Physiological aspects | Genetic research | Tumor suppressor genes | Genetic aspects | Research | Studies | Oncology | Tumors
Journal Article
QJM, ISSN 1460-2725, 2016, Volume 109, Issue 6, pp. 367 - 372
Glucose and glutamine metabolismin cancer cells are markedly elevated relative to non-transformed normal cells. This metabolic reprogramming enables the...
TRIAL | APOPTOSIS | MEDICINE, GENERAL & INTERNAL | INHIBITION | STRATEGY | 6-PHOSPHOFRUCTO-2-KINASE PFKFB3 | GROWTH | MCT1 | GLUTAMINE-METABOLISM | VEMURAFENIB | Neoplasms - metabolism | Humans | Neoplasms - enzymology | Tumor Microenvironment | Antineoplastic Agents - therapeutic use | Neoplasms - drug therapy | Oxidative Phosphorylation - drug effects | Molecular Targeted Therapy - trends | Drug Design | Biomarkers, Tumor - metabolism | Antineoplastic Agents - pharmacology | Cell Proliferation - drug effects | Cell Transformation, Neoplastic - drug effects | Gene Expression Regulation, Neoplastic - drug effects | Energy Metabolism - drug effects | Review
TRIAL | APOPTOSIS | MEDICINE, GENERAL & INTERNAL | INHIBITION | STRATEGY | 6-PHOSPHOFRUCTO-2-KINASE PFKFB3 | GROWTH | MCT1 | GLUTAMINE-METABOLISM | VEMURAFENIB | Neoplasms - metabolism | Humans | Neoplasms - enzymology | Tumor Microenvironment | Antineoplastic Agents - therapeutic use | Neoplasms - drug therapy | Oxidative Phosphorylation - drug effects | Molecular Targeted Therapy - trends | Drug Design | Biomarkers, Tumor - metabolism | Antineoplastic Agents - pharmacology | Cell Proliferation - drug effects | Cell Transformation, Neoplastic - drug effects | Gene Expression Regulation, Neoplastic - drug effects | Energy Metabolism - drug effects | Review
Journal Article
Cell Death and Disease, ISSN 2041-4889, 2014, Volume 5, Issue 7, pp. e1337 - e1337
The control of glucose metabolism and the cell cycle must be coordinated in order to guarantee sufficient ATP and anabolic substrates at distinct phases of the...
OVEREXPRESSION | HUMAN BRAIN | APC/C-CDH1 | KINASE | 6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE | PROLIFERATION | DECREASES GLYCOLYSIS | FRUCTOSE 2,6-BISPHOSPHATE | CANCER | P27(KIP1) | CELL BIOLOGY | CDC2 Protein Kinase - genetics | Phosphorylation | Down-Regulation | Humans | Cell Nucleus - enzymology | CDC2 Protein Kinase - metabolism | Cyclin-Dependent Kinase Inhibitor p27 - metabolism | Cell Nucleus - metabolism | Phosphofructokinase-2 - metabolism | Cell Cycle | Cell Nucleus - genetics | Phosphofructokinase-2 - genetics | Apoptosis | Cyclin-Dependent Kinase Inhibitor p27 - genetics | Original
OVEREXPRESSION | HUMAN BRAIN | APC/C-CDH1 | KINASE | 6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE | PROLIFERATION | DECREASES GLYCOLYSIS | FRUCTOSE 2,6-BISPHOSPHATE | CANCER | P27(KIP1) | CELL BIOLOGY | CDC2 Protein Kinase - genetics | Phosphorylation | Down-Regulation | Humans | Cell Nucleus - enzymology | CDC2 Protein Kinase - metabolism | Cyclin-Dependent Kinase Inhibitor p27 - metabolism | Cell Nucleus - metabolism | Phosphofructokinase-2 - metabolism | Cell Cycle | Cell Nucleus - genetics | Phosphofructokinase-2 - genetics | Apoptosis | Cyclin-Dependent Kinase Inhibitor p27 - genetics | Original
Journal Article
Oncogene, ISSN 0950-9232, 07/2011, Volume 30, Issue 30, pp. 3370 - 3380
Choline kinase-alpha expression and activity are increased in multiple human neoplasms as a result of growth factor stimulation and activation of...
metabolism | in silico | phosphocholine | chemotherapy | choline kinase | RAS ACTIVATION | PHOSPHOLIPASE-D | BIOCHEMISTRY & MOLECULAR BIOLOGY | BREAST-CANCER-CELLS | CELL BIOLOGY | ONCOLOGY | PROSTATE-CANCER | GROWTH-FACTORS | GENETICS & HEREDITY | RAF-1 | PHOSPHATIDIC-ACID | INHIBITORS | PHOSPHATIDYLCHOLINE | P-31 | Choline Kinase - metabolism | Humans | Actins - metabolism | Acetamides - pharmacology | Phosphatidylinositol 3-Kinases - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | Choline Kinase - chemistry | Female | Cell Membrane - metabolism | Phosphorylation - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Cell Membrane - drug effects | Choline Kinase - antagonists & inhibitors | Proto-Oncogene Proteins p21(ras) - metabolism | Computational Biology | Enzyme Inhibitors - pharmacology | Models, Molecular | Phosphorylcholine - metabolism | Triazoles - pharmacology | Xenograft Model Antitumor Assays | Animals | MAP Kinase Signaling System - drug effects | Protein Conformation | Cell Proliferation - drug effects | Mice | HeLa Cells | Mitogen-Activated Protein Kinases - metabolism | Choline Kinase | In silico | Chemotherapy | Metabolism | Phosphocholine
metabolism | in silico | phosphocholine | chemotherapy | choline kinase | RAS ACTIVATION | PHOSPHOLIPASE-D | BIOCHEMISTRY & MOLECULAR BIOLOGY | BREAST-CANCER-CELLS | CELL BIOLOGY | ONCOLOGY | PROSTATE-CANCER | GROWTH-FACTORS | GENETICS & HEREDITY | RAF-1 | PHOSPHATIDIC-ACID | INHIBITORS | PHOSPHATIDYLCHOLINE | P-31 | Choline Kinase - metabolism | Humans | Actins - metabolism | Acetamides - pharmacology | Phosphatidylinositol 3-Kinases - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | Choline Kinase - chemistry | Female | Cell Membrane - metabolism | Phosphorylation - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Cell Membrane - drug effects | Choline Kinase - antagonists & inhibitors | Proto-Oncogene Proteins p21(ras) - metabolism | Computational Biology | Enzyme Inhibitors - pharmacology | Models, Molecular | Phosphorylcholine - metabolism | Triazoles - pharmacology | Xenograft Model Antitumor Assays | Animals | MAP Kinase Signaling System - drug effects | Protein Conformation | Cell Proliferation - drug effects | Mice | HeLa Cells | Mitogen-Activated Protein Kinases - metabolism | Choline Kinase | In silico | Chemotherapy | Metabolism | Phosphocholine
Journal Article
5.
Full Text
Observation of an Unusual Upward-Going Cosmic-Ray-like Event in the Third Flight of ANITA
Physical Review Letters, ISSN 0031-9007, 10/2018, Volume 121, Issue 16, p. 161102
We report on an upward traveling, radio-detected cosmic-ray-like impulsive event with characteristics closely matching an extensive air shower. This event,...
ENERGY | SHOWERS | AIR | PHYSICS, MULTIDISCIPLINARY | EMISSION | Physics - High Energy Astrophysical Phenomena | ASTRONOMY AND ASTROPHYSICS | PHYSICS OF ELEMENTARY PARTICLES AND FIELDS | extrasolar neutrino astronomy | cosmic ray & astroparticle detectors | cosmic rays & astroparticles | particle astrophysics
ENERGY | SHOWERS | AIR | PHYSICS, MULTIDISCIPLINARY | EMISSION | Physics - High Energy Astrophysical Phenomena | ASTRONOMY AND ASTROPHYSICS | PHYSICS OF ELEMENTARY PARTICLES AND FIELDS | extrasolar neutrino astronomy | cosmic ray & astroparticle detectors | cosmic rays & astroparticles | particle astrophysics
Journal Article
Physical Review Letters, ISSN 0031-9007, 08/2016, Volume 117, Issue 7, p. 071101
We report on four radio-detected cosmic-ray (CR) or CR-like events observed with the Antarctic Impulsive Transient Antenna (ANITA), a NASA-sponsored...
AIR-SHOWERS | ENERGY | RADIO-EMISSION | PHYSICS, MULTIDISCIPLINARY | Origins | Decay | Antarctica | Air showers | Earth surface | Cross sections | Antennas | Payloads | Physics - High Energy Astrophysical Phenomena
AIR-SHOWERS | ENERGY | RADIO-EMISSION | PHYSICS, MULTIDISCIPLINARY | Origins | Decay | Antarctica | Air showers | Earth surface | Cross sections | Antennas | Payloads | Physics - High Energy Astrophysical Phenomena
Journal Article
Astroparticle Physics, ISSN 0927-6505, 04/2016, Volume 77, Issue C, pp. 32 - 43
The first flight of the Antarctic Impulsive Transient Antenna (ANITA) experiment recorded 16 radio signals that were emitted by cosmic-ray induced air showers....
Radio detection | Cosmic rays | Air shower | INDUCED AIR-SHOWERS | DETECTOR | ATMOSPHERIC SHOWERS | TELESCOPE ARRAY EXPERIMENT | PULSES | COREAS SIMULATIONS | ASTRONOMY & ASTROPHYSICS | LOPES MEASUREMENTS | REAS 3.11 | SURFACE | RADIO-EMISSION | PHYSICS, PARTICLES & FIELDS | Measurement | Monte Carlo method | Monte Carlo methods | Computer simulation | Deflection | Flux | Antarctica | Air showers | Estimates | ASTRONOMY AND ASTROPHYSICS | ASTRO | Astrophysics
Radio detection | Cosmic rays | Air shower | INDUCED AIR-SHOWERS | DETECTOR | ATMOSPHERIC SHOWERS | TELESCOPE ARRAY EXPERIMENT | PULSES | COREAS SIMULATIONS | ASTRONOMY & ASTROPHYSICS | LOPES MEASUREMENTS | REAS 3.11 | SURFACE | RADIO-EMISSION | PHYSICS, PARTICLES & FIELDS | Measurement | Monte Carlo method | Monte Carlo methods | Computer simulation | Deflection | Flux | Antarctica | Air showers | Estimates | ASTRONOMY AND ASTROPHYSICS | ASTRO | Astrophysics
Journal Article
Nuclear Inst. and Methods in Physics Research, A, ISSN 0168-9002, 02/2019, Volume 918, Issue C, pp. 60 - 66
The NASA supported High-Altitude Calibration (HiCal)-2 instrument flew as a companion balloon to the ANITA-4 experiment in December 2016. Based on a...
High-voltage | Radio | Antarctica | Ice properties | Pulser | Pulse | INSTRUMENTS & INSTRUMENTATION | NUCLEAR SCIENCE & TECHNOLOGY | PHYSICS, NUCLEAR | PHYSICS, PARTICLES & FIELDS | Arctic research | Astronomy | INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND TECHNOLOGY
High-voltage | Radio | Antarctica | Ice properties | Pulser | Pulse | INSTRUMENTS & INSTRUMENTATION | NUCLEAR SCIENCE & TECHNOLOGY | PHYSICS, NUCLEAR | PHYSICS, PARTICLES & FIELDS | Arctic research | Astronomy | INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND TECHNOLOGY
Journal Article
Nuclear Inst. and Methods in Physics Research, A, ISSN 0168-9002, 06/2018, Volume 894, pp. 47 - 56
The Antarctic Impulsive Transient Antenna (ANITA) is a NASA long-duration balloon experiment with the primary goal of detecting ultra-high-energy ( ) neutrinos...
Ultra-high-energy | Neutrino radio detection | Military communications satellites | Notch filtering | INSTRUMENTS & INSTRUMENTATION | NUCLEAR SCIENCE & TECHNOLOGY | PHYSICS, NUCLEAR | PHYSICS, PARTICLES & FIELDS | Physics - Instrumentation and Methods for Astrophysics
Ultra-high-energy | Neutrino radio detection | Military communications satellites | Notch filtering | INSTRUMENTS & INSTRUMENTATION | NUCLEAR SCIENCE & TECHNOLOGY | PHYSICS, NUCLEAR | PHYSICS, PARTICLES & FIELDS | Physics - Instrumentation and Methods for Astrophysics
Journal Article
Physical Review Letters, ISSN 0031-9007, 04/2016, Volume 116, Issue 14, p. 141103
For 50 years, cosmic-ray air showers have been detected by their radio emission. We present the first laboratory measurements that validate electrodynamics...
NEUTRINO DETECTION | ENERGY | PHYSICS, MULTIDISCIPLINARY | COREAS | LOFAR | CODALEMA | SIMULATIONS | RADIATION | CHARGE | MHZ | PULSES | Radio emission | Particle beams | Computer simulation | Linearity | Cascades | Air showers | Magnetic fields | Charged particles | Astrophysics, Experiment-HEP,ASTRO, HEPEX
NEUTRINO DETECTION | ENERGY | PHYSICS, MULTIDISCIPLINARY | COREAS | LOFAR | CODALEMA | SIMULATIONS | RADIATION | CHARGE | MHZ | PULSES | Radio emission | Particle beams | Computer simulation | Linearity | Cascades | Air showers | Magnetic fields | Charged particles | Astrophysics, Experiment-HEP,ASTRO, HEPEX
Journal Article
JOURNAL OF INSTRUMENTATION, ISSN 1748-0221, 08/2019, Volume 14, Issue 8, pp. P08011 - P08011
A Monte Carlo simulation program for the radio detection of Ultra High Energy (UHE) neutrino interactions in the Antarctic ice as viewed by the Antarctic...
INSTRUMENTS & INSTRUMENTATION | Simulation methods and programs | Particle detectors | SHOWERS | THICKNESS | Neutrino detectors | Balloon instrumentation | Physics - Instrumentation and Methods for Astrophysics
INSTRUMENTS & INSTRUMENTATION | Simulation methods and programs | Particle detectors | SHOWERS | THICKNESS | Neutrino detectors | Balloon instrumentation | Physics - Instrumentation and Methods for Astrophysics
Journal Article
Oncogene, ISSN 0950-9232, 07/2011, Volume 30, Issue 30, p. 3370
Choline kinase-[alpha] expression and activity are increased in multiple human neoplasms as a result of growth factor stimulation and activation of...
Care and treatment | Choline | Physiological aspects | Genetic aspects | Research | Gene expression | Cancer | Mitogen-activated protein kinases | Proteins | Oncology | Chemotherapy | Kinases | Molecular biology | Metabolism
Care and treatment | Choline | Physiological aspects | Genetic aspects | Research | Gene expression | Cancer | Mitogen-activated protein kinases | Proteins | Oncology | Chemotherapy | Kinases | Molecular biology | Metabolism
Journal Article
Journal of Astronomical Instrumentation, ISSN 2251-1717, 06/2017, Volume 6, Issue 2
The primary science goal of the NASA-sponsored ANITA project is measurement of ultra-high energy neutrinos and cosmic rays, observed via radio-frequency...
instrumentation: detectors | instrumentation: interferometers | Balloons | Radio waves | Radio signals | Beams (radiation) | Terrestrial environments | Clutter | Cosmic rays | Radar clutter | Mathematical analysis | Polar environments | Neutrinos | Receivers & amplifiers | Radar | Energy measurement | Surface roughness | Wave reflection | Surveys | Satellites | Systematic errors | Incidence angle | Signal reflection | Angle of reflection | Curvature | Antennas | Antenna arrays | Reflectance
instrumentation: detectors | instrumentation: interferometers | Balloons | Radio waves | Radio signals | Beams (radiation) | Terrestrial environments | Clutter | Cosmic rays | Radar clutter | Mathematical analysis | Polar environments | Neutrinos | Receivers & amplifiers | Radar | Energy measurement | Surface roughness | Wave reflection | Surveys | Satellites | Systematic errors | Incidence angle | Signal reflection | Angle of reflection | Curvature | Antennas | Antenna arrays | Reflectance
Journal Article
Physical Review D, ISSN 2470-0010, 07/2018, Volume 98, Issue 2
The Antarctic Impulsive Transient Antenna, a NASA long-duration balloon payload, searches for radio emission from interactions of ultrahigh-energy neutrinos in...
ASTRONOMY & ASTROPHYSICS | PHYSICS, PARTICLES & FIELDS | cosmic ray sources | ASTRONOMY AND ASTROPHYSICS | extrasolar neutrino astronomy | OTHER INSTRUMENTATION | cosmic ray composition and spectra
ASTRONOMY & ASTROPHYSICS | PHYSICS, PARTICLES & FIELDS | cosmic ray sources | ASTRONOMY AND ASTROPHYSICS | extrasolar neutrino astronomy | OTHER INSTRUMENTATION | cosmic ray composition and spectra
Journal Article
Proceedings of Science, 2017
Conference Proceeding