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science & technology (65) 65
life sciences & biomedicine (50) 50
humans (44) 44
animals (27) 27
ethanol - toxicity (18) 18
biological and medical sciences (17) 17
ethanol - metabolism (15) 15
hepatocytes - drug effects (15) 15
medical sciences (15) 15
toxicology (14) 14
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alcohol dehydrogenase - metabolism (13) 13
cell line (13) 13
physical sciences (13) 13
ethanol (12) 12
gastroenterology & hepatology (12) 12
hep g2 cells (12) 12
hepatocytes - metabolism (12) 12
oxidative stress (12) 12
oxidative stress - drug effects (12) 12
rats (12) 12
acetaldehyde (11) 11
biochemistry & molecular biology (11) 11
reactive oxygen species - metabolism (11) 11
apoptosis - drug effects (10) 10
mice (10) 10
pharmacology & pharmacy (10) 10
acetaldehyde - metabolism (9) 9
alcohol dehydrogenase (8) 8
alcohol dehydrogenase - genetics (8) 8
cell line, tumor (8) 8
cell survival - drug effects (8) 8
chemistry (8) 8
cytochrome p-450 cyp2e1 - metabolism (8) 8
ethanol - pharmacology (8) 8
physiological aspects (8) 8
alcoholic pancreatitis (7) 7
alcoholism and acute alcohol poisoning (7) 7
astronomy & astrophysics (7) 7
cytochrome p-450 (7) 7
cytochrome p-450 cyp2e1 - genetics (7) 7
ethanol metabolism (7) 7
liver (7) 7
liver diseases (7) 7
male (7) 7
mice, inbred c57bl (7) 7
alcoholic liver disease (6) 6
analysis (6) 6
apoptosis (6) 6
oxidation-reduction (6) 6
pyrazoles - pharmacology (6) 6
substance abuse (6) 6
alcohol dehydrogenase - biosynthesis (5) 5
alcohol, denatured (5) 5
alcoholism (5) 5
antioxidants - pharmacology (5) 5
central nervous system depressants - toxicity (5) 5
cyp2e1 (5) 5
cytochrome p450 2e1 (5) 5
ethanol - administration & dosage (5) 5
glutathione - metabolism (5) 5
liver - enzymology (5) 5
proteins (5) 5
tumor cells, cultured (5) 5
alcoholic fatty liver (4) 4
biophysics (4) 4
carcinoma, hepatocellular (4) 4
carcinoma, hepatocellular - metabolism (4) 4
cell research (4) 4
exact sciences and technology (4) 4
female (4) 4
gastroenterology. liver. pancreas. abdomen (4) 4
hepatocytes - enzymology (4) 4
hepatocytes - pathology (4) 4
interferon-gamma - pharmacology (4) 4
liver - cytology (4) 4
liver - drug effects (4) 4
malondialdehyde - metabolism (4) 4
pancreatitis (4) 4
physics - solar and stellar astrophysics (4) 4
rats, sprague-dawley (4) 4
recombinant proteins - metabolism (4) 4
stars: oscillations (4) 4
technology (4) 4
transfection (4) 4
abridged index medicus (3) 3
acetaldehyde - toxicity (3) 3
acute pancreatitis (3) 3
alcohol dehydrogenase - antagonists & inhibitors (3) 3
astrophysics (3) 3
biology (3) 3
cdc2 protein kinase - metabolism (3) 3
cell biology (3) 3
cell cycle (3) 3
cell division - drug effects (3) 3
cells, cultured (3) 3
central nervous system depressants - metabolism (3) 3
cyclin-dependent kinases (3) 3
cytochrome p-450 cyp2e1 - biosynthesis (3) 3
cytochrome p450 family 2 (3) 3
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1. Full Text Mucin-1 is required for Coxsackie Virus B3-induced inflammation in pancreatitis
by Liu, Xiang and Clemens, Dahn L and Grunkemeyer, James A and Price, Jeffrey D and O'Connell, Kelly and Chapman, Nora M and Storz, Peter and Wen, Haitao and Cox, Jesse L and Reid, Whitney L and Hollingsworth, Michael A and Thayer, Sarah
Scientific reports, ISSN 2045-2322, 07/2019, Volume 9, Issue 1, pp. 10656 - 11
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | CC chemokine receptors | NF-κB protein | Leukocyte migration | Intercellular adhesion molecule 1 | Pancreatitis | Inflammation | Macrophages | VLA-4 antigen | Metastases | Mucin | CCR2 protein | Pancreatic cancer | Bone marrow | Monocyte chemoattractant protein 1 | Index Medicus
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2. Full Text Novel antioxidant properties of doxycycline
by Clemens, Dahn L and Clemens, Dahn L and Duryee, Michael J and Duryee, Michael J and Sarmiento, Cleofes and Chiou, Andrew and McGowan, Jacob D and Hunter, Carlos D and Hunter, Carlos D and Schlichte, Sarah L and Tian, Jun and Tian, Jun and Klassen, Lynell W and Klassen, Lynell W and O’dell, James R and O'Dell, James R and Thiele, Geoffrey M and Thiele, Geoffrey M and Mikuls, Ted R and Mikuls, Ted R and Zimmerman, Matthew C and Zimmerman, Matthew C and Anderson, Daniel R and Anderson, Daniel R
International journal of molecular sciences, ISSN 1661-6596, 2018, Volume 19, Issue 12, p. 4078
Oxidative stress | Post transnational modification | Electron paramagnetic resonance | Anti-oxidant | Doxycycline | Biochemistry & Molecular Biology | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Chemistry, Multidisciplinary | Science & Technology | Free Radical Scavengers - pharmacology | Malondialdehyde - metabolism | Doxycycline - chemistry | Free Radical Scavengers - chemistry | Humans | Malondialdehyde - chemistry | Superoxides - chemistry | Hydrogen Peroxide - metabolism | Hydrogen Peroxide - chemistry | Inflammation - metabolism | Cell-Free System | Inflammation - drug therapy | NF-E2-Related Factor 2 - metabolism | HEK293 Cells | Superoxides - metabolism | Doxycycline - pharmacology | Oxidative Stress - drug effects | Index Medicus | post transnational modification | anti-oxidant | electron paramagnetic resonance | doxycycline | oxidative stress
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3. Full Text Inhibition of CYP2E1 leads to decreased malondialdehyde–acetaldehyde adduct formation in VL-17A cells under chronic alcohol exposure
by Swaminathan, Kavitha and Clemens, Dahn L and Dey, Aparajita
Life sciences (1973), ISSN 0024-3205, 03/2013, Volume 92, Issue 6-7, pp. 325 - 336
Aldehyde-adducts | Alcohol | CYP2E1 | Liver cells | Pharmacology & Pharmacy | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Alcohol Dehydrogenase - biosynthesis | Malondialdehyde - metabolism | Cell Line | Cell Survival - drug effects | Acetaldehyde - metabolism | Reactive Oxygen Species - metabolism | Cytochrome P-450 CYP2E1 Inhibitors | Drug Administration Schedule | Ethanol - toxicity | Apoptosis - drug effects | Humans | Alcohol Dehydrogenase - antagonists & inhibitors | Caspase 3 - metabolism | Enzyme Inhibitors - pharmacology | Ethanol - administration & dosage | Allyl Compounds - pharmacology | Hep G2 Cells | Cytochrome P-450 CYP2E1 - biosynthesis | Pyrazoles - pharmacology | Sulfides - pharmacology | Life insurance | Cytochrome P-450 | Acetaldehyde | Index Medicus
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4. Full Text Effects of ethanol on hepatic cellular replication and cell cycle progression
by Clemens, Dahn L
World journal of gastroenterology : WJG, ISSN 1007-9327, 10/2007, Volume 13, Issue 37, pp. 4955 - 4959
Cyclin-dependent kinases | Ethanol metabolism | Liver regeneration | Cell cycle | Acetaldehyde | Alcoholic liver disease | Gastroenterology & Hepatology | Life Sciences & Biomedicine | Science & Technology | Central Nervous System Depressants - pharmacology | Liver Diseases, Alcoholic - pathology | Ethanol - pharmacology | Liver - drug effects | Humans | Cell Proliferation - drug effects | Liver - cytology | Cell Cycle - drug effects | Index Medicus | Topic Highlight
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5. Full Text Retinoid regulation of antiviral innate immunity in hepatocytes
by Cho, Noell E and Bang, Bo‐Ram and Gurung, Purnima and Li, Meng and Clemens, Dahn L and Underhill, T. Michael and James, Laura P and Chase, Jenifer R and Saito, Takeshi
Hepatology (Baltimore, Md.), ISSN 0270-9139, 06/2016, Volume 63, Issue 6, pp. 1783 - 1795
Gastroenterology & Hepatology | Life Sciences & Biomedicine | Science & Technology | Liver Failure - etiology | Cell Line | Ethanol - metabolism | Humans | Mice, Inbred C57BL | Gene Expression Regulation | Hepatitis C, Chronic - complications | Hepatocytes - metabolism | Hepatocytes - immunology | Immunity, Innate | Vitamin A - metabolism | Animals | Ethanol - adverse effects | Liver Diseases, Alcoholic - complications | Alcohol | Liver diseases | Dehydrogenases | Liver | Rodents | Index Medicus
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6. Full Text Multilevel regulation of autophagosome content by ethanol oxidation in HepG2 cells
by Thomes, Paul G and Ehlers, Rebecca A and Trambly, Casey S and Clemens, Dahn L and Fox, Howard S and Tuma, Dean J and Donohue, Jr, Terrence M
Autophagy, ISSN 1554-8627, 01/2013, Volume 9, Issue 1, pp. 63 - 73
oxidant stress | alcohol dehydrogenase | autophagy | cytochrome P450 2E1 | acetaldehyde | lysosome | Binding | Proteins | Landes | Calcium | Bioscience | Biology | Cell | Cycle | Cancer | Organogenesis | Alcohol dehydrogenase | Autophagy | Oxidant stress | Cytochrome P450 2E1 | Lysosome | Acetaldehyde | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Ethanol - metabolism | Lysosome-Associated Membrane Glycoproteins - metabolism | Ethanol - toxicity | Glutathione - analogs & derivatives | Microtubule-Associated Proteins - genetics | Oxidation-Reduction | Microtubule-Associated Proteins - metabolism | Humans | Phagosomes - metabolism | RNA, Messenger - genetics | Autophagy - physiology | Hepatocytes - metabolism | RNA, Messenger - metabolism | Vacuoles - drug effects | Autophagy - drug effects | Hep G2 Cells | Glutathione - pharmacology | Models, Biological | Vacuoles - metabolism | Acetaldehyde - pharmacology | Hepatocytes - drug effects | Phagosomes - drug effects | Pyrazoles - pharmacology | Index Medicus | Basic Research Paper
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7. Full Text Alcoholic pancreatitis:Lessons from the liver
by Dahn L Clemens Katrina J Mahan
World journal of gastroenterology : WJG, ISSN 1007-9327, 2010, Volume 16, Issue 11, pp. 1314 - 1320
Stellate cells | Alcohol metabolism | Fibrosis | Alcoholic pancreatitis | Gastroenterology & Hepatology | Life Sciences & Biomedicine | Science & Technology | Acute Disease | Liver - pathology | Ethanol - metabolism | Pancreas - physiopathology | Ethanol - toxicity | Humans | Pancreas - cytology | Pancreas - pathology | Pancreatitis, Chronic - physiopathology | Pancreatitis, Alcoholic - physiopathology | Liver - physiopathology | Regeneration - physiology | Pancreatitis, Chronic - pathology | Animals | Cell Death - physiology | Pancreatitis, Alcoholic - pathology | Liver - cytology | Central Nervous System Depressants - toxicity | Central Nervous System Depressants - metabolism | Pancreatitis, Alcoholic - etiology | Index Medicus | Topic Highlight
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8. Full Text Autophagy Reduces Acute Ethanol-Induced Hepatotoxicity and Steatosis in Mice
by Ding, Wen–Xing and Li, Min and Chen, Xiaoyun and Ni, Hong–Min and Lin, Chih–Wen and Gao, Wentao and Lu, Binfeng and Stolz, Donna B and Clemens, Dahn L and Yin, Xiao–Ming
Gastroenterology (New York, N.Y. 1943), ISSN 0016-5085, 2010, Volume 139, Issue 5, pp. 1740 - 1752
Gastroenterology and Hepatology | GFP-LC3 | Long-Lived Protein Degradation | Bodipy Staining | Autophagy Flux | Gastroenterology & Hepatology | Life Sciences & Biomedicine | Science & Technology | Cell Line | Acute Disease | Reactive Oxygen Species - metabolism | Ethanol - toxicity | Fatty Liver, Alcoholic - etiology | Mice, Inbred C57BL | Hepatocytes - pathology | Male | Mice, Transgenic | Autophagy - physiology | Hepatocytes - metabolism | Fatty Liver, Alcoholic - metabolism | Disease Progression | Animals | Mice | Fatty Liver, Alcoholic - pathology | Hepatocytes - drug effects | Disease Models, Animal | Liver diseases | RNA | Proteolysis | Alcoholism | Cytochrome P-450 | Acetylcysteine | Phospholipids | Index Medicus | Abridged Index Medicus | bodipy staining | long-lived protein degradation | autophagy flux
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9. Full Text GSH protects against oxidative stress and toxicity in VL-17A cells exposed to high glucose
by Kumar, S Mathan and Kumar, S Mathan and Swaminathan, Kavitha and Swaminathan, Kavitha and Clemens, Dahn L and Clemens, Dahn L and Dey, Aparajita and Dey, Aparajita
European journal of nutrition, ISSN 1436-6207, 3/2015, Volume 54, Issue 2, pp. 223 - 234
Chemistry | Hyperglycemia | Reactive oxygen species | Nutrition | Liver | Injury | Glutathione | Life Sciences & Biomedicine | Nutrition & Dietetics | Science & Technology | Buthionine Sulfoximine - pharmacology | Maleates - pharmacology | Reactive Oxygen Species - metabolism | Apoptosis - drug effects | Glutathione - metabolism | Humans | Acetylcysteine - metabolism | Cytochrome P-450 CYP2E1 - genetics | Cytochrome P-450 CYP2E1 - metabolism | Hepatocytes - metabolism | Clone Cells | Hepatocytes - drug effects | Antimetabolites - pharmacology | Alcohol Dehydrogenase - metabolism | Recombinant Proteins - metabolism | Cell Survival - drug effects | Glucose - adverse effects | Lactoylglutathione Lyase - metabolism | Glutathione - antagonists & inhibitors | Antioxidants - pharmacology | Hep G2 Cells | Hyperglycemia - metabolism | Ursodeoxycholic Acid - pharmacology | Reactive Oxygen Species - antagonists & inhibitors | Alcohol Dehydrogenase - genetics | Oxidative Stress - drug effects | Oxidative stress | Glucose metabolism | Cysteine | Thiols | Analysis | Ursodiol | Glucose | Dextrose | Index Medicus
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10. Full Text Hepatic mitochondrial dysfunction induced by fatty acids and ethanol
by Gyamfi, Daniel and Everitt, Hannah E and Tewfik, Ihab and Clemens, Dahn L and Patel, Vinood B
Free radical biology & medicine, ISSN 0891-5849, 12/2012, Volume 53, Issue 11, pp. 2131 - 2145
Alcohol | Mitochondria | Free radicals | Membrane potential | Fatty acids | Biochemistry & Molecular Biology | Endocrinology & Metabolism | Life Sciences & Biomedicine | Science & Technology | L-Lactate Dehydrogenase - metabolism | Palmitic Acid - pharmacology | Reactive Oxygen Species - metabolism | Uncoupling Agents - pharmacology | Oxidative Stress | Rats, Wistar | Mitochondria, Liver - metabolism | Humans | Male | Adenosine Diphosphate - physiology | Mitochondria, Liver - physiology | Membrane Potential, Mitochondrial | Rotenone - pharmacology | Cell Survival - drug effects | Fatty Liver - metabolism | Oxidation-Reduction | Oxygen Consumption | Rats | Triglycerides - metabolism | Ethanol - pharmacology | Animals | Energy Metabolism | Succinic Acid - pharmacology | Arachidonic Acid - pharmacology | Arachidonic Acid - physiology | Cell Line, Tumor | Niacinamide | Purines | Obesity | Unsaturated fatty acids | Alcohol, Denatured | Mitochondrial DNA | Cyanides | Liver cirrhosis | Saturated fatty acids | Hospitals, Veterans | Index Medicus
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11. Full Text Direct antioxidant properties of methotrexate: Inhibition of malondialdehyde-acetaldehyde-protein adduct formation and superoxide scavenging
by Zimmerman, Matthew C and Clemens, Dahn L and Duryee, Michael J and Sarmiento, Cleofes and Chiou, Andrew and Hunter, Carlos D and Tian, Jun and Klassen, Lynell W and O'Dell, James R and Thiele, Geoffrey M and Mikuls, Ted R and Anderson, Daniel R
Redox biology, ISSN 2213-2317, 10/2017, Volume 13, Issue C, pp. 588 - 593
Electron Paramagnetic Resonance (EPR) Spectroscopy | Superoxide | Malondialdehyde-Acetaldehyde (MAA) Adducts | Methotrexate | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Free Radical Scavengers - pharmacology | Malondialdehyde - metabolism | Methotrexate - pharmacology | Cell Survival - drug effects | Acetaldehyde - metabolism | Signal Transduction - drug effects | Albumins - metabolism | Humans | NF-E2-Related Factor 2 - metabolism | HEK293 Cells | Superoxides - metabolism | Protein Binding | Index Medicus
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