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Biophysical Journal, ISSN 0006-3495, 02/2018, Volume 114, Issue 3, pp. 177a - 178a
Journal Article
Cell Reports, ISSN 2211-1247, 09/2019, Volume 28, Issue 10, pp. 2509 - 2516.e5
V-domain immunoglobulin (Ig) suppressor of T cell activation (VISTA) is an immune checkpoint protein that inhibits the T cell response against cancer. Similar... 
IGSF11 | VISTA | PD-1H | cancer immunotherapy | high resolution crystal structure | VSIG3 | B7-H5 | yeast display | epitope mapping | checkpoint inhibitor | ANTIBODIES | THERAPY | IMMUNE-CHECKPOINT | LIGANDS | AFFINITY | CONSTRUCTION | PROTEINS | YEAST SURFACE DISPLAY | EXPRESSION | CELL BIOLOGY
Journal Article
Nature Medicine, ISSN 1078-8956, 11/2019, Volume 25, Issue 11, pp. 1783 - 1795
Proinflammatory cytokines in the tumor microenvironment can promote tumor growth, yet their value as therapeutic targets remains underexploited. We validated... 
Adenocarcinoma | Animal models | Cytokines | Therapeutic applications | Guanosine | Xenotransplantation | Inflammation | Ciliary neurotrophic factor | Anticancer properties | Signaling | Fc receptors | Lungs | Xenografts | Antitumor activity | Genetic engineering | Mutation | Tumors
Journal Article
Structure, ISSN 0969-2126, 09/2019, Volume 27, Issue 9, pp. 1443 - 1451.e6
Targeting both integrins αVβ3 and α5β1 simultaneously appears to be more effective in cancer therapy than targeting each one alone. The structural requirements... 
protein crystallography | cancer therapy | integrins | NMR | cell adhesion | cancer diagnosis | conformational flexibility | receptors/structure-function | molecular dynamics
Journal Article
Methods in Molecular Biology, ISSN 1064-3745, 2015, Volume 1319, pp. 155 - 175
Journal Article
Angewandte Chemie International Edition, ISSN 1433-7851, 08/2016, Volume 55, Issue 34, pp. 9796 - 9796
A knottin miniprotein first isolated from the seeds of the squirting cucumber has been engineered to bind selectively to tumor‐associated integrin receptors.... 
peptides | integrins | drug delivery | knottins | antitumor agents
Journal Article
Structure, ISSN 0969-2126, 09/2019, Volume 27, Issue 9, p. 1443
Targeting both integrins [alpha]V[beta]3 and [alpha]5[beta]1 simultaneously appears to be more effective in cancer therapy than targeting each one alone. The... 
Molecular dynamics | Integrins | Promiscuity
Journal Article
Nucleic acids research, 04/2017, Volume 45, Issue 7, p. 3615
Our understanding of translation underpins our capacity to engineer living systems. The canonical start codon (AUG) and a few near-cognates (GUG, UUG) are... 
Codon | Escherichia coli - genetics | Plasmids - genetics | Green Fluorescent Proteins - genetics | Peptide Chain Initiation, Translational | Codon, Initiator | Luciferases - genetics
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 08/2011, Volume 108, Issue 34, pp. 14067 - 14072
Journal Article
Analytical Chemistry, ISSN 0003-2700, 01/2016, Volume 88, Issue 2, p. 1266
  For the first time, an in vivo sampling mode of direct immersion-solid phase microextraction (DI-SPME) was employed to capture the metabolome of living plant... 
Tissue | Metabolites | Extraction processes | Solids | Flowers & plants | Mass spectrometry
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 03/2015, Volume 137, Issue 8, p. 6
Journal Article
Analytical Chemistry (Washington), ISSN 0003-2700, 01/2016, Volume 88, Issue 2, pp. 1266 - 1266
For the first time, an in vivo sampling mode of direct immersion-solid phase microextraction (DI-SPME) was employed to capture the metabolome of living plant... 
Apples | Analytical chemistry | Maturation | Metabolites | Mathematical analysis | Feasibility | Sampling | Fruits
Journal Article
Circulation, ISSN 0009-7322, 11/2016, Volume 134, Issue Suppl_1 Suppl 1, pp. A20275 - A20275
ObjectiveHepatocyte growth factor is cardioprotective, anti-apoptotic, and pro-angiogenic; yet, is limited in clinical translation due to its high... 
Journal Article
Cancer Research, ISSN 0008-5472, 11/2010, Volume 70, Issue 22, pp. 9022 - 9030
Journal Article
Current Opinion in Chemical Biology, ISSN 1367-5931, 10/2016, Volume 34, pp. 143 - 150
Journal Article
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