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index medicus (3) 3
analysis (2) 2
cancer (2) 2
care and treatment (2) 2
oncology (2) 2
research (2) 2
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6-4 photoproducts (1) 1
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1. Full Text CRL4 ubiquitin ligase stimulates Fanconi anemia pathway-induced single-stranded DNA-RPA signaling
by Codilupi, T and Taube, D and Naegeli, H
BMC CANCER, ISSN 1471-2407, 11/2019, Volume 19, Issue 1, pp. 1 - 16
Background DNA-crosslinking agents like cisplatin and mitomycin C (MMC) are indispensible for the treatment of many solid malignancies. These anticancer drugs... 
TARGET | CELLS | Fanconi anemia | CUL4 | CANCER | Cisplatin | DAMAGE | Chemotherapy | ONCOLOGY | FANCD2 | S-PHASE | INTERSTRAND CROSS-LINKS | NEDD8-ACTIVATING ENZYME | Crosslink | MOLECULAR-BASIS | ssDNA | ATR | Ubiquitin | Nucleases | DNA replication | Care and treatment | Mitomycin | RNA | Research | Fanconi's anemia | Crosslinked polymers | Ligases | Cell death | Analysis | DNA | Cancer | Crosslink - CUL4 - Fanconi anemia
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2. Full Text Chromatin remodeler CHD1 promotes XPC‐to‐TFIIH handover of nucleosomal UV lesions in nucleotide excision repair
by Rüthemann, Peter and Balbo Pogliano, Chiara and Codilupi, Tamara and Garajovà, Zuzana and Naegeli, Hanspeter
The EMBO Journal, ISSN 0261-4189, 11/2017, Volume 36, Issue 22, pp. 3372 - 3386
Ultraviolet (UV) light induces mutagenic cyclobutane pyrimidine dimers (CPDs) in nucleosomal DNA that is tightly wrapped around histone octamers. How... 
chromatin remodeling | skin cancer | UV light | DNA damage | nucleosomes | DAMAGED DNA | COMPLEX | TRANSCRIPTION ELONGATION-FACTORS | UBIQUITIN LIGASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | DNA-BINDING PROTEIN | CELL BIOLOGY | CIS-SYN | CYCLOBUTANE PYRIMIDINE DIMERS | STRUCTURAL BASIS | DUAL INCISION | 6-4 PHOTOPRODUCTS | Pyrimidine Dimers - metabolism | Chromatin - metabolism | Cell Death - radiation effects | Xeroderma Pigmentosum - metabolism | Humans | DNA Repair - radiation effects | Nucleosomes - metabolism | DNA-Binding Proteins - metabolism | DNA Helicases - metabolism | Ultraviolet Rays | Chromatin Assembly and Disassembly - radiation effects | HEK293 Cells | Nucleosomes - radiation effects | Transcription Factor TFIIH - metabolism | DNA Damage | HeLa Cells | Genome, Human | RNA, Small Interfering - metabolism | Chromatin | Immunoprecipitation | DNA polymerase | Toxicity | Downstream effects | Xeroderma pigmentosum | Cytotoxicity | Genomes | Compounds | Recruitment | DNA helicase | XPC protein | Sensors | Lesions | Localization | Repair | Relocation | Deoxyribonucleic acid--DNA | Fractionation | U.V. radiation | Nucleotide excision repair | Damage localization | Ultraviolet radiation | Depletion | Irradiation | Nucleosomes | Dimers | Cyclobutane | Immunofluorescence | Cyclobutane pyrimidine dimers | Chromatin, Epigenetics, Genomics & Functional Genomics | DNA Replication, Repair & Recombination
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3. Full Text Targeting compensatory MEK/ERK activation increases JAK inhibitor efficacy in myeloproliferative neoplasms
by Stivala, Simona and Codilupi, Tamara and Brkic, Sime and Baerenwaldt, Anne and Ghosh, Nilabh and Hao-Shen, Hui and Dirnhofer, Stephan and Dettmer, Matthias S and Simillion, Cedric and Kaufmann, Beat A and Chiu, Sophia and Keller, Matthew and Kleppe, Maria and Hilpert, Morgane and Buser, Andreas S and Passweg, Jakob R and Radimerski, Thomas and Skoda, Radek C and Levine, Ross L and Meyer, Sara C
Journal of Clinical Investigation, ISSN 0021-9738, 04/2019, Volume 129, Issue 4, pp. 1596 - 1611
Constitutive JAK2 signaling is central to myeloproliferative neoplasm (MPN) pathogenesis and results in activation of STAT, PI3K/AKT, and MEK/ERK signaling.... 
MEDICINE, RESEARCH & EXPERIMENTAL | POLYCYTHEMIA-VERA | STEM-CELLS | MEK INHIBITION | STAT PATHWAY ACTIVATION | TYROSINE KINASE JAK2 | BRAF | AVAILABLE THERAPY | THROMBOPOIETIN RECEPTOR | HEMATOPOIETIC STEM | RUXOLITINIB | Cell proliferation | Care and treatment | Usage | Life expectancy | Analysis | Transplantation | Research | Myeloproliferative disorders | Hematopoietic stem cells | Platelet-derived growth factor | Health aspects | Tumors | Animal models | Phosphorylation | Transcription factors | Transplants & implants | Leukemia | AKT protein | Kinases | Proteins | Cell activation | Cell growth | Janus kinase 2 | Cell cycle | Bone marrow | Growth factors | Cell survival | Cytokines | Melanoma | Extracellular signal-regulated kinase | Gene expression | Platelet-derived growth factor BB | 1-Phosphatidylinositol 3-kinase | Medical prognosis | Cell lines | Fibrosis | Stem cells | Ligands | Mutation | Cancer
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4. Full Text Chromatin remodeler CHD 1 promotes XPC ‐to‐ TFIIH handover of nucleosomal UV lesions in nucleotide excision repair
by Rüthemann, Peter and Balbo Pogliano, Chiara and Codilupi, Tamara and Garajovà, Zuzana and Naegeli, Hanspeter
The EMBO Journal, ISSN 0261-4189, 11/2017, Volume 36, Issue 22, pp. 3372 - 3386
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