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Journal Article
Journal of the National Cancer Institute, ISSN 0027-8874, 09/2017, Volume 109, Issue 9
Background: The efficacy of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) in EGFR-mutant non-small cell lung cancer (NSCLC) is... 
SURVIVAL | ACTIVATION | INHIBITION | ONCOLOGY | EPIDERMAL-GROWTH-FACTOR | SENSITIVITY | LUNG-CANCER CELLS | DRUG-RESISTANCE | MUTATIONS | NF-KAPPA-B | FACTOR RECEPTOR | Lung Neoplasms - drug therapy | Adenocarcinoma of Lung | Humans | Lung Neoplasms - metabolism | Middle Aged | ErbB Receptors - genetics | Male | Phosphoproteins - antagonists & inhibitors | Phosphoproteins - metabolism | RNA, Messenger - biosynthesis | Adenocarcinoma - metabolism | Adaptor Proteins, Signal Transducing - antagonists & inhibitors | Aged, 80 and over | Adult | Female | Adenocarcinoma - genetics | Retrospective Studies | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | Lung Neoplasms - genetics | ErbB Receptors - antagonists & inhibitors | ErbB Receptors - metabolism | Phosphoproteins - biosynthesis | Signal Transduction | RNA, Messenger - genetics | Phosphoproteins - genetics | Adenocarcinoma - drug therapy | STAT3 Transcription Factor - biosynthesis | Protein Kinase Inhibitors - administration & dosage | Animals | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Mice, Nude | Adaptor Proteins, Signal Transducing - genetics | Cell Line, Tumor | Adaptor Proteins, Signal Transducing - biosynthesis | Aged | Mice | Adaptor Proteins, Signal Transducing - metabolism | STAT3 Transcription Factor - antagonists & inhibitors
Journal Article
The Prostate, ISSN 0270-4137, 04/2013, Volume 73, Issue 5, pp. 512 - 521
Journal Article
Current Opinion in Pharmacology, ISSN 1471-4892, 2011, Volume 11, Issue 1, pp. 94 - 100
Research highlights ► 5-HT6 receptor ligands are promising candidates for treating cognitive dysfunction. ► Several neurotransmitter systems mediate 5-HT6... 
Internal Medicine | Medical Education | MEDICINAL CHEMISTRY | SEROTONIN RECEPTOR | ANTAGONIST | MESSENGER-RNA | RAT | ALZHEIMERS-DISEASE | ACETYLCHOLINE-RELEASE | DOUBLE-BLIND | PHARMACOLOGY & PHARMACY | CENTRAL-NERVOUS-SYSTEM | G-PROTEIN
Journal Article
Journal of Thoracic Oncology, ISSN 1556-0864, 04/2016, Volume 11, Issue 4, pp. S87 - S88
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 07/2013, Volume 711, Issue 1-3, pp. 63 - 72
Journal Article
European Journal of Neuroscience, ISSN 0953-816X, 10/2003, Volume 18, Issue 8, pp. 2188 - 2196
Journal Article
Journal of Thoracic Oncology, ISSN 1556-0864, 04/2016, Volume 11, Issue 4 Suppl, pp. S87 - S88
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 03/2005, Volume 48, Issue 6, pp. 1781 - 1795
Journal Article
Pharmacology and Therapeutics, ISSN 0163-7258, 02/2008, Volume 117, Issue 2, pp. 207 - 231
The increasing global prevalence of obesity unequivocally demonstrates that neither behavioural (diet and exercise) nor pharmacological approaches to this... 
ligands | Obesity | Treatment | 5-HT | Metabolic disorders | Rodent models | SEROTONIN RECEPTOR | metabolic disorders | treatment | LOCALIZATION | CLINICAL-TRIAL | BINDING AFFINITIES | INTENTIONAL WEIGHT-LOSS | MESSENGER-RNA | rodent models | 5-HT6 ligands | PHARMACOLOGY & PHARMACY | CENTRAL-NERVOUS-SYSTEM | RAT-BRAIN | D-FENFLURAMINE | ANTAGONISTS | obesity | Metabolic Syndrome - etiology | Central Nervous System - metabolism | Obesity - drug therapy | Humans | Receptors, Serotonin - drug effects | Body Weight - drug effects | Anti-Obesity Agents - adverse effects | Metabolic Syndrome - metabolism | Structure-Activity Relationship | Metabolic Syndrome - drug therapy | Serotonin Receptor Agonists - pharmacology | Serotonin Antagonists - adverse effects | Serotonin Antagonists - chemistry | Metabolic Syndrome - physiopathology | Molecular Structure | Metabolic Syndrome - epidemiology | Disease Models, Animal | Satiety Response - drug effects | Drug Partial Agonism | Obesity - complications | Serotonin Receptor Agonists - chemistry | Obesity - physiopathology | Treatment Outcome | Serotonin Antagonists - pharmacology | Serotonin Receptor Agonists - adverse effects | Receptors, Serotonin - metabolism | Obesity - metabolism | Eating - drug effects | Anti-Obesity Agents - chemistry | Animals | Weight Loss | Obesity - epidemiology | Central Nervous System - drug effects | Ligands | Anti-Obesity Agents - pharmacology
Journal Article
Pain, ISSN 0304-3959, 06/2010, Volume 149, Issue 3, pp. 483 - 494
Journal Article
British Journal of Cancer, ISSN 0007-0920, 2017, Volume 117, Issue 12, pp. 1777 - 1786
Background: Although chemotherapy is the cornerstone treatment for patients with metastatic colorectal cancer (mCRC), acquired chemoresistance is common and... 
Nuclear internalisation | Acquired resistance | IGF-1R | Colorectal cancer | BRAF mutation | colorectal cancer | I RECEPTOR | TUMOR-CELLS | COMBINATION | acquired resistance | INSULIN | nuclear internalisation | MUTATION STATUS | ONCOLOGY | POOR-PROGNOSIS | KRAS | INHIBITOR | TRANSCRIPTION FACTOR | EXPRESSION | Leucovorin - administration & dosage | Receptor, IGF Type 1 - metabolism | Molecular Chaperones - metabolism | Proto-Oncogene Proteins p21(ras) - genetics | Colorectal Neoplasms - genetics | Humans | Middle Aged | Panitumumab | Drug Resistance, Neoplasm | Male | Protein Inhibitors of Activated STAT - metabolism | Protein Transport - drug effects | Cell Nucleus - metabolism | Colorectal Neoplasms - drug therapy | Protein Inhibitors of Activated STAT - genetics | Camptothecin - administration & dosage | Camptothecin - analogs & derivatives | Cell Survival - drug effects | Bevacizumab - administration & dosage | Antibodies, Monoclonal - pharmacology | HCT116 Cells | Curcumin - pharmacology | Molecular Chaperones - genetics | Pyrimidines - pharmacology | Dasatinib - pharmacology | Signal Transduction - drug effects | Sorafenib | Fluorouracil - pharmacology | Niacinamide - analogs & derivatives | Antineoplastic Combined Chemotherapy Protocols - administration & dosage | Molecular Targeted Therapy | Organoplatinum Compounds - pharmacology | Organoplatinum Compounds - administration & dosage | Fluorouracil - administration & dosage | Oxaliplatin | Female | Antineoplastic Agents - pharmacology | Gene Silencing | Fatty Acids, Unsaturated - pharmacology | HT29 Cells | Pyrroles - pharmacology | Antibodies, Monoclonal - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Proto-Oncogene Proteins B-raf - genetics | Cetuximab - administration & dosage | Aged | Phenylurea Compounds - pharmacology | Niacinamide - pharmacology | Colorectal Neoplasms - pathology | Immunohistochemistry | Medical research | Cell survival | Insulin-like growth factor I | RNA-mediated interference | Colorectal carcinoma | Chemoresistance | Clinical trials | Insulin-like growth factors | Metastasis | Insulin | Patients | Survival | Metastases | Proteins | SUMO protein | Chemotherapy | Cell lines | Monoclonal antibodies | Tumors | Cancer | Translational Therapeutics
Journal Article
Journal of Crohn's and Colitis, ISSN 1873-9946, 02/2017, Volume 11, Issue suppl_1, pp. S95 - S96
Journal Article
Journal of Crohn's and Colitis, ISSN 1873-9946, 02/2017, Volume 11, Issue suppl_1, pp. S77 - S78
Journal Article