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Journal Article
Immunity, ISSN 1074-7613, 06/2016, Volume 44, Issue 6, pp. 1444 - 1454
Journal Article
Cancer Research, ISSN 0008-5472, 07/2010, Volume 70, Issue 13, pp. 5213 - 5219
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 03/2013, Volume 19, Issue 5, pp. 1225 - 1231
Journal Article
Nature, ISSN 0028-0836, 12/2010, Volume 468, Issue 7326, pp. 968 - 972
Oncogenic mutations in the serine/threonine kinase B-RAF (also known as BRAF) are found in 50-70% of malignant melanomas. Pre-clinical studies have... 
TRANSFORMATION | CELLS | TUMOR PROGRESSION | GENE | SIGNALING PATHWAY | MULTIDISCIPLINARY SCIENCES | BRAF | B-RAF | KAPPA-B | MUTATIONS | CANCER | Allosteric Regulation | Humans | Gene Expression Regulation, Neoplastic | Melanoma - enzymology | Gene Expression Profiling | MAP Kinase Signaling System | Mitogen-Activated Protein Kinase Kinases - metabolism | Melanoma - genetics | Indoles - pharmacology | Proto-Oncogene Proteins B-raf - metabolism | Proto-Oncogene Proteins B-raf - chemistry | Melanoma - metabolism | Proto-Oncogene Proteins - metabolism | Gene Library | Proto-Oncogene Proteins c-raf - genetics | MAP Kinase Kinase Kinases - genetics | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | Proto-Oncogene Proteins - genetics | Clinical Trials as Topic | MAP Kinase Kinase Kinases - metabolism | Enzyme Activation - drug effects | Open Reading Frames - genetics | Sulfonamides - pharmacology | Proto-Oncogene Proteins c-raf - metabolism | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Drug Resistance, Neoplasm - genetics | Sulfonamides - therapeutic use | Protein Kinase Inhibitors - therapeutic use | Proto-Oncogene Proteins B-raf - genetics | Melanoma - drug therapy | Cell Line, Tumor | Indoles - therapeutic use | Protein Kinase Inhibitors - pharmacology | Drug Resistance, Neoplasm - drug effects | Mitogen-Activated Protein Kinases - metabolism | Protein research | Research | Properties | Protein kinases | Cancer cells | Cell lines | Biochemistry | Mutation | Kinases | Genes | Cancer | Index Medicus
Journal Article
Journal Article
Cancer Discovery, ISSN 2159-8274, 03/2012, Volume 2, Issue 3, pp. 227 - 235
BRAF mutations occur in 10% to 15% of colorectal cancers and confer adverse outcome in the metastatic setting. Although RAF inhibitors such as vemurafenib... 
CELLS | CETUXIMAB | MELANOMA | ONCOLOGY | KINASE | MUTATION | RESISTANCE | WILD-TYPE BRAF | KRAS | ANTITUMOR-ACTIVITY | MEK INHIBITORS
Journal Article
Blood, ISSN 0006-4971, 2009, Volume 114, Issue 3, pp. 535 - 546
Journal Article
Journal Article
Nature, ISSN 0028-0836, 06/2018, Volume 558, Issue 7709, pp. 307 - 312
Cancer immunotherapy based on genetically redirecting T cells has been used successfully to treat B cell malignancies(1-3). In this strategy, the T cell genome... 
B-CELL | 5-METHYLCYTOSINE | CONVERSION | MULTIDISCIPLINARY SCIENCES | 5-HYDROXYMETHYLCYTOSINE | MUTATIONS | PROTEINS | CD28 COSTIMULATION | DNA INTEGRATION | 5-FORMYLCYTOSINE | LYMPHOCYTES | Clone Cells - cytology | Dioxygenases - metabolism | Immunotherapy - methods | Epigenesis, Genetic | Humans | Male | Adoptive Transfer | Leukemia, Lymphocytic, Chronic, B-Cell - genetics | Recombinant Fusion Proteins - metabolism | T-Lymphocytes - transplantation | T-Lymphocytes - metabolism | Clone Cells - immunology | HEK293 Cells | Cell Differentiation | Transgenes | Leukemia, Lymphocytic, Chronic, B-Cell - immunology | Antigens, CD19 - immunology | Clinical Trials as Topic | Leukemia, Lymphocytic, Chronic, B-Cell - pathology | Leukemia, Lymphocytic, Chronic, B-Cell - therapy | Dioxygenases - genetics | 5-Methylcytosine - metabolism | T-Lymphocytes - cytology | Alleles | Recombinant Fusion Proteins - genetics | T-Lymphocytes - immunology | Aged | Mutation | Genetic engineering | Research | T cells | Immunotherapy | Oncology, Experimental | Cancer | Leukemia | Differentiation (biology) | Insertion | Genomes | Lymphocytes T | Lymph nodes | Anticancer properties | Proteins | Infusion | Receptors | Lymphocytes | Peripheral blood | Bone marrow | Remission | Oxidation | Bioinformatics | Deoxyribonucleic acid--DNA | Dioxygenase | Antigens | Chronic lymphatic leukemia | Phenotypes | Transposons | CD19 antigen | Cloning | T cell receptors | Cell differentiation | Patients | Progeny | Lymphocytes B | Stem cells | Epigenetics | Tumors | Index Medicus
Journal Article
Blood, ISSN 0006-4971, 03/2016, Volume 127, Issue 9, pp. 1117 - 1127
Journal Article