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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 6/2016, Volume 113, Issue 26, pp. 7124 - 7129
Journal Article
Leukemia, ISSN 0887-6924, 09/2017, Volume 31, Issue 9, pp. 1951 - 1961
The PROTAC (proteolysis-targeting chimera) ARV-825 recruits bromodomain and extraterminal (BET) proteins to the E3 ubiquitin ligase cereblon, leading to... 
TRANSFORMATION | PATHOGENESIS | JAK2 INHIBITOR | ONCOLOGY | ACUTE MYELOGENOUS LEUKEMIA | KINASE | DEGRADATION | ACUTE MYELOID-LEUKEMIA | OVERCOMES RESISTANCE | HEMATOLOGY | CANCER | BRD4 | Antigens, CD34 | Apoptosis - drug effects | Leukemia, Myeloid, Acute - pathology | Humans | Leukemia | Ubiquitin-Protein Ligases - metabolism | Nuclear Proteins - metabolism | Myeloproliferative Disorders - pathology | Thalidomide - pharmacology | Azepines - therapeutic use | Azepines - pharmacology | Transcription Factors - metabolism | Thalidomide - analogs & derivatives | Animals | Tumor Burden - drug effects | Proteolysis | Cell Line, Tumor | Leukemia, Myeloid, Acute - drug therapy | Mice | Thalidomide - therapeutic use | Chimera | Pyrazoles - pharmacology | Care and treatment | Usage | Messenger RNA | Chimeras (Organisms) | Research | Mass spectrometry | Myeloproliferative disorders | Ubiquitin | Surgical implants | c-Myc protein | In vitro testing | mRNA | Myc protein | Cyclin-dependent kinase 4 | Degradation | Proteins | Biomedical materials | Bcl-x protein | Janus kinase 2 | Biocompatibility | Ubiquitin-protein ligase | CD34 antigen | Cell survival | Stat3 protein | Hemopoiesis | Cytometry | Protein arrays | Depletion | Inhibitors | Ribonucleic acids | Cells (biology) | Bcl protein | Bet protein | In vivo methods and tests | Acute myeloid leukemia | Apoptosis | Secondary AML | PROTAC | protein degradation
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 01/2018, Volume 61, Issue 2, pp. 583 - 598
Proteolysis targeting chimeras (PROTACs) are bifunctional molecules that recruit an E3 ligase to a target protein to facilitate ubiquitination and subsequent... 
SMALL-MOLECULE PROTACS | COMPLEX | CHEMISTRY, MEDICINAL | TBK1 | THERAPY | PROTEIN-DEGRADATION | CLINICAL CANDIDATES | STRATEGY | INHIBITORS | CANCER | E3 UBIQUITIN LIGASE
Journal Article
The Journal of clinical investigation, ISSN 0021-9738, 07/2003, Volume 112, Issue 2, pp. 197 - 208
Journal Article
Journal Article
Leukemia, ISSN 0887-6924, 10/2018, Volume 32, Issue 10, pp. 2224 - 2239
Bromodomain and extraterminal (BET) domain containing protein (BRD)-4 modulates the expression of oncogenes such as c-myc, and is a promising therapeutic... 
INHIBITION | THERAPEUTIC STRATEGY | ONCOLOGY | POOR-PROGNOSIS | KINASE | C-MYC | DEGRADATION | DRUG-RESISTANCE | HEMATOLOGY | PHASE-I | CANCER | BET BROMODOMAINS | Cell Survival - drug effects | Humans | Tumor Suppressor Protein p53 - metabolism | Nuclear Proteins - metabolism | Multiple Myeloma - metabolism | Proto-Oncogene Proteins c-myc - metabolism | Xenograft Model Antitumor Assays | Protein Domains - drug effects | Amino Acid Motifs - drug effects | Multiple Myeloma - drug therapy | Animals | Proteins - metabolism | Ubiquitination - drug effects | Signal Transduction - drug effects | Cell Cycle Checkpoints - drug effects | Cell Line, Tumor | Female | Mice, Inbred NOD | Antineoplastic Agents - pharmacology | Mice | Proto-Oncogene Proteins c-akt - metabolism | Drug Resistance, Neoplasm - drug effects | Molecular targeted therapy | Care and treatment | Innovations | Multiple myeloma | Development and progression | Genetic aspects | Gene expression | Health aspects | Oncogenes | Bortezomib | Dexamethasone | Immunomodulation | Therapeutic applications | Downstream effects | p53 Protein | Xenotransplantation | c-Myc protein | AKT protein | Myc protein | Tumor cell lines | Patients | Proteins | Time dependence | Ubiquitination | Molecular modelling | Cell lines | Xenografts | Proteasomes | Viability | Cancer | Apoptosis | multiple myeloma | PROTACs | drug resistance | BET protein family | c-MYC | BRD4
Journal Article
JOURNAL OF CLINICAL INVESTIGATION, ISSN 0021-9738, 07/2003, Volume 112, Issue 2, pp. 197 - 208
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 06/2016, Volume 113, Issue 26, p. 7124
  Prostate cancer has the second highest incidence among cancers in men worldwide and is the second leading cause of cancer deaths of men in the United States.... 
Proteins | Molecules | Medical prognosis | Rodents | Medical treatment | Prostate cancer
Journal Article
Journal Article
mAbs, ISSN 1942-0862, 11/2012, Volume 4, Issue 6, pp. 710 - 723
Journal Article
Nanotechnology Law and Business, ISSN 1546-2080, 2005, Volume 2, Issue 4, pp. 376 - 382
Journal Article
Veterinary Ophthalmology, ISSN 1463-5216, 07/2012, Volume 15, Issue 4, pp. 263 - 270
Journal Article
Journal of Bone and Joint Surgery - Series A, ISSN 0021-9355, 04/1997, Volume 79, Issue 4, pp. 583 - 586
Journal Article
The Annals of Thoracic Surgery, ISSN 0003-4975, 12/1998, Volume 66, Issue 6, pp. 2029 - 2036
Background. The mechanism of clinical improvement after transmyocardial laser revascularization (TMR) is unknown. One hypothesis holds that TMR causes... 
SURGERY | CARDIAC & CARDIOVASCULAR SYSTEMS | RESPIRATORY SYSTEM | GLUCOSE | DISEASE | CO2 | POSITRON EMISSION TOMOGRAPHY | CHANNELS | MYOCARDIAL BLOOD-FLOW
Journal Article