Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2013, Volume 110, Issue 30, pp. 12474 - 12479
The physiological functions of hydrogen sulfide (H₂S) include vasorelaxation, stimulation of cellular bioenergetics, and promotion of angiogenesis. Analysis of...
Sulfides | Angiogenesis | Cell growth | HCT116 cells | Hydrogen | Epithelial cells | Colorectal cancer | Cell lines | Endothelial cells | Tumors | PROTEIN | EPITHELIAL-CELLS | AMINOOXYACETIC ACID | PHOSPHATASE | MULTIDISCIPLINARY SCIENCES | MITOCHONDRIA | H2S | SIGNALS | GAS | MICE | FLOW | Hydrogen Sulfide - metabolism | Cell Proliferation | Colonic Neoplasms - blood supply | Humans | Neovascularization, Pathologic | Cystathionine beta-Synthase - metabolism | Colonic Neoplasms - metabolism | HT29 Cells | Animals | Energy Metabolism | Colonic Neoplasms - pathology | Female | Mice | Mice, Inbred BALB C | Biological Sciences
Sulfides | Angiogenesis | Cell growth | HCT116 cells | Hydrogen | Epithelial cells | Colorectal cancer | Cell lines | Endothelial cells | Tumors | PROTEIN | EPITHELIAL-CELLS | AMINOOXYACETIC ACID | PHOSPHATASE | MULTIDISCIPLINARY SCIENCES | MITOCHONDRIA | H2S | SIGNALS | GAS | MICE | FLOW | Hydrogen Sulfide - metabolism | Cell Proliferation | Colonic Neoplasms - blood supply | Humans | Neovascularization, Pathologic | Cystathionine beta-Synthase - metabolism | Colonic Neoplasms - metabolism | HT29 Cells | Animals | Energy Metabolism | Colonic Neoplasms - pathology | Female | Mice | Mice, Inbred BALB C | Biological Sciences
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 6/2012, Volume 109, Issue 23, pp. 9161 - 9166
Hydrogen sulfide (H₂S) is a unique gasotransmitter, with regulatory roles in the cardiovascular, nervous, and immune systems. Some of the vascular actions of...
Angiogenesis | Sulfides | Phosphorylation | Cell growth | Hydrogen | Small interfering RNA | Oxides | Physiological regulation | Endothelial cells | Vasodilation | SOLUBLE GUANYLYL CYCLASE | MOLECULE | MULTIDISCIPLINARY SCIENCES | H2S | TARGETS | GROWTH-FACTOR | MODEL | Hydrogen Sulfide - metabolism | Neovascularization, Physiologic - drug effects | Nitric Oxide - pharmacology | Cystathionine gamma-Lyase - metabolism | Phosphoproteins - metabolism | Cyclic GMP-Dependent Protein Kinases - metabolism | Laminin | Microfilament Proteins - metabolism | Nitric Oxide Synthase Type III - metabolism | Vasodilation - physiology | Wound Healing - drug effects | Cell Line | Hydrogen Sulfide - pharmacology | Proteoglycans | Endothelial Cells - metabolism | Rats | Cell Adhesion Molecules - metabolism | Rats, Sprague-Dawley | Blotting, Western | Gene Expression Regulation - drug effects | Neovascularization, Physiologic - physiology | Animals | Analysis of Variance | Cyclic GMP - metabolism | Collagen | Mice | Vasodilation - drug effects | Nitric Oxide - metabolism | Drug Combinations | Biological Sciences
Angiogenesis | Sulfides | Phosphorylation | Cell growth | Hydrogen | Small interfering RNA | Oxides | Physiological regulation | Endothelial cells | Vasodilation | SOLUBLE GUANYLYL CYCLASE | MOLECULE | MULTIDISCIPLINARY SCIENCES | H2S | TARGETS | GROWTH-FACTOR | MODEL | Hydrogen Sulfide - metabolism | Neovascularization, Physiologic - drug effects | Nitric Oxide - pharmacology | Cystathionine gamma-Lyase - metabolism | Phosphoproteins - metabolism | Cyclic GMP-Dependent Protein Kinases - metabolism | Laminin | Microfilament Proteins - metabolism | Nitric Oxide Synthase Type III - metabolism | Vasodilation - physiology | Wound Healing - drug effects | Cell Line | Hydrogen Sulfide - pharmacology | Proteoglycans | Endothelial Cells - metabolism | Rats | Cell Adhesion Molecules - metabolism | Rats, Sprague-Dawley | Blotting, Western | Gene Expression Regulation - drug effects | Neovascularization, Physiologic - physiology | Animals | Analysis of Variance | Cyclic GMP - metabolism | Collagen | Mice | Vasodilation - drug effects | Nitric Oxide - metabolism | Drug Combinations | Biological Sciences
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 04/2014, Volume 171, Issue 8, pp. 2099 - 2122
Until recently, hydrogen sulfide (H2S) was exclusively viewed a toxic gas and an environmental hazard, with its toxicity primarily attributed to the inhibition...
nitric oxide | free radicals | gasotransmitters | bioenergetics | 3‐mercaptopyruvate sulfurtransferase | cysteine | blood vessels | cytochrome c oxidase | superoxide | mitochondrial electron transport | 3-mercaptopyruvate sulfurtransferase | SPRAGUE-DAWLEY RATS | OXIDATION | ENDOGENOUS H2S | LUNG | SULFUR | CYTOCHROME-C-OXIDASE | ORIGIN | NITRIC-OXIDE | PHARMACOLOGY & PHARMACY | COLONIC EPITHELIAL-CELLS | Hydrogen Sulfide - metabolism | Colon - physiology | Hydrogen Sulfide - toxicity | Humans | Mitochondria - metabolism | Gasotransmitters - physiology | Gasotransmitters - toxicity | Epithelial Cells - physiology | Animals | Models, Biological | Cell Respiration - physiology | Gasotransmitters - metabolism | Electron Transport - physiology | Energy Metabolism - physiology | Mitochondria - physiology | Hydrogen sulfide | Laws, regulations and rules | Nitric oxide | Colorectal cancer | Physiological aspects | Cytochrome oxidase | Mitochondrial DNA | Superoxide | Cells | Bioenergetics | Medical research | Index Medicus | Life Sciences | Energy, Injury & Beyond | Mitochondrial Pharmacology | Themed Issue
nitric oxide | free radicals | gasotransmitters | bioenergetics | 3‐mercaptopyruvate sulfurtransferase | cysteine | blood vessels | cytochrome c oxidase | superoxide | mitochondrial electron transport | 3-mercaptopyruvate sulfurtransferase | SPRAGUE-DAWLEY RATS | OXIDATION | ENDOGENOUS H2S | LUNG | SULFUR | CYTOCHROME-C-OXIDASE | ORIGIN | NITRIC-OXIDE | PHARMACOLOGY & PHARMACY | COLONIC EPITHELIAL-CELLS | Hydrogen Sulfide - metabolism | Colon - physiology | Hydrogen Sulfide - toxicity | Humans | Mitochondria - metabolism | Gasotransmitters - physiology | Gasotransmitters - toxicity | Epithelial Cells - physiology | Animals | Models, Biological | Cell Respiration - physiology | Gasotransmitters - metabolism | Electron Transport - physiology | Energy Metabolism - physiology | Mitochondria - physiology | Hydrogen sulfide | Laws, regulations and rules | Nitric oxide | Colorectal cancer | Physiological aspects | Cytochrome oxidase | Mitochondrial DNA | Superoxide | Cells | Bioenergetics | Medical research | Index Medicus | Life Sciences | Energy, Injury & Beyond | Mitochondrial Pharmacology | Themed Issue
Journal Article
BRITISH JOURNAL OF PHARMACOLOGY, ISSN 0007-1188, 06/2013, Volume 169, Issue 4, pp. 922 - 932
Background and Purpose Hydrogen sulfide (H2S) is a signalling molecule that belongs to the gasotransmitter family. Two major sources for endogenous enzymatic...
nitric oxide | HYDROXYLAMINE | pyridoxal-5-phosphate | MECHANISM | MEDIATOR | ALANINE AMINOTRANSFERASE | HYDROGEN-SULFIDE | cystathionine -lyase | DL-propargylglycine | INACTIVATION | hydrogen sulfide | cyano-L-alanine | ASPARTATE-AMINOTRANSFERASE | GAMMA-CYSTATHIONASE | cystathionine -synthase | PHARMACOLOGY & PHARMACY | aminooxyacetic acid | BETA-SYNTHASE | BINDING | Proteins | Hydrogen sulfide | Phosphates | Cysteine | Hydroxides | Nitric oxide | Physiological aspects | Nitriles | Television broadcasting industry
nitric oxide | HYDROXYLAMINE | pyridoxal-5-phosphate | MECHANISM | MEDIATOR | ALANINE AMINOTRANSFERASE | HYDROGEN-SULFIDE | cystathionine -lyase | DL-propargylglycine | INACTIVATION | hydrogen sulfide | cyano-L-alanine | ASPARTATE-AMINOTRANSFERASE | GAMMA-CYSTATHIONASE | cystathionine -synthase | PHARMACOLOGY & PHARMACY | aminooxyacetic acid | BETA-SYNTHASE | BINDING | Proteins | Hydrogen sulfide | Phosphates | Cysteine | Hydroxides | Nitric oxide | Physiological aspects | Nitriles | Television broadcasting industry
Journal Article
Nitric Oxide, ISSN 1089-8603, 05/2014, Volume 39, pp. S26 - S27
Previous studies reported both beneficial and detrimental roles of hydrogen sulfide (H.sub.2S) in various models of critical illness. The goal of our study was...
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2011, Volume 108, Issue 33, pp. 13829 - 13834
The goal of the present studies was to investigate the role of changes in hydrogen sulfide (H2S) homeostasis in the pathogenesis of hyperglycemic endothelial...
Diabetic angiopathies | Sulfides | Enzymes | Hyperglycemia | Reactive oxygen species | Diabetes complications | Hydrogen | Diabetes | Endothelial cells | Type 1 diabetes mellitus | POLY(ADP-RIBOSE) POLYMERASE | OXIDATIVE STRESS | SUPEROXIDE-PRODUCTION | NITROSATIVE STRESS | MULTIDISCIPLINARY SCIENCES | H2S | COMPLICATIONS | MECHANISMS | DYSFUNCTION | PC12 CELLS | RAT MODEL | Hydrogen Sulfide - metabolism | Cell Line | Hydrogen Sulfide - pharmacology | Endothelial Cells | Reactive Oxygen Species - metabolism | Homeostasis | Rats | Endothelium, Vascular - drug effects | Glucose - pharmacology | Mitochondria - metabolism | Mitochondria - drug effects | Protective Agents - therapeutic use | Hyperglycemia - drug therapy | Hydrogen Sulfide - therapeutic use | Animals | Diabetes Mellitus, Experimental | Hyperglycemia - pathology | Hydrogen sulfide | Care and treatment | Physiological aspects | Vascular endothelium | Genetic aspects | Mitochondrial DNA | Health aspects | Biological Sciences
Diabetic angiopathies | Sulfides | Enzymes | Hyperglycemia | Reactive oxygen species | Diabetes complications | Hydrogen | Diabetes | Endothelial cells | Type 1 diabetes mellitus | POLY(ADP-RIBOSE) POLYMERASE | OXIDATIVE STRESS | SUPEROXIDE-PRODUCTION | NITROSATIVE STRESS | MULTIDISCIPLINARY SCIENCES | H2S | COMPLICATIONS | MECHANISMS | DYSFUNCTION | PC12 CELLS | RAT MODEL | Hydrogen Sulfide - metabolism | Cell Line | Hydrogen Sulfide - pharmacology | Endothelial Cells | Reactive Oxygen Species - metabolism | Homeostasis | Rats | Endothelium, Vascular - drug effects | Glucose - pharmacology | Mitochondria - metabolism | Mitochondria - drug effects | Protective Agents - therapeutic use | Hyperglycemia - drug therapy | Hydrogen Sulfide - therapeutic use | Animals | Diabetes Mellitus, Experimental | Hyperglycemia - pathology | Hydrogen sulfide | Care and treatment | Physiological aspects | Vascular endothelium | Genetic aspects | Mitochondrial DNA | Health aspects | Biological Sciences
Journal Article
FASEB Journal, ISSN 0892-6638, 02/2013, Volume 27, Issue 2, pp. 601 - 611
It is well established that exposure of mammalian cells to hydrogen sulfide (H2S) suppresses mitochondrial function by inhibiting cytochrome-c oxidase (CcOX;...
Hepatocyte | ATP | Gasotransmitter | OXIDATION | CELLS | HOMOCYSTEINE | hepatocyte | RAT | BIOCHEMISTRY & MOLECULAR BIOLOGY | H2S | DEHYDROGENASE | CELL BIOLOGY | SUSPENDED ANIMATION | INHIBITION | LIVER | BIOLOGY | gasotransmitter | CYSTATHIONINE-BETA-SYNTHASE | Hydrogen Sulfide - metabolism | Cell Line | Cysteine - analogs & derivatives | Quinone Reductases - metabolism | RNA, Small Interfering - genetics | Electron Transport | Mitochondria, Liver - metabolism | Oxidative Phosphorylation | Rats | Sulfurtransferases - genetics | Male | Rats, Sprague-Dawley | Citric Acid Cycle | Sulfurtransferases - antagonists & inhibitors | Animals | Energy Metabolism | Models, Biological | Base Sequence | Quinone Reductases - antagonists & inhibitors | Quinone Reductases - genetics | Cysteine - metabolism | Mice | Sulfurtransferases - metabolism
Hepatocyte | ATP | Gasotransmitter | OXIDATION | CELLS | HOMOCYSTEINE | hepatocyte | RAT | BIOCHEMISTRY & MOLECULAR BIOLOGY | H2S | DEHYDROGENASE | CELL BIOLOGY | SUSPENDED ANIMATION | INHIBITION | LIVER | BIOLOGY | gasotransmitter | CYSTATHIONINE-BETA-SYNTHASE | Hydrogen Sulfide - metabolism | Cell Line | Cysteine - analogs & derivatives | Quinone Reductases - metabolism | RNA, Small Interfering - genetics | Electron Transport | Mitochondria, Liver - metabolism | Oxidative Phosphorylation | Rats | Sulfurtransferases - genetics | Male | Rats, Sprague-Dawley | Citric Acid Cycle | Sulfurtransferases - antagonists & inhibitors | Animals | Energy Metabolism | Models, Biological | Base Sequence | Quinone Reductases - antagonists & inhibitors | Quinone Reductases - genetics | Cysteine - metabolism | Mice | Sulfurtransferases - metabolism
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 06/2013, Volume 169, Issue 4, pp. 922 - 932
Background and Purpose Hydrogen sulfide (H2S) is a signalling molecule that belongs to the gasotransmitter family. Two major sources for endogenous enzymatic...
DL‐propargylglycine | nitric oxide | hydrogen sulfide | cystathionine γ‐lyase | pyridoxal‐5′‐phosphate | cystathionine β‐synthase | aminooxyacetic acid | β‐cyano‐L‐alanine | cystathionine γ-lyase | DL-propargylglycine | cystathionine β-synthase | β-cyano-L-alanine | pyridoxal-5′-phosphate | Hydrogen Sulfide - metabolism | Glycine - analogs & derivatives | Cystathionine beta-Synthase - antagonists & inhibitors | Humans | Cystathionine gamma-Lyase - metabolism | Recombinant Fusion Proteins - metabolism | Alanine - analogs & derivatives | Glutathione Transferase - genetics | Alkynes - pharmacology | Aorta, Thoracic - drug effects | Cystathionine gamma-Lyase - genetics | Nitric Oxide Donors - pharmacology | Cystathionine beta-Synthase - genetics | Peptide Fragments - genetics | Alanine - pharmacology | Peptide Fragments - metabolism | Enzyme Inhibitors - pharmacology | Aorta, Thoracic - metabolism | Glutathione Transferase - metabolism | Rats | Cystathionine beta-Synthase - metabolism | Recombinant Fusion Proteins - chemistry | Glutathione Transferase - chemistry | Cystathionine gamma-Lyase - antagonists & inhibitors | Rats, Sprague-Dawley | Hydrogen Sulfide - analysis | Aorta, Thoracic - enzymology | Animals | Glycine - pharmacology | Kinetics | Vasodilation - drug effects | In Vitro Techniques | Nitric Oxide - metabolism | Research Papers
DL‐propargylglycine | nitric oxide | hydrogen sulfide | cystathionine γ‐lyase | pyridoxal‐5′‐phosphate | cystathionine β‐synthase | aminooxyacetic acid | β‐cyano‐L‐alanine | cystathionine γ-lyase | DL-propargylglycine | cystathionine β-synthase | β-cyano-L-alanine | pyridoxal-5′-phosphate | Hydrogen Sulfide - metabolism | Glycine - analogs & derivatives | Cystathionine beta-Synthase - antagonists & inhibitors | Humans | Cystathionine gamma-Lyase - metabolism | Recombinant Fusion Proteins - metabolism | Alanine - analogs & derivatives | Glutathione Transferase - genetics | Alkynes - pharmacology | Aorta, Thoracic - drug effects | Cystathionine gamma-Lyase - genetics | Nitric Oxide Donors - pharmacology | Cystathionine beta-Synthase - genetics | Peptide Fragments - genetics | Alanine - pharmacology | Peptide Fragments - metabolism | Enzyme Inhibitors - pharmacology | Aorta, Thoracic - metabolism | Glutathione Transferase - metabolism | Rats | Cystathionine beta-Synthase - metabolism | Recombinant Fusion Proteins - chemistry | Glutathione Transferase - chemistry | Cystathionine gamma-Lyase - antagonists & inhibitors | Rats, Sprague-Dawley | Hydrogen Sulfide - analysis | Aorta, Thoracic - enzymology | Animals | Glycine - pharmacology | Kinetics | Vasodilation - drug effects | In Vitro Techniques | Nitric Oxide - metabolism | Research Papers
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 04/2014, Volume 171, Issue 8, pp. 2123 - 2146
Emerging work demonstrates the dual regulation of mitochondrial function by hydrogen sulfide (H2S), including, at lower concentrations, a stimulatory effect as...
nitric oxide | free radicals | ischaemia | gasotransmitters | bioenergetics | 3‐mercaptopyruvate sulfurtransferase | cysteine | shock | blood vessels | suspended animation | superoxide | mitochondrial electron transport | 3-mercaptopyruvate sulfurtransferase | ISCHEMIA/REPERFUSION INJURY | OXIDATIVE STRESS | NITRIC-OXIDE SYNTHASE | ISCHEMIA-REPERFUSION INJURY | COLON-CANCER | GLUCOSE-INDUCED APOPTOSIS | ANIMATION-LIKE STATE | IN-VITRO MODEL | PHARMACOLOGY & PHARMACY | CYSTATHIONINE-BETA-SYNTHASE | Hydrogen Sulfide - metabolism | Gasotransmitters - therapeutic use | Hydrogen Sulfide - pharmacology | Diabetes Complications - physiopathology | Gasotransmitters - adverse effects | Humans | Shock - physiopathology | Hydrogen Sulfide - adverse effects | Mitochondria - metabolism | Gasotransmitters - physiology | Gasotransmitters - pharmacology | Hydrogen Sulfide - therapeutic use | Animals | Gasotransmitters - metabolism | Hibernation - physiology | Neoplasms - physiopathology | Energy Metabolism - physiology | Mitochondria - physiology | Energy Metabolism - drug effects | Hydrogen sulfide | Cysteine | Biological products | Nitric oxide | Colorectal cancer | Cytochrome oxidase | Superoxide | Health aspects | Medical research | Energy, Injury & Beyond | Mitochondrial Pharmacology | Themed Issue
nitric oxide | free radicals | ischaemia | gasotransmitters | bioenergetics | 3‐mercaptopyruvate sulfurtransferase | cysteine | shock | blood vessels | suspended animation | superoxide | mitochondrial electron transport | 3-mercaptopyruvate sulfurtransferase | ISCHEMIA/REPERFUSION INJURY | OXIDATIVE STRESS | NITRIC-OXIDE SYNTHASE | ISCHEMIA-REPERFUSION INJURY | COLON-CANCER | GLUCOSE-INDUCED APOPTOSIS | ANIMATION-LIKE STATE | IN-VITRO MODEL | PHARMACOLOGY & PHARMACY | CYSTATHIONINE-BETA-SYNTHASE | Hydrogen Sulfide - metabolism | Gasotransmitters - therapeutic use | Hydrogen Sulfide - pharmacology | Diabetes Complications - physiopathology | Gasotransmitters - adverse effects | Humans | Shock - physiopathology | Hydrogen Sulfide - adverse effects | Mitochondria - metabolism | Gasotransmitters - physiology | Gasotransmitters - pharmacology | Hydrogen Sulfide - therapeutic use | Animals | Gasotransmitters - metabolism | Hibernation - physiology | Neoplasms - physiopathology | Energy Metabolism - physiology | Mitochondria - physiology | Energy Metabolism - drug effects | Hydrogen sulfide | Cysteine | Biological products | Nitric oxide | Colorectal cancer | Cytochrome oxidase | Superoxide | Health aspects | Medical research | Energy, Injury & Beyond | Mitochondrial Pharmacology | Themed Issue
Journal Article
Antioxidants & Redox Signaling, ISSN 1523-0864, 02/2015, Volume 22, Issue 5, pp. 424 - 448
Significance: Cancer represents a major socioeconomic problem; there is a significant need for novel therapeutic approaches targeting tumor-specific pathways....
Forum Review Articles | STRUCTURAL INSIGHTS | GASTROESOPHAGEAL CANCER | PROTEIN-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ENDOCRINOLOGY & METABOLISM | GENE-EXPRESSION | SYNTHASE-DEFICIENT MICE | GAMMA-LYASE | MITOCHONDRIAL BIOENERGETIC FUNCTION | HYDROGEN-SULFIDE | CELL-LINES | PLASMA HOMOCYSTEINE | Hydrogen Sulfide - metabolism | Hydrogen Sulfide - pharmacology | Humans | Hydrogen Sulfide - chemistry | Antineoplastic Agents - therapeutic use | Cystathionine beta-Synthase - metabolism | Animals | Colorectal Neoplasms - drug therapy | Aminooxyacetic Acid - therapeutic use | Female | Cell Proliferation - drug effects | Ovarian Neoplasms - metabolism | Cystathionine beta-Synthase - pharmacology | Ovarian Neoplasms - drug therapy | Colorectal Neoplasms - metabolism | Cystathionine beta-Synthase - chemistry | Energy Metabolism - drug effects | Cell proliferation | Care and treatment | Usage | Analysis | Colorectal cancer | Therapeutics | Cell metabolism | Diagnosis | Homeopathy | Materia medica and therapeutics | Forum Review
Forum Review Articles | STRUCTURAL INSIGHTS | GASTROESOPHAGEAL CANCER | PROTEIN-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ENDOCRINOLOGY & METABOLISM | GENE-EXPRESSION | SYNTHASE-DEFICIENT MICE | GAMMA-LYASE | MITOCHONDRIAL BIOENERGETIC FUNCTION | HYDROGEN-SULFIDE | CELL-LINES | PLASMA HOMOCYSTEINE | Hydrogen Sulfide - metabolism | Hydrogen Sulfide - pharmacology | Humans | Hydrogen Sulfide - chemistry | Antineoplastic Agents - therapeutic use | Cystathionine beta-Synthase - metabolism | Animals | Colorectal Neoplasms - drug therapy | Aminooxyacetic Acid - therapeutic use | Female | Cell Proliferation - drug effects | Ovarian Neoplasms - metabolism | Cystathionine beta-Synthase - pharmacology | Ovarian Neoplasms - drug therapy | Colorectal Neoplasms - metabolism | Cystathionine beta-Synthase - chemistry | Energy Metabolism - drug effects | Cell proliferation | Care and treatment | Usage | Analysis | Colorectal cancer | Therapeutics | Cell metabolism | Diagnosis | Homeopathy | Materia medica and therapeutics | Forum Review
Journal Article
Current Vascular Pharmacology, ISSN 1570-1611, 2013, Volume 11, Issue 2, pp. 208 - 221
Various forms of circulatory shock (including septic shock) lead to an impairment of vascular function, which importantly contributes to the development of...
Peroxynitrite | Nitric oxide | cGMP | Sepsis | Smooth muscle | Superoxide | Vascular | Circulatory shock | Endotoxin | Blood flow | Endothelium | endothelium | nitric oxide | OXIDATIVE STRESS | peroxynitrite | ENDOTHELIAL DYSFUNCTION | POTASSIUM CHANNELS | NITRIC-OXIDE SYNTHASE | smooth muscle | CYSTATHIONINE BETA-SYNTHASE | AORTIC RINGS | vascular | MERCAPTOPYRUVATE SULFURTRANSFERASE | circulatory shock | SMOOTH-MUSCLE | SENSITIVE K+ CHANNEL | PHARMACOLOGY & PHARMACY | PERIPHERAL VASCULAR DISEASE | 1-MEDIATED NEUROGENIC INFLAMMATION | superoxide | blood flow | endotoxin
Peroxynitrite | Nitric oxide | cGMP | Sepsis | Smooth muscle | Superoxide | Vascular | Circulatory shock | Endotoxin | Blood flow | Endothelium | endothelium | nitric oxide | OXIDATIVE STRESS | peroxynitrite | ENDOTHELIAL DYSFUNCTION | POTASSIUM CHANNELS | NITRIC-OXIDE SYNTHASE | smooth muscle | CYSTATHIONINE BETA-SYNTHASE | AORTIC RINGS | vascular | MERCAPTOPYRUVATE SULFURTRANSFERASE | circulatory shock | SMOOTH-MUSCLE | SENSITIVE K+ CHANNEL | PHARMACOLOGY & PHARMACY | PERIPHERAL VASCULAR DISEASE | 1-MEDIATED NEUROGENIC INFLAMMATION | superoxide | blood flow | endotoxin
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2015, Volume 135, Issue 2, pp. AB165 - AB165
Infected mice treated with GYY4137 showed reduced viral titers and attenuated RSV-induced body weight loss, with faster recovery, compared to the untreated...
Allergy and Immunology | Hydrogen sulfide | Health aspects | Infections | Drug therapy | Rodents | Viral infections
Allergy and Immunology | Hydrogen sulfide | Health aspects | Infections | Drug therapy | Rodents | Viral infections
Journal Article
Diabetes, ISSN 0012-1797, 03/2013, Volume 62, Issue 3, pp. 953 - 964
We have conducted a phenotypic screening in endothelial cells exposed to elevated extracellular glucose (an in vitro model of hyperglycemia) to identify...
OXIDATIVE STRESS | ASSAY | DRUGS | ENDOCRINOLOGY & METABOLISM | INJURY | 3 MAJOR PATHWAYS | HYPERGLYCEMIC DAMAGE | Antidepressive Agents, Second-Generation - adverse effects | Reactive Oxygen Species - metabolism | Humans | Cytoplasm - metabolism | Endothelium, Vascular - drug effects | Male | Cytoplasm - pathology | Paroxetine - adverse effects | Diabetic Angiopathies - physiopathology | Cell Nucleus - metabolism | Diabetic Angiopathies - pathology | Cell Nucleus - pathology | Aorta, Thoracic - drug effects | DNA, Mitochondrial - chemistry | DNA Damage - drug effects | Cell Line | Diabetic Angiopathies - metabolism | Endothelium, Vascular - physiopathology | Rats | Serotonin Uptake Inhibitors - adverse effects | Antidepressive Agents, Second-Generation - pharmacology | Mitochondria - metabolism | Antioxidants - pharmacology | Diabetic Angiopathies - drug therapy | Mitochondria - drug effects | Mitochondria - pathology | Aorta, Thoracic - physiopathology | Rats, Sprague-Dawley | Cardiovascular Agents - pharmacology | Reactive Oxygen Species - antagonists & inhibitors | Animals | Endothelium, Vascular - metabolism | Antioxidants - adverse effects | Endothelium, Vascular - pathology | Mice | Oxidative Stress - drug effects | Cardiovascular Agents - adverse effects | Cell Nucleus - drug effects | In Vitro Techniques | Paroxetine - pharmacology | Serotonin Uptake Inhibitors - pharmacology | Cytoplasm - drug effects | Physiological aspects | Paroxetine | Research | Analysis | Endothelium | Complications
OXIDATIVE STRESS | ASSAY | DRUGS | ENDOCRINOLOGY & METABOLISM | INJURY | 3 MAJOR PATHWAYS | HYPERGLYCEMIC DAMAGE | Antidepressive Agents, Second-Generation - adverse effects | Reactive Oxygen Species - metabolism | Humans | Cytoplasm - metabolism | Endothelium, Vascular - drug effects | Male | Cytoplasm - pathology | Paroxetine - adverse effects | Diabetic Angiopathies - physiopathology | Cell Nucleus - metabolism | Diabetic Angiopathies - pathology | Cell Nucleus - pathology | Aorta, Thoracic - drug effects | DNA, Mitochondrial - chemistry | DNA Damage - drug effects | Cell Line | Diabetic Angiopathies - metabolism | Endothelium, Vascular - physiopathology | Rats | Serotonin Uptake Inhibitors - adverse effects | Antidepressive Agents, Second-Generation - pharmacology | Mitochondria - metabolism | Antioxidants - pharmacology | Diabetic Angiopathies - drug therapy | Mitochondria - drug effects | Mitochondria - pathology | Aorta, Thoracic - physiopathology | Rats, Sprague-Dawley | Cardiovascular Agents - pharmacology | Reactive Oxygen Species - antagonists & inhibitors | Animals | Endothelium, Vascular - metabolism | Antioxidants - adverse effects | Endothelium, Vascular - pathology | Mice | Oxidative Stress - drug effects | Cardiovascular Agents - adverse effects | Cell Nucleus - drug effects | In Vitro Techniques | Paroxetine - pharmacology | Serotonin Uptake Inhibitors - pharmacology | Cytoplasm - drug effects | Physiological aspects | Paroxetine | Research | Analysis | Endothelium | Complications
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 11/2013, Volume 86, Issue 9, pp. 1311 - 1319
Although hydrogen sulfide (H S) is generally known as a mitochondrial poison, recent studies show that lower concentrations of H S play a physiological role in...
cAMP | Isolated mitochondria | Phosphodiesterase | OXIDATIVE-PHOSPHORYLATION | CELLS | ANGIOGENESIS | MOUSE | CYTOCHROME-C-OXIDASE | CYCLIC-AMP | PATHWAY | PHARMACOLOGY & PHARMACY | MICE | CELLULAR BIOENERGETICS | STRESS | Cyclic AMP-Dependent Protein Kinases - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 2 - antagonists & inhibitors | Hydrogen Sulfide - pharmacology | Electron Transport - drug effects | Mitochondria, Liver - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 2 - metabolism | Enzyme Inhibitors - pharmacology | Rats | Male | Enzyme Activation - drug effects | Rats, Sprague-Dawley | Cyclic Nucleotide Phosphodiesterases, Type 2 - genetics | Mitochondria, Liver - drug effects | Animals | In Vitro Techniques | Cyclic AMP - metabolism | Hydrogen sulfide | Electron transport | Protein kinases | Index Medicus
cAMP | Isolated mitochondria | Phosphodiesterase | OXIDATIVE-PHOSPHORYLATION | CELLS | ANGIOGENESIS | MOUSE | CYTOCHROME-C-OXIDASE | CYCLIC-AMP | PATHWAY | PHARMACOLOGY & PHARMACY | MICE | CELLULAR BIOENERGETICS | STRESS | Cyclic AMP-Dependent Protein Kinases - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 2 - antagonists & inhibitors | Hydrogen Sulfide - pharmacology | Electron Transport - drug effects | Mitochondria, Liver - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 2 - metabolism | Enzyme Inhibitors - pharmacology | Rats | Male | Enzyme Activation - drug effects | Rats, Sprague-Dawley | Cyclic Nucleotide Phosphodiesterases, Type 2 - genetics | Mitochondria, Liver - drug effects | Animals | In Vitro Techniques | Cyclic AMP - metabolism | Hydrogen sulfide | Electron transport | Protein kinases | Index Medicus
Journal Article