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DMM Disease Models and Mechanisms, ISSN 1754-8403, 03/2019, Volume 12, Issue 3, p. dmm037697
To decrease bowel cancer incidence and improve survival, we need to understand the mechanisms that drive tumorigenesis. Recently, B-cell lymphoma 3 (BCL-3; a... 
NF-κB | BCL3 | NF-kappaB | Spheroid | Wnt | ASCL2 | LGR5 | HUMAN COLON | ONCOPROTEIN | ACTIVATION | SMALL-INTESTINE | PATHOLOGY | CELL BIOLOGY | IN-VITRO | NF-kappa B | EPITHELIAL-CELLS | GENE | NF-KAPPA-B | EXPRESSION | CANDIDATE PROTOONCOGENE BCL-3
Journal Article
The EMBO Journal, ISSN 0261-4189, 07/2013, Volume 32, Issue 13, pp. 1903 - 1916
The Wnt/β‐catenin signalling and autophagy pathways each play important roles during development, adult tissue homeostasis and tumorigenesis. Here we identify... 
cancer | autophagy | LC3 | p62 | Wnt/β‐catenin | Autophagy | Wnt/β-catenin | Cancer | CELLS | OXIDATIVE STRESS | BIOCHEMISTRY & MOLECULAR BIOLOGY | P62/SQSTM1 | CASPASE CLEAVAGE | SELECTIVE AUTOPHAGY | CELL BIOLOGY | TRANSCRIPTION FACTOR NRF2 | STRUCTURAL BASIS | COLORECTAL-CANCER | Wnt/beta-catenin | RNA, Small Interfering - genetics | Colonic Neoplasms - genetics | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Sequestosome-1 Protein | Humans | Wnt Proteins - metabolism | Antigens, CD - genetics | Colonic Neoplasms - metabolism | Immunoenzyme Techniques | Antigens, CD - metabolism | Lysosomes - metabolism | Wnt Proteins - genetics | Chromatin Immunoprecipitation | Proteolysis | Tumor Cells, Cultured | Real-Time Polymerase Chain Reaction | Recombinant Proteins - metabolism | Transcription Factor 4 | Leukocyte Immunoglobulin-like Receptor B1 | Phagosomes - metabolism | RNA, Messenger - genetics | Recombinant Proteins - genetics | Transcription Factors - genetics | Reverse Transcriptase Polymerase Chain Reaction | beta Catenin - metabolism | Blotting, Western | beta Catenin - genetics | Mice, Knockout | Transcription Factors - metabolism | Animals | beta Catenin - antagonists & inhibitors | Colonic Neoplasms - pathology | Adaptor Proteins, Signal Transducing - genetics | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - genetics | Fluorescent Antibody Technique | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - metabolism | Mice | Proteasome Endopeptidase Complex - metabolism | Adaptor Proteins, Signal Transducing - metabolism | Receptors, Immunologic - genetics | Receptors, Immunologic - metabolism | Index Medicus | β-catenin | Wnt
Journal Article
EMBO Molecular Medicine, ISSN 1757-4676, 11/2018, Volume 10, Issue 11, pp. e8699 - n/a
Journal Article
Gut, ISSN 0017-5749, 07/2016, Volume 65, Issue 7, pp. 1151 - 1164
Journal Article
Carcinogenesis, ISSN 0143-3334, 04/2008, Volume 29, Issue 4, p. 849
  Although expression of the anti-apoptotic protein Bcl-2-associated athanogene-1 (BAG-1) has been reported as up-regulated in a number of malignancies, we... 
Journal Article
INTERNATIONAL JOURNAL OF ONCOLOGY, ISSN 1019-6439, 07/2010, Volume 37, Issue 1, pp. 187 - 193
Despite recent advances in understanding colorectal tumour biology, there is still a need to improve the 5-year survival rate of patients with colorectal... 
CARCINOMA-CELLS | ACTIVATION | cannabinoid | ANTICANCER AGENTS | cyclooxygenase-2 | RECEPTOR | colorectal carcinoma | arachidonoylethanolamide (anandamide | BCL-2 | METABOLISM | ONCOLOGY | CYCLOOXYGENASE-2 EXPRESSION | BAX | non-apoptotic cell death | INHIBITOR | AEA | TUMOR-GROWTH
Journal Article
EMBO Journal, ISSN 0261-4189, 07/2013, Volume 32, Issue 13, p. 1903
  The Wnt/[beta]-catenin signalling and autophagy pathways each play important roles during development, adult tissue homeostasis and tumorigenesis. Here we... 
Signaling | Angiogenesis | Gene expression | Autophagy | Cancer
Journal Article
ONCOGENE, ISSN 0950-9232, 05/2012, Volume 31, Issue 22, pp. 2761 - 2772
Understanding the mechanisms that promote aberrant tumour cell survival is critical for the determination of novel strategies to combat colorectal cancer... 
CANCER-CELLS | DNA-BINDING | TRANSCRIPTIONAL ACTIVATION | colorectal cancer | ONCOPROTEIN BCL-3 | PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | RECEPTOR | ALTERNATIVE TRANSLATION INITIATION | BAG-1 | EGFR | CELL BIOLOGY | NF-kappa B | ONCOLOGY | GENETICS & HEREDITY | SQUAMOUS-CELL CARCINOMA | COX2 | EXPRESSION | p50 homodimers | RNA, Small Interfering - genetics | Receptor, Epidermal Growth Factor - genetics | Cell Proliferation | Immunoprecipitation | Luciferases - metabolism | Embryo, Mammalian | Colorectal Neoplasms - genetics | Humans | Protein Multimerization | Gene Expression Regulation, Neoplastic | NF-kappa B p50 Subunit - genetics | Immunoenzyme Techniques | DNA-Binding Proteins - metabolism | Receptor, Epidermal Growth Factor - metabolism | Transfection | Chromatin Immunoprecipitation | Cyclooxygenase 2 - genetics | Fibroblasts | Electrophoretic Mobility Shift Assay | Real-Time Polymerase Chain Reaction | Colorectal Neoplasms - metabolism | Promoter Regions, Genetic | NF-kappa B - antagonists & inhibitors | NF-kappa B p50 Subunit - metabolism | RNA, Messenger - genetics | Cells, Cultured | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Mice, Knockout | Transcription Factors - metabolism | Animals | Cyclooxygenase 2 - metabolism | NF-kappa B - physiology | Mice | Cell Transformation, Neoplastic - pathology | Colorectal Neoplasms - pathology | Apoptosis | Index Medicus | Phosphorylation | Cell survival | Epidermal growth factor receptors | Transcription | Colorectal cancer | Data processing | Embryo fibroblasts | Regulatory sequences | siRNA | Adenoma | Gene expression | Carcinogenesis | Metastases | NF- Kappa B protein | Microenvironments | Cyclooxygenase-2
Journal Article
Carcinogenesis, ISSN 0143-3334, 4/2008, Volume 29, Issue 4, pp. 849 - 857
Although expression of the anti-apoptotic protein Bcl-2-associated athanogene-1 (BAG-1) has been reported as up-regulated in a number of malignancies, we show... 
BREAST-CANCER | PROTEIN | EPITHELIAL-CELLS | CARCINOMA CELLS | ONCOLOGY | INDUCED APOPTOSIS | CYCLIN D1 | GROWTH | TRANSCRIPTION | ALTERNATIVE TRANSLATION INITIATION | EXPRESSION
Journal Article
International Journal of Cancer, ISSN 0020-7136, 09/2003, Volume 106, Issue 3, pp. 364 - 371
Journal Article