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PLoS ONE, ISSN 1932-6203, 12/2015, Volume 10, Issue 12, p. e0144597
The transcription factor Pax6 is an important regulator of development and cell differentiation in various organs. Thus, Pax6 was shown to promote neural... 
IDENTITY | ALPHA-CELLS | MOUSE PANCREAS | MULTIDISCIPLINARY SCIENCES | BETA-CELLS | INSULIN-SECRETION | 7B2 | MICE | ENZYMATIC-ACTIVITY | DIFFERENTIATION | EXPRESSION | Paired Box Transcription Factors - genetics | Homeodomain Proteins - metabolism | Somatostatin-Secreting Cells - cytology | Male | Cell Lineage - drug effects | Pancreatic Polypeptide-Secreting Cells - metabolism | Pancreatic Polypeptide-Secreting Cells - cytology | Glucagon-Secreting Cells - drug effects | Insulin-Secreting Cells - metabolism | Gene Expression Regulation, Developmental | Glucagon-Secreting Cells - metabolism | Somatostatin-Secreting Cells - drug effects | Female | Integrases - metabolism | Cell Differentiation | Insulin-Secreting Cells - cytology | Eye Proteins - genetics | Insulin - genetics | Cell Lineage - genetics | Genes, Reporter | Repressor Proteins - metabolism | Glucagon-Secreting Cells - cytology | Signal Transduction | Bacterial Proteins - genetics | Ghrelin - genetics | Repressor Proteins - genetics | PAX6 Transcription Factor | Pancreatic Polypeptide-Secreting Cells - drug effects | Homeodomain Proteins - genetics | Mice, Knockout | Ghrelin - metabolism | Insulin - metabolism | Animals | Eye Proteins - metabolism | Insulin-Secreting Cells - drug effects | Tamoxifen - pharmacology | Bacterial Proteins - metabolism | Luminescent Proteins - genetics | Mice | Integrases - genetics | Somatostatin-Secreting Cells - metabolism | Paired Box Transcription Factors - metabolism | Crosses, Genetic | Luminescent Proteins - metabolism | Care and treatment | Research | Glucagon | Pancreas | Ghrelin | Risk factors | Spinal cord | Cerebral cortex | Transcription factors | Deactivation | Maturation | Developmental biology | Genes | Cortex | Organs | Glucose | Kinases | Cell differentiation | Inactivation | Insulin | Proteins | Pax6 protein | Rodents | Diabetes | Alzheimers disease | Life Sciences | Development Biology
Journal Article
PLoS Genetics, ISSN 1553-7390, 10/2013, Volume 9, Issue 10, p. e1003934
Journal Article
Cell Cycle, ISSN 1538-4101, 04/2017, Volume 16, Issue 8, pp. 727 - 728
Journal Article
BMC Developmental Biology, ISSN 1471-213X, 2011, Volume 11, Issue 1, pp. 52 - 52
Background: Nkx2.2 and Arx represent key transcription factors implicated in the specification of islet cell subtypes during pancreas development. Mice... 
Pax4 | ghrelin | Pax6 | Arx | Nkx2.2 | somatostatin | PROGENITOR CELLS | MOUSE PANCREAS | ISLET-CELL | TRANSCRIPTION | INSULIN-RELEASE | DEVELOPMENTAL BIOLOGY | ENDOCRINE PANCREAS | GENE | MICE | Paired Box Transcription Factors - biosynthesis | Paired Box Transcription Factors - genetics | Paired Box Transcription Factors - deficiency | Homeodomain Proteins - metabolism | Transcription Factors - deficiency | Ghrelin - biosynthesis | Cell Differentiation - genetics | Insulin-Secreting Cells - metabolism | Repressor Proteins - deficiency | Gene Expression Regulation, Developmental | Glucagon-Secreting Cells - metabolism | Nerve Tissue Proteins - biosynthesis | Insulin-Secreting Cells - cytology | Eye Proteins - genetics | POU Domain Factors - biosynthesis | Cell Lineage - genetics | Glucagon-Secreting Cells - cytology | Somatostatin - genetics | Homeodomain Proteins - biosynthesis | Ghrelin - genetics | Islet Amyloid Polypeptide - metabolism | Repressor Proteins - genetics | Transcription Factors - biosynthesis | PAX6 Transcription Factor | Transcription Factors - genetics | Homeodomain Proteins - genetics | Somatostatin - biosynthesis | Mice, Knockout | Animals | Repressor Proteins - biosynthesis | Trans-Activators - metabolism | Mice | Paired Box Transcription Factors - metabolism | Eye Proteins - biosynthesis | Physiological aspects | Embryonic development | Transcription factors | Pancreatic beta cells | Genetic aspects | Research | Proteins | Rodents | Glucose | Pancreas | Comparative analysis | Cells | Manuscripts | Life Sciences | Development Biology
Journal Article
PLoS ONE, ISSN 1932-6203, 08/2018, Volume 13, Issue 8, p. e0201536
In the context of type 1 diabetes research and the development of insulin-producing beta-cell replacement strategies, whether pancreatic ductal cells retain... 
PROGENITORS | ACTIVATION | REGENERATION | MULTIDISCIPLINARY SCIENCES | BETA-CELLS | ENDOCRINE | ADULT PANCREAS | MICE | DIFFERENTIATION | EXPRESSION | LINEAGES | Drinking water | Animal models | Diabetes mellitus | Ontogeny | Diabetes mellitus (insulin dependent) | Insulin | Regeneration | Ethics | Hyperglycemia | Transgenic animals | Rodents | Occupational health | Regulation | Diabetes | Islets of Langerhans | Pancreas | Hypertrophy
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2012, Volume 7, Issue 5, p. e36449
Intestinal hormones are key regulators of digestion and energy homeostasis secreted by rare enteroendocrine cells. These cells produce over ten different... 
ENDOCRINE PANCREAS | GLUCOSE-HOMEOSTASIS | GUT HORMONES | CELL FATE SPECIFICATION | ABNORMAL GENITALIA | BETA-CELLS | GASTROINTESTINAL-TRACT | BIOLOGY | GENE-EXPRESSION | ALPHA-CELL | PANCREATIC-ISLET CELLS | Paired Box Transcription Factors - genetics | Paired Box Transcription Factors - deficiency | Enteroendocrine Cells - classification | Homeodomain Proteins - metabolism | Transcription Factors - deficiency | Intestines - metabolism | Mice, 129 Strain | Enteroendocrine Cells - cytology | Peptide Hormones - genetics | Glucagon-Like Peptide 1 - genetics | Cell Differentiation - genetics | Basic Helix-Loop-Helix Transcription Factors - metabolism | Enteroendocrine Cells - metabolism | Cell Lineage - genetics | Gene Expression | Somatostatin - genetics | Basic Helix-Loop-Helix Transcription Factors - genetics | Gene Expression Regulation | Transcription Factors - genetics | Nerve Tissue Proteins - genetics | Homeodomain Proteins - genetics | Mice, Knockout | Nerve Tissue Proteins - metabolism | Transcription Factors - metabolism | Animals | Models, Biological | Mice | Mutation | Paired Box Transcription Factors - metabolism | Gastrin | DNA binding proteins | Diabetes therapy | Regulators | Transcription factors | Peptides | Homeostasis | Hormones | Small intestine | Homeobox | Proteins | Genotype & phenotype | Specifications | Ghrelin | Rodents | Genetics | Colon | Somatostatin | Pancreas | Serotonin | Secretion | Diarrhea | Cell lineage | Gene expression | Insulin | Embryos | Mutants | Energy balance | Molecular modelling | Stem cells | Cells (biology) | Islets of Langerhans | Diabetes | Cholecystokinin | Differentiation | Life Sciences | Development Biology
Journal Article
CELL, ISSN 0092-8674, 01/2017, Volume 168, Issue 1-2, pp. 86 - 86
Journal Article
The EMBO Journal, ISSN 0261-4189, 03/2006, Volume 25, Issue 6, pp. 1344 - 1352
Neurogenin 3 (Ngn3) is key for endocrine cell specification in the embryonic pancreas and induction of a neuroendocrine cell differentiation program by... 
transdifferentiation | beta cell | duct cell | development | diabetes | Development | Duct cell | Diabetes | Transdifferentiation | Beta cell | NEUROGENIN3 | PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | BETA-CELLS | NEUROENDOCRINE DIFFERENTIATION | CELL BIOLOGY | GENE | MICE | TRANSCRIPTION FACTOR | ISLET CELLS | EXPRESSION | IA-1 | Homeodomain Proteins - metabolism | Male | Pancreatic Ducts - metabolism | DNA-Binding Proteins - metabolism | Basic Helix-Loop-Helix Transcription Factors - metabolism | Chromatin Immunoprecipitation | Gene Expression Regulation, Developmental | Islets of Langerhans - metabolism | Islets of Langerhans - cytology | Female | Transcription, Genetic | Cell Differentiation | Repressor Proteins - metabolism | Basic Helix-Loop-Helix Transcription Factors - physiology | Nerve Tissue Proteins - physiology | Pancreatic Ducts - cytology | Zinc Fingers | Basic Helix-Loop-Helix Transcription Factors - genetics | Repressor Proteins - genetics | Mice, Transgenic | PAX6 Transcription Factor | Islets of Langerhans - embryology | DNA-Binding Proteins - genetics | Nerve Tissue Proteins - genetics | Nerve Tissue Proteins - metabolism | Pregnancy | Transcription Factors - metabolism | Insulin - metabolism | Animals | Eye Proteins - metabolism | Glucagon - metabolism | Mice | Paired Box Transcription Factors - metabolism | Mutation | Pancreas | Gene expression | Embryos | Stem cells
Journal Article
Cell, ISSN 0092-8674, 01/2017, Volume 168, Issue 1-2, pp. 73 - 85.e11
Journal Article