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Journal Article
Nature, ISSN 0028-0836, 2016, Volume 538, Issue 7625, pp. 344 - 349
Antimalarial drugs have thus far been chiefly derived from two sources-natural products and synthetic drug-like compounds. Here we investigate whether... 
IN-VITRO | TRANSFER-RNA SYNTHETASE | MALARIA CONTROL | PLASMODIUM-FALCIPARUM | MULTIDISCIPLINARY SCIENCES | DRUG DISCOVERY | LIVER | TARGETS | PROTEIN-SYNTHESIS | NEXT-GENERATION | HEPATIC STAGES | Azabicyclo Compounds - pharmacology | Plasmodium falciparum - enzymology | Malaria, Falciparum - prevention & control | Male | Plasmodium falciparum - cytology | Azetidines - pharmacology | Plasmodium falciparum - drug effects | Cytosol - enzymology | Malaria, Falciparum - transmission | Liver - drug effects | Azabicyclo Compounds - chemical synthesis | Azabicyclo Compounds - therapeutic use | Female | Safety | Antimalarials - chemical synthesis | Disease Models, Animal | Life Cycle Stages - drug effects | Malaria, Falciparum - drug therapy | Azabicyclo Compounds - administration & dosage | Azetidines - adverse effects | Phenylurea Compounds - therapeutic use | Antimalarials - therapeutic use | Macaca mulatta - parasitology | Phenylalanine-tRNA Ligase - antagonists & inhibitors | Drug Discovery | Antimalarials - pharmacology | Animals | Azetidines - administration & dosage | Phenylurea Compounds - chemical synthesis | Antimalarials - administration & dosage | Azetidines - therapeutic use | Phenylurea Compounds - administration & dosage | Mice | Phenylurea Compounds - pharmacology | Liver - parasitology | Plasmodium falciparum - growth & development | Prevention | Antimalarials | Disease transmission | Health aspects | Transfer RNA | Proteins | Cytochrome | Malaria | Liver | Parasites | Kinases | Drug resistance | Drug dosages
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 06/2005, Volume 127, Issue 22, pp. 8160 - 8167
A capillary-based flow system has been developed for conducting microscale organic synthesis with the aid of microwave irradiation. The capillary internal... 
REACTORS | COUPLING REACTIONS | CHEMISTRY | ALDEHYDES | TECHNOLOGY | CHEMISTRY, MULTIDISCIPLINARY | METATHESIS | Thin films | Synthesis | Research | Dielectric films | Capillarity | Organic compounds
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 08/2017, Volume 139, Issue 32, pp. 11300 - 11306
The development of new antimalarial therapeutics is necessary to address the increasing resistance to current drugs. Bicyclic azetidines targeting Plasmodium... 
FUNCTIONALIZATION | DIVERSITY-ORIENTED SYNTHESIS | C-H ARYLATION | ALKYLATION | PALLADIUM-CATALYZED ARYLATION | MALARIA | BOND ACTIVATION | STEREOSELECTIVE-SYNTHESIS | DERIVATIVES | CHEMISTRY, MULTIDISCIPLINARY | UNACTIVATED METHYLENE
Journal Article
2009, ISBN 9781854376077, 160
Book
PLoS ONE, ISSN 1932-6203, 03/2015, Volume 10, Issue 3, p. e0120295
Journal Article
Age and Ageing, ISSN 0002-0729, 09/2019, Volume 48, Issue Supplement_3, pp. iii17 - iii65
Abstract Background As illustrated in a cross-sectional study at a Galway hospital, delirium is common with a 29% incidence in hospitalised older adults. This... 
Journal Article
Chemistry – A European Journal, ISSN 0947-6539, 12/2005, Volume 11, Issue 24, pp. 7223 - 7227
A continuous flow, microwave‐assisted, parallel‐capillary microreactor has been developed. Libraries of drug candidates were prepared on the milligram scale... 
microwaves | combinatorial chemistry | cross‐coupling | microreactors | parallel synthesis | Combinatorial chemistry | Cross-coupling | Parallel synthesis | Microwaves | Microreactors | ORGANIC-SYNTHESIS | REACTORS | cross-coupling | CHEMISTRY | LIBRARY | MICROREACTOR | CHEMISTRY, MULTIDISCIPLINARY
Journal Article
Organic Letters, ISSN 1523-7060, 05/2007, Volume 9, Issue 11, pp. 2123 - 2126
Diversification of enantioenriched Michael adducts through functional group pairing to gain access to a range of five- to ten-membered complex fused and... 
CHEMISTRY, ORGANIC | OLEFIN METATHESIS | NITRILE | PAUSON-KHAND | CYCLOADDITIONS | ORIENTED SYNTHESIS | Models, Molecular | Molecular Structure | Hydrocarbons, Cyclic - chemical synthesis
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 12/2010, Volume 132, Issue 47, pp. 16962 - 16976
Journal Article
The Journal of Organic Chemistry, ISSN 0022-3263, 10/2011, Volume 76, Issue 19, pp. 8042 - 8048
Journal Article
Future Medicinal Chemistry, ISSN 1756-8919, 12/2012, Volume 4, Issue 18, pp. 2279 - 2294
Journal Article
Journal of Infectious Diseases, ISSN 0022-1899, 04/2015, Volume 211, Issue 7, pp. 1097 - 1103
Background. The emergence and spread of drug resistance to current antimalarial therapies remains a pressing concern, escalating the need for compounds that... 
drug development | drug resistance | malaria | diversity-oriented synthesis | target identification | cytochrome b | INFECTIOUS DISEASES | BC INHIBITORS | DRUG DISCOVERY | VALIDATION | MICROBIOLOGY | IMMUNOLOGY | MALARIA PARASITES | ATOVAQUONE | DATABASE | RESISTANCE | CHEMISTRY | QI SITE | MOLECULAR-BASIS | Plasmodium falciparum - enzymology | Protozoan Proteins - antagonists & inhibitors | Humans | Molecular Sequence Data | Ubiquinone - metabolism | Drug Discovery - methods | Plasmodium falciparum - drug effects | Enzyme Inhibitors - chemical synthesis | Protozoan Proteins - genetics | Cytochromes b - chemistry | Lactams, Macrocyclic - chemistry | Cytochromes b - antagonists & inhibitors | Phenylurea Compounds - chemistry | Base Sequence | Enzyme Inhibitors - chemistry | Lactams, Macrocyclic - chemical synthesis | Plasmodium falciparum - genetics | Protozoan Proteins - chemistry | Antimalarials - chemical synthesis | Drug Resistance | Malaria, Falciparum - drug therapy | Catalytic Domain | Oxidation-Reduction | Enzyme Inhibitors - pharmacology | Lactams, Macrocyclic - pharmacology | Antimalarials - pharmacology | Drug Synergism | Malaria, Falciparum - parasitology | High-Throughput Screening Assays | Phenylurea Compounds - chemical synthesis | Cytochromes b - genetics | Small Molecule Libraries | Antimalarials - chemistry | High-Throughput Nucleotide Sequencing | Phenylurea Compounds - pharmacology | Cytochrome b | Research | Drug resistance | Health aspects | Major and Brief Reports
Journal Article