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1. GxE interactions in genome-wide association studies
by Conti, David V
2016, Statistical genetics
Bayesian statistical decision theory | Genome-Wide Association Study | methods | Statistical methods | Gene-Environment Interaction | Physiological effect | Genotype-environment interaction | Tobacco Use Disorder | Bayes Theorem | Genetics | Polymorphism, Single Nucleotide | Genetic aspects | metabolism | Nicotine | Smoking
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2. Full Text Elevated numbers of PD-L1 expressing B cells are associated with the development of AIDS-NHL
by Epeldegui, M and Conti, DV and Guo, Y and Cozen, W and Penichet, ML and Martinez-Maza, O
SCIENTIFIC REPORTS, ISSN 2045-2322, 06/2019, Volume 9, Issue 1, pp. 9371 - 9
The risk for non-Hodgkin lymphoma (NHL) is markedly increased in persons living with human immunodeficiency virus (HIV) infection, and remains elevated in... 
BIOMARKERS | DIAGNOSIS | CYTOKINES | MULTIDISCIPLINARY SCIENCES | SERUM-LEVELS | IMMUNE ACTIVATION | MARKERS | NON-HODGKIN-LYMPHOMA | COHORT | HYPERMUTATION | Flow cytometry | CD19 antigen | CD40 antigen | Immunoregulation | Secretion | Lymphocytes T | Lymphoma | CD40L protein | Cell activation | Acquired immune deficiency syndrome--AIDS | Lymphocytes B | Cell death | Etiology | Human immunodeficiency virus--HIV | CD38 antigen | PD-L1 protein | Interleukin 1 | Interleukin 10 | Peripheral blood mononuclear cells | Diagnosis | Hodgkin's disease | Apoptosis
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3. Full Text Elucidation of causal direction between asthma and obesity: a bi-directional Mendelian randomization study
by Xu, SJ and Gilliland, FD and Conti, DV
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, ISSN 0300-5771, 06/2019, Volume 48, Issue 3, pp. 899 - 907
Background: Observational associations between asthma and obesity are well established, but inferring causality is challenging. We leveraged publicly available... 
summary statistics | METAANALYSIS | body mass index | BIAS | WEIGHT-LOSS | RISK | asthma | LOCI | Mendelian randomization | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | bi-directional causal estimation | DISEASE | BODY-MASS INDEX | INSTRUMENTS | PSORIASIS | GENOME-WIDE ASSOCIATION
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4. Full Text A Unified Model for the Analysis of Gene-Environment Interaction
by Gauderman, W James and Kim, Andre and Conti, David V and Morrison, John and Thomas, Duncan C and Vora, Hita and Lewinger, Juan Pablo
American Journal of Epidemiology, ISSN 0002-9262, 04/2019, Volume 188, Issue 4, pp. 760 - 767
Abstract Gene-environment (G × E) interaction is important for many complex traits. In a case-control study of a disease trait, logistic regression is the... 
power (statistics) | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | INDEPENDENCE | ENZYMES | gene-environment interaction | CASE-ONLY DESIGNS | SAMPLE-SIZE REQUIREMENTS | ASTHMA | PHOSPHODIESTERASES | genome-wide association studies | case-control studies
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5. Full Text Using Bayes model averaging to leverage both gene main effects and G ×  E interactions to identify genomic regions in genome‐wide association studies
by Moss, Lilit C and Gauderman, William J and Lewinger, Juan Pablo and Conti, David V
Genetic Epidemiology, ISSN 0741-0395, 03/2019, Volume 43, Issue 2, pp. 150 - 165
Genome‐wide association studies typically search for marginal associations between a single‐nucleotide polymorphism (SNP) and a disease trait while... 
environmental factor | genome‐wide scan | bayesian model | power | case–control studies | genome-wide scan | Genetic Predisposition to Disease | Genome-Wide Association Study | Humans | Genetic Loci | Genetic Markers | Gene-Environment Interaction | Asthma - genetics | Case-Control Studies | Computer Simulation | Bayes Theorem | ROC Curve | Models, Genetic | Polymorphism, Single Nucleotide | Genome, Human | Statistical analysis | Genomes | Single-nucleotide polymorphism | Mathematical models | Gene polymorphism | Bayesian analysis | Power | Index Medicus
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6. Full Text A Genome-wide Association Study of Prostate Cancer in Latinos
by Du, Zhaohui and Hopp, Hannah and Ingles, Sue Ann and Huff, Chad and Sheng, Xin and Weaver, Brandi and Stern, Mariana and Hoffmann, Thomas J and John, Esther M and Van Den Eeden, Stephen K and Strom, Sara and Leach, Robin J and Thompson, Jr, Ian M and Witte, John S and Conti, David V and Haiman, Christopher A
International journal of cancer, ISSN 0020-7136, 06/2019
Latinos represent less than 1% of samples analyzed to date in genome-wide association studies of cancer. The clinical value of genetic information in guiding... 
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7. Full Text Shared heritability and functional enrichment across six solid cancers
by Jiang, Xia and Jiang, Xia and Finucane, Hilary K and Finucane, Hilary K and Schumacher, Fredrick R and Schumacher, Fredrick R and Schmit, Stephanie L and Tyrer, Jonathan P and Tyrer, Jonathan P and Han, Younghun and Han, Younghun and Michailidou, Kyriaki and Michailidou, Kyriaki and Lesseur, Corina and Kuchenbaecker, Karoline B and Kuchenbaecker, Karoline B and Dennis, Joe and Conti, David V and Casey, Graham and Gaudet, Mia M and Huyghe, Jeroen R and Albanes, Demetrius and Aldrich, Melinda C and Aldrich, Melinda C and Andrew, Angeline S and Andrew, Angeline S and Andrulis, Irene L and Anton-Culver, Hoda and Anton-Culver, Hoda and Antoniou, Antonis C and Antoniou, Antonis C and Antonenkova, Natalia N and Antonenkova, Natalia N and Arnold, Susanne M and Aronson, Kristan J and Aronson, Kristan J and Arun, Banu K and Arun, Banu K and Bandera, Elisa V and Bandera, Elisa V and Barkardottir, Rosa B and Barnes, Daniel R and Batra, Jyotsna and Beckmann, Matthias W and Benitez, Javier and Benitez, Javier and Benlloch, Sara and Benlloch, Sara and Berchuck, Andrew and Berchuck, Andrew and Berndt, Sonja I and Bickeböller, Heike and Bien, Stephanie A and Bien, Stephanie A and Blomqvist, Carl and Blomqvist, Carl and Boccia, Stefania and Bogdanova, Natalia V and Bogdanova, Natalia V and Bojesen, Stig E and Bolla, Manjeet K and Bolla, Manjeet K and Brauch, Hiltrud and Brenner, Hermann and Brenton, James D and Brenton, James D and Brook, Mark N and Brook, Mark N and Brunet, Joan and Brunet, Joan and Brunnström, Hans and Buchanan, Daniel D and Buchanan, Daniel D and Burwinkel, Barbara and Burwinkel, Barbara and Butzow, Ralf and Cadoni, Gabriella and Caldés, Trinidad and Caldés, Trinidad and Caligo, Maria A and Caligo, Maria A and Campbell, Ian and Campbell, Ian and Campbell, Peter T and Cancel-Tassin, Géraldine and Cancel-Tassin, Géraldine and Cannon-Albright, Lisa and Cannon-Albright, Lisa and Campa, Daniele and Campa, Daniele and Caporaso, Neil and Carvalho, André L and Carvalho, André L and Chan, Andrew T and Chan, Andrew T and Chang-Claude, Jenny and Chang-Claude, Jenny and Chanock, Stephen J and Chanock, Stephen J and Chen, Chu and ...
Nature Communications, ISSN 2041-1723, 01/2019, Volume 10, Issue 1, pp. 431 - 23
Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association... 
BREAST-CANCER | LUNG-CANCER | RISK-FACTORS | PARTITIONING HERITABILITY | MULTIDISCIPLINARY SCIENCES | SUSCEPTIBILITY LOCI | GENETIC ARCHITECTURE | ANALYSES IDENTIFY | MENDELIAN RANDOMIZATION | CELL-TYPES | GENOME-WIDE ASSOCIATION | Lung Neoplasms - ethnology | Colorectal Neoplasms - genetics | Humans | Ovarian Neoplasms - pathology | Lung Neoplasms - pathology | Male | Prostatic Neoplasms - diagnosis | Case-Control Studies | Colorectal Neoplasms - diagnosis | Ovarian Neoplasms - ethnology | Inheritance Patterns | Ovarian Neoplasms - genetics | Mental Disorders - genetics | Prostatic Neoplasms - genetics | Smoking - physiopathology | Head and Neck Neoplasms - ethnology | Female | Neoplasm Proteins - genetics | Breast Neoplasms - ethnology | Lung Neoplasms - genetics | Prostatic Neoplasms - pathology | Genetic Predisposition to Disease | Genome-Wide Association Study | Colorectal Neoplasms - ethnology | Ovarian Neoplasms - diagnosis | European Continental Ancestry Group | Smoking - genetics | Prostatic Neoplasms - ethnology | Head and Neck Neoplasms - pathology | Mental Disorders - physiopathology | Smoking - ethnology | Phenotype | Breast Neoplasms - genetics | Breast Neoplasms - pathology | Head and Neck Neoplasms - diagnosis | Head and Neck Neoplasms - genetics | Breast Neoplasms - diagnosis | Mental Disorders - ethnology | Polymorphism, Single Nucleotide | Colorectal Neoplasms - pathology | Lung Neoplasms - diagnosis | Enrichment | Correlation | Statistical analysis | Ovarian carcinoma | Mental disorders | Lung cancer | Colorectal carcinoma | Genomes | Breast cancer | Regulatory sequences | Ovarian cancer | Etiology | Breast | Heritability | Neck | Solid tumors | Prostate cancer | Prostate | Cancer | Smoking
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8. Full Text DNA methylation patterns of adult survivors of adolescent/young adult Hodgkin lymphoma compared to their unaffected monozygotic twin
by Wang, Jun and Van Den Berg, David and Hwang, Amie E and Weisenberger, Daniel and Triche, Timothy and Nathwani, Bharat N and Conti, David V and Siegmund, Kim and Mack, Thomas M and Horvath, Steve and Cozen, Wendy
Leukemia & Lymphoma, ISSN 1042-8194, 05/2019, Volume 60, Issue 6, pp. 1429 - 1437
DNA methylation (DNAm) silences gene expression and may play a role in immune dysregulation that is characteristic of adolescent/young adult Hodgkin lymphoma... 
saliva | twins | survivors | DNA methylation | AYA | blood | Hodgkin lymphoma | MORTALITY | LONG-TERM SURVIVORS | FATIGUE | RISK | DRUG-RESISTANCE | BREAST-CANCER | CHILDHOOD-CANCER | ONCOLOGY | DISEASE | HEMATOLOGY | AGE | REVEALS
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9. Full Text Using Bayes model averaging to leverage both gene main effects and GxE interactions to identify genomic regions in genome-wide association studies
by Moss, Lilit C and Gauderman, William J and Lewinger, Juan Pablo and Conti, David V
Genetic Epidemiology, ISSN 0741-0395, 03/2019, Volume 43, Issue 2, p. 150
Leverage (Finance) | Analysis | Genes | Genomics | Models | Single nucleotide polymorphisms
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10. Full Text Reply to Xiaoling Lin, Brian T. Helfand, and Jianfeng Xu's Letter to the Editor re: Daniel A. Leongamornlert, Edward J. Saunders, Sarah Wakerell, et al. Germline DNA Repair Gene Mutations in Young-onset Prostate Cancer Cases in the UK: Evidence for a More Extensive Genetic Panel. Eur Urol. In press. https://doi.org/10.1016/j.eururo.2019.01.050
by Kote-Jarai, Zsofia and Leongamornlert, Daniel A and Saunders, Edward J and Conti, David V and Eeles, Rosalind A
European urology, ISSN 0302-2838, 06/2019
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11. Full Text HiLDA: a statistical approach to investigate differences in mutational signatures
by Yang, Z and Pandey, P and Shibata, D and Conti, DV and Marjoram, P and Siegmund, KD
PEERJ, ISSN 2167-8359, 08/2019, Volume 7, p. e7557
We propose a hierarchical latent Dirichlet allocation model (HiLDA) for characterizing somatic mutation data in cancer. The method allows us to infer... 
Somatic mutation | Deconvolution | Mutational signatures | MULTIDISCIPLINARY SCIENCES | Colorectal cancer | Latent dirichlet allocation | ESOPHAGEAL ADENOCARCINOMA | Genetic aspects | Colon cancer | Analysis | Investigations | Esophageal cancer
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12. Full Text Using Bayes model averaging to leverage both gene main effects and G × E interactions to identify genomic regions in genome-wide association studies
: MOSS et al
by Moss, Lilit C and Gauderman, William J and Lewinger, Juan Pablo and Conti, David V
Genetic Epidemiology, ISSN 0741-0395, 03/2019, Volume 43, Issue 2, pp. 150 - 165
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13. Full Text Partitioning the Heritability of Tourette Syndrome and Obsessive Compulsive Disorder Reveals Differences in Genetic Architecture
by Davis, Lea K and Yu, Dongmei and Keenan, Clare L and Gamazon, Eric R and Konkashbaev, Anuar I and Derks, Eske M and Neale, Benjamin M and Yang, Jian and Lee, S. Hong and Evans, Patrick and Barr, Cathy L and Bellodi, Laura and Benarroch, Fortu and Berrio, Gabriel Bedoya and Bienvenu, Oscar J and Bloch, Michael H and Blom, Rianne M and Bruun, Ruth D and Budman, Cathy L and Camarena, Beatriz and Campbell, Desmond and Cappi, Carolina and Cardona Silgado, Julio C and Cath, Danielle C and Cavallini, Maria C and Chavira, Denise A and Chouinard, Sylvain and Conti, David V and Cook, Edwin H and Coric, Vladimir and Cullen, Bernadette A and Deforce, Dieter and Delorme, Richard and Dion, Yves and Edlund, Christopher K and Egberts, Karin and Falkai, Peter and Fernandez, Thomas V and Gallagher, Patience J and Garrido, Helena and Geller, Daniel and Girard, Simon L and Grabe, Hans J and Grados, Marco A and Greenberg, Benjamin D and Gross-Tsur, Varda and Haddad, Stephen and Heiman, Gary A and Hemmings, Sian M. J and Hounie, Ana G and Illmann, Cornelia and Jankovic, Joseph and Jenike, Michael A and Kennedy, James L and King, Robert A and Kremeyer, Barbara and Kurlan, Roger and Lanzagorta, Nuria and Leboyer, Marion and Leckman, James F and Lennertz, Leonhard and Liu, Chunyu and Lochner, Christine and Lowe, Thomas L and Macciardi, Fabio and McCracken, James T and McGrath, Lauren M and Mesa Restrepo, Sana C and Moessner, Rainald and Morgan, Jubel and Muller, Heike and Murphy, Dennis L and Naarden, Allan L and Ochoa, William Cornejo and Ophoff, Roel A and Osiecki, Lisa and Pakstis, Anew J and Pato, Michele T and Pato, Carlos N and Piacentini, John and Pittenger, Christopher and Pollak, Yehuda and Rauch, Scott L and Renner, Tobias J and Reus, Victor I and Richter, Margaret A and Riddle, Mark A and Robertson, Mary M and Romero, Roxana and Rosàrio, Maria C and Rosenberg, David and Rouleau, Guy A and Ruhrmann, Stephan and Ruiz-Linares, Anes and Sampaio, Aline S and Samuels, Jack and Sandor, Paul and Sheppard, Brooke and Singer, Harvey S and Smit, Jan H and ...
PLoS genetics, ISSN 1553-7390, 2013, Volume 9, Issue 10, p. e1003864
The direct estimation of heritability from genome-wide common variant data as implemented in the program Genome-wide Complex Trait Analysis (GCTA) has provided... 
GILLES | SCHOOL | AUTISM | NEUROPSYCHIATRIC DISORDERS | GENETICS & HEREDITY | MISSING HERITABILITY | RISK | TIC DISORDERS | PREVALENCE | EXPRESSION | FAMILY | Tourette Syndrome - genetics | Obsessive-Compulsive Disorder - genetics | Genome-Wide Association Study | Phenotype | Quantitative Trait, Heritable | Tourette Syndrome - pathology | Gene Frequency | Humans | Obsessive-Compulsive Disorder - pathology | Polymorphism, Single Nucleotide | Tourette's syndrome | Neurogenetics | Physiological aspects | Genetic aspects | Obsessive-compulsive disorder | Research | Cell differentiation | Architecture | Alcoholism | Genomes | Gene expression | Estimates | Risk factors | Studies | Brain research | Neuroses | Genetics | Tourette syndrome | Health risk assessment | Chromosomes | Child & adolescent psychiatry
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14. Full Text Prostate cancer meta-analysis from more than 145,000 men to identify 65 novel prostate cancer susceptibility loci
by Eeles, Rosalind and Al Olama, Ali Amin and Berndt, Sonja and Wiklund, Fredrik and Conti, David V and Ahmed, Mahbubl and Benlloch, Sara and Easton, Douglas and Kraft, Peter and Chanock, Stephen J and Kote-Jarai, Zsofia and Haiman, Christopher and Schumacher, Fredrick R
Journal of Clinical Oncology, ISSN 0732-183X, 02/2017, Volume 2017, Issue 1_suppl, pp. 1 - 1
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