European Journal of Haematology, ISSN 0902-4441, 10/2019, Volume 103, Issue 4, pp. 379 - 384
Objectives Inherited dysfibrinogenemia is a rare disorder, for which clinical studies related to the risk of bleeding or thrombosis and the type of causative...
thrombophilia | dysfibrinogenemia | inherited bleeding disorders | fibrinogen | gene mutation | Pregnancy | Ischemia | Fibrinogen | Mutation | Thromboembolism | Health risk assessment | Thrombosis | Bleeding
thrombophilia | dysfibrinogenemia | inherited bleeding disorders | fibrinogen | gene mutation | Pregnancy | Ischemia | Fibrinogen | Mutation | Thromboembolism | Health risk assessment | Thrombosis | Bleeding
Journal Article
Human Gene Therapy, ISSN 1043-0342, 11/2014, Volume 25, Issue 11, pp. A1 - A121
Journal Article
Frontiers in Oncology, ISSN 2234-943X, 2014, Volume 4, p. 2
Multidrug resistance (MDR) is a complex phenomenon principally due to the overexpression of some transmembrane proteins belonging to the ATP binding cassette...
Multitarget drugs | MDR | P-gp | MDR reverting activity | Dual effect | dual effect | multitarget drugs
Multitarget drugs | MDR | P-gp | MDR reverting activity | Dual effect | dual effect | multitarget drugs
Journal Article
Journal of Magnetic Resonance, ISSN 1090-7807, 10/2018, Volume 295, pp. 27 - 37
Perfluorocarbon nano- and micron-sized emulsions are a new field of investigation in cancer treatment due to their ability to be used as imaging contrast...
Theranostic droplets | Oxygen partial pressure | Multi-nucleus NMR | Fluorinated surfactant | Size effect | T1 mapping
Theranostic droplets | Oxygen partial pressure | Multi-nucleus NMR | Fluorinated surfactant | Size effect | T1 mapping
Journal Article
Frontiers in Pharmacology, ISSN 1663-9812, 2014, Volume 5, p. 163
CSCs are responsible for the high rate of recurrence and chemoresistance of different types of cancer. The current antineoplastic agents able to inhibit bulk...
MDR | P-gp | TICs markers | HTS | CSCs | INITIATING CELLS | PANCREATIC-CANCER | ALDEHYDE DEHYDROGENASE 1 | ACUTE MYELOID-LEUKEMIA | OVARIAN-CANCER | DRUG-RESISTANCE | CANCER STEM-CELLS | COLON-CARCINOMA CELLS | PHARMACOLOGY & PHARMACY | KAPPA-B PATHWAY | MULTIDRUG-RESISTANCE
MDR | P-gp | TICs markers | HTS | CSCs | INITIATING CELLS | PANCREATIC-CANCER | ALDEHYDE DEHYDROGENASE 1 | ACUTE MYELOID-LEUKEMIA | OVARIAN-CANCER | DRUG-RESISTANCE | CANCER STEM-CELLS | COLON-CARCINOMA CELLS | PHARMACOLOGY & PHARMACY | KAPPA-B PATHWAY | MULTIDRUG-RESISTANCE
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 01/2015, Volume 89, pp. 691 - 700
6,7-Dimethoxytetrahydroisoquinoline is widely used as basic moiety in σ receptor ligands, in order to provide σ σ selectivity. This same moiety is also widely...
P-glycoprotein | 6,7-Dimethoxytetrahydroisoquinoline | σ2 receptor | Conformational analysis | Tetrahydroisoquinolines - pharmacology | Animals | Tetrahydroisoquinolines - chemistry | Tetrahydroisoquinolines - metabolism | Protein Binding - drug effects | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Cells, Cultured | Dogs | Molecular Structure | ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors | Receptors, sigma - metabolism
P-glycoprotein | 6,7-Dimethoxytetrahydroisoquinoline | σ2 receptor | Conformational analysis | Tetrahydroisoquinolines - pharmacology | Animals | Tetrahydroisoquinolines - chemistry | Tetrahydroisoquinolines - metabolism | Protein Binding - drug effects | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Cells, Cultured | Dogs | Molecular Structure | ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors | Receptors, sigma - metabolism
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 01/2015, Volume 89, pp. 691 - 700
6,7-Dimethoxytetrahydroisoquinoline is widely used as basic moiety in receptor ligands, in order to provide versus selectivity. This same moiety is also widely...
P-glycoprotein | Conformational analysis | 67-Dimethoxytetrahydroisoquinoline | σ2 receptor
P-glycoprotein | Conformational analysis | 67-Dimethoxytetrahydroisoquinoline | σ2 receptor
Journal Article
Journal of the European Ceramic Society, ISSN 0955-2219, 04/2017, Volume 37, Issue 4, pp. 1779 - 1788
This study is focused on Roman lead-glazed inkwells from the archaeological site of the “ (Rome, Italy) dated in the half 2nd century AD. Optical microscopy...
Lead-glazed ceramic | Microprobe analysis | Pb-bearing alkali feldspar | X-ray maps | Roman inkwells
Lead-glazed ceramic | Microprobe analysis | Pb-bearing alkali feldspar | X-ray maps | Roman inkwells
Journal Article
Nature Genetics, ISSN 1061-4036, 10/2016, Volume 48, Issue 10, pp. 1131 - 1141
Esophageal adenocarcinoma (EAC) has a poor outcome, and targeted therapy trials have thus far been disappointing owing to a lack of robust stratification...
CTLA-4 BLOCKADE | DNA-DAMAGE CHECKPOINT | GASTROESOPHAGEAL CANCER | PD-1 BLOCKADE | MUTANT-CELLS | PANCREATIC-CANCER | GENETICS & HEREDITY | ADAPTIVE IMMUNE RESISTANCE | OVARIAN-CANCER | RANDOMIZED PHASE-2 TRIAL | PARP INHIBITORS | Adenocarcinoma - classification | Humans | Male | Antineoplastic Agents - therapeutic use | DNA, Neoplasm | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Female | Adenocarcinoma - genetics | Esophageal Neoplasms - therapy | Adenocarcinoma - immunology | Receptor Protein-Tyrosine Kinases - metabolism | Esophageal Neoplasms - immunology | Sequence Analysis, DNA | Genetic Heterogeneity | Poly(ADP-ribose) Polymerase Inhibitors - therapeutic use | CD8 Antigens - immunology | Esophageal Neoplasms - classification | Adenocarcinoma - therapy | Esophageal Neoplasms - genetics | Cell Line, Tumor | Aged | DNA Damage | Mutation | Genome, Human | Cohort Studies | Medical research | Biomedical research | Funding | Genomes | Experiments | Cancer therapies | Cell adhesion & migration | Esophagus | Consortia | Signal transduction | Hospitals | Cell cycle | Cancer
CTLA-4 BLOCKADE | DNA-DAMAGE CHECKPOINT | GASTROESOPHAGEAL CANCER | PD-1 BLOCKADE | MUTANT-CELLS | PANCREATIC-CANCER | GENETICS & HEREDITY | ADAPTIVE IMMUNE RESISTANCE | OVARIAN-CANCER | RANDOMIZED PHASE-2 TRIAL | PARP INHIBITORS | Adenocarcinoma - classification | Humans | Male | Antineoplastic Agents - therapeutic use | DNA, Neoplasm | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Female | Adenocarcinoma - genetics | Esophageal Neoplasms - therapy | Adenocarcinoma - immunology | Receptor Protein-Tyrosine Kinases - metabolism | Esophageal Neoplasms - immunology | Sequence Analysis, DNA | Genetic Heterogeneity | Poly(ADP-ribose) Polymerase Inhibitors - therapeutic use | CD8 Antigens - immunology | Esophageal Neoplasms - classification | Adenocarcinoma - therapy | Esophageal Neoplasms - genetics | Cell Line, Tumor | Aged | DNA Damage | Mutation | Genome, Human | Cohort Studies | Medical research | Biomedical research | Funding | Genomes | Experiments | Cancer therapies | Cell adhesion & migration | Esophagus | Consortia | Signal transduction | Hospitals | Cell cycle | Cancer
Journal Article
Blood, ISSN 0006-4971, 11/2013, Volume 122, Issue 21, pp. 4794 - 4794
Introduction Acquired and inherited thrombophilias are associated with unfavourable pregnancy outcome. Low-molecular-weight heparin (LMWH) has demonstrated...
Journal Article
Linear Algebra and Its Applications, ISSN 0024-3795, 04/2017, Volume 518, pp. 177 - 197
Let be a Hilbert space, the algebra of bounded linear operators on and a positive operator such that is in the p-Schatten class, for some . Given with closed...
Operator approximation | Schatten p classes | Oblique projections | SHORTED OPERATORS | MATHEMATICS | MATHEMATICS, APPLIED | NORM INEQUALITIES | SPACES | PROJECTIONS | GENERALIZED INVERSES | GLOBAL MINIMUM | ORTHOGONALITY | Algebra
Operator approximation | Schatten p classes | Oblique projections | SHORTED OPERATORS | MATHEMATICS | MATHEMATICS, APPLIED | NORM INEQUALITIES | SPACES | PROJECTIONS | GENERALIZED INVERSES | GLOBAL MINIMUM | ORTHOGONALITY | Algebra
Journal Article
Scientific reports, ISSN 2045-2322, 01/2019, Volume 9, Issue 1, pp. 318 - 5
A correction has been published and is appended to both the HTML and PDF versions of this paper. The error has not been fixed in the paper.
Adenocarcinoma | Esophagus
Adenocarcinoma | Esophagus
Journal Article
JOURNAL OF THE EUROPEAN CERAMIC SOCIETY, ISSN 0955-2219, 04/2017, Volume 37, Issue 4, pp. 1779 - 1788
This study is focused on Roman lead-glazed inkwells from the archaeological site of the "Nuovo Mercato di Testaccio" (Rome, Italy) dated in the half 2nd...
Pb-bearing alkali feldspar | KHIRBET AL-BATRAWY | EBLA SYRIA | Lead-glazed ceramic | ANCIENT-POTTERY | MATERIALS SCIENCE, CERAMICS | LEAD GLAZES | FINGERPRINTS | FELDSPAR | PALACE | Microprobe analysis | X-ray maps | MICRO-RAMAN SPECTROSCOPY | ANTIQUITY | Roman inkwells | CERAMICS | Archaeology | Analysis
Pb-bearing alkali feldspar | KHIRBET AL-BATRAWY | EBLA SYRIA | Lead-glazed ceramic | ANCIENT-POTTERY | MATERIALS SCIENCE, CERAMICS | LEAD GLAZES | FINGERPRINTS | FELDSPAR | PALACE | Microprobe analysis | X-ray maps | MICRO-RAMAN SPECTROSCOPY | ANTIQUITY | Roman inkwells | CERAMICS | Archaeology | Analysis
Journal Article
Blood, ISSN 0006-4971, 11/2012, Volume 120, Issue 21, pp. 4371 - 4371
Abstract Abstract 4371 Background/Aim: Using of a software for venous thromboprophylaxis prescription in hospitalized patients. Evaluation of the prescriptive...
Journal Article
Journal of Magnetic Resonance, ISSN 1090-7807, 10/2018, Volume 295, pp. 27 - 37
Objective: Perfluorocarbon nano- and micron-sized emulsions are a new field of investigation in cancer treatment due to their ability to be used as imaging...
Theranostic droplets | Oxygen partial pressure | mapping | Multi-nucleus NMR | Fluorinated surfactant | Size effect
Theranostic droplets | Oxygen partial pressure | mapping | Multi-nucleus NMR | Fluorinated surfactant | Size effect
Journal Article
BLOOD TRANSFUSION, ISSN 1723-2007, 05/2019, Volume 17, Issue 3, pp. 171 - 180
Background. Management of venous thromboembolism ( VTE) in patients with haematologic malignancies and thrombocytopenia is clinically challenging due to the...
VEIN THROMBOSIS | RISK-FACTORS | thrombocytopenia | STEM-CELL-TRANSPLANTATION | VENA-CAVA FILTER | anticoagulant treatment | SECONDARY PREVENTION | consensus | CLINICAL-PRACTICE GUIDELINES | MOLECULAR-WEIGHT HEPARIN | PULMONARY-EMBOLISM | HEMATOLOGICAL MALIGNANCIES | ANTITHROMBOTIC THERAPY | HEMATOLOGY | venous thrombosis | blood cancer | Original
VEIN THROMBOSIS | RISK-FACTORS | thrombocytopenia | STEM-CELL-TRANSPLANTATION | VENA-CAVA FILTER | anticoagulant treatment | SECONDARY PREVENTION | consensus | CLINICAL-PRACTICE GUIDELINES | MOLECULAR-WEIGHT HEPARIN | PULMONARY-EMBOLISM | HEMATOLOGICAL MALIGNANCIES | ANTITHROMBOTIC THERAPY | HEMATOLOGY | venous thrombosis | blood cancer | Original
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 01/2018, Volume 144, pp. 359 - 371
The aggressiveness of pancreatic cancer urgently requires more efficient treatment options. Because the sigma-2 (σ ) receptor was recently proposed as a...
Sigma-2 receptors | Mithocondrial superoxide | Pancreatic cancer | Thiosemicarbazones | Multifunctional compounds | COLLATERAL SENSITIVITY | CHEMISTRY, MEDICINAL | CELL-LINES | IDENTIFICATION | PGRMC1 PROTEIN | CANCER | STRUCTURE-AFFINITY | LIGANDS | MEMBRANE COMPONENT 1 | BINDING | DERIVATIVES | Pancreatic Neoplasms - metabolism | Antineoplastic Agents - chemical synthesis | Humans | Receptors, sigma - antagonists & inhibitors | Structure-Activity Relationship | Dose-Response Relationship, Drug | Neoplasms, Experimental - pathology | Pancreatic Neoplasms - drug therapy | Thiosemicarbazones - chemistry | Female | Antineoplastic Agents - pharmacology | Molecular Structure | Thiosemicarbazones - pharmacology | Cell Death - drug effects | Receptors, sigma - metabolism | Disease Models, Animal | Cell Survival - drug effects | Mice, Inbred C57BL | Pancreatic Neoplasms - pathology | Chelating Agents - chemistry | Thiosemicarbazones - chemical synthesis | Chelating Agents - pharmacology | Antineoplastic Agents - chemistry | ATP Binding Cassette Transporter, Subfamily B, Member 1 - antagonists & inhibitors | ATP Binding Cassette Transporter, Subfamily B, Member 1 - metabolism | Animals | Cell Proliferation - drug effects | Mice | Neoplasms, Experimental - metabolism | Chelating Agents - chemical synthesis | Neoplasms, Experimental - drug therapy | Drug Screening Assays, Antitumor
Sigma-2 receptors | Mithocondrial superoxide | Pancreatic cancer | Thiosemicarbazones | Multifunctional compounds | COLLATERAL SENSITIVITY | CHEMISTRY, MEDICINAL | CELL-LINES | IDENTIFICATION | PGRMC1 PROTEIN | CANCER | STRUCTURE-AFFINITY | LIGANDS | MEMBRANE COMPONENT 1 | BINDING | DERIVATIVES | Pancreatic Neoplasms - metabolism | Antineoplastic Agents - chemical synthesis | Humans | Receptors, sigma - antagonists & inhibitors | Structure-Activity Relationship | Dose-Response Relationship, Drug | Neoplasms, Experimental - pathology | Pancreatic Neoplasms - drug therapy | Thiosemicarbazones - chemistry | Female | Antineoplastic Agents - pharmacology | Molecular Structure | Thiosemicarbazones - pharmacology | Cell Death - drug effects | Receptors, sigma - metabolism | Disease Models, Animal | Cell Survival - drug effects | Mice, Inbred C57BL | Pancreatic Neoplasms - pathology | Chelating Agents - chemistry | Thiosemicarbazones - chemical synthesis | Chelating Agents - pharmacology | Antineoplastic Agents - chemistry | ATP Binding Cassette Transporter, Subfamily B, Member 1 - antagonists & inhibitors | ATP Binding Cassette Transporter, Subfamily B, Member 1 - metabolism | Animals | Cell Proliferation - drug effects | Mice | Neoplasms, Experimental - metabolism | Chelating Agents - chemical synthesis | Neoplasms, Experimental - drug therapy | Drug Screening Assays, Antitumor
Journal Article