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PLoS genetics, 01/2018, Volume 14, Issue 1, p. e1007145
Central corneal thickness (CCT) is one of the most heritable ocular traits and it is also a phenotypic risk factor for primary open angle glaucoma (POAG). The... 
Journal Article
by Fritsche, Lars G and Igl, Wilmar and Bailey, Jessica N. Cooke and Grassmann, Felix and Sengupta, Sebanti and Bragg-Gresham, Jennifer L and Burdon, Kathryn and Hebbring, Scott J and Wen, Cindy and Gorski, Mathias and Kim, Ivana K and Cho, David and Zack, Donald and Souied, Eric and Scholl, Henik and Bala, Elisa and ELee, Kristine and Hunter, David J and Sardell, Rebecca J and Mitchell, Paul and Merriam, Joanna E and Cipriani, Francesco and Hoffman, Joshua D and Schick, Tina and Lechanteur, Yara T.E and Guymer, Robyn and Johnson, Matthew and Jiang, Yingda and Stanton, Chloe M and Buitendijk, Gabrielle and Zhan, Xiaowei and Kwong, Alan M and Boleda, Alexis and Brooks, Matthew and Gieser, Linn and Ratna Priya, Rinki and Branham, Kari E and Foerster, Johanna R and Heckenlively, John R and Othman, Mohammad I and Vote, Brendan J and Liang, Helena Hai and Souzeau, Emmanuelle and McAllister, Ian L and Isaacs, Timothy and Hall, Janette and Lake, Stewart and Mackey, David A and Constable, Ian J and Craig, Jamie E and Kitchner, Terrie E and Yang, Zhenglin and Su, Zhiguang and Luo, Hongrong and Chen, Daniel and Ouyang, Hong and Flagg, Ken and Lin, Danni and Mao, Guanping and Ferreyra, Henry and Stark, Klaus and Strachwitz, Claudia and Wolf, Armin and Brandl, Caroline and Rudolph, Guenther and Olden, Matthias and Morrison, Margaux A and Morgan, Denise and Schu, Matthew and Ahn, Jeeyun and Silvestri, Giuliana and ETsironi, Evangelia and Park, Kyu Hyung and Farrer, Lindsay and Orlin, Anton and Brucker, Alexander and Li, Mingyao and Curcio, Christine A and Mohand-Sa'd, Saddek and Sahel, José-Alain and Audo, Isabelle and Benchaboune, Mustapha and Cree, Angela and Rennie, Christina A and Goverdhan, Srinivas V and Grunin, Michelle and Hagbi-Levi, Shira and Campochiaro, Peter and Katsanis, Nicholas and Holz, Frank G and Blond, Frédéric and Blanché, Hél'ne and Deleuze, Jean-Fran'ois and Igo Jr., Robert and Truitt, Barbara and Peachey, Neal S and Meuer, Stacy M and Myers, Chelsea E and Moore, Emily L and Klein, Ronald and ...
Nature Genetics, ISSN 1061-4036, 02/2016, Volume 48, Issue 2, pp. 134 - 143
Journal Article
Current Genetic Medicine Reports, ISSN 2167-4876, 12/2017, Volume 5, Issue 4, pp. 167 - 174
Individuals of African descent are at highest risk for developing primary open-angle glaucoma (POAG), a devastating disease and major contributor of blindness... 
Internal Medicine | Glaucoma genetics | Medicine & Public Health | African American primary open-angle glaucoma | Glaucoma | African Americans | Population studies | Genetics | Environmental factors | Blindness | African American primary open angle glaucoma | glaucoma genetics
Journal Article
by Hysi, Pirro G and Cheng, Ching-Yu and Springelkamp, Henriët and Macgregor, Stuart and Bailey, Jessica N. Cooke and Wojciechowski, Robert and Vitart, Veronique and Nag, Abhishek and Hewitt, Alex W and Höhn, René and Venturini, Cristina and Mirshahi, Alireza and Ramdas, Wishal D and Thorleifsson, Gudmar and Vithana, Eranga and Khor, Chiea-Chuen and Stefansson, Arni B and Liao, Jiemin and Haines, Jonathan L and Amin, Najaf and Wang, Ya Xing and Wild, Philipp S and Ozel, Ayse B and Li, Jun Z and Fleck, Brian W and Zeller, Tanja and Staffieri, Sana E and teo, Yik-Ying and Cuellar-Partida, Gabriel and Luo, Xiaoyan and Allingham, R. Rand and Richards, Julia E and Senft, Anea and Karssen, Lennart C and Zheng, Yingfeng and Bellenguez, Céline and Xu, Liang and Iglesias, Aiana I and Wilson, James F and Kang, Jae H and van Leeuwen, Elisabeth M and Jonsson, Vesteinn and Thorsteinsdottir, Unnur and Despriet, Dominiek D. G and Ennis, Sarah and Moroi, Sayoko E and Martin, Nicholas G and Jansonius, Nomdo M and Yazar, Seyhan and Tai, E.-Shyong and Amouyel, Philippe and Kirwan, James and van Koolwijk, Leonieke M. E and Hauser, Michael A and Jonasson, Fridbert and Leo, Paul and Loomis, Stephanie J and Fogarty, Rhys and Rivadeneira, Fernando and Kearns, Lisa and Lackner, Karl J and de Jong, Paulus T. V. M and Simpson, Claire L and Pennell, Craig E and Oostra, Ben A and Uitterlinden, Ané G and Saw, Seang-Mei and Lotery, Anew J and Bailey-Wilson, Joan E and Hofman, Albert and Vingerling, Johannes R and Maubaret, Cécilia and Pfeiffer, Norbert and Wolfs, Roger C. W and Lemij, Hans G and Young, Terri L and Pasquale, Louis R and Delcourt, Cécile and Spector, Timothy D and Klaver, Caroline C. W and Small, Kerrin S and Burdon, Kathryn P and Stefansson, Kari and Wong, Tien-Yin and Viswanathan, Ananth and Mackey, David A and Craig, Jamie E and Wiggs, Janey L and van Duijn, Cornelia M and Hammond, Christopher J and Aung, Tin and NEIGHBORHOOD Consortium and BMES GWAS Grp and Wellcome Trust Case Control Conso and Wellcome Trust Case Control Consortium 2 and BMES GWAS Group
Nature genetics, ISSN 1061-4036, 2014, Volume 46, Issue 10, pp. 1126 - 1130
Journal Article
by Bailey, Jessica N Cooke and Loomis, Stephanie J and Kang, Jae H and Allingham, R. Rand and Gharahkhani, Puya and Khor, Chiea Chuen and Burdon, Kathryn P and Aschard, Hugues and Chasman, Daniel I and Igo, Robert P and Hysi, Pirro G and Glastonbury, Craig A and Ashley-Koch, Allison and Brilliant, Murray and Brown, Andrew A and Budenz, Donald L and Buil, Alfonso and Cheng, Ching-Yu and Choi, Hyon and Christen, William G and Curhan, Gary and De Vivo, Immaculata and Fingert, John H and Foster, Paul J and Fuchs, Charles and Gaasterland, Douglas and Gaasterland, Terry and Hewitt, Alex W and Hu, Frank and Hunter, David J and Khawaja, Anthony P and Lee, Richard K and Li, Zheng and Lichter, Paul R and Mackey, David A and McGuffin, Peter and Mitchell, Paul and Moroi, Sayoko E and Perera, Shamira A and Pepper, Keating W and Qi, Qibin and Realini, Tony and Richards, Julia E and Ridker, Paul M and Rimm, Eric and Ritch, Robert and Ritchie, Marylyn and Schuman, Joel S and Scott, William K and Singh, Kuldev and Sit, Arthur J and Song, Yeunjoo E and Tamimi, Rulla M and Topouzis, Fotis and Viswanathan, Ananth C and Verma, Shefali Setia and Vollrath, Douglas and Wang, Jie Jin and Weisschuh, Nicole and Wissinger, Bernd and Wollstein, Gadi and Wong, Tien Y and Yaspan, Brian L and Zack, Donald J and Zhang, Kang and Weinreb, Robert N and Pericak-Vance, Margaret A and Small, Kerrin and Hammond, Christopher J and Aung, Tin and Liu, Yutao and Vithana, Eranga N and MacGregor, Stuart and Craig, Jamie E and Kraft, Peter and Howell, Gareth and Hauser, Michael A and Pasquale, Louis R and Haines, Jonathan L and Wiggs, Janey L and EPIC Norfolk Eye Study and ANZRAG Consortium
Nature Genetics, ISSN 1061-4036, 02/2016, Volume 48, Issue 2, pp. 189 - 194
Journal Article
Nature genetics, ISSN 1061-4036, 10/2014, Volume 46, Issue 10, pp. 1120 - 1125
Primary open-angle glaucoma (POAG) is a major cause of irreversible blindness worldwide. We performed a genome-wide association study in an Australian... 
BIOLOGICAL FUNCTION | GENE | AQUEOUS-HUMOR | ABILITY | GENETICS & HEREDITY | IDENTIFICATION | GENOME-WIDE ASSOCIATION | AFAP-110 | Glaucoma | Genetic aspects | Genetic variation | Health aspects | Risk factors | Studies | Genotype & phenotype | American Recovery & Reinvestment Act 2009-US | Genomes | Gene loci | Chromosomes | Meta-analysis | Index Medicus
Journal Article
by Aung, T and Ozaki, M and Lee, M.C and Schlotzer-Schrehardt, U and Thorleifsson, G and Mizoguchi, T and Igo, R.P., Jr and Haripriya, A and Williams, S.E and Astakhov, Y.S and Orr, A.C and Burdon, K.P and Nakano, S and Mori, K and Abu-Amero, K and Hauser, M and Li, Z and Prakadeeswari, G and Bailey, J.N and Cherecheanu, A.P and Kang, J.H and Nelson, S and Hayashi, K and Manabe, S.I and Kazama, S and Zarnowski, T and Inoue, K and Irkec, M and Coca-Prados, M and Sugiyama, K and Jarvela, I and Schlottmann, P and Lerner, S.F and Lamari, H and Nilgun, Y and Bikbov, M and Park, K.H and Cha, S.C and Yamashiro, K and Zenteno, J.C and Jonas, J.B and Kumar, R.S.S and Perera, S.A and Chan, A.S.Y and Kobakhidze, N and George, R and Vijaya, L and Do, T and Edward, D.P and Juan Marcos, L. de and Pakravan, M and Moghimi, S and Ideta, R and Bach-Holm, D and Kappelgaard, P and Wirostko, B and Thomas, S and Gaston, D and Bedard, K and Greer, W.L and Yang, Z and Chen, X and Huang, L and Sang, J and Jia, H and Jia, L and Qiao, C and Zhang, H and Liu, X and Zhao, B and Wang, Y.X and Xu, L and Leruez, S and Reynier, P and Chichua, G and Tabagari, S and Uebe, S and Zenkel, M and Berner, D and Mossbock, G and Weisschuh, N and Hoja, U and Welge-Luessen, U.C and Mardin, C and Founti, P and Chatzikyriakidou, A and Pappas, T and Anastasopoulos, E and Lambropoulos, A and Ghosh, A and Shetty, R and Porporato, N and Saravanan, V and Venkatesh, R and Shivkumar, C and Kalpana, N and Sarangapani, S and Kanavi, M.R and Beni, A.N and Yazdani, S and ...
Nature Genetics, ISSN 1061-4036, 2017, Volume 49, Issue 7, pp. 993 - 1004
Exfoliation syndrome (XFS) is the most common known risk factor for secondary glaucoma and a major cause of blindness worldwide. Variants in two genes, LOXL1... 
INDIVIDUALS | RISK LOCI | PSEUDOEXFOLIATION SYNDROME | INFLAMMATORY-BOWEL-DISEASE | METAANALYSIS | POLYMORPHISMS | COMMON SEQUENCE VARIANTS | GENETICS & HEREDITY | GLAUCOMA | BLOOD-PRESSURE | GENOME-WIDE ASSOCIATION | Haplotypes | Humans | Asian Continental Ancestry Group - genetics | Extracellular Matrix - metabolism | Male | Gene Expression Profiling | Mutation, Missense | Amino Acid Oxidoreductases - genetics | Exfoliation Syndrome - ethnology | RNA, Messenger - biosynthesis | Aged, 80 and over | Female | Spheroids, Cellular | Calcium Channels - genetics | Molecular Chaperones - biosynthesis | Eye - metabolism | Genetic Predisposition to Disease | Genome-Wide Association Study | Amino Acid Oxidoreductases - physiology | Molecular Chaperones - genetics | Cell Adhesion | Point Mutation | Alleles | Exfoliation Syndrome - genetics | Amino Acid Substitution | Exfoliatins | Disease susceptibility | Genetic aspects | Analysis | Risk factors | Glaucoma | Genes | Principal components analysis | Cardiovascular disease | Genomes | Biology | Loci | Exfoliation | Studies | Collaboration | Blindness | Alzheimers disease | Index Medicus | Life Sciences | Populations and Evolution | Microbiology and Parasitology | Parasitology | Quantitative Methods | Computer Science | Genetics | Santé publique et épidémiologie | Bioinformatics | Human genetics | Virology
Journal Article
by Springelkamp, Henriët and Höhn, René and Mishra, Aniket and Hysi, Pirro G and Khor, Chiea-Chuen and Loomis, Stephanie J and Bailey, Jessica N. Cooke and Gibson, Jane and Thorleifsson, Gudmar and Janssen, Sarah F and Luo, Xiaoyan and Ramdas, Wishal D and Vithana, Eranga and Nongpiur, Monisha E and Montgomery, Grant W and Xu, Liang and Mountain, Jenny E and Gharahkhani, Puya and Lu, Yi and Amin, Najaf and Karssen, Lennart C and Sim, Kar-Seng and van Leeuwen, Elisabeth M and Iglesias, Aiana I and Verhoeven, Virginie J. M and Hauser, Michael A and Loon, Seng-Chee and Despriet, Dominiek D. G and Nag, Abhishek and Venturini, Cristina and Sanfilippo, Paul G and Schillert, Arne and Kang, Jae H and Landers, John and Jonasson, Fridbert and Cree, Angela J and van Koolwijk, Leonieke M. E and Rivadeneira, Fernando and Souzeau, Emmanuelle and Jonsson, Vesteinn and Menon, Geeta and Weinreb, Robert N and de Jong, Paulus T. V. M and Oostra, Ben A and Uitterlinden, Ané G and Hofman, Albert and Ennis, Sarah and Thorsteinsdottir, Unnur and Burdon, Kathryn P and Spector, Timothy D and Mirshahi, Alireza and Saw, Seang-Mei and Vingerling, Johannes R and teo, Yik-Ying and Haines, Jonathan L and Wolfs, Roger C. W and Lemij, Hans G and Tai, E.-Shyong and Jansonius, Nomdo M and Jonas, Jost B and Cheng, Ching-Yu and Aung, Tin and Viswanathan, Ananth C and Klaver, Caroline C. W and Craig, Jamie E and Macgregor, Stuart and Mackey, David A and Lotery, Anew J and Stefansson, Kari and Bergen, Arthur A. B and Young, Terri L and Wiggs, Janey L and Pfeiffer, Norbert and Wong, Tien-Yin and Pasquale, Louis R and Hewitt, Alex W and van Duijn, Cornelia M and Hammond, Christopher J and Mitchell, Paul and Wang, Jie Jin and Rochtchina, Elena and Attia, John and Scott, Rodney and Holliday, Elizabeth G and Baird, Paul N and Xie, Jing and Inouye, Michael and Viswanathan, Ananth and Sim, Xueling and Allingham, R. Rand and Brilliant, Murray H and Budenz, Donald L and Christen, William G and Fingert, John and Friedman, David S and Gaasterland, Douglas and Gaasterland, Terry and Kang, Jae Hee and Kraft, Peter and Lee, Richard K and ... and Blue Mt Eye Study GWAS Grp and NEIGHBORHOOD Consortium and Wellcome Trust Case Control Consor and Blue Mountains Eye Study—GWAS group and Wellcome Trust Case Control Consortium 2 (WTCCC2)
Nature communications, ISSN 2041-1723, 2014, Volume 5, Issue 1, pp. 4883 - 4883
Journal Article
by Iglesias, Adriana I and Mishra, Aniket and Vitart, Veronique and Bykhovskaya, Yelena and Höhn, René and Springelkamp, Henriët and Cuellar-Partida, Gabriel and Gharahkhani, Puya and Bailey, Jessica N. Cooke and Willoughby, Colin E and Li, Xiaohui and Yazar, Seyhan and Nag, Abhishek and Khawaja, Anthony P and Polašek, Ozren and Siscovick, David and Mitchell, Paul and Tham, Yih Chung and Haines, Jonathan L and Kearns, Lisa S and Hayward, Caroline and Shi, Yuan and Van Leeuwen, Elisabeth M and Taylor, Kent D and Wang, Jie Jin and Rochtchina, Elena and Attia, John and Scott, Rodney and Holliday, Elizabeth G and Baird, Paul N and Xie, Jing and Inouye, Michael and Viswanathan, Ananth and Sim, Xueling and Bonnemaijer, Pieter and Rotter, Jerome I and Martin, Nicholas G and Zeller, Tanja and Mills, Richard A and Staffieri, Sandra E and Jonas, Jost B and Schmidtmann, Irene and Boutin, Thibaud and Kang, Jae H and Lucas, Sionne E. M and Wong, Tien Yin and Beutel, Manfred E and Wilson, James F and Allingham, R. Rand and Brilliant, Murray H and Budenz, Donald L and Christen, William G and Fingert, John and Friedman, David S and Gaasterland, Douglas and Gaasterland, Terry and Hauser, Michael A and Kraft, Peter and Lee, Richard K and Lichter, Paul R and Liu, Yutao and Loomis, Stephanie J and Moroi, Sayoko E and Pericak-Vance, Margaret A and Realini, Anthony and Richards, Julia E and Schuman, Joel S and Scott, William K and Singh, Kuldev and Sit, Arthur J and Vollrath, Douglas and Weinreb, Robert N and Wollstein, Gadi and Zack, Donald J and Zhang, Kang and Donnelly, Peter and Barroso, Ines and Blackwell, Jenefer M and Bramon, Elvira and Brown, Matthew A and Casas, Juan P and Corvin, Aiden and Deloukas, Panos and Duncanson, Audrey and Jankowski, Janusz and Markus, Hugh S and Mathew, Christopher G and Palmer, Colin N. A and Plomin, Robert and Rautanen, Anna and Sawcer, Stephen J and Trembath, Richard C and Wood, Nicholas W and Spencer, Chris C. A and Band, Gavin and Bellenguez, Céline and Freeman, Colin and Hellenthal, Garrett and Giannoulatou, Eleni and Pirinen, Matti and ... and Blue Mountains Eye Study-GWAS Grp and NEIGHBORHOOD Consortium and Wellcome Trust Case Control Consor and Blue Mountains Eye Study—GWAS group and Wellcome Trust Case Control Consortium 2 (WTCCC2)
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 1 - 11
Central corneal thickness (CCT) is a highly heritable trait associated with complex eye diseases such as keratoconus and glaucoma. We perform a genome-wide... 
DECORIN | CHROMATIN STATES | POLYMORPHISMS | RISK-FACTOR | MULTIDISCIPLINARY SCIENCES | MOUSE | GENE-EXPRESSION | MUTATIONS | HERITABILITY | LUMICAN | KERATOCONUS | Glaucoma | Cornea | Genes | Myopia | Association analysis | Genomes | Gene expression | Tissues | Connective tissues | Keratoconus | Collagen | Eye diseases | Extracellular matrix | Index Medicus
Journal Article