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Nature Medicine, ISSN 1078-8956, 08/2013, Volume 19, Issue 8, pp. 1047 - 1053
Journal Article
Cancer Cell, ISSN 1535-6108, 01/2012, Volume 21, Issue 1, pp. 66 - 81
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 9/2011, Volume 108, Issue 38, pp. 16002 - 16007
Increased numbers of S100A4⁺ cells are associated with poor prognosis in patients who have cancer. Although the metastatic capabilities of S100A4⁺ cancer cells... 
Cell growth | Lungs | Stromal cells | Bone marrow | Fibroblasts | Breast cancer | Metastasis | Cancer | Tumors | Nodules | Metastasis-associated fibroblasts | Metastatic microenvironment | Stromal fibroblasts | Tumor microenvironment | BEVACIZUMAB | MULTIDISCIPLINARY SCIENCES | metastasis-associated fibroblasts | HUMAN BREAST-CANCER | stromal fibroblasts | metastatic microenvironment | MESSENGER-RNA | GENE | COLORECTAL-CANCER | P9KA | tumor microenvironment | PROGNOSTIC-SIGNIFICANCE | EXPRESSION | CALCIUM-BINDING PROTEIN | ENDOTHELIAL GROWTH-FACTOR | Immunohistochemistry | Neoplasms - metabolism | Tenascin - genetics | Oligonucleotide Array Sequence Analysis | S100 Calcium-Binding Protein A4 | Humans | Male | Gene Expression Profiling | Green Fluorescent Proteins - genetics | Vascular Endothelial Growth Factor A - metabolism | Vascular Endothelial Growth Factor A - genetics | Tenascin - metabolism | Neoplasm Metastasis | S100 Proteins - genetics | Neoplasms - genetics | Stromal Cells - drug effects | Female | Ganciclovir - pharmacology | Extracellular Matrix Proteins - metabolism | Fibroblasts - metabolism | Tumor Microenvironment - drug effects | Green Fluorescent Proteins - metabolism | Thymidine Kinase - genetics | Extracellular Matrix Proteins - genetics | Stromal Cells - metabolism | Mice, Transgenic | S100 Proteins - metabolism | Mice, Knockout | Animals | Fibroblasts - drug effects | Thymidine Kinase - metabolism | Cell Line, Tumor | Mice | Neoplasms - pathology | Proteins | Rodents | Index Medicus | Biological Sciences
Journal Article
Nature, ISSN 0028-0836, 07/2016, Volume 535, Issue 7610, pp. 148 - 152
The non-receptor protein tyrosine phosphatase SHP2, encoded by PTPN11, has an important role in signal transduction downstream of growth factor receptor... 
TARGET | POTENT | PTPN11 | PROTOONCOGENE | MULTIDISCIPLINARY SCIENCES | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - metabolism | Humans | Extracellular Signal-Regulated MAP Kinases - metabolism | Oncogene Protein p21(ras) - metabolism | Pyrimidines - chemistry | Piperidines - pharmacology | Inhibitory Concentration 50 | Female | Allosteric Regulation - drug effects | Piperidines - chemistry | Reproducibility of Results | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - antagonists & inhibitors | Models, Molecular | Neoplasms - enzymology | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - chemistry | Pyrimidines - pharmacology | Receptor Protein-Tyrosine Kinases - metabolism | Neoplasms - drug therapy | Xenograft Model Antitumor Assays | Animals | MAP Kinase Signaling System - drug effects | Mice, Nude | Piperidines - therapeutic use | Pyrimidines - therapeutic use | Protein Stability - drug effects | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - genetics | Neoplasms - pathology | Protein Structure, Tertiary - drug effects | Phosphatases | Observations | Health aspects | Phosphotransferases | Protein-protein interactions | Signal transduction | Cell growth | Peptides | Kinases | Phosphatase | Drug dosages | Cancer | Index Medicus | BASIC BIOLOGICAL SCIENCES
Journal Article
Cell Reports, ISSN 2211-1247, 02/2015, Volume 10, Issue 7, pp. 1066 - 1081
Journal Article
Nature Medicine, ISSN 1078-8956, 05/2015, Volume 21, Issue 5, pp. 440 - 448
Journal Article
Nature Genetics, ISSN 1061-4036, 11/2013, Volume 45, Issue 11, pp. 1386 - 1393
Journal Article
Nature Medicine, ISSN 1078-8956, 2014, Volume 20, Issue 1, pp. 87 - 92
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 9/2008, Volume 105, Issue 39, pp. 15040 - 15045
Tumstatin is an angiogenesis inhibitor that binds to αvβ3 integrin and suppresses tumor growth. Previous deletion mutagenesis studies identified a 25-aa... 
Angiogenesis | Cell growth | Collagens | Antibodies | Amino acids | Kidney cells | Endothelial cells | Tumors | Integrins | Mutant proteins | Tumstatin peptide | αVβ3 integrin | Bevacizumab | DOMAIN | angiogenesis | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | IV COLLAGEN | ALPHA(V)BETA INTEGRIN | BREAST-CANCER | alpha v beta 3 integrin | ALPHA-V-BETA-3 | tumstatin peptide | bevacizumab | GROWTH-FACTOR | INHIBITOR | BASEMENT-MEMBRANE | Autoantigens - therapeutic use | Neoplasm Transplantation | Autoantigens - metabolism | Cell Proliferation | Humans | Antibodies, Monoclonal - therapeutic use | Autoantigens - genetics | Collagen Type IV - therapeutic use | Integrin alphaVbeta3 - metabolism | Aspartic Acid - genetics | Antibodies, Monoclonal, Humanized | Collagen Type IV - pharmacology | Angiogenesis Inhibitors - therapeutic use | Carcinoma, Renal Cell - drug therapy | Leucine - genetics | Carcinoma, Renal Cell - blood supply | Autoantigens - pharmacology | Collagen Type IV - metabolism | Leucine - metabolism | Angiogenesis Inhibitors - genetics | Mutagenesis, Site-Directed | Endothelial Cells - metabolism | Antibodies, Monoclonal - pharmacology | Mice, Inbred C57BL | Cells, Cultured | Angiogenesis Inhibitors - pharmacology | Antineoplastic Combined Chemotherapy Protocols | Xenograft Model Antitumor Assays | Angiogenesis Inhibitors - metabolism | Animals | Valine - metabolism | Neovascularization, Pathologic - drug therapy | Collagen Type IV - genetics | Amino Acid Substitution - genetics | Aspartic Acid - metabolism | Protein Conformation | Valine - genetics | Mice | Kidney Neoplasms - drug therapy | Kidney Neoplasms - blood supply | Endothelial Cells - drug effects | Prevention | Usage | Drug therapy, Combination | Research | Health aspects | Identification and classification | Mutation | Peptides | Cells | Cancer | Index Medicus | Biological Sciences | αvβ3 integrin
Journal Article
by Townsend, Elizabeth C and Murakami, Mark A and Murakami, Masato and Christodoulou, Alexandra and Christie, Amanda L and Köster, Johannes and DeSouza, Tiffany A and Morgan, Elizabeth A and Kallgren, Scott P and Liu, Huiyun and Wu, Shuo-Chieh and Plana, Olivia and Montero, Joan and Stevenson, Kristen E and Rao, Prakash and Vadhi, Raga and Andreeff, Michael and Armand, Philippe and Ballen, Karen K and Barzaghi-Rinaudo, Patrizia and Cahill, Sarah and Clark, Rachael A and Cooke, Vesselina G and Davids, Matthew S and DeAngelo, Daniel J and Dorfman, David M and Eaton, Hilary and Ebert, Benjamin L and Etchin, Julia and Firestone, Brant and Fisher, David C and Freedman, Arnold S and Galinsky, Ilene A and Gao, Hui and Garcia, Jacqueline S and Garnache-Ottou, Francine and Graubert, Timothy A and Gutierrez, Alejandro and Halilovic, Ensar and Harris, Marian H and Herbert, Zachary T and Horwitz, Steven M and Inghirami, Giorgio and Intlekofer, Andrew M and Ito, Moriko and Izraeli, Shai and Jacobsen, Eric D and Jacobson, Caron A and Jeay, Sébastien and Jeremias, Irmela and Kelliher, Michelle A and Koch, Raphael and Konopleva, Marina and Kopp, Nadja and Kornblau, Steven M and Kung, Andrew L and Kupper, Thomas S and LeBoeuf, Nicole R and LaCasce, Ann S and Lees, Emma and Li, Loretta S and Look, A. Thomas and Muschen, Markus and Neuberg, Donna and Ng, Samuel Y and Odejide, Oreofe O and Orkin, Stuart H and Paquette, Rachel R and Place, Andrew E and Roderick, Justine E and Ryan, Jeremy A and Sallan, Stephen E and Shoji, Brent and Silverman, Lewis B and Soiffer, Robert J and Steensma, David P and Stegmaier, Kimberly and Stone, Richard M and Tamburini, Jerome and Thorner, Aaron R and van Hummelen, Paul and Wadleigh, Martha and Wiesmann, Marion and Weng, Andrew P and Wuerthner, Jens U and Williams, David A and Wollison, Bruce M and Lane, Andrew A and Letai, Anthony and Bertagnolli, Monica M and Ritz, Jerome and Brown, Myles and Long, Henry and Aster, Jon C and Shipp, Margaret A and Griffin, James D and Weinstock, David M
Cancer Cell, ISSN 1535-6108, 04/2016, Volume 29, Issue 4, pp. 574 - 586