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1. Full Text Guidelines for the use and interpretation of assays for monitoring autophagy
by Klionsky, Daniel J and Abdalla, Fabio C and Abeliovich, Hagai and Abraham, Robert T and Acevedo-Arozena, Abraham and Adeli, Khosrow and Agholme, Lotta and Agnello, Maria and Agostinis, Patrizia and Aguirre-Ghiso, Julio A and Ahn, Hyung Jun and Ait-Mohamed, Ouardia and Ait-Si-Ali, Slimane and Akematsu, Takahiko and Akira, Shizuo and Al-Younes, Hesham M and Al-Zeer, Munir A and Albert, Matthew L and Albin, Roger L and Alegre-Abarrategui, Javier and Aleo, Maria Francesca and Alirezaei, Mehrdad and Almasan, Alexandru and Almonte-Becerril, Maylin and Amano, Atsuo and Amaravadi, Ravi K and Amarnath, Shoba and Amer, Amal O and Andrieu-Abadie, Nathalie and Anantharam, Vellareddy and Ann, David K and Anoopkumar-Dukie, Shailendra and Aoki, Hiroshi and Apostolova, Nadezda and Arancia, Giuseppe and Aris, John P and Asanuma, Katsuhiko and Asare, Nana Y.O and Ashida, Hisashi and Askanas, Valerie and Askew, David S and Auberger, Patrick and Baba, Misuzu and Backues, Steven K and Baehrecke, Eric H and Bahr, Ben A and Bai, Xue-Yuan and Bailly, Yannick and Baiocchi, Robert and Baldini, Giulia and Balduini, Walter and Ballabio, Andrea and Bamber, Bruce A and Bampton, Edward T.W and Juhász, Gábor and Bartholomew, Clinton R and Bassham, Diane C and Bast, Robert C and Batoko, Henri and Bay, Boon-Huat and Beau, Isabelle and Béchet, Daniel M and Begley, Thomas J and Behl, Christian and Behrends, Christian and Bekri, Soumeya and Bellaire, Bryan and Bendall, Linda J and Benetti, Luca and Berliocchi, Laura and Bernardi, Henri and Bernassola, Francesca and Besteiro, Sébastien and Bhatia-Kissova, Ingrid and Bi, Xiaoning and Biard-Piechaczyk, Martine and Blum, Janice S and Boise, Lawrence H and Bonaldo, Paolo and Boone, David L and Bornhauser, Beat C and Bortoluci, Karina R and Bossis, Ioannis and Bost, Frédéric and Bourquin, Jean-Pierre and Boya, Patricia and Boyer-Guittaut, Michaël and Bozhkov, Peter V and Brady, Nathan R and Brancolini, Claudio and Brech, Andreas and Brenman, Jay E and Brennand, Ana and Bresnick, Emery H and Brest, Patrick and Bridges, Dave and Bristol, Molly L and Brookes, Paul S and Brown, Eric J and Brumell, John H and ... and Linköpings universitet and Institutionen för klinisk och experimentell medicin and Geriatrik and Institutionen för medicin och hälsa and Farmakologi and Experimentell patologi and Hälsouniversitetet and Cellbiologi
Autophagy, ISSN 1554-8627, 04/2012, Volume 8, Issue 4, pp. 445 - 544
In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and... 
stress | vacuole | autolysosome | flux | LC3 | autophagosome | lysosome | phagophore | Binding | Proteins | Landes | Calcium | Bioscience | Biology | Cell | Cycle | Cancer | Organogenesis | Phagophore | Lysosome | Autolysosome | Flux | Autophagosome | Vacuole | Stress | ACTIVATED PROTEIN-KINASE | CHAPERONE-MEDIATED AUTOPHAGY | VACUOLE TARGETING PATHWAY | ENDOPLASMIC-RETICULUM STRESS | ISOLATED RAT HEPATOCYTES | STARVATION-INDUCED AUTOPHAGY | GLUCAGON-INDUCED AUTOPHAGY | CELL BIOLOGY | PROGRAMMED CELL-DEATH | BREAST-CANCER CELLS | BETAINE HOMOCYSTEINE METHYLTRANSFERASE | Biological Assay - methods | Animals | Autophagy - genetics | Models, Biological | Humans | Life Sciences | Cellular Biology | Review | Medical and Health Sciences | Medicin och hälsovetenskap
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2. Full Text The transcriptional landscape of age in human peripheral blood
by Peters, Marjolein and Joehanes, Roby and Pilling, Luke and Schurmann, Claudia and Conneely, Karen N and Powell, Joseph and Reinmaa, Eva and Sutphin, George L and Zhernakova, Alexana and Schramm, Katharina and Wilson, Yana A and Kobes, Sayuko and Tukiainen, Taru and Ramos, Yolande and Göring, Harald H and Fornage, Myriam and Liu, YongMei and Gharib, Sina and Stranger, Barbara and Jager, Philip and Aviv, Abraham and Levy, Daniel and Murabito, Joanne and Munson, Peter J and Huan, Tianxiao and Hofman, Albert and Uitterlinden, Ané and Rivadeneira Ramirez, Fernando and van Rooij, Jeroen and Stolk, Lisette and Broer, Linda and Verbiest, Michael and Jhamai, Mila and Arp, Pascal and Metspalu, Anes and Tserel, Liina and Milani, Lili and Samani, Nilesh and Peterson, Pärt and Kasela, Silva and Codd, Veryan and Peters, Annette and Ward-Caviness, Cavin K and Herder, Christian and Waldenberger, Melanie and Roden, Michael and Singmann, Paula and Zeilinger, Sonja and Illig, Thomas and Homuth, Georg and Grabe, Hans Jörgen and Völzke, Henry and Steil, Leif and Kocher, Thomas and Murray, Anna and Melzer, David and Yaghootkar, Hanieh and Bandinelli, S and Moses, Eric and Kent, Jack and Curran, Joanne and Johnson, Matthew and Williams-Blangero, Sarah and Westra, Harm-Jan and McRae, Allan F and Smith, Jennifer A and Kardia, Sharon and Hovatta, Iiris and Perola, Markus and Ripatti, Samuli and Salomaa, Veikko and Henders, Anjali and Martin, Nicholas and Smith, Alicia K and Mehta, Divya and Binder, Elisabeth B and Nylocks, K. Maria and Kennedy, Elizabeth M and Klengel, Torsten and Ding, Jingzhong and Suchy-Dicey, Astrid and Enquobahrie, D and Brody, Jennifer and Rotter, Jerome I and Chen, Yii-Der I and Houwing-Duistermaat, Jeanine and Kloppenburg, Margreet and Slagboom, Eline and Helmer, Quinta and Hollander, Wouter and Bean, Shannon and Raj, Towfique and Bakhshi, Noman and Wang, Qiao Ping and Oyston, Lisa J and Psaty, Bruce and Tracy, Russell and Montgomery, Grant and Turner, Stephen and Blangero, John and ... and NABEC UKBEC Consortium and NABEC/UKBEC Consortium
Nature Communications, ISSN 2041-1723, 10/2015, Volume 6, Issue 1, p. 8570
textabstractDisease incidences increase with age, but the molecular characteristics of ageing that lead to increased disease susceptibility remain inadequately... 
LIFE-SPAN | OXIDATIVE STRESS | METHYLATION | PROFILES | GLYCOSAMINOGLYCANS | HUMAN LONGEVITY | DROSOPHILA-MELANOGASTER | MULTIDISCIPLINARY SCIENCES | PATTERNS | GENE-EXPRESSION CHANGES | GENOME-WIDE ASSOCIATION | Aging - blood | DNA Methylation | Humans | Transcriptome | European Continental Ancestry Group | Gene Expression Profiling | Biomarkers - blood
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3. Full Text Therapeutic Clearance of Amyloid by Antibodies to Serum Amyloid P Component
by Richards, Duncan B and Cookson, Louise M and Berges, Alienor C and Barton, Sharon V and Lane, Thirusha and Ritter, James M and Fontana, Marianna and Moon, James C and Pinzani, Massimo and Gillmore, Julian D and Hawkins, Philip N and Pepys, Mark B
The New England Journal of Medicine, ISSN 0028-4793, 09/2015, Volume 373, Issue 12, pp. 1106 - 1114
A two-step process, in which circulating levels of amyloid P are reduced and then anti–serum amyloid P antibody is given to activate macrophage clearance... 
MEDICINE, GENERAL & INTERNAL | CARDIOVASCULAR MAGNETIC-RESONANCE | QUANTIFICATION | VOLUME | SCINTIGRAPHY | TISSUE | LIVER | SYSTEMIC AMYLOIDOSIS | AL AMYLOIDOSIS | PHARMACOLOGICAL DEPLETION | Liver - pathology | Serum Amyloid P-Component - immunology | Humans | Immunoglobulin G | Middle Aged | Antibodies, Monoclonal - adverse effects | Carboxylic Acids - pharmacokinetics | Pyrrolidines - administration & dosage | Pyrrolidines - adverse effects | Amyloidosis - diagnostic imaging | Dose-Response Relationship, Drug | Carboxylic Acids - adverse effects | Liver - drug effects | Liver - diagnostic imaging | Adult | Carboxylic Acids - administration & dosage | Serum Amyloid P-Component - antagonists & inhibitors | Immunoglobulin Light-chain Amyloidosis | Pyrrolidines - pharmacokinetics | Antibodies, Monoclonal - pharmacokinetics | Amyloidosis - drug therapy | Serum Amyloid P-Component - analysis | Antibodies, Monoclonal - administration & dosage | Radionuclide Imaging | Aged | Infusions, Intravenous | Monoclonal antibodies | Care and treatment | Amyloidosis | Dosage and administration | Immunoglobulins | Kidneys | Mortality | Liver | Inflammation | Scintigraphy | Macrophages | SAP protein | Patients | Lymph nodes | Atrophy | Proteins | Magnetic resonance imaging | Rodents | Giant cells | Drug therapy | Drug dosages | Amyloid P component
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4. Full Text The relationship between perioperative blood transfusion and overall mortality in patients undergoing radical cystectomy for bladder cancer
by Morgan, Todd M., M.D and Barocas, Daniel A., M.D., M.P.H and Chang, Sam S., M.D and Phillips, Sharon E., M.S.P.H and Salem, Shady, M.D and Clark, Peter E., M.D and Penson, David F., M.D., M.P.H and Smith, Joseph A., M.D and Cookson, Michael S., M.D
Urologic Oncology: Seminars and Original Investigations, ISSN 1078-1439, 2013, Volume 31, Issue 6, pp. 871 - 877
Abstract Objectives The relationship between perioperative blood transfusion (PBT) and oncologic outcomes is controversial. In patients undergoing surgery for... 
Urology | Cystectomy | Transfusion | Bladder cancer | Blood | LONG-TERM SURVIVAL | SURVIVAL FOLLOWING SURGERY | CRITICALLY-ILL | MORBIDITY | ONCOLOGY | COLORECTAL-CANCER | DISEASE | PROSTATECTOMY | UROLOGY & NEPHROLOGY | RECURRENCE | KIDNEY | CARCINOMA | Urinary Bladder Neoplasms - mortality | Erythrocyte Transfusion | Humans | Middle Aged | Kaplan-Meier Estimate | Proportional Hazards Models | Male | Treatment Outcome | Models, Statistical | Urinary Bladder Neoplasms - surgery | Urinary Bladder Neoplasms - therapy | Aged, 80 and over | Female | Aged | Retrospective Studies | Cystectomy - methods | Cohort Studies | Colon cancer | Blood transfusion | Patient outcomes | Mortality | Bladder Cancer
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5. Full Text Langerin-expressing dendritic cells in human tissues are related to CD1C + dendritic cells and distinct from langerhans cells and CD141 high XCR1 + dendritic cells
by Bigley, Venetia and McGovern, Naomi and Milne, Paul and Dickinson, Rachel and Pagan, Sarah and Cookson, Sharon and Haniffa, Muzlifah and Collin, Matthew
Journal of Leukocyte Biology, ISSN 0741-5400, 04/2015, Volume 97, Issue 4, pp. 627 - 634
Differentiation | GATA2 | Antigen presenting cell | HSCT | DCML deficiency
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6. Full Text BioSAXS Measurements Reveal That Two Antimicrobial Peptides Induce Similar Molecular Changes in Gram-Negative and Gram-Positive Bacteria
by von Gundlach, A and Ashby, MP and Gani, J and Lopez-Perez, PM and Cookson, AR and Huws, SA and Rumancev, C and Garamus, VM and Mikut, R and Rosenhahn, A and Hilpert, K
FRONTIERS IN PHARMACOLOGY, ISSN 1663-9812, 09/2019, Volume 10
Two highly active short broad-spectrum AMPs (14D and 69D) with unknown mode of action have been investigated in regards to their effect against the... 
ANTIBIOTIC DODECAPEPTIDE | mode of action | SPOT SYNTHESIS | BEAMLINE | ACQUISITION | X-RAY-SCATTERING | ARRAYS | SAXS | ESCHERICHIA-COLI-CELLS | MRSA | electron microscopy | PHARMACOLOGY & PHARMACY | antimicrobial peptide | E. coli | Methicillin | Bacteria | Peptides | Staphylococcus aureus
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7. Full Text Demographic history and rare allele sharing among human populations
by Simon Gravel and Brenna M. Henn and Ryan N. Gutenkunst and Amit R. Indap and Gabor T. Marth and Andrew G. Clark and Fuli Yu and Richard A. Gibbs and Carlos D. Bustamante and 1000 Genomes Project and The 1000 Genomes Project
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2011, Volume 108, Issue 29, pp. 11983 - 11988
High-throughput sequencing technology enables population-level surveys of human genomic variation. Here, we examine the joint allele frequency distributions... 
Demography | Population growth | Exons | Population estimates | Population size | Genomes | Sequencing | Population genetics | Parametric models | Human genetics | Human evolution | Genetic drift | Demographic inference | ANIMALS | population genetics | NUMBER | VARIANTS | genetic drift | SIZES | MULTIDISCIPLINARY SCIENCES | demographic inference | CAPTURE PROBABILITIES VARY | RATES | HUMAN GENOME | human evolution | FREQUENCY-SPECTRUM | DIVERGENCE | SELECTION | Genetic Variation | Genetics, Population | Genetic Drift | Gene Frequency | Humans | Genes - genetics | Models, Genetic | Continental Population Groups - genetics | Genomics - methods | Sequence Analysis, DNA | Evolution, Molecular | Genetic aspects | Research | Genetic variation | Biological Sciences
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8. Full Text Human Tissues Contain CD141 hi Cross-Presenting Dendritic Cells with Functional Homology to Mouse CD103 + Nonlymphoid Dendritic Cells
by Haniffa, Muzlifah and Shin, Amanda and Bigley, Venetia and McGovern, Naomi and Teo, Pearline and See, Peter and Wasan, Pavandip Singh and Wang, Xiao-Nong and Malinarich, Frano and Malleret, Benoit and Larbi, Anis and Tan, Pearlie and Zhao, Helen and Poidinger, Michael and Pagan, Sarah and Cookson, Sharon and Dickinson, Rachel and Dimmick, Ian and Jarrett, Ruth F and Renia, Laurent and Tam, John and Song, Colin and Connolly, John and Chan, Jerry K.Y and Gehring, Adam and Bertoletti, Antonio and Collin, Matthew and Ginhoux, Florent
Immunity, ISSN 1074-7613, 07/2012, Volume 37, Issue 1, pp. 60 - 73
Dendritic cell (DC)-mediated cross-presentation of exogenous antigens acquired in the periphery is critical for the initiation of CD8 T cell responses. Several... 
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9. Full Text MTOR independent regulation of macroautophagy by Leucine Rich Repeat Kinase 2 via Beclin-1
by Manzoni, Claudia and Mamais, Adamantios and Roosen, Dorien A and Dihanich, Sybille and Soutar, Marc P. M and Plun-Favreau, Helene and Bandopadhyay, Rina and Hardy, John and Tooze, Sharon A and Cookson, Mark R and Lewis, Patrick A
Scientific Reports, ISSN 2045-2322, 10/2016, Volume 6, Issue 1, p. 35106
Leucine rich repeat kinase 2 is a complex enzyme with both kinase and GTPase activities, closely linked to the pathogenesis of several human disorders... 
SH-SY5Y CELLS | BCL-X-L | GTPASE ACTIVITY | MEDIATED AUTOPHAGY | AUTOPHAGIC ACTIVITY | PHOSPHORYLATION | PATHWAY | MULTIDISCIPLINARY SCIENCES | LRRK2 G2019S MUTATION | INHIBITOR | PARKINSONS-DISEASE | Astrocytes - cytology | Astrocytes - drug effects | Cell Line | Parkinson Disease - pathology | TOR Serine-Threonine Kinases - metabolism | Microtubule-Associated Proteins - metabolism | Humans | Cells, Cultured | Autophagy - physiology | Autophagy-Related Protein-1 Homolog - metabolism | Autophagy - drug effects | Animals | Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 - antagonists & inhibitors | Mice | Parkinson Disease - metabolism | Protein Kinase Inhibitors - pharmacology | Mutation | Beclin-1 - metabolism | Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 - metabolism | Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 - genetics | Astrocytes - metabolism | Parkinson Disease - etiology | TOR protein | Cell culture | Parkinson's disease | Neurodegenerative diseases | Leprosy | Crohn's disease | Rapamycin | Leucine | Kinases | 1-Phosphatidylinositol 3-kinase | Signal transduction | LRRK2 protein | Movement disorders | Guanosinetriphosphatase | Cancer
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