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1. Full Text HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials
by Swerdlow, Daniel I, Dr and Preiss, David, Dr and Kuchenbaecker, Karoline B, MSc and Holmes, Michael V, PhD and Engmann, Jorgen E L, MSc and Shah, Tina, PhD and Sofat, Reecha, MD and Stender, Stefan, MD and Johnson, Paul C D, PhD and Scott, Robert A, PhD and Leusink, Maarten, MSc and Verweij, Niek, MD and Sharp, Stephen J, MSc and Guo, Yiran, PhD and Giambartolomei, Claudia, MSc and Chung, Christina, MSc and Peasey, Anne, PhD and Amuzu, Antoinette, MSc and Li, KaWah, MSc and Palmen, Jutta, MSc and Howard, Philip, MSc and Cooper, Jackie A, MSc and Drenos, Fotios, PhD and Li, Yun R, BSc and Lowe, Gordon, Prof and Gallacher, John, PhD and Stewart, Marlene C W, PhD and Tzoulaki, Ioanna, PhD and Buxbaum, Sarah G, PhD and van der A, Daphne L, PhD and Forouhi, Nita G, MRCP and Onland-Moret, N Charlotte, PhD and van der Schouw, Yvonne T, Prof and Schnabel, Renate B, MD and Hubacek, Jaroslav A, PhD and Kubinova, Ruzena, MD and Baceviciene, Migle, MD and Tamosiunas, Abdonas, Prof and Pajak, Andrzej, Prof and Topor-Madry, Romanvan, MD and Stepaniak, Urszula, PhD and Malyutina, Sofia, Prof and Baldassarre, Damiano, PhD and Sennblad, Bengt, PhD and Tremoli, Elena, Prof and de Faire, Ulf, Prof and Veglia, Fabrizio, PhD and Ford, Ian, Prof and Jukema, J Wouter, Prof and Westendorp, Rudi G J, Prof and de Borst, Gert Jan, MD and de Jong, Pim A, MD and Algra, Ale, Prof and Spiering, Wilko, MD and der Zee, Anke H Maitland-van, PhD and Klungel, Olaf H, PharmD and de Boer, Anthonius, Prof and Doevendans, Pieter A, Prof and Eaton, Charles B, Prof and Robinson, Jennifer G, Prof and Duggan, David, PhD and Kjekshus, John, Prof and Downs, John R, MD and Gotto, Antonio M, MD and Keech, Anthony C, MD and Marchioli, Roberto, MD and Tognoni, Gianni, MD and Sever, Peter S, Prof and Poulter, Neil R, Prof and Waters, David D, MD and Pedersen, Terje R, MD and Amarenco, Pierre, MD and Nakamura, Haruo, MD and McMurray, John J V, Prof and Lewsey, James D, PhD and Chasman, Daniel I, PhD and Ridker, Paul M, MD and Maggioni, Aldo P, Prof and Tavazzi, Luigi, Prof and Ray, Kausik K, Prof and Seshasai, Sreenivasa Rao Kondapally, MD and Manson, JoAnn E, Prof and Price, Jackie F, MD and Whincup, Peter H, Prof and Morris, Richard W, Prof and Lawlor, Debbie A, Prof and Smith, George Davey, Prof and Ben-Shlomo, Yoav, Prof and Schreiner, Pamela J, Prof and Fornage, Myriam, Prof and Siscovick, David S, Prof and Cushman, Mary, MD and Kumari, Meena, PhD and Wareham, Nick J, Prof and Verschuren, W M Monique, PhD and Redline, Susan, Prof and Patel, Sanjay R, MD and Whittaker, John C, Prof and Hamsten, Anders, Prof and Delaney, Joseph A, PhD and ... and MAGIC Consortium and InterAct Consortium and DIAGRAM Consortium
The Lancet, ISSN 0140-6736, 01/2015, Volume 385, Issue 9965, pp. 351 - 361
Summary Background Statins increase the risk of new-onset type 2 diabetes mellitus. We aimed to assess whether this increase in risk is a consequence of... 
Internal Medicine | LDL CHOLESTEROL | MEDICINE, GENERAL & INTERNAL | HIGH-DOSE ATORVASTATIN | METAANALYSIS | STATIN THERAPY | ASSOCIATION ANALYSES | DISEASE | PREVENTION | BODY-MASS INDEX | RISK | MENDELIAN RANDOMIZATION | Body Mass Index | Genetic Testing | Cholesterol, HDL - metabolism | Diabetes Mellitus, Type 2 - genetics | Humans | Middle Aged | Risk Factors | Male | Body Weight - genetics | Randomized Controlled Trials as Topic | Hydroxymethylglutaryl-CoA Reductase Inhibitors - adverse effects | Cholesterol, LDL - metabolism | Polymorphism, Single Nucleotide - genetics | Female | Aged | Hydroxymethylglutaryl CoA Reductases - genetics | Type 2 diabetes | Genetic research | Enzymes | Thiols | Diabetes | Low density lipoprotein | Statins | Cholesterol | Risk factors | Index Medicus | Abridged Index Medicus
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2. Full Text Use of low-density lipoprotein cholesterol gene score to distinguish patients with polygenic and monogenic familial hypercholesterolaemia: a case-control study
by Talmud, Philippa J, Prof and Shah, Sonia, MSc and Whittall, Ros, MSc and Futema, Marta, BSc and Howard, Philip, BSc and Cooper, Jackie A, MSc and Harrison, Seamus C, MRCS and Li, KaWah, MSc and Drenos, Fotios, PhD and Karpe, Frederik, PhD and Neil, H Andrew W, Prof and Descamps, Olivier S, PhD and Langenberg, Claudia, PhD and Lench, Nicholas, PhD and Kivimaki, Mika, Prof and Whittaker, John, Prof and Hingorani, Aroon D, Prof and Kumari, Meena, PhD and Humphries, Steve E, Prof
Lancet, The, ISSN 0140-6736, 2013, Volume 381, Issue 9874, pp. 1293 - 1301
Summary Background Familial hypercholesterolaemia is a common autosomal-dominant disorder caused by mutations in three known genes. DNA-based cascade testing... 
Internal Medicine | INDIVIDUALS | POPULATION | DIAGNOSIS | MEDICINE, GENERAL & INTERNAL | DEFECTS | MUTATION DETECTION RATE | CASCADE TESTING PROJECT | LIPID-LEVELS | DISEASE | ATHEROSCLEROSIS | CORONARY RISK | Hyperlipoproteinemia Type II - blood | Humans | Middle Aged | Male | United Kingdom | Genetic Testing - methods | Multifactorial Inheritance | Case-Control Studies | Cholesterol, LDL - genetics | Belgium | Alleles | Cholesterol, LDL - blood | Female | Hyperlipoproteinemia Type II - genetics | Genetic aspects | Hypercholesterolemia | Research | Gene mutations | Analysis | Heart | Genealogy | Cardiovascular disease | Lipids | Genomes | Mutation | Low density lipoprotein | Cholesterol | Deoxyribonucleic acid--DNA | Index Medicus | Abridged Index Medicus
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3. Full Text Association of vitamin D status with arterial blood pressure and hypertension risk: a mendelian randomisation study
by Vimaleswaran, Karani S, PhD and Cavadino, Alana, MSc and Berry, Diane J, PhD and Jorde, Rolf, Prof and Dieffenbach, Aida Karina, PhD and Lu, Chen, PhD and Alves, Alexessander Couto, PhD and Heerspink, Hiddo J Lambers, PhD and Tikkanen, Emmi, PhD and Eriksson, Joel, MD and Wong, Andrew, PhD and Mangino, Massimo, PhD and Jablonski, Kathleen A, PhD and Nolte, Ilja M, PhD and Houston, Denise K, PhD and Ahluwalia, Tarunveer Singh, PhD and van der Most, Peter J, MSc and Pasko, Dorota, MSc and Zgaga, Lina, PhD and Thiering, Elisabeth, MSc and Vitart, Veronique, PhD and Fraser, Ross M, PhD and Huffman, Jennifer E, MSc and de Boer, Rudolf A, Prof and Schöttker, Ben, PhD and Saum, Kai-Uwe, MPH and McCarthy, Mark I, Prof and Dupuis, Josée, Prof and Herzig, Karl-Heinz, Prof and Sebert, Sylvain, PhD and Pouta, Anneli, MD and Laitinen, Jaana, PhD and Kleber, Marcus E, PhD and Navis, Gerjan, Prof and Lorentzon, Mattias, Prof and Jameson, Karen, MSc and Arden, Nigel, Prof and Cooper, Jackie A, MSc and Acharya, Jayshree, PhD and Hardy, Rebecca, Prof and Raitakari, Olli, Prof and Ripatti, Samuli, Prof and Billings, Liana K, MD and Lahti, Jari, PhD and Osmond, Clive, Prof and Penninx, Brenda W, Prof and Rejnmark, Lars, MD and Lohman, Kurt K, MStat and Paternoster, Lavinia, PhD and Stolk, Ronald P, Prof and Hernandez, Dena G, MS and Byberg, Liisa, PhD and Hagström, Emil, MD and Melhus, Håkan, Prof and Ingelsson, Erik, Prof and Mellström, Dan, Prof and Ljunggren, Östen, Prof and Tzoulaki, Ioanna, PhD and McLachlan, Stela, MD and Theodoratou, Evropi, PhD and Tiesler, Carla M T, MSc and Jula, Antti, MD and Navarro, Pau, PhD and Wright, Alan F, Prof and Polasek, Ozren, MD and Wilson, James F, DPhil and Rudan, Igor, Prof and Salomaa, Veikko, Prof and Heinrich, Joachim, PhD and Campbell, Harry, Prof and Price, Jacqueline F, MD and Karlsson, Magnus, Prof and Lind, Lars, MD and Michaëlsson, Karl, Prof and Bandinelli, Stefania and Frayling, Timothy M, Prof and Hartman, Catharina A, PhD and Sørensen, Thorkild I A, Prof and Kritchevsky, Stephen B, Prof and Langdahl, Bente Lomholt, Prof and Eriksson, Johan G, Prof and Florez, Jose C, Prof and Spector, Tim D, Prof and Lehtimäki, Terho, Prof and Kuh, Diana, Prof and Humphries, Steve E, Prof and Cooper, Cyrus, Prof and Ohlsson, Claes, Prof and März, Winfried, Prof and de Borst, Martin H, MD and Kumari, Meena, Prof and Kivimaki, Mika, Prof and Wang, Thomas J, Prof and Power, Chris, Prof and Brenner, Hermann, Prof and Grimnes, Guri, MD and van der Harst, Pim, MD and Snieder, Harold, Prof and Hingorani, Aroon D, Prof and Pilz, Stefan, Prof and ... and ICBP and LifeLines Cohort Study Investigato and CHARGE Consortium and Global Blood Pressure Genetics Gl and Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium and International Consortium for Blood Pressure (ICBP) and Global Blood Pressure Genetics (Global BPGen) consortium and LifeLines Cohort Study investigators and Caroline Hayward and Medicinska fakulteten and Science for Life Laboratory, SciLifeLab and Medicinska och farmaceutiska vetenskapsområdet and Kardiologi and Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm and Ortopedi and Uppsala universitet and Uppsala kliniska forskningscentrum (UCR) and Kardiovaskulär epidemiologi and Institutionen för medicinska vetenskaper and Molekylär epidemiologi and Institutionen för kirurgiska vetenskaper and Endokrinologi och mineralmetabolism and Klinisk farmakogenomik och osteoporos
Lancet Diabetes & Endocrinology, The, ISSN 2213-8587, 2014, Volume 2, Issue 9, pp. 719 - 729
Summary Background Low plasma 25-hydroxyvitamin D (25[OH]D) concentration is associated with high arterial blood pressure and hypertension risk, but whether... 
Endocrinology & Metabolism | Other | TRIAL | METAANALYSIS | RENIN-ANGIOTENSIN SYSTEM | D SUPPLEMENTATION | DISEASE | ENDOCRINOLOGY & METABOLISM | GENETIC-VARIANTS | OUTCOMES | HEALTH | KIDNEY | GENOME-WIDE ASSOCIATION | Body Mass Index | Genetic Predisposition to Disease | Vitamin D Deficiency - genetics | Humans | Middle Aged | Male | Randomized Controlled Trials as Topic | Hypertension - blood | Cytochrome P450 Family 2 | Vitamin D Deficiency - prevention & control | Phenotype | Cholestanetriol 26-Monooxygenase - genetics | Vitamin D Deficiency - blood | Mendelian Randomization Analysis | Hypertension - prevention & control | Adult | Female | Oxidoreductases Acting on CH-CH Group Donors - genetics | Vitamin D - administration & dosage | Vitamin D - analogs & derivatives | Polymorphism, Single Nucleotide | Hypertension - genetics | Index Medicus | Clinical Medicine | Medical and Health Sciences | Endokrinologi och diabetes | Klinisk medicin | Medicin och hälsovetenskap | Endocrinology and Diabetes
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4. Full Text An analysis of drug modulation of abdominal aortic aneurysm growth through 25 years of surveillance
by Thompson, Andrew, MD, FRCS and Cooper, Jackie A., MSc and Fabricius, Michael, MB BS and Humphries, Steve E., PhD, MRCP, FRCPath and Ashton, Hilary A., MSc and Hafez, Hany, PhD, FRCS
Journal of Vascular Surgery, ISSN 0741-5214, 2010, Volume 52, Issue 1, pp. 55 - 61.e2
Background A modest (41%) reduction in abdominal aortic aneurysm (AAA) growth rate is likely to delay AAA-related events (surgery or rupture) by 5 years,... 
Surgery | MORTALITY | SURGERY | RATES | MEDICAL-MANAGEMENT | EXPANSION | RUPTURE | PERIPHERAL VASCULAR DISEASE | RANDOMIZED CONTROLLED-TRIAL | STATINS | Multivariate Analysis | Markov Chains | Aortic Aneurysm, Abdominal - drug therapy | Aortic Aneurysm, Abdominal - mortality | Risk Assessment | Humans | Risk Factors | Aortic Aneurysm, Abdominal - diagnostic imaging | Male | Models, Statistical | Drug Prescriptions | Mass Screening - methods | Aorta, Abdominal - drug effects | Disease Progression | Aorta, Abdominal - diagnostic imaging | Polypharmacy | Time Factors | Ultrasonography | Female | Aged | Dilatation, Pathologic | Monte Carlo Method | Drugs | Abdominal aneurysm | Analysis | Index Medicus
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5. Full Text Secretory Phospholipase A2 -IIA and Cardiovascular Disease
by Holmes, Michael V., MSc and Simon, Tabassome, MD, PhD and Exeter, Holly J., PhD and Folkersen, Lasse, PhD and Asselbergs, Folkert W., MD, PhD and Guardiola, Montse, PhD and Cooper, Jackie A., MSc and Palmen, Jutta, MSc and Hubacek, Jaroslav A., DSc, PhD and Carruthers, Kathryn F., MPhil and Horne, Benjamin D., PhD, MPH and Brunisholz, Kimberly D., MST and Mega, Jessica L., MD, MPH and van Iperen, Erik P.A., MSc and Li, Mingyao, PhD and Leusink, Maarten, MSc and Trompet, Stella, PhD and Verschuren, Jeffrey J.W., MD, MSc and Hovingh, G. Kees, MD, PhD and Dehghan, Abbas, MD, PhD and Nelson, Christopher P., PhD and Kotti, Salma, PharmD, PhD and Danchin, Nicolas, MD, PhD and Scholz, Markus, PhD and Haase, Christiane L., PhD and Rothenbacher, Dietrich, MD and Swerdlow, Daniel I., MBBS, PhD and Kuchenbaecker, Karoline B., Dipl Psych, MSc and Staines-Urias, Eleonora, MD, MSc and Goel, Anuj, MSc and van 't Hooft, Ferdinand, MD, PhD and Gertow, Karl, PhD and de Faire, Ulf, MD, PhD and Panayiotou, Andrie G., PhD and Tremoli, Elena, PhD and Baldassarre, Damiano, PhD and Veglia, Fabrizio, PhD and Holdt, Lesca M., MD, PhD and Beutner, Frank, MD, PhD and Gansevoort, Ron T., MD, PhD and Navis, Gerjan J., MD, PhD and Mateo Leach, Irene, PhD and Breitling, Lutz P., MD and Brenner, Hermann, MD, MPH and Thiery, Joachim, MD, MBA and Dallmeier, Dhayana, MD and Franco-Cereceda, Anders, MD, PhD and Boer, Jolanda M.A., PhD and Stephens, Jeffrey W., PhD and Hofker, Marten H., PhD and Tedgui, Alain, PhD and Hofman, Albert, MD, PhD and Uitterlinden, André G., PhD and Adamkova, Vera, MD, PhD and Pitha, Jan, MD, PhD and Onland-Moret, N. Charlotte, PhD and Cramer, Maarten J., MD, PhD and Nathoe, Hendrik M., MD, PhD and Spiering, Wilko, MD, PhD and Klungel, Olaf H., PharmD, PhD and Kumari, Meena, PhD and Whincup, Peter H and Morrow, David A., MD and Braund, Peter S., MSc and Hall, Alistair S., PhD and Olsson, Anders G., MD, PhD and Doevendans, Pieter A., MD, PhD and Trip, Mieke D., MD, PhD and Tobin, Martin D., PhD and Hamsten, Anders, PhD and Watkins, Hugh, PhD and Koenig, Wolfgang, MD and Nicolaides, Andrew N., PhD and Teupser, Daniel, MD, PhD and Day, Ian N.M and Carlquist, John F., PhD and Gaunt, Tom R., PhD and Ford, Ian, PhD and Sattar, Naveed and Tsimikas, Sotirios, MD and Schwartz, Gregory G., MD PhD and Lawlor, Debbie A., PhD and Morris, Richard W., PhD and Sandhu, Manjinder S., PhD and Poledne, Rudolf, PhD and Maitland-van der Zee, Anke H., PhD and Khaw, Kay-Tee, MBBChir and Keating, Brendan J., PhD and van der Harst, Pim, MD, PhD and Price, Jackie F., MD and Mehta, Shamir R., MD, MSc and Yusuf, Salim, MBBS, DPhil and Witteman, Jaqueline C.M., PhD and Franco, Oscar H., MD, PhD and Jukema, J. Wouter, MD, PhD and de Knijff, Peter, PhD and Tybjaerg-Hansen, Anne, MD, DMSc and Rader, Daniel J., MD and Farrall, Martin, MD, PhD and Samani, Nilesh J., MD and ...
JACC (Journal of the American College of Cardiology), ISSN 0735-1097, 2013, Volume 62, Issue 21, pp. 1966 - 1976
Objectives This study sought to investigate the role of secretory phospholipase A2 (sPLA2 )-IIA in cardiovascular disease. Background Higher circulating levels... 
Cardiovascular | Internal Medicine | drug development | epidemiology | genetics | cardiovascular diseases | Mendelian randomization | Studies | Cardiovascular disease | Heart attacks | Drug therapy | Mortality | Cholesterol
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6. Full Text Influence of genetic risk factors on coronary heart disease occurrence in Afro-Caribbeans
by Larifla, Laurent, MD and Beaney, Katherine E., BSc and Foucan, Lydia, MD and Bangou, Jacqueline, PhD and Michel, Carl T., MD and Martino, Jean, MD and Velayoudom-Cephise, Fritz-Line, MD and Cooper, Jackie A., MSc and Humphries, Steve E., PhD
Canadian Journal of Cardiology, ISSN 0828-282X, 2015, Volume 32, Issue 8, pp. 978 - 985
Abstract Background Despite excessive rates of cardiovascular risk factors such as hypertension, diabetes and obesity, Afro-Caribbeans have lower mortality... 
Cardiovascular | ETHNIC-DIFFERENCES | MORTALITY | CARDIAC & CARDIOVASCULAR SYSTEMS | COUNTRIES | CHOLESTEROL | GLUCOSE-INTOLERANCE | SUSCEPTIBILITY | CARDIOVASCULAR-DISEASE | HYPERTENSION | ASSOCIATION | ENGLAND | European Continental Ancestry Group - genetics | Genetic Predisposition to Disease | Risk Assessment | Gene Frequency | Humans | Middle Aged | Genotype | Male | Coronary Disease - ethnology | Guadeloupe - ethnology | Case-Control Studies | Coronary Disease - genetics | Smoking - epidemiology | Diabetes Mellitus - epidemiology | Female | Polymorphism, Single Nucleotide | African Continental Ancestry Group - genetics | Hypertension - epidemiology | Hypercholesterolemia - epidemiology | Index Medicus | Clinical Research
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7. Full Text Risk thresholds for alcohol consumption: combined analysis of individual-participant data for 599 912 current drinkers in 83 prospective studies
by Wood, Angela M and Kaptoge, Stephen and Butterworth, Adam S and Butterworth, Adam and Willeit, Peter and Warnakula, Samantha and Bolton, Thomas and Paige, Ellie and Paul, Dirk S and Sweeting, Michael and Burgess, Stephen and Bell, Steven and Astle, William and Stevens, David and Koulman, Albert and Selmer, Randi M and Verschuren, Monique and Verschuren, W M Monique and Sato, Shinichi and Njølstad, Inger and Woodward, Mark and Salomaa, Veikko and Nordestgaard, Børge G and Yeap, Bu B and Fletcher, Astrid and Melander, Olle and Kuller, Lewis H and Balkau, Beverley and Marmot, Michael and Koenig, Wolfgang and Casiglia, Edoardo and Cooper, Cyrus and Cooper, Jackie A and Arndt, Volker and Franco, Oscar H and Wennberg, Maria and Wennberg, Patrik and Gallacher, John and de la Cámara, Agustín Gómez and Völzke, Henry and Dahm, Christina C and Dale, Caroline E and Bergmann, Manuela M and Bergmann, Manuela and Crespo, Carlos J and Crespo, Carlos and van der Schouw, Yvonne T and Kaaks, Rudolf and Simons, Leon A and Lagiou, Pagona and Schoufour, Josje D and Boer, Jolanda M A and Boer, Jolanda M.A and Key, Timothy J and Rodriguez, Beatriz and Rodriguez, Carlos J and Moreno-Iribas, Conchi and Davidson, Karina W and Taylor, James O and Sacerdote, Carlotta and Wallace, Robert B and Quiros, J Ramon and Quiros, J. Ramon and Tumino, Rosario and Blazer, Dan G and Linneberg, Allan and Daimon, Makoto and Panico, Salvatore and Howard, Barbara and Skeie, Guri and Strandberg, Timo and Weiderpass, Elisabete and Nietert, Paul J and Psaty, Bruce M and Kromhout, Daan and Salamanca-Fernandez, Elena and Kiechl, Stefan and Krumholz, Harlan M and Grioni, Sara and Palli, Domenico and Huerta, José M and Price, Jackie and Sundström, Johan and Arriola, Larraitz and Arima, Hisatomi and Travis, Ruth C and Panagiotakos, Demosthenes B and Karakatsani, Anna and Trichopoulou, Antonia and Kühn, Tilman and Grobbee, Diederick E and Barrett-Connor, Elizabeth and van Schoor, Natasja and Boeing, Heiner and Overvad, Kim and Kauhanen, Jussi and Wareham, Nick and Langenberg, Claudia and Forouhi, Nita and Després, Jean-Pierre and ... and Emerging Risk Factors Collabora and Emerging Risk Factors Collaboration/EPIC-CVD/UK Biobank Alcohol Study Group and Medicinska fakulteten and Institutionen för folkhälsa och klinisk medicin and Umeå universitet
The Lancet, ISSN 0140-6736, 04/2018, Volume 391, Issue 10129, pp. 1513 - 1523
Low-risk limits recommended for alcohol consumption vary substantially across different national guidelines. To define thresholds associated with lowest risk... 
MORTALITY | STROKE | MEDICINE, GENERAL & INTERNAL | METAANALYSIS | CHOLESTEROL | PATTERN | CARDIOVASCULAR-DISEASE | CORONARY-HEART-DISEASE | ASSOCIATION | CANCER | BLOOD-PRESSURE | Cardiovascular Diseases - etiology | Prospective Studies | Humans | Middle Aged | Female | Male | Alcohol Drinking - adverse effects | Alcohol Drinking - mortality | Drinking of alcoholic beverages | Myocardial infarction | Heart attacks | Sex | Income | Alcohol | Cardiovascular disease | Dosage | Risk factors | Guidelines | Alcohol use | Aorta | Heart diseases | Age | Consumption | Medical research | Cerebral infarction | Data analysis | Stroke | Life expectancy | Risk groups | Thresholds | Drinking behavior | Mortality | Diabetes mellitus | Health risks | Data processing | Risk analysis | Disease control | Cholesterol | Studies | Lipoproteins | Life span | Collaboration | Infarction | Diabetes | Cardiovascular diseases | Health risk assessment | Smoking | Index Medicus | Abridged Index Medicus | Community medicine, Social medicine: 801 | Samfunnsmedisin, sosialmedisin: 801 | VDP | Helsefag: 800 | Health sciences: 800 | Medisinske Fag: 700 | Medical disciplines: 700 | Medical and Health Sciences | Medicin och hälsovetenskap | Beroendelära | Public Health, Global Health, Social Medicine and Epidemiology | Hälsovetenskaper | Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi | Substance Abuse | Health Sciences | Human Nutrition & Health | Human Nutrition | Afdeling Humane voeding | Humane Voeding | Humane Voeding & Gezondheid | Human Nutrition (HNE)
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8. Full Text PCSK9 genetic variants and risk of type 2 diabetes: a mendelian randomisation study
by Schmidt, Amand F, Dr and Swerdlow, Daniel I, PhD and Holmes, Michael V, PhD and Patel, Riyaz S, MD and Fairhurst-Hunter, Zammy, MSc and Lyall, Donald M, PhD and Hartwig, Fernando Pires, MSc and Horta, Bernardo Lessa, Prof and Hyppönen, Elina, Prof and Power, Christine, Prof and Moldovan, Max, PhD and van Iperen, Erik, MSc and Hovingh, G Kees, Prof and Demuth, Ilja, PhD and Norman, Kristina, PhD and Steinhagen-Thiessen, Elisabeth, Prof and Demuth, Juri, PhD and Bertram, Lars, Prof and Liu, Tian, PhD and Coassin, Stefan, PhD and Willeit, Johann, Prof and Kiechl, Stefan, MD and Willeit, Karin, MD and Mason, Dan, PhD and Wright, John, Prof and Morris, Richard, Prof and Wanamethee, Goya, Prof and Whincup, Peter, Prof and Ben-Shlomo, Yoav, Prof and McLachlan, Stela, PhD and Price, Jackie F, Prof and Kivimaki, Mika, Prof and Welch, Catherine, PhD and Sanchez-Galvez, Adelaida, PhD and Marques-Vidal, Pedro, PhD and Nicolaides, Andrew, PhD and Panayiotou, Andrie G, PhD and Onland-Moret, N Charlotte, PhD and van der Schouw, Yvonne T, Prof and Matullo, Giuseppe, PhD and Fiorito, Giovanni, PhD and Guarrera, Simonetta, MSc and Sacerdote, Carlotta, PhD and Wareham, Nicholas J, Prof and Langenberg, Claudia, PhD and Scott, Robert, PhD and Luan, Jian'an, PhD and Bobak, Martin, Prof and Malyutina, Sofia, Prof and Pająk, Andrzej, PhD and Kubinova, Ruzena, PhD and Tamosiunas, Abdonas, Prof and Pikhart, Hynek, PhD and Husemoen, Lise Lotte Nystrup, PhD and Grarup, Niels, PhD and Pedersen, Oluf, PhD and Hansen, Torben, PhD and Linneberg, Allan, Prof and Simonsen, Kenneth Starup, PhD and Cooper, Jackie, MSc and Humphries, Steve E, Prof and Brilliant, Murray, PhD and Kitchner, Terrie, CCRP and Hakonarson, Hakon, PhD and Carrell, David S, PhD and McCarty, Catherine A, PhD and Kirchner, H Lester, PhD and Larson, Eric B, MD and Crosslin, David R, PhD and de Andrade, Mariza, Prof and Roden, Dan M, Prof and Denny, Joshua C, MD and Carty, Cara, PhD and Hancock, Stephen, MSciStud and Attia, John, PhD and Holliday, Elizabeth, PhD and O'Donnell, Martin, PhD and Yusuf, Salim, Prof and Chong, Michael, MSc and Pare, Guillaume, Prof and van der Harst, Pim, Prof and Said, M Abdullah, BSc and Eppinga, Ruben N, PhD and Verweij, Niek, PhD and Snieder, Harold, Prof and Christen, Tim, MSc and Mook-Kanamori, Dennis O, PhD and Gustafsson, Stefan, PhD and Lind, Lars, Prof and Ingelsson, Erik, Prof and Pazoki, Raha, PhD and Franco, Oscar, PhD and Hofman, Albert, Prof and Uitterlinden, Andre, PhD and Dehghan, Abbas, PhD and Teumer, Alexander, PhD and Baumeister, Sebastian, PhD and Dörr, Marcus, Prof and Lerch, Markus M, Prof and Völker, Uwe, Prof and ... and UCLEB Consortium and LifeLines Cohort Study Grp and UCLEB consortium and LifeLines Cohort study group and Medicinska fakulteten and Science for Life Laboratory, SciLifeLab and Medicinska och farmaceutiska vetenskapsområdet and Uppsala universitet and Institutionen för medicinska vetenskaper and Molekylär epidemiologi
Lancet Diabetes & Endocrinology, The, ISSN 2213-8587, 2017, Volume 5, Issue 2, pp. 97 - 105
Summary Background Statin treatment and variants in the gene encoding HMG-CoA reductase are associated with reductions in both the concentration of LDL... 
Endocrinology & Metabolism | Other | STATIN THERAPY | LDL | DISEASE | ENDOCRINOLOGY & METABOLISM | ARCHITECTURE | COMMON | HYPERCHOLESTEROLEMIA | ASSOCIATION | INSIGHTS | Mendelian Randomization Analysis - methods | Genetic Predisposition to Disease - genetics | Randomized Controlled Trials as Topic - methods | Diabetes Mellitus, Type 2 - genetics | Humans | Proprotein Convertase 9 - genetics | Case-Control Studies | Cholesterol, LDL - genetics | Diabetes Mellitus, Type 2 - diagnosis | Diabetes Mellitus, Type 2 - blood | Cholesterol, LDL - blood | Genetic Variation - genetics | Blood Glucose - metabolism | Cohort Studies | Type 2 diabetes | Genetic variation | Analysis | Body weight | Dosage and administration | Risk factors | Statins | Index Medicus | Life Sciences | Clinical Medicine | Medical and Health Sciences | Endokrinologi och diabetes | Klinisk medicin | Medicin och hälsovetenskap | Endocrinology and Diabetes
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