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1. Full Text Use of low-density lipoprotein cholesterol gene score to distinguish patients with polygenic and monogenic familial hypercholesterolaemia: a case-control study
by Talmud, Philippa J, Prof and Shah, Sonia, MSc and Whittall, Ros, MSc and Futema, Marta, BSc and Howard, Philip, BSc and Cooper, Jackie A, MSc and Harrison, Seamus C, MRCS and Li, KaWah, MSc and Drenos, Fotios, PhD and Karpe, Frederik, PhD and Neil, H Andrew W, Prof and Descamps, Olivier S, PhD and Langenberg, Claudia, PhD and Lench, Nicholas, PhD and Kivimaki, Mika, Prof and Whittaker, John, Prof and Hingorani, Aroon D, Prof and Kumari, Meena, PhD and Humphries, Steve E, Prof
The Lancet (British edition), ISSN 0140-6736, 2013, Volume 381, Issue 9874, pp. 1293 - 1301
Internal Medicine | Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Public health. Hygiene-occupational medicine | Public health. Hygiene | General aspects | Biological and medical sciences | Metabolic diseases | Medical sciences | Epidemiology | Disorders of blood lipids. Hyperlipoproteinemia | Hyperlipoproteinemia Type II - blood | Humans | Middle Aged | Male | United Kingdom | Genetic Testing - methods | Multifactorial Inheritance | Case-Control Studies | Cholesterol, LDL - genetics | Belgium | Alleles | Cholesterol, LDL - blood | Female | Hyperlipoproteinemia Type II - genetics | Genetic aspects | Hypercholesterolemia | Research | Gene mutations | Analysis | Heart | Genealogy | Cardiovascular disease | Lipids | Genomes | Mutation | Low density lipoprotein | Cholesterol | Deoxyribonucleic acid--DNA | Index Medicus | Abridged Index Medicus
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2. Full Text PCSK9 genetic variants and risk of type 2 diabetes: a mendelian randomisation study
by Schmidt, Amand F, Dr and Holmes, Michael V, PhD and Hartwig, Fernando Pires, MSc and Horta, Bernardo Lessa, Prof and Hyppönen, Elina, Prof and Hovingh, G Kees, Prof and Norman, Kristina, PhD and Demuth, Juri, PhD and Bertram, Lars, Prof and Liu, Tian, PhD and Coassin, Stefan, PhD and Willeit, Johann, Prof and Kiechl, Stefan, MD and Mason, Dan, PhD and Wright, John, Prof and Wanamethee, Goya, Prof and Whincup, Peter, Prof and Ben-Shlomo, Yoav, Prof and McLachlan, Stela, PhD and Price, Jackie F, Prof and Welch, Catherine, PhD and Sanchez-Galvez, Adelaida, PhD and Marques-Vidal, Pedro, PhD and Nicolaides, Andrew, PhD and Panayiotou, Andrie G, PhD and Onland-Moret, N Charlotte, PhD and van der Schouw, Yvonne T, Prof and Matullo, Giuseppe, PhD and Guarrera, Simonetta, MSc and Sacerdote, Carlotta, PhD and Wareham, Nicholas J, Prof and Langenberg, Claudia, PhD and Scott, Robert, PhD and Luan, Jian'an, PhD and Bobak, Martin, Prof and Malyutina, Sofia, Prof and Pająk, Andrzej, PhD and Tamosiunas, Abdonas, Prof and Pikhart, Hynek, PhD and Husemoen, Lise Lotte Nystrup, PhD and Grarup, Niels, PhD and Pedersen, Oluf, PhD and Hansen, Torben, PhD and Cooper, Jackie, MSc and Humphries, Steve E, Prof and Kitchner, Terrie, CCRP and Hakonarson, Hakon, PhD and McCarty, Catherine A, PhD and Kirchner, H Lester, PhD and Larson, Eric B, MD and de Andrade, Mariza, Prof and Roden, Dan M, Prof and Denny, Joshua C, MD and Carty, Cara, PhD and Hancock, Stephen, MSciStud and Attia, John, PhD and Holliday, Elizabeth, PhD and O'Donnell, Martin, PhD and Pare, Guillaume, Prof and van der Harst, Pim, Prof and Eppinga, Ruben N, PhD and Verweij, Niek, PhD and Christen, Tim, MSc and Mook-Kanamori, Dennis O, PhD and Gustafsson, Stefan, PhD and Lind, Lars, Prof and Ingelsson, Erik, Prof and Pazoki, Raha, PhD and Uitterlinden, Andre, PhD and Baumeister, Sebastian, PhD and Dörr, Marcus, Prof and Lerch, Markus M, Prof and Völker, Uwe, Prof and Völzke, Henry, Prof and Ward, Joey, PhD and Pell, Jill P, PhD and Smith, Daniel J, PhD and Maitland-van der Zee, Anke H, Prof and Young, Robin, PhD and Ford, Ian, PhD and Padmanabhan, Sandosh, Prof and Bots, Michiel L, Prof and Grobbee, Diederick E, Prof and Froguel, Philippe, Prof and Thuillier, Dorothée, MSc and Balkau, Beverley, PhD and Bonnefond, Amélie, PhD and Cariou, Bertrand, Prof and Smart, Melissa, PhD and Bao, Yanchun, PhD and Kumari, Meena, Prof and Ridker, Paul M, Prof and Chasman, Daniel I, PhD and Reiner, Alex P, MD and Lange, Leslie A, Prof and Ritchie, Marylyn D, PhD and Casas, Juan-Pablo, Prof and Keating, Brendan J, PhD and Hingorani, Aroon D, Prof and Sattar, Naveed, Prof and UCLEB consortium and LifeLines Cohort study group and UCLEB Consortium and LifeLines Cohort Study Grp
The lancet. Diabetes & endocrinology, ISSN 2213-8587, 2017, Volume 5, Issue 2, pp. 97 - 105
Endocrinology & Metabolism | Other | PATHWAYS | HEART-DISEASE | METAANALYSIS | CHOLESTEROL | STATIN THERAPY | ARCHITECTURE | COMMON | HYPERCHOLESTEROLEMIA | ASSOCIATION | INSIGHTS | Life Sciences & Biomedicine | Science & Technology | Mendelian Randomization Analysis - methods | Genetic Predisposition to Disease - genetics | Randomized Controlled Trials as Topic - methods | Diabetes Mellitus, Type 2 - genetics | Humans | Proprotein Convertase 9 - genetics | Case-Control Studies | Cholesterol, LDL - genetics | Diabetes Mellitus, Type 2 - diagnosis | Diabetes Mellitus, Type 2 - blood | Cholesterol, LDL - blood | Genetic Variation - genetics | Blood Glucose - metabolism | Cohort Studies | Type 2 diabetes | Genetic variation | Analysis | Body weight | Dosage and administration | Risk factors | Statins | Index Medicus | Life Sciences
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3. Full Text An analysis of drug modulation of abdominal aortic aneurysm growth through 25 years of surveillance
by Thompson, Andrew, MD, FRCS and Cooper, Jackie A., MSc and Fabricius, Michael, MB BS and Humphries, Steve E., PhD, MRCP, FRCPath and Ashton, Hilary A., MSc and Hafez, Hany, PhD, FRCS
Journal of vascular surgery, ISSN 0741-5214, 2010, Volume 52, Issue 1, pp. 55 - 61.e2
Surgery | Peripheral Vascular Disease | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Cardiology. Vascular system | Vascular surgery: aorta, extremities, vena cava. Surgery of the lymphatic vessels | Biological and medical sciences | Medical sciences | Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases | Blood and lymphatic vessels | Diseases of the aorta | Multivariate Analysis | Markov Chains | Aortic Aneurysm, Abdominal - drug therapy | Aortic Aneurysm, Abdominal - mortality | Risk Assessment | Humans | Risk Factors | Aortic Aneurysm, Abdominal - diagnostic imaging | Male | Models, Statistical | Drug Prescriptions | Mass Screening - methods | Aorta, Abdominal - drug effects | Disease Progression | Aorta, Abdominal - diagnostic imaging | Polypharmacy | Time Factors | Ultrasonography | Female | Aged | Dilatation, Pathologic | Monte Carlo Method | Drugs | Abdominal aneurysm | Analysis | Index Medicus
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4. Full Text The effect of intravenous interferon-beta-1a (FP-1201) on lung CD73 expression and on acute respiratory distress syndrome mortality: an open-label study
by Bellingan, Geoff, MD and Maksimow, Mikael, PhD and Howell, David C, MD and Stotz, Martin, MD and Beale, Richard, MB and Beatty, Monika, MD and Walsh, Timothy, MD and Binning, Alexander, MD and Davidson, Alan, MD and Kuper, Martin, MD and Shah, Sanjoy, MD and Cooper, Jackie, MSc and Waris, Matti, PhD and Yegutkin, Gennady G, PhD and Jalkanen, Juho, MD and Salmi, Marko, Prof and Piippo, Ilse, MD and Jalkanen, Markku, PhD and Montgomery, Hugh, Prof and Jalkanen, Sirpa, Prof
The lancet respiratory medicine, ISSN 2213-2600, 2014, Volume 2, Issue 2, pp. 98 - 107
Pulmonary/Respiratory | Respiratory System | Life Sciences & Biomedicine | Critical Care Medicine | General & Internal Medicine | Science & Technology | Up-Regulation | Adjuvants, Immunologic - administration & dosage | Humans | Middle Aged | Male | Respiratory Distress Syndrome, Adult - mortality | Respiratory Distress Syndrome, Adult - metabolism | Case-Control Studies | 5'-Nucleotidase - blood | Interferon-beta - therapeutic use | Respiratory Distress Syndrome, Adult - blood | Aged, 80 and over | Adult | Female | Lung - metabolism | Adjuvants, Immunologic - therapeutic use | Biomarkers - metabolism | Interferon-beta - administration & dosage | Cells, Cultured - drug effects | Intensive Care Units | Kaplan-Meier Estimate | Treatment Outcome | United Kingdom | Respiratory Distress Syndrome, Adult - drug therapy | Interferon beta-1a | Aged | 5'-Nucleotidase - metabolism | In Vitro Techniques | Cohort Studies | Index Medicus
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5. Full Text Influence of Genetic Risk Factors on Coronary Heart Disease Occurrence in Afro-Caribbeans
by Larifla, Laurent, MD and Beaney, Katherine E., BSc and Foucan, Lydia, MD and Bangou, Jacqueline, PhD and Michel, Carl T., MD and Martino, Jean, MD and Velayoudom-Cephise, Fritz-Line, MD and Cooper, Jackie A., MSc and Humphries, Steve E., PhD
Canadian journal of cardiology, ISSN 0828-282X, 2016, Volume 32, Issue 8, pp. 978 - 985
Cardiovascular | Cardiac & Cardiovascular Systems | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | European Continental Ancestry Group - genetics | Genetic Predisposition to Disease | Risk Assessment | Gene Frequency | Humans | Middle Aged | Genotype | Male | Coronary Disease - ethnology | Guadeloupe - ethnology | Case-Control Studies | Coronary Disease - genetics | Smoking - epidemiology | Diabetes Mellitus - epidemiology | Female | Polymorphism, Single Nucleotide | African Continental Ancestry Group - genetics | Hypertension - epidemiology | Hypercholesterolemia - epidemiology | Index Medicus | Clinical Research
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6. Full Text Plasma urate concentration and risk of coronary heart disease: a Mendelian randomisation analysis
by White, Jon, Dr and Sofat, Reecha, MRCP and Hemani, Gibran, PhD and Shah, Tina, PhD and Engmann, Jorgen, MSc and Dale, Caroline, PhD and Shah, Sonia, PhD and Kruger, Felix A, PhD and Giambartolomei, Claudia, PhD and Swerdlow, Daniel I, PhD and Palmer, Tom, PhD and McLachlan, Stela, PhD and Langenberg, Claudia, PhD and Zabaneh, Delilah, PhD and Lovering, Ruth, PhD and Cavadino, Alana, MSc and Jefferis, Barbara, PhD and Finan, Chris, PhD and Wong, Andrew, PhD and Amuzu, Antoinette, MA and Ong, Ken, PhD and Gaunt, Tom R, PhD and Warren, Helen, PhD and Davies, Teri-Louise, PhD and Drenos, Fotios, PhD and Cooper, Jackie, MSc and Ebrahim, Shah, Prof and Lawlor, Debbie A, Prof and Talmud, Philippa J, Prof and Humphries, Steve E, Prof and Power, Christine, Prof and Hypponen, Elina, Prof and Richards, Marcus, Prof and Hardy, Rebecca, Prof and Kuh, Diana, Prof and Wareham, Nicholas, Prof and Ben-Shlomo, Yoav, Prof and Day, Ian N, Prof and Whincup, Peter, Prof and Morris, Richard, Prof and Strachan, Mark W J, Prof and Price, Jacqueline, Prof and Kumari, Meena, Prof and Kivimaki, Mika, Prof and Plagnol, Vincent, PhD and Whittaker, John C, Prof and Smith, George Davey, Prof and Dudbridge, Frank, Prof and Casas, Juan P, Prof and Holmes, Michael V, Dr and Hingorani, Aroon D, Prof and UCLEB (University College London-London School of Hygiene & Tropical Medicine-Edinburgh-Bristol Consortium and International Consortium for Blood Pressure (ICBP) and ICBP and UCLEB Univ Coll London
The lancet. Diabetes & endocrinology, ISSN 2213-8587, 2016, Volume 4, Issue 4, pp. 327 - 336
Endocrinology & Metabolism | Other | Life Sciences & Biomedicine | Science & Technology | Coronary Disease - blood | Mendelian Randomization Analysis - methods | Meta-Analysis as Topic | Humans | Risk Factors | Coronary Disease - etiology | Observational Studies as Topic | Uric Acid - blood | Uric Acid - adverse effects | Index Medicus
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7. Full Text Mesh, graft, or standard repair for women having primary transvaginal anterior or posterior compartment prolapse surgery: two parallel-group, multicentre, randomised, controlled trials (PROSPECT)
by Glazener, Cathryn MA, Prof and Breeman, Suzanne, PhD and Elders, Andrew, MSc and Hemming, Christine, MD and Cooper, Kevin G, MD and Freeman, Robert M, Prof and Smith, Anthony RB, Prof and Reid, Fiona, MD and Hagen, Suzanne, Prof and Montgomery, Isobel and Kilonzo, Mary, MSc and Boyers, Dwayne, MSc and McDonald, Alison, MSc and McPherson, Gladys, PhD and MacLennan, Graeme, MSc and Norrie, John, Prof and PROSPECT study group and PROSPECT Study Grp
The Lancet (British edition), ISSN 0140-6736, 2016, Volume 389, Issue 10067, pp. 381 - 392
Internal Medicine | Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Uterine Prolapse - surgery | Humans | Middle Aged | Intestinal Mucosa - transplantation | Reconstructive Surgical Procedures - methods | Animals | Heterografts | Surgical Mesh | Cattle | Swine | Collagen | Pelvic Organ Prolapse - surgery | Female | Skin Transplantation | Aged | United Kingdom | Hospitals | Political corruption | Surgery | Prolapse | Analysis | Abdominal surgery | Women | Surgical outcomes | Surgical techniques | Clinical trials | Urogenital system | Quality of life | Index Medicus | Abridged Index Medicus
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8. Full Text COMPARATIVE COST-EFFECTIVENESS MODELS FOR THE TREATMENT OF MULTIPLE MYELOMA
by Cooper, Keith and Picot, Joanna and Bryant, Jackie and Clegg, Andrew
International journal of technology assessment in health care, ISSN 0266-4623, 01/2014, Volume 30, Issue 1, pp. 90 - 97
Assessments | Bortezomib | Cost-utility analysis | Thalidomide | Multiple myeloma | Health Care Sciences & Services | Public, Environmental & Occupational Health | Life Sciences & Biomedicine | Medical Informatics | Science & Technology | Prednisolone - administration & dosage | Prednisolone - economics | Humans | Pyrazines - administration & dosage | Boronic Acids - economics | United Kingdom | Models, Economic | Thalidomide - administration & dosage | Disease Progression | Melphalan - economics | Thalidomide - economics | Melphalan - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Cost-Benefit Analysis | Multiple Myeloma - diet therapy | Antineoplastic Combined Chemotherapy Protocols - economics | Survival Analysis | Boronic Acids - administration & dosage | Pyrazines - economics | Studies | Medical research | Survival analysis | Economic models | Chemotherapy | Costs | Foreign exchange rates | Decision making | Medical treatment | Cost analysis | Index Medicus | Health care | Sensitivity analysis | Cost effectiveness | Resource allocation | Mathematical models | Survival | Prednisolone
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9. Full Text New genetic loci link adipose and insulin biology to body fat distribution
by Shungin, Dmitry and Winkler, Thomas W and Croteau-Chonka, Damien C and Ferreira, Teresa and Locke, Adam E and Mägi, Reedik and Strawbridge, Rona J and Pers, Tune H and Fischer, Krista and Justice, Anne E and Workalemahu, Tsegaselassie and Wu, Joseph M. W and Buchkovich, Martin L and Heard-Costa, Nancy L and Roman, Tamara S and ng, Alexander W and Song, Ci and Gustafsson, Stefan and Day, Felix R and Esko, Tonu and Fall, Tove and Kutalik, Zoltán and Luan, Jian'an and Randall, Joshua C and Scherag, Ané and Vedantam, Sailaja and Wood, Anew R and Chen, Jin and Fehrmann, Rudolf and Karjalainen, Juha and Kahali, Bratati and Liu, Ching-Ti and Schmidt, Ellen M and Absher, Devin and Amin, Najaf and Anderson, Denise and Beekman, Marian and Bragg-Gresham, Jennifer L and Buyske, Steven and Demirkan, Ayse and Ehret, Georg B and Feitosa, Mary F and Goel, Anuj and Jackson, Anne U and Johnson, Toby and Kleber, Marcus E and PAGE Consortium and LifeLines Cohort Study and CARDIOGRAMplusC4D Consortium and MuTHER Consortium and ICBP and ADIPOGEN Consortium and CKDGen Consortium and GEFOS Consortium and Int Endogene Consortium and GENIE Consortium and MAGIC Investigators and ReproGen Consortium and GLGC and ADIPOGen Consortium and International Endogene Consortium and The PAGE Consortium and The International Endogene Consortium and The MAGIC Investigators and The ReproGen Consortium and The CKDGen Consortium and The ADIPOGen Consortium and The ICBP and The CARDIOGRAMplusC4D Consortium and The GENIE Consortium and The GLGC and The GEFOS Consortium and The MuTHER Consortium and The LifeLines Cohort Study and Göteborgs universitet and Gothenburg University and Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition and Sahlgrenska Academy and Centre for Bone and Arthritis Research and Sahlgrenska akademin and Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
Nature (London), ISSN 0028-0836, 2015, Volume 518, Issue 7538, pp. 187 - U378
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Body Mass Index | Genome-Wide Association Study | Age Factors | Neovascularization, Physiologic - genetics | Epigenesis, Genetic | Humans | Male | Continental Population Groups - genetics | Sex Characteristics | Obesity - genetics | Europe - ethnology | Genome, Human - genetics | Adipose Tissue - metabolism | Insulin - metabolism | Models, Biological | Adipocytes - metabolism | Insulin Resistance - genetics | Polymorphism, Single Nucleotide - genetics | Female | Body Fat Distribution | Transcription, Genetic - genetics | Adipogenesis - genetics | Waist-Hip Ratio | Quantitative Trait Loci - genetics | Adipose tissues | Quantitative trait loci | Genetic research | Genetic aspects | Research | Metabolism | Health aspects | Studies | Body mass index | Genealogy | Body fat | Insulin resistance | Genetics | Genomes | Abdomen | Meta-analysis | Index Medicus | Life Sciences | Adipocytes/metabolism Adipogenesis/genetics Adipose Tissue/metabolism Age Factors Body Fat Distribution Body Mass Index Continental Population Groups/genetics Epigenesis, Genetic Europe/ethnology Female Genome, Human/genetics Genome-Wide Association Study Humans Insulin/metabolism Insulin Resistance/genetics Male Models, Biological Neovascularization, Physiologic/genetics Obesity/genetics Polymorphism, Single Nucleotide/genetics Quantitative Trait Loci/genetics Sex Characteristics Transcription, Genetic/genetics Waist-Hip Ratio | Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi | Endokrinologi och diabetes | Public Health, Global Health, Social Medicine and Epidemiology | Endocrinology and Diabetes | Genetic: genetics | Insulin Resistance: genetics | Adipocytes: metabolism | Transcription | Medical and Health Sciences | Physiologic: genetics | Insulin: metabolism | Medicin och hälsovetenskap | Human: genetics | Obesity: genetics | Europe: ethnology | Adipose Tissue: metabolism | Single Nucleotide: genetics | Klinisk medicin | Clinical Medicine | Quantitative Trait Loci: genetics | Neovascularization | Genome | Adipogenesis: genetics | Continental Population Groups: genetics | Polymorphism
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