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1. Full Text Therapeutic strategies to target RAS-mutant cancers
by Ryan, Meagan B and Corcoran, Ryan B
Nature reviews. Clinical oncology, ISSN 1759-4774, 11/2018, Volume 15, Issue 11, pp. 709 - 720
Life Sciences & Biomedicine | Oncology | Science & Technology | Clinical trials | Immune system | Cancer | Index Medicus
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2. Full Text Combined BRAF and MEK inhibition with dabrafenib and trametinib in BRAF V600-Mutant colorectal cancer
by Corcoran, Ryan B and Atreya, Chloe E and Falchook, Gerald S and Kwak, Eunice L and Ryan, David P and Bendell, Johanna C and Hamid, Omid and Messersmith, Wells A and Daud, Adil and Kurzrock, Razelle and Pierobon, Mariaelena and Sun, Peng and Cunningham, Elizabeth and Little, Shonda and Orford, Keith and Motwani, Monica and Bai, Yuchen and Patel, Kiran and Venook, Alan P and Kopetz, Scott
Journal of clinical oncology, ISSN 0732-183X, 12/2015, Volume 33, Issue 34, pp. 4023 - 4031
Life Sciences & Biomedicine | Oncology | Science & Technology | Microsatellite Instability | Prognosis | Follow-Up Studies | Colorectal Neoplasms - genetics | Humans | Middle Aged | Oximes - administration & dosage | Imidazoles - administration & dosage | Male | Pyridones - administration & dosage | Colorectal Neoplasms - drug therapy | Female | MAP Kinase Kinase 1 - antagonists & inhibitors | PTEN Phosphohydrolase - genetics | Mutation - genetics | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Xenograft Model Antitumor Assays | Animals | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Biopsy | Proto-Oncogene Proteins B-raf - genetics | Mice | Pyrimidinones - administration & dosage | Colorectal Neoplasms - pathology | Neoplasm Staging | Cohort Studies | Index Medicus | Gic5 | ORIGINAL REPORTS | Gic7
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3. Full Text Liquid versus tissue biopsy for detecting acquired resistance and tumor heterogeneity in gastrointestinal cancers
by Parikh, Aparna R and Leshchiner, Ignaty and Elagina, Liudmila and Goyal, Lipika and Levovitz, Chaya and Siravegna, Giulia and Livitz, Dimitri and Rhrissorrakrai, Kahn and Martin, Elizabeth E and Van Seventer, Emily E and Hanna, Megan and Slowik, Kara and Utro, Filippo and Pinto, Christopher J and Wong, Alicia and Danysh, Brian P and de la Cruz, Ferran Fece and Fetter, Isobel J and Nadres, Brandon and Shahzade, Heather A and Allen, Jill N and Blaszkowsky, Lawrence S and Clark, Jeffrey W and Giantonio, Bruce and Murphy, Janet E and Nipp, Ryan D and Roeland, Eric and Ryan, David P and Weekes, Colin D and Kwak, Eunice L and Faris, Jason E and Wo, Jennifer Y and Aguet, Francois and Dey-Guha, Ipsita and Hazar-Rethinam, Mehlika and Dias-Santagata, Dora and Ting, David T and Zhu, Andrew X and Hong, Theodore S and Golub, Todd R and Iafrate, A. John and Adalsteinsson, Viktor A and Bardelli, Alberto and Parida, Laxmi and Juric, Dejan and Getz, Gad and Corcoran, Ryan B
Nature medicine, ISSN 1078-8956, 09/2019, Volume 25, Issue 9, pp. 1415 - 1421
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Cell Biology | Research & Experimental Medicine | Liquid Biopsy | Gastrointestinal Neoplasms - genetics | Humans | Middle Aged | Male | Cell-Free Nucleic Acids - genetics | Genetic Heterogeneity | Whole Exome Sequencing | Gastrointestinal Neoplasms - pathology | Drug Resistance, Neoplasm - genetics | DNA, Neoplasm - blood | Gastrointestinal Neoplasms - blood | Autopsy | Proto-Oncogene Proteins B-raf - genetics | Cell-Free Nucleic Acids - blood | Female | DNA, Neoplasm - genetics | Mutation | Cohort Studies | Therapy | Sequences | Autopsies | Data acquisition | Case reports | Heterogeneity | Alterations | Biopsy | Lesions | Target acquisition | Deoxyribonucleic acid--DNA | Tumors | Index Medicus | cell-free DNA | liquid biopsy | Acquired resistance
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4. Full Text Receptor tyrosine kinases exert dominant control over PI3K signaling in human KRAS mutant colorectal cancers
by Ebi, Hiromichi and Corcoran, Ryan B and Singh, Anurag and Chen, Zhao and Song, Youngchul and Lifshits, Eugene and Ryan, David P and Meyerhardt, Jeffrey A and Benes, Cyril and Settleman, Jeffrey and Wong, Kwok-Kin and Cantley, Lewis C and Engelman, Jeffrey A
The Journal of clinical investigation, ISSN 0021-9738, 11/2011, Volume 121, Issue 11, pp. 4311 - 4321
Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Neoplasm Transplantation | RNA, Small Interfering - genetics | ras Proteins - genetics | Proto-Oncogene Proteins p21(ras) | Colorectal Neoplasms - genetics | Humans | Male | Transplantation, Heterologous | DNA Primers - genetics | Phosphatidylinositol 3-Kinases - metabolism | Gene Knockdown Techniques | MAP Kinase Signaling System | Base Sequence | Colorectal Neoplasms - drug therapy | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Proto-Oncogene Proteins c-akt - metabolism | Colorectal Neoplasms - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | Signal Transduction | ras Proteins - antagonists & inhibitors | Proto-Oncogene Proteins - genetics | Receptor Protein-Tyrosine Kinases - metabolism | Phosphatidylinositol 3-Kinases - genetics | Animals | Class I Phosphatidylinositol 3-Kinases | Mice, Nude | Proto-Oncogene Proteins B-raf - genetics | Cell Line, Tumor | Mice | Protein Kinase Inhibitors - pharmacology | Mutation | Colorectal Neoplasms - pathology | Apoptosis | Tyrosine | Care and treatment | Gene mutations | Colorectal cancer | Cellular signal transduction | Genetic aspects | Research | Diagnosis | Properties | Genetic regulation | Identification and classification | Index Medicus | Abridged Index Medicus
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5. Full Text Application of Cell-free DNA Analysis to Cancer Treatment
by Corcoran, Ryan B and Chabner, Bruce A
The New England journal of medicine, ISSN 0028-4793, 11/2018, Volume 379, Issue 18, pp. 1754 - 1765
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Circulating Tumor DNA - analysis | Neoplasms - therapy | Neoplasms - genetics | Standard of Care | Liquid Biopsy - methods | Humans | DNA, Neoplasm - analysis | Neoplasms - diagnosis | Circulating Tumor DNA - blood | Mutation | Care and treatment | Cancer patients | Usage | Genetic aspects | Nucleotide sequencing | Health aspects | Cancer | DNA sequencing | Fluids | DNA methylation | Patients | Cancer therapies | Deoxyribonucleic acid--DNA | Tumors | Index Medicus | Abridged Index Medicus
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6. Full Text Liquid biopsy versus tumor biopsy for clinical-trial recruitment
by Corcoran, Ryan B
Nature medicine, ISSN 1078-8956, 12/2020, Volume 26, Issue 12, pp. 1815 - 1816
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Cell Biology | Research & Experimental Medicine | Liquid Biopsy | Gastrointestinal Neoplasms | Circulating Tumor DNA | Biopsy | Humans | Japan | Clinical trials | Care and treatment | Methods | Cancer | Testing | Index Medicus
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7. Full Text Expanded RAS: Refining the patient population
by Atreya, Chloe E and Corcoran, Ryan B and Kopetz, Scott
Journal of clinical oncology, ISSN 0732-183X, 03/2015, Volume 33, Issue 7, pp. 682 - 685
Life Sciences & Biomedicine | Oncology | Science & Technology | Leucovorin - administration & dosage | ras Proteins - genetics | Proto-Oncogene Proteins p21(ras) | Antineoplastic Combined Chemotherapy Protocols - administration & dosage | Humans | Antibodies, Monoclonal - therapeutic use | Membrane Proteins - analysis | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Bevacizumab | Polymerase Chain Reaction - methods | Organoplatinum Compounds - administration & dosage | Proto-Oncogene Proteins B-raf - analysis | Codon | Fluorouracil - administration & dosage | Antibodies, Monoclonal, Humanized - pharmacology | Proto-Oncogene Proteins - analysis | GTP Phosphohydrolases - analysis | Camptothecin - administration & dosage | Cetuximab | Molecular Targeted Therapy - methods | Camptothecin - analogs & derivatives | Antibodies, Monoclonal, Humanized - therapeutic use | Membrane Proteins - genetics | Antibodies, Monoclonal - pharmacology | Proto-Oncogene Proteins - genetics | ras Proteins - analysis | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | GTP Phosphohydrolases - genetics | Proto-Oncogene Proteins B-raf - genetics | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Mutation | Index Medicus | To15 | Comments and Controversies | Gic5 | Gic7
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8. Full Text The PI3K Pathway As Drug Target in Human Cancer
by Kevin D. Courtney and Ryan B. Corcoran and Jeffrey A. Engelman
Journal of clinical oncology, ISSN 0732-183X, 02/2010, Volume 28, Issue 6, pp. 1075 - 1083
Life Sciences & Biomedicine | Oncology | Science & Technology | Biological and medical sciences | Medical sciences | Tumors | Animals | Humans | Neoplasms - enzymology | Antineoplastic Agents - therapeutic use | Phosphatidylinositol 3-Kinases - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Neoplasms - drug therapy | Index Medicus | Bon | Biology of Neoplasia | To11
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9. Full Text Potential therapeutic strategies to overcome acquired resistance to BRAF or MEK Inhibitors in BRAF mutant cancers
by Corcoran, Ryan B and Settleman, Jeffrey and Engelman, Jeffrey A
Oncotarget, ISSN 1949-2553, 04/2011, Volume 2, Issue 4, pp. 336 - 346
MEK | NRAS | Acquired resistance | Colorectal cancer | Melanoma | PDGFR | BRAF | IGF1R | Index Medicus
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