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1. Full Text Effects on the incidence of cardiovascular events of the addition of pioglitazone versus sulfonylureas in patients with type 2 diabetes inadequately controlled with metformin (TOSCA.IT): a randomised, multicentre trial
by Vaccaro, Olga and Masulli, Maria and Nicolucci, Antonio and Bonora, Enzo and Del Prato, Stefano and Maggioni, Aldo Pietro and Maggioni, Aldo P and Rivellese, Angela A and Rivellese, Angela Albarosa and Squatrito, Sebastiano and Giorda, Carlo B and Sesti, Giorgio and Mocarelli, Paolo and Lucisano, Giuseppe and Sacco, Michele and Signorini, Stefano and Cappellini, Fabrizio and Perriello, Gabriele and Babini, Massimiliano and Babini, Anna Carla and Lapolla, Annunziata and Gregori, Giovanna and Giordano, Carla and Corsi, Simona and Corsi, Laura and Corsi, Anna and Buzzetti, Raffaella and Clemente, Gennaro and Di Cianni, Graziano and Iannarelli, Rossella and Cordera, Renzo and La Macchia, Olga and Zamboni, Chiara and Scaranna, Cristiana and Boemi, Massimo and Iovine, Ciro and Lauro, Davide and Leotta, Sergio and Dall'Aglio, Elisabetta and Cannarsa, Emanuela and Tonutti, Laura and Pugliese, Giuseppe and Bossi, Antonio C and Bossi, Antonio Carlo and Anichini, Roberto and Dotta, Francesco and Di Benedetto, Antonino and Citro, Giuseppe and Antenucci, Daniela and Ricci, Lucia and Giorgino, Francesco and Santini, Costanza and Gnasso, Agostino and De Cosmo, Salvatore and Zavaroni, Donatella and Vedovato, Monica and Consoli, Agostino and Calabrese, Maria and di Bartolo, Paolo and Fornengo, Paolo and Riccardi, Gabriele and D'Angelo, Federica and D'Angelo, Paola and Giansanti, Roberto and Tanase, Laura and Lanari, Luigi and Testa, Ivano and Pancani, Francesca and Ranchelli, Anna and Vagheggi, Paolo and Scatona, Alessia and Fontana, Lucia and Laviola, Luigi and Tarantino, Lucia and Ippolito, Claudia and Ippolito, Giulio and Gigantelli, Vittoria and Manicone, Mariangela and Conte, Eleonora and Trevisan, Roberto and Rota, Giuseppe and Rota, Rossella and Dodesini, Alessandro R and Reggiani, Giulio Marchesini and Montesi, Luca and Mazzella, Natalia and Forlani, Gabriele and Caselli, Chiara and Di Luzio, Raffaella and Mazzotti, Arianna and Aiello, Antimo and Barrea, Angelina and Musto, Antonio and D'Amico, Fiorentina and Sinagra, Tiziana and Longhitano, Sara and Trowpea, Vanessa and Sparti, Maria and Italia, Salvatore and Lisi, Enrico and ... and Thizolidinediones Sulfonylureas Ca and Italian Diabetes Society and Thiazolidinediones Or Sulfonylureas Cardiovascular Accidents Intervention Trial (TOSCA.IT) study group
The Lancet Diabetes & Endocrinology, ISSN 2213-8587, 11/2017, Volume 5, Issue 11, pp. 887 - 897
The best treatment option for patients with type 2 diabetes in whom treatment with metformin alone fails to achieve adequate glycaemic control is debated. We... 
MORTALITY | INSULIN | GLYCEMIC CONTROL | IMPACT | METAANALYSIS | GLUCOSE-LOWERING DRUGS | ENDOCRINOLOGY & METABOLISM | FOLLOW-UP | RISK | GLIMEPIRIDE | Hypoglycemic Agents - therapeutic use | Cardiovascular Diseases - etiology | Metformin - therapeutic use | Cardiovascular Diseases - drug therapy | Humans | Middle Aged | Pioglitazone | Sulfonylurea Compounds - therapeutic use | Male | Treatment Outcome | Diabetes Mellitus, Type 2 - epidemiology | Incidence | Thiazolidinediones - therapeutic use | Cardiovascular Diseases - epidemiology | Female | Aged | Drug Therapy, Combination | Diabetes Mellitus, Type 2 - complications
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2. Full Text "Delirium Day": A nationwide point prevalence study of delirium in older hospitalized patients using an easy standardized diagnostic tool
by Bellelli, Giuseppe and Morandi, Alessandro and Di Santo, Simona G and Mazzone, Andrea and Cherubini, Antonio and Mossello, Enrico and Bo, Mario and Bianchetti, Angelo and Rozzini, Renzo and Zanetti, Ermellina and Musicco, Massimo and Ferrari, Alberto and Ferrara, Nicola and Trabucchi, Marco and Boffelli, Stefano and Stefano, Fabio Di and Filippi, Francesco De and Guerini, Fabio and Bertoletti, Erik and March, Albert and Margiotta, Alessandro and Mecocci, Patrizia and Addesi, Desireè and Fantò, Fausto and Dijik, Babette and Porrino, Paola and Cotroneo, Antonino Maria and Galli, Giovanni and Bruni, Amalia Cecilia and Bernardini, Bruno and Corsini, Carla and Cagnin, Annachiara and Zurlo, Amedeo and Barbagallo, Giuseppe and Lunardelli, Maria Lia and Martini, Emilio and Battaglia, Giuseppe and Latella, Raffaele and Petritola, Donatella and Sinforiani, Elena and Cester, Alberto and Formilan, Marino and Carbone, Pasqualina and Appollonio, Ildebrando and Cereda, Diletta and Tremolizzo, Lucio and Bottacchi, Edo and Lucchetti, Lucio and Mariani, Claudio and Rapazzini, Piero and Romanelli, Giuseppe and Marengoni, Alessandra and Zuliani, Giovanni and Bianchi, Lara and Suardi, Teresa and Muti, Ettore and Bottura, Renato and Sgrò, Giovanni and Mandas, Antonella and Serchisu, Luca and Crippa, Patrizia and Ivaldi, Claudio and Ungar, Andrea and Villani, Daniele and Raimondi, Clara and Mussi, Chiara and Isaia, Giancarlo and Provenzano, Giuseppe and Mari, Daniela and Odetti, Patrizio and Monacelli, Fiammetta and Incalzi, Raffaele Antonelli and Pluderi, Alice and Bellamoli, Claudio and Terranova, Luciano and Scarpini, Elio and D'Amico, Ferdinando and Cavallini, Maria Chiara and Guerrini, Gianbattista and Scotuzzi, Anna Maria and Chiarello, Antonino and Pilotto, Alberto and Tognini, Sara and Dell'Aquila, Giuseppina and Toigo, Gabriele and Ceschia, Giuliano and Piccinini, Maristella and Fabbo, Andrea and Zoli, Marco and Forti, Paola and Wenter, Christian and Basile, Giorgio and Lasagni, Anna and Padovani, Alessandro and Rozzini, Luca and Cottino, Maria and Vitali, Silvia and Tripi, Gabriele and Avanzi, Stefano and Annoni, Giorgio and ... and Italian Study Grp Delirium ISGoD and Italian Study Group on Delirium (ISGoD)
BMC Medicine, ISSN 1741-7015, 07/2016, Volume 14, Issue 1, p. 106
Background: To date, delirium prevalence in adult acute hospital populations has been estimated generally from pooled findings of single-center studies and/or... 
Delirium | Prevalence | Hospital | Multicenter | 4AT | MORTALITY | DEMENTIA | ASSOCIATIONS | QUALITATIVE EVALUATION | SYMPTOMS | HIP FRACTURE PATIENTS | CARE | MEDICINE, GENERAL & INTERNAL | ELDERLY MEDICAL INPATIENTS | POSTOPERATIVE DELIRIUM | PEOPLE | Delirium - epidemiology | Prospective Studies | Cross-Sectional Studies | Humans | Logistic Models | Male | Inpatients - statistics & numerical data | Aged, 80 and over | Female | Italy - epidemiology | Surveys and Questionnaires | Aged | Odds Ratio | Delirium - diagnosis | Psychological aspects | Aged patients | Statistics | Health aspects
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3. Full Text New genetic loci link adipose and insulin biology to body fat distribution
by Shungin, Dmitry and Winkler, Thomas W and Croteau-Chonka, Damien C and Ferreira, Teresa and Locke, Adam E and Mägi, Reedik and Strawbridge, Rona J and Pers, Tune H and Fischer, Krista and Justice, Anne E and Workalemahu, Tsegaselassie and Wu, Joseph M. W and Buchkovich, Martin L and Heard-Costa, Nancy L and Roman, Tamara S and ng, Alexander W and Song, Ci and Gustafsson, Stefan and Day, Felix R and Esko, Tonu and Fall, Tove and Kutalik, Zoltán and Luan, Jian'an and Randall, Joshua C and Scherag, Ané and Vedantam, Sailaja and Wood, Anew R and Chen, Jin and Fehrmann, Rudolf and Karjalainen, Juha and Kahali, Bratati and Liu, Ching-Ti and Schmidt, Ellen M and Absher, Devin and Amin, Najaf and Anderson, Denise and Beekman, Marian and Bragg-Gresham, Jennifer L and Buyske, Steven and Demirkan, Ayse and Ehret, Georg B and Feitosa, Mary F and Goel, Anuj and Jackson, Anne U and Johnson, Toby and Kleber, Marcus E and Kristiansson, Kati and Mangino, Massimo and Mateo Leach, Irene and Medina-Gomez, Carolina and Palmer, Cameron D and Pasko, Dorota and Pechlivanis, Sonali and Peters, Marjolein J and Prokopenko, Inga and Stančáková, Alena and Ju Sung, Yun and Tanaka, Toshiko and Teumer, Alexander and van Vliet-Ostaptchouk, Jana V and Yengo, Loïc and Zhang, Weihua and Albrecht, Eva and Ärnlöv, Johan and Arscott, Gillian M and Bandinelli, Stefania and Barrett, Amy and Bellis, Claire and Bennett, Amanda J and Berne, Christian and Blüher, Matthias and Böhringer, Stefan and Bonnet, Fabrice and Böttcher, Yvonne and Bruinenberg, Marcel and Carba, Delia B and Caspersen, Ida H and Clarke, Robert and Daw, E. Warwick and Deelen, Joris and Deelman, Ewa and Delgado, Graciela and Doney, Alex S. F and Eklund, Niina and Erdos, Michael R and Estrada, Karol and Eury, Elodie and Frieich, Nele and Garcia, Melissa E and Gieaitis, Vilmantas and Gigante, Bruna and Go, Alan S and Golay, Alain and Grallert, Harald and Grammer, Tanja B and Gräßler, Jürgen and Grewal, Jagvir and Groves, Christopher J and Haller, Toomas and Hallmans, Goran and ... and PAGE Consortium and LifeLines Cohort Study and CARDIOGRAMplusC4D Consortium and MuTHER Consortium and ICBP and ADIPOGEN Consortium and CKDGen Consortium and GEFOS Consortium and Int Endogene Consortium and GENIE Consortium and MAGIC Investigators and ReproGen Consortium and GLGC and ADIPOGen Consortium and International Endogene Consortium and The PAGE Consortium and The International Endogene Consortium and The MAGIC Investigators and The ReproGen Consortium and The CKDGen Consortium and The ADIPOGen Consortium and The ICBP and The CARDIOGRAMplusC4D Consortium and The GENIE Consortium and The GLGC and The GEFOS Consortium and The MuTHER Consortium and The LifeLines Cohort Study and Högskolan Dalarna and Akademin Utbildning, hälsa och samhälle and Medicinsk vetenskap
Nature, ISSN 0028-0836, 2015, Volume 518, Issue 7538, pp. 187 - U378
Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our... 
HUMAN HEIGHT | ABDOMINAL ADIPOSITY | MULTIDISCIPLINARY SCIENCES | COMMON SNPS | SUSCEPTIBILITY LOCI | GLYCEMIC TRAITS | FALSE DISCOVERY | MESENCHYMAL STEM-CELLS | GENOME-WIDE ASSOCIATION | ADIPOGENIC DIFFERENTIATION | SEXUAL-DIMORPHISM | Body Mass Index | Genome-Wide Association Study | Age Factors | Neovascularization, Physiologic - genetics | Epigenesis, Genetic | Humans | Male | Continental Population Groups - genetics | Sex Characteristics | Obesity - genetics | Europe - ethnology | Genome, Human - genetics | Adipose Tissue - metabolism | Insulin - metabolism | Models, Biological | Adipocytes - metabolism | Insulin Resistance - genetics | Polymorphism, Single Nucleotide - genetics | Female | Body Fat Distribution | Transcription, Genetic - genetics | Adipogenesis - genetics | Waist-Hip Ratio | Quantitative Trait Loci - genetics | Adipose tissues | Quantitative trait loci | Genetic research | Genetic aspects | Research | Metabolism | Health aspects | Studies | Body mass index | Genealogy | Body fat | Insulin resistance | Genetics | Genomes | Abdomen | Meta-analysis | Life Sciences | Adipocytes/metabolism Adipogenesis/genetics Adipose Tissue/metabolism Age Factors Body Fat Distribution Body Mass Index Continental Population Groups/genetics Epigenesis, Genetic Europe/ethnology Female Genome, Human/genetics Genome-Wide Association Study Humans Insulin/metabolism Insulin Resistance/genetics Male Models, Biological Neovascularization, Physiologic/genetics Obesity/genetics Polymorphism, Single Nucleotide/genetics Quantitative Trait Loci/genetics Sex Characteristics Transcription, Genetic/genetics Waist-Hip Ratio | Clinical Medicine | Hälsa och välfärd | Medical and Health Sciences | Klinisk medicin | Medicin och hälsovetenskap | Health and Welfare
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4. Full Text Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma
by Chambers, John C and Zhang, Weihua and Sehmi, Joban and Li, Xinzhong and Wass, Mark N and van der Harst, Pim and Holm, Hilma and Sanna, Serena and Kavousi, Maryam and Baumeister, Sebastian E and Coin, Lachlan J and Deng, Guohong and Gieger, Christian and Heard-Costa, Nancy L and Hottenga, Jouke-Jan and Kühnel, Brigitte and Kumar, Vinod and Lagou, Vasiliki and Liang, Liming and Luan, Jian'an and Vidal, Peo Marques and Mateo Leach, Irene and O'Reilly, Paul F and Peden, John F and Rahmioglu, Nilufer and Soininen, Pasi and Speliotes, Elizabeth K and Yuan, Xin and Thorleifsson, Gudmar and Alizadeh, Behrooz Z and Atwood, Larry D and Borecki, Ingrid B and Brown, Morris J and Charoen, Pimphen and Cucca, Francesco and Das, Debashish and de Geus, Eco J. C and Dixon, Anna L and Döring, Angela and Ehret, Georg and Eyjolfsson, Gudmundur I and Farrall, Martin and Forouhi, Nita G and Frieich, Nele and Goessling, Wolfram and Gudbjartsson, Daniel F and Harris, Tamara B and Hartikainen, Anna-Liisa and Heath, Simon and Hirschfield, Gideon M and Hofman, Albert and Homuth, Georg and Hyppönen, Elina and Janssen, Harry L. A and Johnson, Toby and Kangas, Antti J and Kema, Ido P and Kühn, Jens P and Lai, Sana and Lathrop, Mark and Lerch, Markus M and Li, Yun and Liang, T. Jake and Lin, Jing-Ping and Loos, Ruth J. F and Martin, Nicholas G and Moffatt, Miriam F and Montgomery, Grant W and Munroe, Patricia B and Musunuru, Kiran and Nakamura, Yusuke and O'Donnell, Christopher J and Olafsson, Isleifur and Penninx, Brenda W and Pouta, Anneli and Prins, Bram P and Prokopenko, Inga and Puls, Ralf and Ruokonen, Aimo and Savolainen, Markku J and Schlessinger, David and Schouten, Jeoffrey N. L and Seedorf, Udo and Sen-Chowdhry, Srijita and Siminovitch, Katherine A and Smit, Johannes H and Spector, Timothy D and Tan, Wenting and Teslovich, Tanya M and Tukiainen, Taru and Uitterlinden, Ane G and van der Klauw, Melanie M and Vasan, Ramachanan S and Wallace, Chris and Wallaschofski, Henri and Wichmann, H.-Erich and Willemsen, Gonneke and Würtz, Peter and Xu, Chun and Yerges-Armstrong, Laura M and ... and Meta-Anal Glucose Insulin-Related and Diabet Genetics Replication and Genetic Invest Anthropometric and Genetics Liver Dis GOLD Consortium and Global Lipids Genetics Consortium and Alcohol Genome-wide Assoc AlcGen and Int Consortium Blood Pressure ICBP and Meta-analyses of Glucose and Insulin-Related Traits Consortium (MAGIC) and Alcohol Genome-wide Association (AlcGen) Consortium and Genetic Investigation of Anthropometric Traits (GIANT) Consortium and Diabetes Genetics Replication and Meta-analyses (DIAGRAM+) Study and International Consortium for Blood Pressure (ICBP-GWAS) and Genetics of Liver Disease (GOLD) Consortium
Nature genetics, ISSN 1061-4036, 2011, Volume 43, Issue 11, pp. 1131 - U129
Concentrations of liver enzymes in plasma are widely used as indicators of liver disease. We carried out a genome-wide association study in 61,089 individuals,... 
C-REACTIVE PROTEIN | COMMON VARIANTS | METABOLIC SYNDROME | HEPATOCELLULAR-CARCINOMA | RISK-FACTORS | SALT EXPORT PUMP | GENETICS & HEREDITY | SUSCEPTIBILITY LOCI | GENETIC-VARIANTS | HEREDITARY CHOLESTASIS | CORONARY-HEART-DISEASE | Genome-Wide Association Study | Polymorphism, Single Nucleotide | Liver - enzymology | Enzymes - blood | Enzymes - genetics | Humans | Enzymes | Weight control | Data collection | Genetics | Gene loci | Genomes | Gene expression | Autoimmune diseases | Metabolic disorders
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