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1. Full Text International Congress of Drug Therapy in HIV Infection 23‐26 October 2016, Glasgow, UK
Journal of the International AIDS Society, ISSN 1758-2652, 10/2016, Volume 19, Issue 8(Suppl 7), pp. 21487 - n/a
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2. Full Text Proteome-wide Analysis and CXCL4 as a Biomarker in Systemic Sclerosis
by van Bon, Lenny and Affandi, Alsya J and Broen, Jasper and Christmann, Romy B and Marijnissen, Renoud J and Stawski, Lukasz and Farina, Giuseppina A and Stifano, Giuseppina and Mathes, Allison L and Cossu, Marta and York, Michael and Collins, Cindy and Wenink, Mark and Huijbens, Richard and Hesselstrand, Roger and Saxne, Tore and DiMarzio, Mike and Wuttge, Dirk and Agarwal, Sandeep K and Reveille, John D and Assassi, Shervin and Mayes, Maureen and Deng, Yanhui and Drenth, Joost P.H and de Graaf, Jacqueline and den Heijer, Martin and Kallenberg, Cees G.M and Bijl, Marc and Loof, Arnoud and van den Berg, Wim B and Joosten, Leo A.B and Smith, Vanessa and de Keyser, Filip and Scorza, Rafaella and Lunardi, Claudio and van Riel, Piet L.C.M and Vonk, Madelon and van Heerde, Waander and Meller, Stephan and Homey, Bernhard and Beretta, Lorenzo and Roest, Mark and Trojanowska, Maria and Lafyatis, Robert and Radstake, Timothy R.D.J
The New England Journal of Medicine, ISSN 0028-4793, 01/2014, Volume 370, Issue 5, pp. 433 - 443
In this study, the level of the chemokine CXCL4, which is secreted by plasmacytoid dendritic cells, was elevated in patients with systemic sclerosis and... 
CELLS | MEDICINE, GENERAL & INTERNAL | ACTIVATION | REVISED CRITERIA | I INTERFERONS | DISEASE | LUPUS-ERYTHEMATOSUS | CLASSIFICATION | PLATELET-FACTOR-4 | SCLERODERMA SKIN | ASSOCIATION | Scleroderma, Systemic - blood | Cytokines - metabolism | Humans | Mice, Inbred C57BL | Middle Aged | Familial Primary Pulmonary Hypertension | Male | Proteome | Pulmonary Fibrosis - blood | Biomarkers - blood | Hypertension, Pulmonary - blood | RNA, Messenger - metabolism | Dendritic Cells - secretion | Animals | Scleroderma, Systemic - etiology | Platelet Factor 4 - secretion | Adult | Female | Mice | Platelet Factor 4 - blood | Skin - pathology | Hypertension | Phenotypes | Dendritic cells | Pathogenesis | Lung diseases | Liver | Arthritis | Inflammation | Gene expression | Patients | Studies | Spondylitis | Cell activation | Systemic lupus erythematosus | Systemic sclerosis | Fibrosis | Toll-like receptors | Plasma levels | Skin | Interferon | Autoimmune diseases | Scleroderma | Ankylosing spondylitis | Chemokines
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3. Full Text Earliest Phase of Systemic Sclerosis Typified by Increased Levels of Inflammatory Proteins in the Serum
by Cossu, Marta and van Bon, Lenny and Preti, Carlo and Rossato, Marzia and Beretta, Lorenzo and Radstake, Timothy R D J
Arthritis & Rheumatology, ISSN 2326-5191, 12/2017, Volume 69, Issue 12, pp. 2359 - 2369
OBJECTIVE: Patients with definite systemic sclerosis (SSc) who lack fibrotic features can be stratified into an intermediate stage of disease severity between... 
Severity of Illness Index | Humans | Middle Aged | Male | Case-Control Studies | Chemokine CXCL11 | Disease Progression | Journal Article | Chemokine CXCL10 | Chitinase-3-Like Protein 1 | Receptors, Tumor Necrosis Factor, Type II | Fibrosis | Scleroderma, Systemic | Biomarkers | Adult | Female | Pulmonary Fibrosis | CRITERIA | INHIBITION | DISEASE SEVERITY | CLASSIFICATION | MICROVASCULAR DAMAGE | LIGAND | SKIN | RHEUMATOLOGY | YKL-40 | PROGRESSION | Chemokine CXCL10 - blood | Scleroderma, Systemic - blood | Scleroderma, Systemic - pathology | Pulmonary Fibrosis - blood | Biomarkers - blood | Receptors, Tumor Necrosis Factor, Type II - blood | Scleroderma, Systemic - complications | Chitinase-3-Like Protein 1 - blood | Chemokine CXCL11 - blood | Pulmonary Fibrosis - etiology | Chitinase | Immunoassay | Inflammation | Criteria | Disease control | Patients | Proteins | Lungs | Systemic sclerosis | CXCL10 protein | Replication | Skin | Interception | CXCL11 protein
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4. Full Text Induction of Inflammation and Fibrosis by Semaphorin 4A in Systemic Sclerosis
by Carvalheiro, Tiago and Affandi, Alsya J and Malvar-Fernández, Beatriz and Dullemond, Ilse and Cossu, Marta and Ottria, Anea and Mertens, Jorre S and Giovannone, Barbara and Bonte-Mineur, Femke and Kok, Marc R and Marut, Wioleta and Reedquist, Kris A and Radstake, Timothy R and García, Samuel
Arthritis and Rheumatology, ISSN 2326-5191, 2019, Volume 71, Issue 10, pp. 1711 - 1722
Objective: To analyze the potential role of semaphorin 4A (Sema4A) in inflammatory and fibrotic processes involved in the pathology of systemic sclerosis... 
Flow cytometry | Helper cells | Confocal microscopy | Lymphocytes T | Assaying | CD28 antigen | Western blotting | Receptors | Lymphocytes | Fibroblasts | Extracellular matrix | Enzyme-linked immunosorbent assay | Phenotypes | Cytokines | Secretion | Therapeutic applications | CD3 antigen | Inflammation | CD4 antigen | Polymerase chain reaction | Monocytes | Microscopy | Systemic sclerosis | Fibrosis | Plasma levels | Skin
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5. Full Text BK-virus progressive multifocal leukoencephalitis in a patient with systemic lupus erythematosus
by Melis, Marta and Badiali, Manuela and Peltz, Teresa and Cossu, Giovanni and Manieli, Cristina and Gianno, Francesca and Melis, Maurizio
Neurological Sciences, ISSN 1590-1874, 9/2018, Volume 39, Issue 9, pp. 1613 - 1615
Neurology | Neurosurgery | Medicine & Public Health | Psychiatry | Neuroradiology | NEUROSCIENCES | CLINICAL NEUROLOGY | Polyomavirus Infections - complications | Brain - diagnostic imaging | Diagnosis, Differential | Lupus Erythematosus, Systemic - complications | Humans | Middle Aged | Tumor Virus Infections - diagnosis | Male | Leukoencephalopathy, Progressive Multifocal - diagnosis | Polyomavirus Infections - pathology | BK Virus | Lupus Erythematosus, Systemic - diagnosis | Tumor Virus Infections - complications | Polyomavirus Infections - diagnosis | Fatal Outcome | Brain - pathology | Leukoencephalopathy, Progressive Multifocal - pathology | Lupus Erythematosus, Systemic - pathology | Tumor Virus Infections - pathology | Leukoencephalopathy, Progressive Multifocal - complications | Leukoencephalitis | Systemic lupus erythematosus
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6. Full Text Concentration‐dependent metabolic effects of metformin in healthy and Fanconi anemia lymphoblast cells
by Ravera, Silvia and Cossu, Vanessa and Tappino, Barbara and Nicchia, Elena and Dufour, Carlo and Cavani, Simona and Sciutto, Andrea and Bolognesi, Claudia and Columbaro, Marta and Degan, Paolo and Cappelli, Enrico
Journal of Cellular Physiology, ISSN 0021-9541, 02/2018, Volume 233, Issue 2, pp. 1736 - 1751
Metformin (MET) is the drug of choice for patients with type 2 diabetes and has been proposed for use in cancer therapy and for treating other metabolic... 
metformin | energetic metabolism | Fanconi anemia | cancerogenesis | oxidative stress | POLYCYSTIC-OVARY-SYNDROME | PHYSIOLOGY | MITOCHONDRIAL ACTIVITY | PROTECTION | CLINICAL PHARMACOKINETICS | CANCER | DEFICIENCY | CELL BIOLOGY | BIOGENESIS | COMPLEX I DEFECTS | EXPRESSION | Lymphocytes - metabolism | Sirtuin 1 - metabolism | Cell Survival - drug effects | AMP-Activated Protein Kinases - metabolism | Leukemia - pathology | Fanconi Anemia - metabolism | Humans | Metformin - pharmacology | Leukemia - drug therapy | Leukemia - metabolism | Metformin - toxicity | Case-Control Studies | Dose-Response Relationship, Drug | Oxidative Phosphorylation - drug effects | Lymphocytes - pathology | Lymphocytes - drug effects | HL-60 Cells | Fanconi Anemia - pathology | DNA Damage | Enzyme Activation | Oxidative Stress - drug effects | Fanconi Anemia - drug therapy | Energy Metabolism - drug effects | Type 2 diabetes | Glucose metabolism | Medical research | DNA damage | Analysis | Leukemia | Medicine, Experimental | Hypoglycemic agents | Fanconi's anemia | Oxidative stress | Phosphorylation | Low concentrations | Anemia | Diabetes mellitus | Cytology | Tumor cell lines | Metabolism | Fanconi syndrome | Patients | SIRT1 protein | DNA repair | Cell morphology | Promyeloid leukemia | Oxidative phosphorylation | Drug metabolism | Metformin | Electron transport | Metabolic disorders | Deoxyribonucleic acid--DNA | Cancer | Index Medicus
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7. Full Text No identical "mesenchymal stem cells" at different times and sites: Human committed progenitors of distinct origin and differentiation potential are incorporated as adventitial cells in microvessels
by Sacchetti, Benedetto and Funari, Alessia and Remoli, Cristina and Giannicola, Giuseppe and Kogler, Gesine and Liedtke, Stefanie and Cossu, Giulio and Serafini, Marta and Sampaolesi, Maurilio and Tagliafico, Enrico and Tenedini, Elena and Saggio, Isabella and Robey, Pamela G and Riminucci, Mara and Bianco, Paolo
Stem Cell Reports, ISSN 2213-6711, 06/2016, Volume 6, Issue 6, pp. 897 - 913
A widely shared view reads that mesenchymal stem/stromal cells ("MSCs") are ubiquitous in human connective tissues, can be defined by a common in vitro... 
mesenchymal stem cell | differentiation | bone marrow stromal cell | skeletal progenitors | hematopoietic microenvironment | transplantation | in vivo assays | myogenic progenitors | Chondrogenesis - genetics | Humans | Pericytes - cytology | Microvessels - metabolism | Transcriptome | Transplantation, Heterologous | Gene Expression Profiling | Mesenchymal Stromal Cells - cytology | Cell Differentiation | Cell Lineage - genetics | Osteogenesis - genetics | Biomarkers - metabolism | Microvessels - cytology | Gene Expression | Bone Marrow Cells - cytology | Pericytes - metabolism | Satellite Cells, Skeletal Muscle - cytology | Mesenchymal Stromal Cells - metabolism | Satellite Cells, Skeletal Muscle - metabolism | Fetal Blood - cytology | Fetal Blood - metabolism | Phenotype | Animals | Mice | Bone Marrow Cells - metabolism | Mesenchymal Stem Cell Transplantation
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8. Full Text A nutritional evaluation of various typical Italian breakfast products: a comparison of macronutrient composition and glycaemic index values
by Cossu, Marta and Chiavaroli, Laura and Dall'Asta, Margherita and Francinelli, Veronica and Scazzina, Francesca and Brighenti, Furio
International Journal of Food Sciences and Nutrition, ISSN 0963-7486, 08/2018, Volume 69, Issue 6, pp. 676 - 681
Breakfast foods with lower glycaemic responses are associated with better body weight control. Glycaemic index (GI) values of some commonly consumed breakfast... 
Breakfast | nutrition | Italian | glycaemic index | METAANALYSIS | ADULT-POPULATION | FOOD SCIENCE & TECHNOLOGY | CARBOHYDRATE | FOODS | INSULIN | RESPONSES | OBESITY | NUTRITION & DIETETICS | FAT | PLASMA-GLUCOSE | CONSUMPTION | Breakfast foods | Cakes | Body weight | Pastries | Glycemic index | Sugar | Bread | Food
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9. Full Text CXCL4 exposure potentiates TLR-driven polarization of human monocyte-derived dendritic cells and increases stimulation of T cells
by Silva-Cardoso, Sana C and Affandi, Alsya J and Spel, Lotte and Cossu, Marta and Van Roon, Joel A.G and Boes, Marianne and Radstake, Timothy R.D.J
Journal of Immunology, ISSN 0022-1767, 07/2017, Volume 199, Issue 1, pp. 253 - 262
Chemokines have been shown to play immune-modulatory functions unrelated to steering cell migration. CXCL4 is a chemokine abundantly produced by activated... 
Journal Article | Immunology | MHC CLASS-I | IMMUNE-RESPONSES | ENDOTHELIAL-CELLS | TOLL-LIKE RECEPTORS | SUBCELLULAR-LOCALIZATION | ANTIGEN PRESENTATION | IMMUNOLOGY | SYSTEMIC-SCLEROSIS | CHEMOKINE PLATELET-FACTOR-4 | PLATELET FACTOR-IV | CROSS-PRESENTATION | Antigens, CD - immunology | B7-2 Antigen - genetics | Immunoglobulins - immunology | Escherichia coli Infections - prevention & control | Interleukin-12 - genetics | Coculture Techniques | Dendritic Cells - immunology | Humans | Platelet Factor 4 - immunology | Dendritic Cells - physiology | Immunoglobulins - genetics | Antigens, CD - genetics | CD4-Positive T-Lymphocytes - physiology | Quinolines - pharmacology | CD4-Positive T-Lymphocytes - immunology | Platelet Factor 4 - pharmacology | Tumor Necrosis Factor-alpha - immunology | Dendritic Cells - drug effects | Cell Differentiation | Membrane Glycoproteins - immunology | B7-2 Antigen - immunology | Escherichia coli - physiology | Poly I-C - pharmacology | Lymphocyte Activation | Cells, Cultured | Escherichia coli Infections - microbiology | Imidazoles - pharmacology | CD8-Positive T-Lymphocytes - physiology | Membrane Glycoproteins - genetics | Phenotype | CD8-Positive T-Lymphocytes - drug effects | Interleukin-12 - immunology | Escherichia coli Infections - immunology | Genes, MHC Class I | Platelet Factor 4 - metabolism | Thiazoles - pharmacology | CD8-Positive T-Lymphocytes - immunology | CD4-Positive T-Lymphocytes - drug effects | Cell proliferation | CD86 antigen | Leukocyte migration | CD8 antigen | Antigen processing | Stimulation | Lymphocytes T | Interleukin 4 | Cell activation | Lymphocytes | Toll-like receptors | Immune system | Immune response | Dendritic cells | Immunomodulation | Secretion | Interleukin 12 | Exposure | T cell receptors | Poly (I:C) | CD4 antigen | CD83 antigen | Monocytes | Major histocompatibility complex | Systemic sclerosis | Internalization | γ-Interferon | Ligands | Interferon | Platelets | Cell migration | Chemokines
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10. Full Text 6-n -propylthiouracil taste disruption and TAS2R38 nontasting form in Parkinson's disease
: Taste Impairment in Parkinson's Disease
by Cossu, Giovanni and Melis, Melania and Sarchioto, Marianna and Melis, Marta and Melis, Maurizio and Morelli, Micaela and Tomassini Barbarossa, Iole
Movement Disorders, ISSN 0885-3185, 08/2018, Volume 33, Issue 8, pp. 1331 - 1339
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11. Full Text Association of MicroRNA-618 Expression With Altered Frequency and Activation of Plasmacytoid Dendritic Cells in Patients With Systemic Sclerosis
by Rossato, M and Affandi, A.J and Thordardottir, S and Wichers, C.G.K and Cossu, M and Broen, J.C and Moret, F.M and Bossini-Castillo, L and Chouri, E and Bon, L. van and Wolters, F and Marut, W and Kroef, M. van der and Silva-Cardoso, S and Bekker, C.P.J and Dolstra, H and Laar, J.M. van and Martin, J and Roon, J.A.G. van and Reedquist, K.A and Beretta, L and Radstake, T.R
Arthritis & Rheumatology, ISSN 2326-5191, 2017, Volume 69, Issue 9, pp. 1891 - 1902
OBJECTIVE: Plasmacytoid dendritic cells (PDCs) are a critical source of type I interferons (IFNs) that can contribute to the onset and maintenance of... 
GENE | AUTOIMMUNITY | DISEASE | INTERFERON-PRODUCING CELLS | LUPUS-ERYTHEMATOSUS | IRF8 | CLASSIFICATION | RHEUMATOLOGY | NF-KAPPA-B | I INTERFERON | NUCLEIC-ACIDS | Up-Regulation | Scleroderma, Systemic - blood | Antigens, CD34 - metabolism | Epigenesis, Genetic | Humans | Middle Aged | Scleroderma, Systemic - genetics | Male | Case-Control Studies | Interferon-alpha - secretion | Adult | Female | MicroRNAs - blood | Dendritic Cells - metabolism | CD34 antigen | Target recognition | Dendritic cells | Pathogenesis | MiRNA | Homeostasis | Activation | Ribonucleic acid--RNA | Patients | Mimicry | Biological effects | Cell activation | Molecular modelling | Production methods | Systemic sclerosis | MicroRNAs | Fibrosis | Peripheral blood | Epigenetics | Skin diseases | Interferon | Lesions | In vitro methods and tests | Immune system
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12. Full Text The meso-angioblast: a multipotent, self-renewing cell that originates from the dorsal aorta and differentiates into most mesodermal tissues
by Maria G. Minasi and Mara Riminucci and Luciana De Angelis and Ugo Borello and Barbara Berarducci and Anna Innocenzi and Arianna Caprioli and Dario Sirabella and Marta Baiocchi and Ruggero De Maria and Renata Boratto and Thierry Jaffredo and Vania Broccoli and Paolo Bianco and Giulio Cossu
Development, ISSN 0950-1991, 06/2002, Volume 129, Issue 11, pp. 2773 - 2783
We have previously reported the origin of a class of skeletal myogenic cells from explants of dorsal aorta. This finding disagrees with the known origin of all... 
Angiogenesis | Pericyte | Histogenesis | Mouse | Stem cells | Mesoderm | Quail | Chimera | Endothelium | stem cells | endothelium | pericyte | angiogenesis | BONE-MARROW | SATELLITE CELLS | DEVELOPMENTAL BIOLOGY | PDGF-B | mesoderm | histogenesis | quail | chimera | mouse | NEURAL STEM-CELLS | SKELETAL-MUSCLE | MUSCLE REGENERATION | IN-VIVO | ENDOTHELIAL-CELLS | MYOGENIC PROGENITORS | Coturnix | Cells, Cultured | Aorta - embryology | Mice, Transgenic | Mesoderm - cytology | Muscle, Smooth, Vascular - cytology | Reverse Transcriptase Polymerase Chain Reaction | Muscle, Smooth, Vascular - embryology | Animals | Cell Differentiation | Mice | Aorta - cytology | Cell Culture Techniques
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13. Full Text LRP10 genetic variants in familial Parkinson's disease and dementia with Lewy bodies: a genome-wide linkage and sequencing study
by Quadri, Marialuisa and Mandemakers, Wim and Grochowska, Martyna M and Masius, Roy and Geut, Hanneke and Fabrizio, Edito and Breedveld, Guido J and Kuipers, Demy and Minneboo, Michelle and Vergouw, Leonie J M and Carreras Mascaro, Ana and Yonova-Doing, Ekaterina and Simons, Erik and Zhao, Tianna and Di Fonzo, Alessio B and Chang, Hsiu-Chen and Parchi, Piero and Melis, Marta and Correia Guedes, Leonor and Criscuolo, Chiara and Thomas, Astrid and Brouwer, Rutger W W and Heijsman, Daphne and Ingrassia, Angela M T and Calandra Buonaura, Giovanna and Rood, Janneke P and Capellari, Sabina and Rozemuller, Annemieke J and Sarchioto, Marianna and Fen Chien, Hsin and Vanacore, Nicola and Olgiati, Simone and Wu-Chou, Yah-Huei and Yeh, Tu-Hsueh and Boon, Agnita J W and Hoogers, Susanne E and Ghazvini, Mehrnaz and IJpma, Arne S and van IJcken, Wilfred F J and Onofrj, Marco and Barone, Paolo and Nicholl, David J and Puschmann, Andreas and De Mari, Michele and Kievit, Anneke J and Barbosa, Egberto and De Michele, Giuseppe and Majoor-Krakauer, Danielle and van Swieten, John C and de Jong, Frank J and Ferreira, Joaquim J and Cossu, Giovanni and Lu, Chin-Song and Meco, Giuseppe and Cortelli, Pietro and van de Berg, Wilma D J and Bonifati, Vincenzo and Int Parkinsonism Genetics Network and International Parkinsonism Genetics Network and Lund University and Klinisk neurogenetik and MultiPark: Multidisciplinary research focused on Parkinson´s disease and Neurologi, Lund and Clinical Neurogenetics and Lunds universitet and Neurology, Lund
The Lancet Neurology, ISSN 1474-4422, 07/2018, Volume 17, Issue 7, pp. 597 - 608
Most patients with Parkinson's disease, Parkinson's disease dementia, and dementia with Lewy bodies do not carry mutations in known disease-causing genes. The... 
Journal Article | DIAGNOSIS | MULTICENTER | MANAGEMENT | VPS35 | GLUCOCEREBROSIDASE MUTATIONS | ASSOCIATION | CLINICAL NEUROLOGY | FEATURES | REVEALS | Parkinson Disease - complications | Genome-Wide Association Study | Humans | Middle Aged | RNA, Messenger - genetics | Male | Dementia - epidemiology | Parkinson Disease - genetics | Dementia - genetics | LDL-Receptor Related Proteins - genetics | Lewy Body Disease - epidemiology | Pluripotent Stem Cells - metabolism | Dementia - etiology | Lewy Body Disease - genetics | Pedigree | Brain - pathology | Parkinson Disease - epidemiology | Family | Female | Heterozygote | Italy | RNA, Messenger - chemistry | Chromosomes, Human, Pair 14 - genetics | Genetic Linkage | Genetic research | Genetic aspects | Analysis | Genomics | Dementia | Parkinson's disease | Laboratories | Neuropathology | Immunocytochemistry | Genes | Parkinsons disease | Aneurysm | Genomes | Proteins | Neurodegeneration | Autopsy | Dementia disorders | Aorta | Chromosome 14 | Movement disorders | Deoxyribonucleic acid--DNA | Linkage analysis | Neurodegenerative diseases | Therapeutic applications | Gene expression | Lewy bodies | Genetic variance | Pathology | Cycloheximide | Brain research | Molecular modelling | Pluripotency | mRNA stability | Neurologi | Clinical Medicine | Neurology | Medical and Health Sciences | Klinisk medicin | Medicin och hälsovetenskap
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14. Full Text Unmet Needs in Systemic Sclerosis Understanding and Treatment : the Knowledge Gaps from a Scientist’s, Clinician’s, and Patient’s Perspective
by Cossu, Marta and Beretta, Lorenzo and Mosterman, Petra and De Hair, Maria J H and Radstake, Timothy R.D.J
Clinical Reviews in Allergy & Immunology, ISSN 1080-0549, 12/2018, Volume 55, Issue 3, pp. 312–331 - 331
Systemic sclerosis (SSc) is a highly heterogeneous disease caused by a complex molecular circuitry. For decades, clinical and molecular research focused on... 
Systemic sclerosis | Patient-reported outcomes (PROs) | Review | Personalized medicine | Immunology and Allergy | Journal Article | Clinical unmet needs | Allergology | Immunology | Medicine & Public Health | Internal Medicine | Signs and symptoms | Circuits | Environmental factors | Inflammation | Patients | Sclerosis | Complexity | Alterations | Experimental design | Fibrosis | Design of experiments
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