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Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 10/2017, Volume 8, Issue 10, pp. 1116 - 1121
Inhibition of mutant IDH1 is being evaluated clinically as a promising treatment option for various cancers with hotspot mutation at Arg132. Having identified... 
Mutant IDH1 | clinical candidate | inhibition of 2-HG production | in vivo anticancer activity | brain penetration | ISOCITRATE DEHYDROGENASE 1 | SELECTIVE-INHIBITION | CHEMISTRY, MEDICINAL | SMALL-MOLECULE | ACUTE MYELOID-LEUKEMIA | OPPORTUNITIES | HYPOXIA | Mutant IDHI | METABOLISM | MUTATIONS
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 11/2008, Volume 51, Issue 22, pp. 7049 - 7052
Journal Article
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 09/2015, Volume 6, Issue 9, pp. 961 - 965
Abrogation of errant signaling along the MAPK pathway through the inhibition of B-RAF kinase is a validated approach for the treatment of pathway-dependent... 
serine/threonine kinases | vegf | tyrosine kinases | map | b-raf | SELECTIVE INHIBITOR | DESIGN | CHEMISTRY, MEDICINAL | VEGF | KINASE INHIBITORS | B-RAF | MAP | CANCER
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 07/2018, Volume 9, Issue 7, pp. 746 - 751
Mutant isocitrate dehydrogenase 1 (IDH1) is an attractive therapeutic target for the treatment of various cancers such as AML, glioma, and glioblastoma. We... 
Mutant IDH1 | clinical candidate | inhibition of 2-HG production | in vivo anticancer activity | brain penetration | ISOCITRATE DEHYDROGENASE 1 | SELECTIVE-INHIBITION | CHEMISTRY, MEDICINAL | SMALL-MOLECULE | GLIOMA | MECHANISMS | IDENTIFICATION | REVEAL | DISCOVERY | IN-VIVO | MUTATIONS
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 12/2014, Volume 5, Issue 12, pp. 1340 - 1340
[This corrects the article DOI: 10.1021/ml5002272.]. 
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 09/2014, Volume 5, Issue 9, pp. 989 - 992
Benzimidazole reverse amides were designed and synthesized as Pan RAF kinase inhibitors. Investigation of the structure–activity relationship of the compounds... 
CSF1R | receptor tyrosine kinases | colony stimulating factor-1 receptor | VEGF | ras-mitogen activated protein kinase | vascular endothelial growth factor receptor | RTKs | tyrosine kinases | MAP | serine threonine kinases | TKs | STKs | CHEMISTRY, MEDICINAL | CSFIR | BRAF | RTKS | Map | HUMAN CANCER
Journal Article
The Journal of Organic Chemistry, ISSN 0022-3263, 07/2002, Volume 67, Issue 15, pp. 5284 - 5294
Sterically stabilized α-lactams react by two distinct acid-catalyzed pathways. Protonation on oxygen results in nucleophilic attack at the acyl carbon and... 
SECONDARY | CHEMISTRY, ORGANIC | AZIRIDINONES | BASE-PROMOTED REACTIONS | SULFONYLATED HYDROXAMIC ACIDS | AMIDES | Oxygen | Chemistry, Organic | Analysis | Physiological aspects | Chemical reactions | Research | Catalysis | Nitrogen | Sialic acids
Journal Article
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