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1. Lyophilization of biopharmaceuticals
by Costantino, Henry R and Pikal, Michael J
2004, Biotechnology, ISBN 0971176760, Volume 2., xxx, 686
Médicaments protéiques | Lyophilisation | Protein drugs | Freeze-drying
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2. Full Text Lapatinib as a component of neoadjuvant therapy for HER2-positive operable breast cancer (NSABP protocol B-41): an open-label, randomised phase 3 trial
by Robidoux, André, Prof and Tang, Gong, PhD and Rastogi, Priya, MD and Geyer, Charles E, Prof and Azar, Catherine A, MD and Atkins, James N, MD and Fehrenbacher, Louis, MD and Bear, Harry D, MD and Baez-Diaz, Louis, MD and Sarwar, Shakir, MD and Margolese, Richard G, MD and Farrar, William B, Prof and Brufsky, Adam M, Prof and Shibata, Henry R, Prof and Bandos, Hanna, PhD and Paik, Soonmyung, Prof and Costantino, Joseph P, Prof and Swain, Sandra M, Prof and Mamounas, Eleftherios P, Prof and Wolmark, Norman, Prof
Lancet Oncology, The, ISSN 1470-2045, 2013, Volume 14, Issue 12, pp. 1183 - 1192
Summary Background We studied the effect on tumour response to neoadjuvant therapy of the substitution of lapatinib for trastuzumab in combination with weekly... 
Hematology, Oncology and Palliative Medicine | SURVIVAL | WOMEN | CELLS | SURGICAL ADJUVANT BREAST | PREOPERATIVE CHEMOTHERAPY | ONCOLOGY | GW572016 | CHEMOTHERAPY PLUS TRASTUZUMAB | PERTUZUMAB | INHIBITOR | DOCETAXEL | Breast Neoplasms - surgery | Cyclophosphamide - administration & dosage | Puerto Rico | United States | Humans | Receptor, ErbB-2 - metabolism | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Protein Kinase Inhibitors - adverse effects | Molecular Targeted Therapy | Breast Neoplasms - enzymology | Antibodies, Monoclonal, Humanized - administration & dosage | Time Factors | Biomarkers, Tumor - metabolism | Mastectomy | Female | Neoadjuvant Therapy | Quinazolines - administration & dosage | Receptor, ErbB-2 - antagonists & inhibitors | Chemotherapy, Adjuvant | Biomarkers, Tumor - antagonists & inhibitors | Odds Ratio | Paclitaxel - administration & dosage | Doxorubicin - administration & dosage | Drug Administration Schedule | Logistic Models | Treatment Outcome | Chi-Square Distribution | Breast Neoplasms - drug therapy | Canada | Protein Kinase Inhibitors - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Breast Neoplasms - pathology | Intention to Treat Analysis | Quinazolines - adverse effects | Trastuzumab | Health maintenance organizations | Neoadjuvant therapy | Medical colleges | Care and treatment | Cyclophosphamide | Anthracyclines | Adjuvant treatment | Breast cancer | Product development | Public health | Cancer | Index Medicus
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3. Full Text Intranasal delivery: Physicochemical and therapeutic aspects
by Costantino, Henry R and Illum, Lisbeth and Brandt, Gordon and Johnson, Paul H and Quay, Steven C
International Journal of Pharmaceutics, ISSN 0378-5173, 2007, Volume 337, Issue 1, pp. 1 - 24
Interest in intranasal (IN) administration as a non-invasive route for drug delivery continues to grow rapidly. The nasal mucosa offers numerous benefits as a... 
Intranasal drug delivery | Pharmacokinetics | Nasal mucosa | Physicochemical properties | IN-VIVO BIOAVAILABILITY | DEPENDENT DIABETIC-PATIENTS | DIMETHYL-BETA-CYCLODEXTRIN | DIFFERENT MOLECULAR-WEIGHTS | NORKETAMINE PLASMA-CONCENTRATIONS | intranasal drug delivery | physicochemical properties | pharmacokinetics | nasal mucosa | PHARMACOLOGY & PHARMACY | CENTRAL-NERVOUS-SYSTEM | ACUTE CHILDHOOD SEIZURES | CSF FOLLOWING INTRANASAL | NASAL DRUG-DELIVERY | WATER-SOLUBLE COMPOUNDS | Cholinesterase Inhibitors - pharmacokinetics | Hypnotics and Sedatives - chemistry | Central Nervous System - metabolism | Molecular Weight | Humans | Vaccines - pharmacokinetics | Cholinesterase Inhibitors - chemistry | Hypnotics and Sedatives - administration & dosage | Antiemetics - administration & dosage | Analgesics - pharmacokinetics | Antiemetics - pharmacokinetics | Inflammation - metabolism | Vaccines - chemistry | Cardiovascular Agents - pharmacokinetics | Drug Compounding | Antiemetics - chemistry | Nasal Mucosa - metabolism | Cardiovascular Agents - administration & dosage | Drug Administration Schedule | Hypnotics and Sedatives - pharmacokinetics | Drug Stability | Solubility | Analgesics - administration & dosage | Administration, Intranasal | Chemistry, Pharmaceutical | Carrier Proteins - metabolism | Cholinesterase Inhibitors - administration & dosage | Analgesics - chemistry | Hydrophobic and Hydrophilic Interactions | Vaccines - administration & dosage | Cardiovascular Agents - chemistry
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4. Full Text Gabapentin enacarbil – clinical efficacy in restless legs syndrome
by Pinky Agarwal and Alida Griffith and Henry R Costantino
Neuropsychiatric Disease and Treatment, ISSN 1176-6328, 04/2010, Volume 2010, Issue Issue 1, pp. 151 - 158
Pinky Agarwal1, Alida Griffith1, Henry R Costantino2, Narendra Vaish31Booth Gardner Parkinson’s Center, Kirkland, WA, USA; 2Costantino Consulting,... 
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5. Full Text Poly(lactide-co-glycolide) microspheres as a moldable scaffold for cartilage tissue engineering
by Mercier, Nichole R and Costantino, Henry R and Tracy, Mark A and Bonassar, Lawrence J
Biomaterials, ISSN 0142-9612, 05/2005, Volume 26, Issue 14, pp. 1945 - 1952
This study demonstrates the use of biodegradable poly(lactide- -glycolide) (PLG) microspheres as a moldable scaffold for cartilage tissue engineering.... 
Cartilage tissue engineering | Cartilage repair | Microsphere | Glycosaminoglycan | PLG | Scaffold | ECM | cartilage tissue engineering | NASAL | MATERIALS SCIENCE, BIOMATERIALS | CHONDROCYTES | ENGINEERING, BIOMEDICAL | NEOCARTILAGE | CONTROLLED-RELEASE | REDIFFERENTIATION | COMPOSITES | scaffold | IN-VIVO | microsphere | DEGRADATION | LOW-OXYGEN TENSION | GROWTH-FACTOR | cartilage repair | ECM glycosaminoglycan | Chondrocytes - cytology | Cell Proliferation | Lactic Acid - chemistry | Tissue Engineering - methods | Cartilage, Articular - cytology | Biocompatible Materials - chemistry | Cells, Cultured | Cartilage, Articular - growth & development | Materials Testing | Cell Culture Techniques - methods | Absorbable Implants | Feasibility Studies | Microspheres | Animals | Chondrocytes - physiology | Cattle | Cell Adhesion - physiology | Polyglycolic Acid - chemistry | Surface Properties | Polymers - chemistry | Porosity | Cell Differentiation - physiology | Glycosaminoglycans | Tissue engineering | Collagen | Cells | Aerospace engineering
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6. Gabapentin enacarbil - clinical efficacy in restless legs syndrome
by Agarwal, Pinky and Griffith, Alida and Costantino, Henry R and Vaish, Narendra
Neuropsychiatric Disease and Treatment, ISSN 1176-6328, 05/2010, Volume 6, pp. 151 - 158
Restless legs syndrome (RLS) is a sleep-related movement disorder commonly involving an unpleasant urge to move the limbs, typically the legs. Dopaminergic... 
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7. Full Text Effect of mannitol crystallization on the stability and aerosol performance of a spray-dried pharmaceutical protein, recombinant humanized anti-lge monoclonal antibody
by Costantino, Henry R and Andya, James D and Nguyen, Phuong-Anh and Dasovich, Nancy and Sweeney, Theresa D and Shire, Steven J and Hsu, Chung C and Maa, Yuh-Fun
Journal of Pharmaceutical Sciences, ISSN 0022-3549, 1998, Volume 87, Issue 11, pp. 1406 - 1411
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8. Full Text Intranasal administration of acetylcholinesterase inhibitors
by Costantino, Henry R and Leonard, Alexis Kays and Brandt, Gordon and Johnson, Paul H and Quay, Steven C
BMC Neuroscience, 12/2008, Volume 9, Issue 3
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9. Full Text Evaluation of lapatinib as a component of neoadjuvant therapy for HER2+ operable breast cancer: 5-year outcomes of NSABP protocol B-41
by Robidoux, Andre and Tang, Gong and Rastogi, Priya and Geyer, Charles E and Azar, Catherine A and Atkins, James Norman and Fehrenbacher, Louis and Bear, Harry Douglas and Baez-Diaz, Luis and Sarwar, Shakir and Margolese, Richard G and Farrar, William Blair and Brufsky, Adam M and Shibata, Henry R and Bandos, Hanna and Paik, Soonmyung and Costantino, Joseph P and Swain, Sandra M and Mamounas, Eleftherios P and Wolmark, Norman
Journal of Clinical Oncology, ISSN 0732-183X, 05/2016, Volume 34, Issue 15_suppl, pp. 501 - 501
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10. Full Text Intranasal insulin: PK profile designed specifically for prandial treatment of Type 2 Diabetes
by Mitchell, Richard L and Costantino, Henry R and Sileno, Anthony and Duffy, Timothy and Brandt, Gordon and Quay, Steven C
Drug Development Research, ISSN 0272-4391, 05/2008, Volume 69, Issue 3, pp. 143 - 152
Insulin is the most effective therapy for lowering glycosylated hemoglobin (A1c) levels in Type 2 diabetics, and yet it is typically the last therapeutic... 
Type 2 diabetes | postprandial hyperglycemia | intranasal insulin | Intranasal insulin | Postprandial hyperglycemia | INHALED INSULIN | GLYCEMIC CONTROL | CHEMISTRY, MEDICINAL | DOSE-RESPONSE | HEALTHY-SUBJECTS | DRUG-DELIVERY | MELLITUS | COMPARATIVE TRIAL | INTESTINAL-ABSORPTION | THERAPY | GLARGINE | PHARMACOLOGY & PHARMACY
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11. Full Text Discovery of tight junction modulators: significance for drug development and delivery
by Johnson, Paul H and Frank, Diane and Costantino, Henry R
Drug Discovery Today, ISSN 1359-6446, 2008, Volume 13, Issue 5, pp. 261 - 267
Tight junction biology has many important applications, from improving knowledge of diseases characterized by the loss of epithelial or endothelial tissue... 
ZONULA OCCLUDENS TOXIN | PROTEIN | EPITHELIAL-CELLS | PERMEABILITY | INFLAMMATION | TETRADECYLMALTOSIDE | PHARMACOLOGY & PHARMACY | INTRANASAL DELIVERY | ENDOCYTOSIS | PLASMA-MEMBRANE | PEPTIDE | Epithelium - drug effects | Peptides - chemistry | Signal Transduction | Humans | Models, Molecular | Epithelium - ultrastructure | Chemistry, Pharmaceutical | Drug Delivery Systems | Peptides - pharmacology | Tight Junctions - ultrastructure | Endocytosis | Tight Junctions - physiology | Animals | Combinatorial Chemistry Techniques | Cell Adhesion - physiology | Drug Design | Epithelium - physiology | Tight Junctions - drug effects | Index Medicus
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12. Full Text Recent trends in stabilizing protein structure upon encapsulation and release from bioerodible polymers
by Pérez, Caroline and Castellanos, Ingrid J and Costantino, Henry R and Al‐Azzam, Wasfi and Griebenow, Kai
Journal of Pharmacy and Pharmacology, ISSN 0022-3573, 03/2002, Volume 54, Issue 3, pp. 301 - 313
Sustained release of pharmaceutical proteins from biocompatible polymers offers new opportunities in the treatment and prevention of disease. The manufacturing... 
HUMAN GROWTH-HORMONE | BIODEGRADABLE MICROSPHERES | ORGANIC-SOLVENTS | LYOPHILIZED PROTEIN | DRUG-DELIVERY | PLGA MICROSPHERES | PHARMACOLOGY & PHARMACY | MOISTURE-INDUCED AGGREGATION | SECONDARY STRUCTURE | INFRARED-SPECTROSCOPY | SOLID-STATE | Biocompatible Materials | Polymers - chemistry | Proteins - chemistry | Delayed-Action Preparations | Chemistry, Pharmaceutical - trends
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13. Full Text Non-aqueous encapsulation of excipient-stabilized spray-freeze dried BSA into poly(lactide- co-glycolide) microspheres results in release of native protein
by Carrasquillo, Karen G and Stanley, Ann M and Aponte-Carro, Juan C and De Jésus, Patricia and Costantino, Henry R and Bosques, Carlos J and Griebenow, Kai
Journal of Controlled Release, ISSN 0168-3659, 2001, Volume 76, Issue 3, pp. 199 - 208
Encapsulation of the model protein bovine serum albumin (BSA) into poly(D,L lactide-co-glycolide) (PLG) microspheres was performed by a non-aqueous oil-in-oil... 
Microspheres | Non-aqueous encapsulation | Protein aggregation | Poly(lactide- co-glycolide) | Spray-freeze drying | Poly(lactide-co-glycolide) | non-aqueous encapsulation | poly(lactide-co-glycolide) | BIODEGRADABLE MICROSPHERES | microspheres | DRUG-DELIVERY | INFRARED-SPECTROSCOPY | CHEMISTRY, MULTIDISCIPLINARY | HUMAN GROWTH-HORMONE | ORGANIC-SOLVENTS | protein aggregation | POLYMER | PHARMACOLOGY & PHARMACY | SECONDARY STRUCTURE | ACID) MICROSPHERES | MICROENCAPSULATION | spray-freeze drying | BOVINE SERUM-ALBUMIN | Serum Albumin, Bovine - administration & dosage | Lactic Acid | Polyglycolic Acid | Freeze Drying | Solubility | Chromatography, High Pressure Liquid | Spectroscopy, Fourier Transform Infrared | Spectrophotometry, Ultraviolet | Drug Carriers | Drug Delivery Systems | Drug Compounding | Polymers | Circular Dichroism
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14. Full Text Gabapentin enacarbil - clinical efficacy in restless legs syndrome
by Agarwal, P and Griffith, A and Costantino, HR and Vaish, N
NEUROPSYCHIATRIC DISEASE AND TREATMENT, ISSN 1178-2021, 2010, Volume 6, Issue 1, pp. 151 - 158
Restless legs syndrome (RLS) is a sleep-related movement disorder commonly involving an unpleasant urge to move the limbs, typically the legs. Dopaminergic... 
SYNDROME SYMPTOMS | AMINOMETHYL)-1-CYCLOHEXANE ACETIC-ACID | PSYCHIATRY | restless legs syndrome | CROSS-OVER | XP13512 | CLINICAL NEUROLOGY | NEUROPATHIC PAIN | movement disorder | B RECEPTORS | DOUBLE-BLIND | HEMODIALYSIS-PATIENTS | AGENT GABAPENTIN | gabapentin enacarbil | CALCIUM-CHANNEL | Restless legs syndrome | Expert Opinion
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