Frontiers in Immunology, ISSN 1664-3224, 06/2016, Volume 7, p. 235
Natural killer (NK) cells are known as frontline responders capable of rapidly mediating a response upon encountering transformed or infected cells. Recent...
ILC | NK cells | Adaptive immunity | Immune regulation | Viral infection | ACTIVATION | viral infection | KILLER-CELLS | IFN-GAMMA | MOUSE | REACTIVITY | IMMUNOLOGY | immune regulation | adaptive immunity | CROSS-TALK | RESPONSES | INFECTION | LYMPHOID-CELLS | LYMPHOCYTES | T cells | Killer cells
ILC | NK cells | Adaptive immunity | Immune regulation | Viral infection | ACTIVATION | viral infection | KILLER-CELLS | IFN-GAMMA | MOUSE | REACTIVITY | IMMUNOLOGY | immune regulation | adaptive immunity | CROSS-TALK | RESPONSES | INFECTION | LYMPHOID-CELLS | LYMPHOCYTES | T cells | Killer cells
Journal Article
Immunity, ISSN 1074-7613, 10/2014, Volume 41, Issue 4, pp. 646 - 656
Natural killer (NK) cells have been reported to control adaptive immune responses that occur in lymphoid organs at the early stages of immune challenge....
AUTOANTIBODIES | IMMUNITY | NATURAL-KILLER-CELLS | APOPTOSIS-INDUCING LIGAND | VIRUS-INFECTION | DENDRITIC CELLS | FUNCTIONAL-ANALYSIS | SJOGRENS-SYNDROME | CYTOMEGALOVIRUS-INFECTION | IMMUNOLOGY | LYMPHOCYTES | Salivary Glands - immunology | Killer Cells, Natural - transplantation | Salivary Glands - pathology | Adoptive Transfer | TNF-Related Apoptosis-Inducing Ligand - immunology | Mice, Knockout | NK Cell Lectin-Like Receptor Subfamily K - biosynthesis | CD4-Positive T-Lymphocytes - immunology | Muromegalovirus - immunology | Animals | Apoptosis - immunology | Autoimmunity - immunology | Salivary Glands - virology | Killer Cells, Natural - immunology | Mice | Mice, Inbred BALB C | Cytotoxicity, Immunologic - immunology | Chronic Disease | Herpesviridae Infections - immunology | Design | Antigens | Cytomegalovirus | Data analysis | Lymphocytes | Infections | Breeding of animals | Charitable foundations | Experiments | Viral infections | Manuscripts | Immune system
AUTOANTIBODIES | IMMUNITY | NATURAL-KILLER-CELLS | APOPTOSIS-INDUCING LIGAND | VIRUS-INFECTION | DENDRITIC CELLS | FUNCTIONAL-ANALYSIS | SJOGRENS-SYNDROME | CYTOMEGALOVIRUS-INFECTION | IMMUNOLOGY | LYMPHOCYTES | Salivary Glands - immunology | Killer Cells, Natural - transplantation | Salivary Glands - pathology | Adoptive Transfer | TNF-Related Apoptosis-Inducing Ligand - immunology | Mice, Knockout | NK Cell Lectin-Like Receptor Subfamily K - biosynthesis | CD4-Positive T-Lymphocytes - immunology | Muromegalovirus - immunology | Animals | Apoptosis - immunology | Autoimmunity - immunology | Salivary Glands - virology | Killer Cells, Natural - immunology | Mice | Mice, Inbred BALB C | Cytotoxicity, Immunologic - immunology | Chronic Disease | Herpesviridae Infections - immunology | Design | Antigens | Cytomegalovirus | Data analysis | Lymphocytes | Infections | Breeding of animals | Charitable foundations | Experiments | Viral infections | Manuscripts | Immune system
Journal Article
Journal of Immunology, ISSN 0022-1767, 02/2011, Volume 186, Issue 3, pp. 1713 - 1722
The Ly49H activating receptor on C57BL/6 (B6) NK cells plays a key role in early resistance to murine cytomegalovirus (MCMV) infection through specific...
KILLER-CELLS | INFECTED CELLS | TARGET-CELLS | MEDIATED RESISTANCE | MULTIGENE FAMILY | MONOCLONAL-ANTIBODY | MAJOR HISTOCOMPATIBILITY COMPLEX | TOPOLOGY PREDICTION | NKG2D RECEPTOR | IMMUNOLOGY | MOUSE CYTOMEGALOVIRUS | Protein Binding - genetics | Epitopes - metabolism | Cricetulus | Species Specificity | Mice, 129 Strain | Epitopes - immunology | Signal Transduction - immunology | Lymphocyte Activation - genetics | Lymphocyte Activation - immunology | Killer Cells, Natural - immunology | Genetic Variation - immunology | CHO Cells | NK Cell Lectin-Like Receptor Subfamily A - metabolism | Cricetinae | Mice, Inbred C57BL | Signal Transduction - genetics | Mice, Inbred NZB | Protein Binding - immunology | Muromegalovirus - immunology | Models, Immunological | Animals | Mice | Mice, Inbred BALB C | Muromegalovirus - genetics | Killer Cells, Natural - metabolism | NK Cell Lectin-Like Receptor Subfamily A - physiology
KILLER-CELLS | INFECTED CELLS | TARGET-CELLS | MEDIATED RESISTANCE | MULTIGENE FAMILY | MONOCLONAL-ANTIBODY | MAJOR HISTOCOMPATIBILITY COMPLEX | TOPOLOGY PREDICTION | NKG2D RECEPTOR | IMMUNOLOGY | MOUSE CYTOMEGALOVIRUS | Protein Binding - genetics | Epitopes - metabolism | Cricetulus | Species Specificity | Mice, 129 Strain | Epitopes - immunology | Signal Transduction - immunology | Lymphocyte Activation - genetics | Lymphocyte Activation - immunology | Killer Cells, Natural - immunology | Genetic Variation - immunology | CHO Cells | NK Cell Lectin-Like Receptor Subfamily A - metabolism | Cricetinae | Mice, Inbred C57BL | Signal Transduction - genetics | Mice, Inbred NZB | Protein Binding - immunology | Muromegalovirus - immunology | Models, Immunological | Animals | Mice | Mice, Inbred BALB C | Muromegalovirus - genetics | Killer Cells, Natural - metabolism | NK Cell Lectin-Like Receptor Subfamily A - physiology
Journal Article
Cancer Research, ISSN 0008-5472, 02/2018, Volume 78, Issue 4, pp. 1003 - 1016
Extracellular adenosine is a key immunosuppressive metabolite that restricts activation of cytotoxic lymphocytes and impairs antitumor immune responses. Here,...
RESPONSES | CD73 | A(2A) RECEPTORS | INHIBITION | PROTECTION | ONCOLOGY | IMMUNOTHERAPY | NK-CELLS | INNATE LYMPHOID-CELLS | EXPRESSION | T-CELLS | Humans | Mice, Inbred C57BL | Melanoma, Experimental - pathology | Male | Melanoma, Experimental - metabolism | Mice, Transgenic | Killer Cells, Natural - pathology | Receptor, Adenosine A2A - metabolism | Mice, Knockout | Tumor Microenvironment - immunology | Signal Transduction - immunology | Animals | Heterografts | Melanoma, Experimental - immunology | Receptor, Adenosine A2A - immunology | Cell Line, Tumor | Killer Cells, Natural - immunology | Mice | Receptor, Adenosine A2A - deficiency | Adenosine | Immune response | Maturation | Homeostasis | Cytotoxicity | T cell receptors | Antagonists | Immunity | Signaling | Cell activation | Immunosuppression | Clonal deletion | Lymphocytes | Deletion | Antitumor activity | Natural killer cells | Life Sciences | Cancer
RESPONSES | CD73 | A(2A) RECEPTORS | INHIBITION | PROTECTION | ONCOLOGY | IMMUNOTHERAPY | NK-CELLS | INNATE LYMPHOID-CELLS | EXPRESSION | T-CELLS | Humans | Mice, Inbred C57BL | Melanoma, Experimental - pathology | Male | Melanoma, Experimental - metabolism | Mice, Transgenic | Killer Cells, Natural - pathology | Receptor, Adenosine A2A - metabolism | Mice, Knockout | Tumor Microenvironment - immunology | Signal Transduction - immunology | Animals | Heterografts | Melanoma, Experimental - immunology | Receptor, Adenosine A2A - immunology | Cell Line, Tumor | Killer Cells, Natural - immunology | Mice | Receptor, Adenosine A2A - deficiency | Adenosine | Immune response | Maturation | Homeostasis | Cytotoxicity | T cell receptors | Antagonists | Immunity | Signaling | Cell activation | Immunosuppression | Clonal deletion | Lymphocytes | Deletion | Antitumor activity | Natural killer cells | Life Sciences | Cancer
Journal Article
PLoS Pathogens, ISSN 1553-7366, 05/2014, Volume 10, Issue 5
Natural Killer (NK) cells are crucial in early resistance to murine cytomegalovirus (MCMV) infection. In B6 mice, the activating Ly49H receptor recognizes...
Cytomegalovirus | Medical research | Rodents | Viral infections | Immune system
Cytomegalovirus | Medical research | Rodents | Viral infections | Immune system
Journal Article
Frontiers in Immunology, ISSN 1664-3224, 06/2016, Volume 7
Journal Article
Journal of Immunology, ISSN 0022-1767, 07/2016, Volume 197, Issue 1, pp. 128 - 140
NK cells possess inhibitory receptors that are responsible for self-MHC class I recognition; beyond their inhibitory function, accumulating evidence indicates...
MHC CLASS-I | NATURAL-KILLER-CELLS | RECOGNITION | TOLERANCE | BONE-MARROW | MISSING-SELF | INHIBITORY RECEPTORS | MICE | EDUCATION | IMMUNOLOGY | EXPRESSION | NK Cell Lectin-Like Receptor Subfamily A - metabolism | Mice, Inbred C57BL | Cells, Cultured | Antigens, Differentiation, T-Lymphocyte - metabolism | Mice, Transgenic | Histocompatibility Antigens Class I - genetics | Immunity, Innate | Lymphocyte Subsets - immunology | Mice, Knockout | Muromegalovirus - immunology | Animals | NK Cell Lectin-Like Receptor Subfamily K - metabolism | Killer Cells, Natural - immunology | Immunologic Memory | NK Cell Lectin-Like Receptor Subfamily A - genetics | Cell Differentiation | Mice | Cytotoxicity, Immunologic | Herpesviridae Infections - immunology
MHC CLASS-I | NATURAL-KILLER-CELLS | RECOGNITION | TOLERANCE | BONE-MARROW | MISSING-SELF | INHIBITORY RECEPTORS | MICE | EDUCATION | IMMUNOLOGY | EXPRESSION | NK Cell Lectin-Like Receptor Subfamily A - metabolism | Mice, Inbred C57BL | Cells, Cultured | Antigens, Differentiation, T-Lymphocyte - metabolism | Mice, Transgenic | Histocompatibility Antigens Class I - genetics | Immunity, Innate | Lymphocyte Subsets - immunology | Mice, Knockout | Muromegalovirus - immunology | Animals | NK Cell Lectin-Like Receptor Subfamily K - metabolism | Killer Cells, Natural - immunology | Immunologic Memory | NK Cell Lectin-Like Receptor Subfamily A - genetics | Cell Differentiation | Mice | Cytotoxicity, Immunologic | Herpesviridae Infections - immunology
Journal Article
PLoS Pathogens, ISSN 1553-7366, 2014, Volume 10, Issue 5, p. e1004161
Natural Killer (NK) cells are crucial in early resistance to murine cytomegalovirus (MCMV) infection. In B6 mice, the activating Ly49H receptor recognizes the...
STRAINS | NATURAL-KILLER-CELLS | RECOGNITION | MICROBIOLOGY | MAJOR HISTOCOMPATIBILITY COMPLEX | MOUSE CYTOMEGALOVIRUS GLYCOPROTEIN | MURINE CYTOMEGALOVIRUS | VIRAL-INFECTION | ACTIVATION RECEPTOR | VIROLOGY | MISSING SELF | MICE | PARASITOLOGY | Muromegalovirus - immunology | Animals | Killer Cells, Natural - virology | Mice, Inbred C57BL | Histocompatibility Antigens Class I - immunology | Cytomegalovirus Infections - virology | Killer Cells, Natural - immunology | Mice, Transgenic | NK Cell Lectin-Like Receptor Subfamily A - genetics | Cytomegalovirus Infections - metabolism | Mice | NK Cell Lectin-Like Receptor Subfamily A - immunology | Care and treatment | Control | Patient outcomes | Cytomegalovirus infections | Genetic aspects | Genetic engineering | Research | Diagnosis | Cytomegalovirus | Medical research | Rodents | Viral infections | Immune system
STRAINS | NATURAL-KILLER-CELLS | RECOGNITION | MICROBIOLOGY | MAJOR HISTOCOMPATIBILITY COMPLEX | MOUSE CYTOMEGALOVIRUS GLYCOPROTEIN | MURINE CYTOMEGALOVIRUS | VIRAL-INFECTION | ACTIVATION RECEPTOR | VIROLOGY | MISSING SELF | MICE | PARASITOLOGY | Muromegalovirus - immunology | Animals | Killer Cells, Natural - virology | Mice, Inbred C57BL | Histocompatibility Antigens Class I - immunology | Cytomegalovirus Infections - virology | Killer Cells, Natural - immunology | Mice, Transgenic | NK Cell Lectin-Like Receptor Subfamily A - genetics | Cytomegalovirus Infections - metabolism | Mice | NK Cell Lectin-Like Receptor Subfamily A - immunology | Care and treatment | Control | Patient outcomes | Cytomegalovirus infections | Genetic aspects | Genetic engineering | Research | Diagnosis | Cytomegalovirus | Medical research | Rodents | Viral infections | Immune system
Journal Article
The Journal of Immunology, ISSN 0022-1767, 02/2007, Volume 178, Issue 3, pp. 1277 - 1284
The Ly49A NK cell receptor interacts with MHC class I (MHC-I) molecules on target cells and negatively regulates NK cell-mediated target cell lysis. We have...
NATURAL-KILLER-CELLS | HISTOCOMPATIBILITY COMPLEX-MOLECULES | INHIBITION | NK CELLS | RECOGNITION | CRYSTAL-STRUCTURE | IMMUNOLOGY | H-2D(D) | EXPRESSION | BINDING | T-LYMPHOCYTES | Histocompatibility Antigens Class I - metabolism | Lectins, C-Type - metabolism | Animals | NK Cell Lectin-Like Receptor Subfamily A | Mice, Inbred C57BL | Killer Cells, Natural - immunology | Protein Binding | Antigens, Ly - metabolism | Ligands | Mice | Receptors, NK Cell Lectin-Like | Receptors, Immunologic - metabolism
NATURAL-KILLER-CELLS | HISTOCOMPATIBILITY COMPLEX-MOLECULES | INHIBITION | NK CELLS | RECOGNITION | CRYSTAL-STRUCTURE | IMMUNOLOGY | H-2D(D) | EXPRESSION | BINDING | T-LYMPHOCYTES | Histocompatibility Antigens Class I - metabolism | Lectins, C-Type - metabolism | Animals | NK Cell Lectin-Like Receptor Subfamily A | Mice, Inbred C57BL | Killer Cells, Natural - immunology | Protein Binding | Antigens, Ly - metabolism | Ligands | Mice | Receptors, NK Cell Lectin-Like | Receptors, Immunologic - metabolism
Journal Article
Journal of Immunology, ISSN 0022-1767, 02/2011, Volume 186, Issue 3, pp. 1713 - 1722
The Ly49H activating receptor on C57BL/6 (B6) NK cells plays a key role in early resistance to murine cytomegalovirus (MCMV) infection through specific...
Journal Article
Nature Immunology, ISSN 1529-2908, 07/2013, Volume 14, Issue 7, pp. 699 - 705
Activating and inhibitory receptors on natural killer (NK) cells have a crucial role in innate immunity, although the basis of the engagement of activating NK...
COMPLEX | CLASS-I LIGAND | RECOGNITION | CRYSTAL-STRUCTURE | BINDING-SITE | CRITICAL RESIDUES | INFECTION | MURINE CYTOMEGALOVIRUS M157 | IMMUNOLOGY | MOUSE CYTOMEGALOVIRUS | ACTIVATION RECEPTOR | Surface Plasmon Resonance | Amino Acid Sequence | Specific Pathogen-Free Organisms | Histocompatibility Antigens Class I - immunology | Models, Molecular | Molecular Sequence Data | Crystallography, X-Ray | NK Cell Lectin-Like Receptor Subfamily A - immunology | Muromegalovirus - immunology | Immunity, Innate - immunology | Signal Transduction - immunology | Animals | Amino Acid Motifs - immunology | Killer Cells, Natural - immunology | Female | Mice | Mice, Inbred BALB C | Herpesviridae Infections - immunology | Physiological aspects | Natural immunity | Killer cells | Research | Viral proteins | Aromatics
COMPLEX | CLASS-I LIGAND | RECOGNITION | CRYSTAL-STRUCTURE | BINDING-SITE | CRITICAL RESIDUES | INFECTION | MURINE CYTOMEGALOVIRUS M157 | IMMUNOLOGY | MOUSE CYTOMEGALOVIRUS | ACTIVATION RECEPTOR | Surface Plasmon Resonance | Amino Acid Sequence | Specific Pathogen-Free Organisms | Histocompatibility Antigens Class I - immunology | Models, Molecular | Molecular Sequence Data | Crystallography, X-Ray | NK Cell Lectin-Like Receptor Subfamily A - immunology | Muromegalovirus - immunology | Immunity, Innate - immunology | Signal Transduction - immunology | Animals | Amino Acid Motifs - immunology | Killer Cells, Natural - immunology | Female | Mice | Mice, Inbred BALB C | Herpesviridae Infections - immunology | Physiological aspects | Natural immunity | Killer cells | Research | Viral proteins | Aromatics
Journal Article
PLoS Pathogens, ISSN 1553-7366, 12/2014, Volume 10, Issue 12, p. e1004526
Many immune response genes are highly polymorphic, consistent with the selective pressure imposed by pathogens over evolutionary time, and the need to balance...
KILLER-CELLS | MICROBIOLOGY | MEDIATED APOPTOSIS | MURINE CYTOMEGALOVIRUS | CELL-DEATH | CYTOKINE RESPONSE | VIROLOGY | CYTOTOXIC LYMPHOCYTES | MOUSE GRANZYME | PICHIA-PASTORIS | PROTEINASE-INHIBITOR 9 | CASPASE ACTIVATION | PARASITOLOGY | Amino Acid Sequence | Granzymes - analysis | CD8-Positive T-Lymphocytes - pathology | Virus Diseases - immunology | Herpesviridae Infections - mortality | Mice, Inbred C57BL | Immunity, Innate - genetics | Molecular Sequence Data | Granzymes - genetics | Mice, Knockout | Granzymes - deficiency | Muromegalovirus - immunology | Herpesviridae Infections - pathology | Animals | Caspases - metabolism | CD8-Positive T-Lymphocytes - virology | Virus Diseases - pathology | Alleles | Genetic Variation - genetics | Mice | Virus Diseases - mortality | Apoptosis | Disease Models, Animal | Herpesviridae Infections - immunology | Immune response | Genetic variation | Genetic research | Genetic aspects | Research | Host-virus relationships | Virus research | Cytomegalovirus | Statistical analysis | Laboratories | Amino acids | Cytotoxicity | Infections | Experiments | Proteins | Lymphocytes | Binomial distribution | Software | Viral infections
KILLER-CELLS | MICROBIOLOGY | MEDIATED APOPTOSIS | MURINE CYTOMEGALOVIRUS | CELL-DEATH | CYTOKINE RESPONSE | VIROLOGY | CYTOTOXIC LYMPHOCYTES | MOUSE GRANZYME | PICHIA-PASTORIS | PROTEINASE-INHIBITOR 9 | CASPASE ACTIVATION | PARASITOLOGY | Amino Acid Sequence | Granzymes - analysis | CD8-Positive T-Lymphocytes - pathology | Virus Diseases - immunology | Herpesviridae Infections - mortality | Mice, Inbred C57BL | Immunity, Innate - genetics | Molecular Sequence Data | Granzymes - genetics | Mice, Knockout | Granzymes - deficiency | Muromegalovirus - immunology | Herpesviridae Infections - pathology | Animals | Caspases - metabolism | CD8-Positive T-Lymphocytes - virology | Virus Diseases - pathology | Alleles | Genetic Variation - genetics | Mice | Virus Diseases - mortality | Apoptosis | Disease Models, Animal | Herpesviridae Infections - immunology | Immune response | Genetic variation | Genetic research | Genetic aspects | Research | Host-virus relationships | Virus research | Cytomegalovirus | Statistical analysis | Laboratories | Amino acids | Cytotoxicity | Infections | Experiments | Proteins | Lymphocytes | Binomial distribution | Software | Viral infections
Journal Article
Future Virology, ISSN 1746-0794, 02/2015, Volume 10, Issue 2, pp. 135 - 154
NK cells constitute a population of lymphocytes involved in innate immune functions. They play a critical role in antiviral immune surveillance. Viruses have...
NK cells | NK cell receptors | cytomegalovirus | immunoevasins | immunotherapy | virus | immune regulation | NATURAL-KILLER-CELLS | MURINE CYTOMEGALOVIRUS | MOUSE CYTOMEGALOVIRUS | CUTTING EDGE | VIROLOGY | HEPATITIS-C VIRUS | HUMAN CYTOMEGALOVIRUS-INFECTION | COMPLEX CLASS-I | INHIBITORY RECEPTOR | HIV-1 INFECTION | POLIOVIRUS RECEPTOR CD155
NK cells | NK cell receptors | cytomegalovirus | immunoevasins | immunotherapy | virus | immune regulation | NATURAL-KILLER-CELLS | MURINE CYTOMEGALOVIRUS | MOUSE CYTOMEGALOVIRUS | CUTTING EDGE | VIROLOGY | HEPATITIS-C VIRUS | HUMAN CYTOMEGALOVIRUS-INFECTION | COMPLEX CLASS-I | INHIBITORY RECEPTOR | HIV-1 INFECTION | POLIOVIRUS RECEPTOR CD155
Journal Article
PLoS Pathogens, ISSN 1553-7366, 12/2014, Volume 10, Issue 12
Many immune response genes are highly polymorphic, consistent with the selective pressure imposed by pathogens over evolutionary time, and the need to...
Cytomegalovirus | Statistical analysis | Laboratories | Amino acids | Cytotoxicity | Infections | Experiments | Proteins | Lymphocytes | Binomial distribution | Software | Viral infections | Apoptosis
Cytomegalovirus | Statistical analysis | Laboratories | Amino acids | Cytotoxicity | Infections | Experiments | Proteins | Lymphocytes | Binomial distribution | Software | Viral infections | Apoptosis
Journal Article
The Journal of Immunology, ISSN 0022-1767, 09/2002, Volume 169, Issue 6, pp. 2979 - 2987
Although much progress has been made in understanding the role of NK cells in bone marrow transplantation, little is known about their function in CD4 T...
COSTIMULATORY REQUIREMENTS | ALLOGRAFT-REJECTION | NATURAL-KILLER-CELLS | IN-VIVO | BONE-MARROW | MOUSE | MARROW GRAFT-REJECTION | MICE | IMMUNOLOGY | CARDIAC ALLOGRAFTS | MHC CLASS-II | Skin Transplantation - immunology | Autoantigens - biosynthesis | Species Specificity | Dendritic Cells - immunology | Th2 Cells - immunology | Autoantigens - genetics | CD4-Positive T-Lymphocytes - immunology | Cell Differentiation - genetics | Lymphocyte Activation - immunology | Killer Cells, Natural - immunology | Female | beta 2-Microglobulin - physiology | Dendritic Cells - metabolism | Antigen-Presenting Cells - metabolism | Immunization | Isoantigens - genetics | CD4-Positive T-Lymphocytes - cytology | Mice, Inbred C57BL | Histocompatibility Antigens Class I - genetics | Antigen-Presenting Cells - immunology | Mice, Knockout | beta 2-Microglobulin - deficiency | Cell Differentiation - immunology | Immunosuppression | Animals | Epitopes, T-Lymphocyte - physiology | Isoantigens - physiology | Mice | Mice, Inbred BALB C | beta 2-Microglobulin - genetics
COSTIMULATORY REQUIREMENTS | ALLOGRAFT-REJECTION | NATURAL-KILLER-CELLS | IN-VIVO | BONE-MARROW | MOUSE | MARROW GRAFT-REJECTION | MICE | IMMUNOLOGY | CARDIAC ALLOGRAFTS | MHC CLASS-II | Skin Transplantation - immunology | Autoantigens - biosynthesis | Species Specificity | Dendritic Cells - immunology | Th2 Cells - immunology | Autoantigens - genetics | CD4-Positive T-Lymphocytes - immunology | Cell Differentiation - genetics | Lymphocyte Activation - immunology | Killer Cells, Natural - immunology | Female | beta 2-Microglobulin - physiology | Dendritic Cells - metabolism | Antigen-Presenting Cells - metabolism | Immunization | Isoantigens - genetics | CD4-Positive T-Lymphocytes - cytology | Mice, Inbred C57BL | Histocompatibility Antigens Class I - genetics | Antigen-Presenting Cells - immunology | Mice, Knockout | beta 2-Microglobulin - deficiency | Cell Differentiation - immunology | Immunosuppression | Animals | Epitopes, T-Lymphocyte - physiology | Isoantigens - physiology | Mice | Mice, Inbred BALB C | beta 2-Microglobulin - genetics
Journal Article
Journal of Immunology, ISSN 0022-1767, 02/2007, Volume 178, Issue 3, pp. 1277 - 1284
The Ly49A NK cell receptor interacts with MHC class I (MHC-I) molecules on target cells and negatively regulates NK cell-mediated target cell lysis. We have...
Journal Article
European Journal of Immunology, ISSN 0014-2980, 11/2008, Volume 38, Issue 11, pp. 2938 - 2942
Effective immunity requires coordinated activation of innate and adaptive immune responses. NK cells are principal mediators of innate immunity, able to...
Cytokines | Cellular immunology | NK cells | Animals | Humans | Dendritic Cells - physiology | Killer Cells, Natural - immunology | T-Lymphocytes - immunology | Immunity, Innate | Tumor Necrosis Factor-alpha - biosynthesis | Interferon-gamma - biosynthesis
Cytokines | Cellular immunology | NK cells | Animals | Humans | Dendritic Cells - physiology | Killer Cells, Natural - immunology | T-Lymphocytes - immunology | Immunity, Innate | Tumor Necrosis Factor-alpha - biosynthesis | Interferon-gamma - biosynthesis
Journal Article
Seminars in Cancer Biology, ISSN 1044-579X, 2006, Volume 16, Issue 5, pp. 333 - 343
Natural killer (NK) cells have originally been identified based on their capacity to kill transformed cells in a seemingly non-specific fashion. Over the last...
Tumor escape | NKG2D | Transformation | Tumor immunity | I-RELATED CHAIN | NATURAL-KILLER-CELL | DOWN-REGULATION | MURINE NKG2D | tumor immunity | transformation | tumor escape | CUTTING EDGE | MEDIATED REJECTION | ACTIVATING IMMUNORECEPTOR NKG2D | NK CELLS | ONCOLOGY | COLORECTAL-CANCER | REGULATORY T-CELLS | Immunotherapy, Adoptive - methods | NK Cell Lectin-Like Receptor Subfamily K | Tumor Escape | Receptors, Immunologic - physiology | Humans | Neoplasms - therapy | Animals | Models, Biological | Neoplasms - immunology | Immunity, Cellular - physiology | Receptors, Natural Killer Cell | Ligands | Immunologic Surveillance - physiology | Tumors
Tumor escape | NKG2D | Transformation | Tumor immunity | I-RELATED CHAIN | NATURAL-KILLER-CELL | DOWN-REGULATION | MURINE NKG2D | tumor immunity | transformation | tumor escape | CUTTING EDGE | MEDIATED REJECTION | ACTIVATING IMMUNORECEPTOR NKG2D | NK CELLS | ONCOLOGY | COLORECTAL-CANCER | REGULATORY T-CELLS | Immunotherapy, Adoptive - methods | NK Cell Lectin-Like Receptor Subfamily K | Tumor Escape | Receptors, Immunologic - physiology | Humans | Neoplasms - therapy | Animals | Models, Biological | Neoplasms - immunology | Immunity, Cellular - physiology | Receptors, Natural Killer Cell | Ligands | Immunologic Surveillance - physiology | Tumors
Journal Article