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amino acid sequence (8) 8
arabidopsis-thaliana (8) 8
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indole alkaloid biosynthesis (8) 8
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madagascar periwinkle (8) 8
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Nature, ISSN 0028-0836, 12/2012, Volume 491, Issue 7427, pp. 138 - 142
Journal Article
Journal Article
Journal Article
Plant Physiology, ISSN 0032-0889, 12/2013, Volume 163, Issue 4, pp. 1792 - 1803
Hydroxylation of tabersonine at the C-16 position, catalyzed by tabersonine 16-hydroxylase (T16H), initiates the synthesis of vindoline that constitutes the... 
Leaves | Enzymes | Cell culture techniques | Alkaloids | RNA | Complementary DNA | Genes | Epidermis | Biosynthesis | Plants | BIOCHEMISTRY AND METABOLISM | MADAGASCAR PERIWINKLE | SUSPENSION-CULTURE | ORGANIZATION | ALKALOID BIOSYNTHESIS | G. DON | PATHWAY | EPIDERMIS | PLANTS | INTERMEDIATE | MOLECULAR-CLONING | PLANT SCIENCES | DNA, Complementary - genetics | Cytochrome P-450 Enzyme System - metabolism | Molecular Sequence Data | Substrate Specificity | Plant Epidermis - genetics | RNA, Messenger - metabolism | Organ Specificity - genetics | Biosynthetic Pathways - genetics | Vinblastine - analogs & derivatives | Gene Expression Regulation, Plant | Catharanthus - cytology | Plant Epidermis - cytology | Plant Proteins - metabolism | Indole Alkaloids - chemistry | Plant Epidermis - enzymology | Endoplasmic Reticulum - enzymology | Biocatalysis | Vinblastine - chemistry | Catharanthus - enzymology | Hydroxylation | Quinolines - chemistry | RNA, Messenger - genetics | Gene Silencing | DNA, Complementary - isolation & purification | Metabolome - genetics | Gene Expression Regulation, Enzymologic | Quinolines - metabolism | Plant Proteins - genetics | Genes, Plant - genetics | Cytochrome P-450 Enzyme System - genetics | Vinblastine - biosynthesis | Catharanthus - genetics | Kinetics | Indole Alkaloids - metabolism | Physiological aspects | Lamiales | Hydroxylases | Research | Index Medicus
Journal Article
Plant Molecular Biology, ISSN 0167-4412, 9/2007, Volume 65, Issue 1, pp. 13 - 30
The monoterpene indole alkaloids (MIAs) from Madagascar periwinkle (Catharanthus roseus) are secondary metabolites of high interest due to their therapeutical... 
Life Sciences | Plant Pathology | Biochemistry, general | Compartmentation | Hydroxymethylbutenyl 4-diphosphate synthase | Methyl erythritol phosphate pathway | Catharanthus roseus | Plant Sciences | Monoterpene indole alkaloids | Coordinated regulation | compartmentation | ARABIDOPSIS-THALIANA | coordinated regulation | BIOCHEMISTRY & MOLECULAR BIOLOGY | hydroxymethylbutenyl 4-diphosphate synthase | 2-C-METHYL-D-ERYTHRITOL 4-PHOSPHATE PATHWAY | CAAX-PRENYLTRANSFERASES | NON-MEVALONATE PATHWAY | INDOLE ALKALOID BIOSYNTHESIS | PLANT SCIENCES | ISOPRENOID BIOSYNTHESIS | 5-PHOSPHATE SYNTHASE | DIPHOSPHATE SYNTHASE GCPE | monoterpene indole alkaloids | TRANSCRIPTION FACTOR | methyl erythritol phosphate pathway | INTERCELLULAR TRANSLOCATION | Enzymes - chemistry | Amino Acid Sequence | Cell Line | Enzymes - immunology | Erythritol - analogs & derivatives | Signal Transduction | Enzymes - isolation & purification | DNA, Complementary - genetics | Gene Expression Regulation, Plant - genetics | Molecular Sequence Data | Iridoids - metabolism | Erythritol - biosynthesis | Microscopy, Immunoelectron | Catharanthus - metabolism | Sequence Alignment | In Situ Hybridization | Sugar Phosphates - biosynthesis | Cloning, Molecular | Monoterpenes - metabolism | Antibodies - immunology | Conserved Sequence | Catharanthus - genetics | Transcription, Genetic - genetics | Enzymes - metabolism | Genetic research | Physiological aspects | Enzymes | Index Medicus
Journal Article
Plant Physiology, ISSN 0032-0889, 11/2016, Volume 172, Issue 3, pp. 1563 - 1577
Journal Article
Plant Molecular Biology, ISSN 0167-4412, 7/2012, Volume 79, Issue 4, pp. 443 - 459
Isopentenyl diphosphate isomerases (IDI) catalyze the interconversion of the two isoprenoid universal C5 units, isopentenyl diphosphate and dimethylally... 
Life Sciences | Plant Pathology | Biochemistry, general | Methylerythritol phosphate pathway | Isopentenyl diphosphate isomerase | Dual targeting | Mevalonate pathway | Catharanthus roseus | Isoprenoid | Plant Sciences | METHYLERYTHRITOL PHOSPHATE-PATHWAY | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI | SUBCELLULAR-LOCALIZATION | PLANT SCIENCES | ORGANIZATION | MEVALONIC ACID PATHWAY | ENZYME | ISOPRENOID BIOSYNTHESIS | COMPLEMENTATION | BIOCHEMISTRY | ARABIDOPSIS | Mitochondria - enzymology | Genes, Plant | Molecular Sequence Data | Isoenzymes - chemistry | Recombinant Fusion Proteins - metabolism | Terpenes - metabolism | Isoenzymes - metabolism | Base Sequence | Plants, Genetically Modified | Cloning, Molecular | Carbon-Carbon Double Bond Isomerases - chemistry | Protein Interaction Domains and Motifs | DNA, Plant - genetics | Transformation, Genetic | Amino Acid Sequence | Catharanthus - enzymology | Isoenzymes - genetics | Recombinant Fusion Proteins - chemistry | Carbon-Carbon Double Bond Isomerases - metabolism | Sequence Homology, Amino Acid | Plastids - enzymology | Carbon-Carbon Double Bond Isomerases - genetics | Recombinant Fusion Proteins - genetics | Catharanthus - genetics | Peroxisomes - enzymology | Enzymes | Plant mitochondria | Metabolites | Flowers & plants | Gene expression | Molecular biology | Plastids | Index Medicus | Indole | Roots | Parenchyma | Epidermis | Flowers | Alkaloids | Leaves | Mitochondria | Peroxisomes | Secondary metabolites | Phloem | Green fluorescent protein | monoterpenoids | Fusion protein | Terpenes | Isopentenyl diphosphate
Journal Article
Trends in Biotechnology, ISSN 0167-7799, 2013, Volume 32, Issue 4, pp. 167 - 168
Journal Article
Planta, ISSN 0032-0935, 5/2006, Volume 223, Issue 6, pp. 1191 - 1200
Catharanthus roseus produces a wide range of secondary metabolites, some of which present high therapeutic values such as antitumoral monoterpenoid indole... 
Petals | Alkaloids | Flavonoids | Epidermal cells | Fluorescence | Epidermis | Plants | Indoles | In situ hybridization | Plant cells | Life Sciences | Microscopy | In situ hybridisation | Forestry | Monoterpenoid indole alkaloids | Ecology | Agriculture | Plant Sciences | Catharanthus | CELLS | monoterpenoid indole alkaloids | SUSPENSION CULTURES | ALKALOID ACCUMULATION | PHENYLALANINE AMMONIA-LYASE | TISSUE LOCALIZATION | PLANT SCIENCES | in situ hybridisation | MESSENGER-RNA | BIOSYNTHESIS | GENE-EXPRESSION | microscopy | flavonoids | JASMONATE | epidermis | INTERCELLULAR TRANSLOCATION | Catharanthus - anatomy & histology | Cells, Cultured | Trans-Cinnamate 4-Monooxygenase - analysis | Acyltransferases - analysis | Trans-Cinnamate 4-Monooxygenase - genetics | Plant Proteins - analysis | Phenylalanine Ammonia-Lyase - analysis | Acyltransferases - metabolism | Acyltransferases - genetics | Plant Epidermis - metabolism | Phenylalanine Ammonia-Lyase - metabolism | Catharanthus - metabolism | Plant Proteins - genetics | Indoles - metabolism | Phenylalanine Ammonia-Lyase - genetics | Trans-Cinnamate 4-Monooxygenase - metabolism | In Situ Hybridization | Monoterpenes - metabolism | Flavonoids - biosynthesis | Plant Proteins - metabolism | Alkaloids - biosynthesis | Catharanthus - genetics | Metabolites | Bacteria | Index Medicus
Journal Article
Journal Article
Science, ISSN 0036-8075, 2018, Volume 360, Issue 6394, pp. 1235 - 1239
Journal Article
Nature Chemical Biology, ISSN 1552-4450, 08/2018, Volume 14, Issue 8, pp. 760 - 763
Cyclization reactions that create complex polycyclic scaffolds are hallmarks of alkaloid biosynthetic pathways. We present the discovery of three homologous... 
SERPENTINE | CATHARANTHUS-ROSEUS | NATURAL-PRODUCTS | BIOCHEMISTRY & MOLECULAR BIOLOGY | AJMALINE | GEISSOSCHIZINE METHYL-ETHER | INDOLE ALKALOID BIOSYNTHESIS | VECTOR | Cytochrome | Cytochromes | Chemical reactions | Homology | Indole | Substrates | Index Medicus
Journal Article
Nature Communications, ISSN 2041-1723, 07/2016, Volume 7, Issue 1, pp. 12116 - 12116
Plants produce an enormous array of biologically active metabolites, often with stereo-chemical variations on the same molecular scaffold. These changes in... 
CATHARANTHUS-ROSEUS | ALCOHOL-DEHYDROGENASE | BIOSYNTHESIS | ALSTONINE | MULTIDISCIPLINARY SCIENCES | SEQUENCE | ALMITRINE-RAUBASINE | MACROMOLECULAR CRYSTALLOGRAPHY | INDOLE ALKALOIDS | SOFTWARE | STRICTOSIDINE | Index Medicus
Journal Article