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Immunity, ISSN 1074-7613, 01/2013, Volume 38, Issue 1, pp. 106 - 118
Journal Article
Nature, ISSN 0028-0836, 11/2016, Volume 539, Issue 7628, pp. 294 - 298
Journal Article
Journal Article
Nature, ISSN 0028-0836, 07/2016, Volume 535, Issue 7613, pp. 517 - 522
Journal Article
Science, ISSN 0036-8075, 1/2005, Volume 307, Issue 5707, pp. 258 - 262
Genetic studies have elucidated mechanisms that regulate aging, but there has been little progress in identifying drugs that delay aging. Here, we report that... 
Anticonvulsants | Pumping | Molecular structure | Developmental biology | Mucosa | Reports | Oviposition | Amyloids | Solar fibrils | Genetic mutation | Worms | MUTANTS | C-ELEGANS | CAENORHABDITIS-ELEGANS | MULTIDISCIPLINARY SCIENCES | ETHOSUXIMIDE | LONG | Longevity - drug effects | Humans | Aging - drug effects | Genes, Helminth | Anticonvulsants - pharmacology | Dose-Response Relationship, Drug | Caenorhabditis elegans - physiology | Lactams - pharmacology | Neurons - physiology | Female | Synaptic Transmission - drug effects | Pharynx - physiology | Trimethadione - therapeutic use | Drug Evaluation, Preclinical | Neurons - drug effects | Disorders of Sex Development | Movement - drug effects | Transcription Factors - physiology | Caenorhabditis elegans - growth & development | Caenorhabditis elegans - genetics | Muscles - physiology | Trimethadione - pharmacology | Ethosuximide - therapeutic use | Anticonvulsants - therapeutic use | Vulva | Transcription Factors - genetics | Aldicarb - pharmacology | Reproduction - drug effects | Animals | Caenorhabditis elegans - drug effects | Muscles - drug effects | Muscles - innervation | Oviposition - drug effects | Epilepsy, Absence - drug therapy | Caenorhabditis elegans Proteins - physiology | Mutation | Pharynx - drug effects | Caenorhabditis elegans Proteins - genetics | Ethosuximide - pharmacology | Forkhead Transcription Factors | Drugs | Usage | Ethosuximide | Aging | Research | Nematoda | Nematodes | Genotype & phenotype
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2018, Volume 8, Issue 1, pp. 12851 - 15
Journal Article
Journal Article
eLife, ISSN 2050-084X, 2013, Volume 2, p. e01340
The Hedgehog (Hh) signal is transduced across the membrane by the heptahelical protein Smoothened (Smo), a developmental regulator, oncoprotein and drug target... 
oxysterol | Hedgehog signaling | Zebrafish | cysteine rich domain | smoothened | MAXIMUM-LIKELIHOOD | STEM-CELLS | PROTEIN | SONIC HEDGEHOG | CYSTEINE-RICH DOMAINS | CRYSTAL-STRUCTURE | PATHWAY ACTIVITY | BIOLOGY | N-TERMINAL DOMAIN | MAMMALIAN-CELLS | PRIMARY CILIUM | Hedgehog Proteins - chemistry | Receptors, G-Protein-Coupled - metabolism | Hedgehog Proteins - metabolism | Crystallography, X-Ray | Structure-Activity Relationship | Hedgehog Proteins - genetics | Gene Expression Regulation, Developmental | Smoothened Receptor | Escherichia coli - metabolism | Binding Sites | Protein Structure, Tertiary | Recombinant Proteins - metabolism | Protein Structure, Secondary | Signal Transduction | Zebrafish Proteins - chemistry | Sterols - chemistry | Zebrafish Proteins - metabolism | Zebrafish Proteins - antagonists & inhibitors | Models, Molecular | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Zebrafish - growth & development | Zebrafish - genetics | Animals | Escherichia coli - genetics | Zebrafish - metabolism | Embryo, Nonmammalian | Receptors, G-Protein-Coupled - antagonists & inhibitors | Protein Binding | Ligands | Mice | Receptors, G-Protein-Coupled - genetics | Zebrafish Proteins - genetics | Receptors, G-Protein-Coupled - chemistry | Wnt protein | Frizzled protein | Genes | Lipids | Biology | Hydrophobicity | Chromatography | Membrane proteins | Medicine | Proteins | Hedgehog protein | Binding sites | Crystal structure | Structure-function relationships
Journal Article
Journal Article