Physical Review Letters, ISSN 0031-9007, 2019, Volume 122, Issue 6, pp. 1 - 12
We analyze the impact of a proposed tidal instability coupling p modes and g modes within neutron stars on GW170817. This nonresonant instability transfers...
PHYSICS, MULTIDISCIPLINARY | NEUTRON-STARS | EXCITATION | Neutron stars | Gravitation | Amplitudes | Parameters | Computer simulation | Saturation | Gravitational waves | Stars | Stability analysis | Maxima | Wave breaking | Impact analysis | Upper bounds | Energy dissipation | Binary stars | Orbital stability | Mathematical models | Bayesian analysis | Extreme values
PHYSICS, MULTIDISCIPLINARY | NEUTRON-STARS | EXCITATION | Neutron stars | Gravitation | Amplitudes | Parameters | Computer simulation | Saturation | Gravitational waves | Stars | Stability analysis | Maxima | Wave breaking | Impact analysis | Upper bounds | Energy dissipation | Binary stars | Orbital stability | Mathematical models | Bayesian analysis | Extreme values
Journal Article
1976, 436
Book
Journal of Medicinal Chemistry, ISSN 0022-2623, 10/2013, Volume 56, Issue 20, pp. 8019 - 8031
The concept of “ligand bias” at G protein coupled receptors has been introduced to describe ligands which preferentially stimulate one intracellular signaling...
Analgesics - pharmacology | Acute Pain - drug therapy | Models, Chemical | Humans | Drug Discovery - methods | Structure-Activity Relationship | Receptors, Opioid, mu - agonists | Analgesics - chemical synthesis | Spiro Compounds - chemical synthesis | HEK293 Cells | Molecular Structure | Spiro Compounds - chemistry | Disease Models, Animal | Severity of Illness Index | Receptors, Opioid, mu - metabolism | Rats | Thiophenes - pharmacology | Thiophenes - chemical synthesis | Animals | Analgesics - chemistry | Mice | Thiophenes - chemistry | Acute Pain - pathology | Spiro Compounds - pharmacology | GTP-Binding Proteins - metabolism
Analgesics - pharmacology | Acute Pain - drug therapy | Models, Chemical | Humans | Drug Discovery - methods | Structure-Activity Relationship | Receptors, Opioid, mu - agonists | Analgesics - chemical synthesis | Spiro Compounds - chemical synthesis | HEK293 Cells | Molecular Structure | Spiro Compounds - chemistry | Disease Models, Animal | Severity of Illness Index | Receptors, Opioid, mu - metabolism | Rats | Thiophenes - pharmacology | Thiophenes - chemical synthesis | Animals | Analgesics - chemistry | Mice | Thiophenes - chemistry | Acute Pain - pathology | Spiro Compounds - pharmacology | GTP-Binding Proteins - metabolism
Journal Article
Angewandte Chemie International Edition, ISSN 1433-7851, 02/2015, Volume 54, Issue 6, pp. 1901 - 1905
Telomeric DNA represents a novel target for the development of anticancer drugs. By application of a catalytic metallodrug strategy, a copper–acridine–ATCUN...
DNA cleavage | peptides | carbon | bioinorganic chemistry | anticancer agents | Anticancer agents | Peptides | Bioinorganic chemistry | Carbon | Dna cleavage | CANCER-CELLS | RECOGNITION | LENGTH | IRES RNA | CHEMISTRY, MULTIDISCIPLINARY | REPLICATIVE SENESCENCE | STRUCTURAL BASIS | HUMAN FIBROBLASTS | AGENTS | TARGETED CLEAVAGE | BINDING | Prevention | Care and treatment | Ionization | Pharmacy | DNA | Genetic research | Fluorescence | Drugstores | Copper | Mass spectrometry | Cancer | Breast cancer | Deoxyribonucleic acid--DNA | Pathways | Catalysts | Deoxyribonucleic acid | Cleavage | Inhibition | Catalysis | Apoptosis
DNA cleavage | peptides | carbon | bioinorganic chemistry | anticancer agents | Anticancer agents | Peptides | Bioinorganic chemistry | Carbon | Dna cleavage | CANCER-CELLS | RECOGNITION | LENGTH | IRES RNA | CHEMISTRY, MULTIDISCIPLINARY | REPLICATIVE SENESCENCE | STRUCTURAL BASIS | HUMAN FIBROBLASTS | AGENTS | TARGETED CLEAVAGE | BINDING | Prevention | Care and treatment | Ionization | Pharmacy | DNA | Genetic research | Fluorescence | Drugstores | Copper | Mass spectrometry | Cancer | Breast cancer | Deoxyribonucleic acid--DNA | Pathways | Catalysts | Deoxyribonucleic acid | Cleavage | Inhibition | Catalysis | Apoptosis
Journal Article
2010, ISBN 082634870X, 175
Book
Physical Chemistry Chemical Physics, ISSN 1463-9076, 2016, Volume 18, Issue 36, pp. 24825 - 24829
Graphitic carbon nitride (g-C3N4) synthesised from a urea precursor is an excellent CO2 reduction photocatalyst using [Co(bpy)(n)](2+) as a co-catalyst. A...
GRAPHITIC CARBON NITRIDE | COMPLEX | SEMICONDUCTOR | EVOLUTION | PHYSICS, ATOMIC, MOLECULAR & CHEMICAL | CHEMISTRY, PHYSICAL | HYDROGEN-PRODUCTION | CHARGE SEPARATION | NI CATALYST | PHOTOCATALYST | VISIBLE-LIGHT IRRADIATION | WATER | Availability | Reduction | Absorption | Precursors | Physical chemistry | Carbon dioxide | Ureas | Photocatalysts
GRAPHITIC CARBON NITRIDE | COMPLEX | SEMICONDUCTOR | EVOLUTION | PHYSICS, ATOMIC, MOLECULAR & CHEMICAL | CHEMISTRY, PHYSICAL | HYDROGEN-PRODUCTION | CHARGE SEPARATION | NI CATALYST | PHOTOCATALYST | VISIBLE-LIGHT IRRADIATION | WATER | Availability | Reduction | Absorption | Precursors | Physical chemistry | Carbon dioxide | Ureas | Photocatalysts
Journal Article
Physical Chemistry Chemical Physics, ISSN 1463-9076, 2016, Volume 18, Issue 36, pp. 24825 - 24829
Graphitic carbon nitride (g-C3N4) synthesised from a urea precursor is an excellent CO2 reduction photocatalyst using [Co(bpy)n]2+ as a co-catalyst. A...
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 5/2016, Volume 113, Issue 19, pp. 5364 - 5369
HLA-G, a nonclassical HLA molecule uniquely expressed in the placenta, is a central component of fetus-induced immune tolerance during pregnancy. The...
Human immune gene regulation | Pregnancy | CRISPR/Cas9 | Immune tolerance | MPRA | Maternal-Fetal Exchange - immunology | Immunogenetic Phenomena - genetics | Placenta - immunology | Humans | Gene Expression Regulation, Developmental - genetics | Maternal-Fetal Exchange - genetics | Enhancer Elements, Genetic - immunology | Gene Expression Regulation, Developmental - immunology | Pregnancy - immunology | Trophoblasts - immunology | Histocompatibility, Maternal-Fetal - genetics | Female | Enhancer Elements, Genetic - genetics | HLA-G Antigens - immunology | HLA-G Antigens - genetics | Histocompatibility, Maternal-Fetal - immunology | Biological Sciences | CRISPR | immune tolerance | human immune gene regulation | pregnancy | Cas9
Human immune gene regulation | Pregnancy | CRISPR/Cas9 | Immune tolerance | MPRA | Maternal-Fetal Exchange - immunology | Immunogenetic Phenomena - genetics | Placenta - immunology | Humans | Gene Expression Regulation, Developmental - genetics | Maternal-Fetal Exchange - genetics | Enhancer Elements, Genetic - immunology | Gene Expression Regulation, Developmental - immunology | Pregnancy - immunology | Trophoblasts - immunology | Histocompatibility, Maternal-Fetal - genetics | Female | Enhancer Elements, Genetic - genetics | HLA-G Antigens - immunology | HLA-G Antigens - genetics | Histocompatibility, Maternal-Fetal - immunology | Biological Sciences | CRISPR | immune tolerance | human immune gene regulation | pregnancy | Cas9
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 04/2006, Volume 281, Issue 16, pp. 10856 - 10864
Parathyroid hormone (PTH) regulates calcium homeostasis via the type I PTH/PTH-related peptide (PTH/PTHrP) receptor (PTH1R). The purpose of the present study...
SIGNAL-REGULATED KINASES | KIDNEY-CELLS | PTH | DESENSITIZATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | COUPLED RECEPTOR | INDEPENDENT FUNCTIONS | INTERMITTENT | ADRENERGIC-RECEPTOR | BONE | PEPTIDE | Protein Kinases - metabolism | Phosphorylation | Immunoprecipitation | Receptor, Parathyroid Hormone, Type 1 - metabolism | Humans | Arrestins - physiology | Maleimides - pharmacology | Immunoblotting | Arrestins - metabolism | MAP Kinase Signaling System | Isoquinolines - pharmacology | Transfection | Time Factors | Indoles - pharmacology | Culture Media, Serum-Free - pharmacology | Cyclic AMP - metabolism | Cyclic AMP-Dependent Protein Kinases - metabolism | Cell Line | GTP-Binding Proteins - physiology | Signal Transduction | Cells, Cultured | DNA - metabolism | Sulfonamides - pharmacology | Mitogen-Activated Protein Kinase 3 - metabolism | beta-Arrestin 2 | beta-Arrestin 1 | beta-Arrestins | Receptor, Parathyroid Hormone, Type 1 - genetics | Ligands | Mutation | DNA, Complementary - metabolism | GTP-Binding Proteins - metabolism | Mitogen-Activated Protein Kinase 1 - metabolism | RNA, Small Interfering - metabolism
SIGNAL-REGULATED KINASES | KIDNEY-CELLS | PTH | DESENSITIZATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | COUPLED RECEPTOR | INDEPENDENT FUNCTIONS | INTERMITTENT | ADRENERGIC-RECEPTOR | BONE | PEPTIDE | Protein Kinases - metabolism | Phosphorylation | Immunoprecipitation | Receptor, Parathyroid Hormone, Type 1 - metabolism | Humans | Arrestins - physiology | Maleimides - pharmacology | Immunoblotting | Arrestins - metabolism | MAP Kinase Signaling System | Isoquinolines - pharmacology | Transfection | Time Factors | Indoles - pharmacology | Culture Media, Serum-Free - pharmacology | Cyclic AMP - metabolism | Cyclic AMP-Dependent Protein Kinases - metabolism | Cell Line | GTP-Binding Proteins - physiology | Signal Transduction | Cells, Cultured | DNA - metabolism | Sulfonamides - pharmacology | Mitogen-Activated Protein Kinase 3 - metabolism | beta-Arrestin 2 | beta-Arrestin 1 | beta-Arrestins | Receptor, Parathyroid Hormone, Type 1 - genetics | Ligands | Mutation | DNA, Complementary - metabolism | GTP-Binding Proteins - metabolism | Mitogen-Activated Protein Kinase 1 - metabolism | RNA, Small Interfering - metabolism
Journal Article
Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics, ISSN 0370-2693, 12/2015, Volume 751, pp. 63 - 80
An observation of the Λ →ψ(2S)Λ decay and a comparison of its branching fraction with that of the Λ →J/ψΛ decay has been made with the ATLAS detector in...
Journal Article
Nature, ISSN 0028-0836, 02/2001, Volume 409, Issue 6823, pp. 1071 - 1077
A multitude of heptahelical receptors use heterotrimeric G proteins to transduce signals to specific effector target molecules. The G protein transducin, Gt,...
Amino Acid Sequence | GTP-Binding Proteins - chemistry | Models, Molecular | Molecular Sequence Data | Crystallography, X-Ray | 3',5'-Cyclic-GMP Phosphodiesterases - chemistry | Transducin - chemistry | Rod Cell Outer Segment - chemistry | Sequence Alignment | 3',5'-Cyclic-GMP Phosphodiesterases - metabolism | Animals | Cattle | RGS Proteins - chemistry | Cloning, Molecular | Protein Binding | RGS Proteins - metabolism | Protein Conformation | Transducin - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 6 | Rod Cell Outer Segment - enzymology | GTP-Binding Proteins - metabolism
Amino Acid Sequence | GTP-Binding Proteins - chemistry | Models, Molecular | Molecular Sequence Data | Crystallography, X-Ray | 3',5'-Cyclic-GMP Phosphodiesterases - chemistry | Transducin - chemistry | Rod Cell Outer Segment - chemistry | Sequence Alignment | 3',5'-Cyclic-GMP Phosphodiesterases - metabolism | Animals | Cattle | RGS Proteins - chemistry | Cloning, Molecular | Protein Binding | RGS Proteins - metabolism | Protein Conformation | Transducin - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 6 | Rod Cell Outer Segment - enzymology | GTP-Binding Proteins - metabolism
Journal Article
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, ISSN 0022-3565, 03/2013, Volume 344, Issue 3, pp. 708 - 717
The concept of ligand bias at G protein-coupled receptors broadens the possibilities for agonist activities and provides the opportunity to develop safer, more...
BETA-ARRESTIN 2 | SIGNAL-TRANSDUCTION | 7-TRANSMEMBRANE RECEPTORS | ACTIVATION | PAIN | BETA-ARRESTIN-2 | TOLERANCE | FUNCTIONAL SELECTIVITY | PHARMACOLOGY & PHARMACY | KNOCKOUT MICE | AGONIST
BETA-ARRESTIN 2 | SIGNAL-TRANSDUCTION | 7-TRANSMEMBRANE RECEPTORS | ACTIVATION | PAIN | BETA-ARRESTIN-2 | TOLERANCE | FUNCTIONAL SELECTIVITY | PHARMACOLOGY & PHARMACY | KNOCKOUT MICE | AGONIST
Journal Article
Biochemical Society Transactions, ISSN 0300-5127, 06/2015, Volume 43, Issue 3, pp. 338 - 342
There has recently been a huge increase in interest in the formation of stable G-quadruplex structures in mRNAs and their functional significance. In neurons,...
Fragile X mental retardation protein (FMRP) | Translation | Purine-rich element-binding protein α (Pur-α) | Messenger RNA (mRNA) | Heterogeneous nuclear ribonucleoprotein (hnRNP) A2 | G-quadruplex | LOCALIZATION | fragile X mental retardation protein (FMRP) | DROSOPHILA MODEL | BIOCHEMISTRY & MOLECULAR BIOLOGY | NRAS PROTOONCOGENE | NEURODEGENERATION | heterogeneous nuclear ribonucleoprotein (hnRNP) A2 | PROTEIN-SYNTHESIS | DENDRITIC SPINES | purine-rich element-binding protein alpha (Pur-alpha) | RNA G-QUADRUPLEXES | translation | messenger RNA (mRNA) | AXONAL MESSENGER-RNA | PUR-ALPHA | HNRNP A2 | Neurons - pathology | RNA, Messenger - biosynthesis | Protein Biosynthesis | Cell Nucleus - metabolism | Cell Nucleus - genetics | Humans | RNA, Messenger - genetics | G-Quadruplexes | Neurons - metabolism | RNA, Messenger - metabolism
Fragile X mental retardation protein (FMRP) | Translation | Purine-rich element-binding protein α (Pur-α) | Messenger RNA (mRNA) | Heterogeneous nuclear ribonucleoprotein (hnRNP) A2 | G-quadruplex | LOCALIZATION | fragile X mental retardation protein (FMRP) | DROSOPHILA MODEL | BIOCHEMISTRY & MOLECULAR BIOLOGY | NRAS PROTOONCOGENE | NEURODEGENERATION | heterogeneous nuclear ribonucleoprotein (hnRNP) A2 | PROTEIN-SYNTHESIS | DENDRITIC SPINES | purine-rich element-binding protein alpha (Pur-alpha) | RNA G-QUADRUPLEXES | translation | messenger RNA (mRNA) | AXONAL MESSENGER-RNA | PUR-ALPHA | HNRNP A2 | Neurons - pathology | RNA, Messenger - biosynthesis | Protein Biosynthesis | Cell Nucleus - metabolism | Cell Nucleus - genetics | Humans | RNA, Messenger - genetics | G-Quadruplexes | Neurons - metabolism | RNA, Messenger - metabolism
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 03/2013, Volume 344, Issue 3, pp. 708 - 717
Journal Article
Physical Review Letters, ISSN 0031-9007, 02/2019, Volume 122, Issue 6, pp. 1 - 12
We analyze the impact of a proposed tidal instability coupling p modes and g modes within neutron stars on GW170817. This nonresonant instability transfers...
Physics and Astronomy(all)
Physics and Astronomy(all)
Journal Article
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 05/2019, Volume 62, Issue 10, pp. 5040 - 5048
Telomere length determines the replicative capacity of mammalian cells. Successive telomere reduction to a critically short length can lead to cellular...
DESIGN | CHEMISTRY, MEDICINAL | BIOMARKER | STRUCTURAL BASIS | DNA | AGENTS | CLEAVAGE | CELLULAR SENESCENCE | CULTURE
DESIGN | CHEMISTRY, MEDICINAL | BIOMARKER | STRUCTURAL BASIS | DNA | AGENTS | CLEAVAGE | CELLULAR SENESCENCE | CULTURE
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 08/2017, Volume 362, Issue 2, pp. 254 - 262
Prescription opioids are a mainstay in the treatment of acute moderate to severe pain. However, chronic use leads to a host of adverse consequences including...
GTP-Binding Proteins - physiology | Drug Administration Schedule | GTP-Binding Proteins - agonists | Humans | Mice, Inbred C57BL | Male | Pain Measurement - drug effects | Receptors, Opioid, mu - agonists | Hyperalgesia - pathology | Dose-Response Relationship, Drug | Pain Measurement - methods | Animals | Hyperalgesia - drug therapy | Analgesics, Opioid - administration & dosage | HEK293 Cells | Mice | Receptors, Opioid, mu - physiology | Index Medicus
GTP-Binding Proteins - physiology | Drug Administration Schedule | GTP-Binding Proteins - agonists | Humans | Mice, Inbred C57BL | Male | Pain Measurement - drug effects | Receptors, Opioid, mu - agonists | Hyperalgesia - pathology | Dose-Response Relationship, Drug | Pain Measurement - methods | Animals | Hyperalgesia - drug therapy | Analgesics, Opioid - administration & dosage | HEK293 Cells | Mice | Receptors, Opioid, mu - physiology | Index Medicus
Journal Article
Xenotransplantation, ISSN 0908-665X, 09/2017, Volume 24, Issue 5, pp. e12346 - n/a
Journal Article