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Lancet Infectious Diseases, The, ISSN 1473-3099, 2015, Volume 15, Issue 9, pp. 992 - 993
To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/S1473-3099(15)00252-2 Byline: Patricia E Fast (a), Josephine H Cox (a) 
Infectious Disease | IMMUNITY | INFECTIOUS DISEASES | Influenza A Virus, H1N1 Subtype - immunology | Influenza Vaccines - immunology | Humans | Female | Male | Antibodies, Viral - blood | Influenza, Human - immunology | Influenza vaccines | AIDS vaccines | Influenza | Immunoglobulins | Vaccines | Vectors (Biology) | Adenoviruses
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 2011, Volume 6, Issue 5, p. e19252
Background: DNA-based vaccines have been safe but weakly immunogenic in humans to date. Methods and Findings: We sought to determine the safety, tolerability,... 
VIRUS ANKARA | NONHUMAN-PRIMATES | PROTECTS MICE | HUMORAL IMMUNE-RESPONSES | PRIME | BOOST | MULTIDISCIPLINARY SCIENCES | PLASMID DNA | PHASE-1 SAFETY | T-CELLS | RHESUS MACAQUES | AIDS Vaccines - pharmacology | Double-Blind Method | Electroporation - standards | Humans | Middle Aged | Cytokines - secretion | Male | Injections, Intramuscular | Electroporation - methods | Vaccines, DNA - administration & dosage | Young Adult | HIV-1 - immunology | Immunity, Cellular - drug effects | Adolescent | Adult | Female | T-Lymphocytes - immunology | AIDS Vaccines - administration & dosage | Vaccines, DNA - pharmacology | Antigens | AIDS vaccines | Immune response | Analysis | Vaccination | DNA | B cells | Research | Biological response modifiers | T cells | HIV (Viruses) | Interferon gamma | Drug delivery systems | Laboratories | CD8 antigen | Lymphocytes T | DNA vaccines | Vaccines | Immunity | Immunology | Acquired immune deficiency syndrome--AIDS | Human immunodeficiency virus--HIV | Enzyme-linked immunosorbent assay | Deoxyribonucleic acid--DNA | Immune system | Cytokines | Secretion | Electroporation | Durability | Injection | Vectors (Biology) | CD4 antigen | Animals | Immunogenicity | Adenoviruses | γ-Interferon | Interferon | Prostate cancer | Acquired immune deficiency syndrome | Deoxyribonucleic acid | AIDS | HIV | Human immunodeficiency virus
Journal Article
by Gaudinski, Martin R and Houser, Katherine V and Morabito, Kaitlyn M and Hu, Zonghui and Yamshchikov, Galina and Rothwell, Ro Shauna and Berkowitz, Nina and Mendoza, Floreliz and Saunders, Jamie G and Novik, Laura and Hendel, Cynthia S and Holman, LaSonji A and Gordon, Ingelise J and Gordon, David N and Cox, Josephine H and Edupuganti, Srilatha and McArthur, Monica A and Rouphael, Nadine G and Lyke, Kirsten E and Cummings, Ginny E and Sitar, Sandra and Bailer, Robert T and Foreman, Bryant M and Burgomaster, Katherine and Pelc, Rebecca S and DeMaso, Christina R and Dowd, Kimberly A and Laurencot, Carolyn and Schwartz, Richard M and Mascola, John R and Graham, Barney S and Pierson, Theodore C and Ledgerwood, Julie E and Chen, Wilbur and Chen, Grace L and Plummer, Sarah and Costner, Pamela and Zephir, Kathryn and Casazza, Joseph and Ola, Abidemi and Victorino, Milalynn and Levinson, Carol and Whalen, William and Wang, Xiaolin and Cunningham, Jennifer and Vasilenko, Olga and Burgos Florez, Maria and Hickman, Somia and Pittman, Iris and Le, Lam and Larkin, Brenda and Andrews, Charla and Apte, Preeti and Hicks, Renunda and Trelles Cartagena, Cora and Williams, Pernell and Boyd, Catina R and Conan-Cibotti, Michelle and Stein, Judy and Kaltovich, Florence and DeCederfelt, Hope and McAdams, Stacey and Renehan, Phyllis and Greenberg, Nancy and Wymer, Nancy and Wadsworth, Linda and Billington, Melissa and Robinson, Toni and Boyce, Colleen and Pa'ahana Brown, Faith and Chrisley, Lisa and Kwon, Alyson and Patel, Prashant and Kominou, Panagoita and Dorsey, Brenda and Eddington, Staci and Telscher, Shinyi and Lee, Myoughee and Mosely, Regina and Ross, April and Ford, Geoffrey and Domjahn, Briyana and Xu, Jianguo and Beck, Allison and Fineman, Rebecca and Heeke, Shiela and Winter, Jean and Nagar, Shashi and Kelley, Colleen and Mulligan, Mark and VRC 319 Study Team and VRC 320 Study Team and VRC 319 and VRC 320 study teams
The Lancet, ISSN 0140-6736, 02/2018, Volume 391, Issue 10120, pp. 552 - 562
Journal Article
PLoS ONE, ISSN 1932-6203, 08/2015, Volume 10, Issue 8, p. e0134287
Background Strategies to enhance the immunogenicity of DNA vaccines in humans include i) co-administration of molecular adjuvants, ii) intramuscular... 
IMMUNIZATION | HUMORAL IMMUNE-RESPONSES | T-CELL RESPONSES | VIVO | MULTIDISCIPLINARY SCIENCES | PLASMID DNA | INFECTION | IL-12 | CLINICAL-APPLICATION | RHESUS MACAQUES | DELIVERY | Demography | Humans | Middle Aged | AIDS Vaccines - immunology | Male | Interferon-gamma - metabolism | AIDS Vaccines - adverse effects | Young Adult | HIV Infections - immunology | Flow Cytometry | Immunization, Secondary | HIV Antibodies - immunology | Immunity, Humoral | Placebos | Adult | Female | DNA, Viral - adverse effects | Immunization | Double-Blind Method | Electroporation | Enzyme-Linked Immunospot Assay | DNA, Viral - immunology | Interleukin-12 - immunology | Adenoviridae - metabolism | CD8-Positive T-Lymphocytes - immunology | Immunity, Cellular | Clinical trials | Economic aspects | Usage | AIDS vaccines | Research | Biological response modifiers | Interleukin | Antibodies | Lymphocytes T | DNA vaccines | Vaccines | Antibody response | Randomization | Acquired immune deficiency syndrome--AIDS | Lymphocytes | Human immunodeficiency virus--HIV | Plasmid DNA | Enzyme-linked immunosorbent assay | Deoxyribonucleic acid--DNA | Recombinant | Antigens | Phenotypes | Abnormalities | Adjuvants | Interleukin 12 | Priming | Molecular chains | Immunogenicity | Plasmids | γ-Interferon | Adults | Interferon | Acquired immune deficiency syndrome | Deoxyribonucleic acid | AIDS | HIV | DNA | Human immunodeficiency virus
Journal Article
The Journal of Infectious Diseases, ISSN 0022-1899, 2/2010, Volume 201, Issue 4, pp. 600 - 607
Background. Human immunodeficiency virus (HIV) vaccine development remains a global priority. We describe the safety and immunogenicity of a multiclade DNA... 
HIV/AIDS | Antigens | AIDS vaccines | Volunteerism | HIV | Genetic vectors | Plasmids | Vaccination | Adenoviruses | Placebos | HIV 1 | SURVIVAL | IMMUNITY | INFECTIOUS DISEASES | MICROBIOLOGY | IMMUNOLOGY | AIDS VACCINE | TRIAL | DOUBLE-BLIND | IMMUNODEFICIENCY VIRUS CHALLENGE | INFECTION | CANDIDATE VACCINE | MONKEYS | MEMORY T-CELLS | Africa, Eastern | HIV Infections - prevention & control | Vaccines, DNA - genetics | Human Immunodeficiency Virus Proteins - immunology | Humans | Middle Aged | AIDS Vaccines - immunology | Vaccines, DNA - immunology | Male | Interferon-gamma - metabolism | Antibodies, Viral - blood | Vaccines, DNA - administration & dosage | AIDS Vaccines - adverse effects | CD4-Positive T-Lymphocytes - immunology | Young Adult | HIV Infections - immunology | Antibodies, Neutralizing - immunology | Leukocytes, Mononuclear - immunology | Plasmids - genetics | Adenoviridae - genetics | Adult | Female | Adenoviridae - immunology | Double-Blind Method | Enzyme-Linked Immunosorbent Assay | Plasmids - immunology | Cells, Cultured | HIV-1 - genetics | Antigens, Viral - immunology | DNA, Viral - immunology | HIV-1 - immunology | Vaccines, DNA - adverse effects | Adolescent | AIDS Vaccines - genetics | Antibodies, Viral - immunology | Human Immunodeficiency Virus Proteins - genetics | AIDS Vaccines - administration & dosage | CD8-Positive T-Lymphocytes - immunology | DNA, Viral - genetics | Antibodies, Neutralizing - blood
Journal Article
PLoS ONE, ISSN 1932-6203, 08/2012, Volume 7, Issue 8, p. e41936
Background: We conducted a phase I, randomized, double-blind, placebo-controlled trial to assess the safety and immunogenicity of escalating doses of two... 
AIDS VACCINE | NEUTRALIZING ANTIBODIES | RHESUS-MONKEYS | EFFICACY TRIAL | CELLULAR IMMUNE-RESPONSES | BIOLOGY | INFECTION | HUMAN-IMMUNODEFICIENCY-VIRUS | QUALITY-ASSURANCE | CD8(+) T-CELLS | RATIONAL DESIGN | HIV Infections - prevention & control | Dose-Response Relationship, Immunologic | Humans | Middle Aged | Vaccination | AIDS Vaccines - immunology | Male | Antibodies, Viral - blood | CD4-Positive T-Lymphocytes - immunology | HIV Infections - immunology | Immunity, Cellular - drug effects | Adult | Female | HIV Infections - blood | Retroviridae Proteins - immunology | Immunity, Cellular - genetics | Double-Blind Method | Adenoviruses, Human - immunology | HIV Infections - genetics | Immunity, Humoral - genetics | HIV-1 - genetics | Retroviridae Proteins - genetics | HIV-1 - immunology | Adolescent | Immunity, Humoral - drug effects | AIDS Vaccines - genetics | Antibodies, Viral - immunology | Adenoviruses, Human - genetics | AIDS Vaccines - administration & dosage | CD8-Positive T-Lymphocytes - immunology | Antigens | AIDS vaccines | Viral proteins | Adenoviruses | Clinical trials | DNA polymerases | Adults | Research | HIV (Viruses) | T cells | RNA-directed DNA polymerase | Laboratories | CD8 antigen | Antibodies | Infections | Lymphocytes T | Vaccines | Multivariate analysis | Proteins | Mens health | Randomization | Immunology | Acquired immune deficiency syndrome--AIDS | Human immunodeficiency virus--HIV | Peripheral blood mononuclear cells | Enzyme-linked immunosorbent assay | Deoxyribonucleic acid--DNA | Recombinant | Expression vectors | Integrase | Women | Immunization | Immunoglobulins | Dentistry | CD4 antigen | Medicine | Nef protein | Immunogenicity | γ-Interferon | Acquired immune deficiency syndrome | Deoxyribonucleic acid | AIDS | HIV | DNA | Human immunodeficiency virus
Journal Article
PLoS ONE, ISSN 1932-6203, 2010, Volume 5, Issue 11, p. e13983
Background: We conducted a Phase I randomized, dose-escalation, route-comparison trial of MVA-CMDR, a candidate HIV-1 vaccine based on a recombinant modified... 
BOOST VACCINE | PRIME | T-CELL RESPONSES | IMMUNE-RESPONSES | DNA | BIOLOGY | SMALLPOX VACCINATION | HUMAN-IMMUNODEFICIENCY-VIRUS | NYVAC-C | HIV-1 VACCINE | SUBTYPE-B | HIV Infections - prevention & control | Headache - etiology | Human Immunodeficiency Virus Proteins - immunology | Immunity, Humoral - immunology | United States | Humans | AIDS Vaccines - immunology | Fatigue - etiology | Male | Vaccination - adverse effects | Thailand | Vaccinia virus - genetics | Dose-Response Relationship, Drug | HIV Infections - immunology | Flow Cytometry | Immunity, Cellular - drug effects | Vaccination - methods | Recombination, Genetic | Adult | Female | Injections, Intradermal | Enzyme-Linked Immunosorbent Assay | Injections, Intramuscular | HIV-1 - genetics | Genetic Vectors - genetics | Immunity, Cellular - immunology | HIV-1 - immunology | Nausea - etiology | Immunity, Humoral - drug effects | Human Immunodeficiency Virus Proteins - genetics | AIDS Vaccines - administration & dosage | AIDS vaccines | Analysis | Vaccination | Clinical trials | T cells | HIV (Viruses) | Health aspects | Vaccinia | Antibodies | Lymphocytes T | Vaccines | Dosage | Assaying | Gene sequencing | Randomization | Acquired immune deficiency syndrome--AIDS | Lymphocytes | Human immunodeficiency virus--HIV | Peripheral blood mononuclear cells | Safety | Enzyme-linked immunosorbent assay | Recombinant | Binding | Good Manufacturing Practice | Immune response (cell-mediated) | Health risks | T cell receptors | Immune response (humoral) | CD4 antigen | Immunogenicity | γ-Interferon | Glycoprotein gp120 | Cytokines | Corticotropin-releasing hormone | Risk factors | Infection | Gag protein | Acquired immune deficiency syndrome | AIDS | HIV | Human immunodeficiency virus
Journal Article
PLoS ONE, ISSN 1932-6203, 2010, Volume 5, Issue 9, pp. 1 - 16
Background: We conducted a double-blind, randomized, placebo-controlled Phase I study of a recombinant replication-defective adenovirus type 5 (rAd5) vector... 
IMMUNITY | NEUTRALIZING ANTIBODIES | ASSAY | REPLICATION | MULTIDISCIPLINARY SCIENCES | CLINICAL-TRIALS | PHASE-1 SAFETY | CANDIDATE | INFECTION | GAG | T-CELLS | HIV Infections - prevention & control | Humans | Middle Aged | AIDS Vaccines - immunology | Vaccines, DNA - immunology | pol Gene Products, Human Immunodeficiency Virus - immunology | Genetic Vectors - adverse effects | Male | AIDS Vaccines - adverse effects | Young Adult | HIV Infections - immunology | Immunization, Secondary | Drug-Related Side Effects and Adverse Reactions | Adenoviridae - genetics | Adult | gag Gene Products, Human Immunodeficiency Virus - genetics | Adenoviridae - immunology | pol Gene Products, Human Immunodeficiency Virus - genetics | pol Gene Products, Human Immunodeficiency Virus - adverse effects | Double-Blind Method | Genetic Vectors - immunology | HIV Infections - virology | HIV-1 - genetics | Genetic Vectors - genetics | HIV-1 - classification | HIV-1 - immunology | Vaccines, DNA - adverse effects | Adolescent | gag Gene Products, Human Immunodeficiency Virus - adverse effects | Antibodies, Viral - immunology | gag Gene Products, Human Immunodeficiency Virus - immunology | HIV antigens | Medical research | AIDS vaccines | Safety and security measures | Biological response modifiers | HIV (Viruses) | Adenoviruses | DNA | Medicine, Experimental | Genetic research | Interferon | Health aspects | HIV infection | Laboratories | Antibodies | Infections | DNA vaccines | Vaccines | Dosage | Immunity | Epidemiology | Proteins | Randomization | Immunology | Acquired immune deficiency syndrome--AIDS | Lymphocytes | Human immunodeficiency virus--HIV | Safety | Public health | Deoxyribonucleic acid--DNA | Enzyme-linked immunosorbent assay | Recombinant | Immune system | Antigens | Immunoglobulins | Immune response | Priming | Immune response (humoral) | Infectious diseases | Nef protein | Immunogenicity | γ-Interferon | Adults | Acquired immune deficiency syndrome | Deoxyribonucleic acid | AIDS | HIV | Human immunodeficiency virus
Journal Article
Journal of Immunology, ISSN 0022-1767, 12/2018, Volume 201, Issue 12, pp. 3804 - 3814
Dengue virus (DENY) and Zika virus (ZIKV) are mosquito-borne pathogens that have a significant impact on human health. Immune sera, mAbs, and memory B cells... 
INFECTION | IMMUNOLOGY | ANTIBODY-RESPONSE | VACCINE | ANTIGEN
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2012, Volume 7, Issue 9, p. e45840
We characterized prime-boost vaccine regimens using heterologous and homologous vector and gene inserts. Heterologous regimens offer a promising approach that... 
SIV | IMMUNOGENICITY | PROTECTION | DNA | MULTIDISCIPLINARY SCIENCES | ANKARA | VACCINE VECTORS | Enzyme-Linked Immunosorbent Assay - methods | CD8-Positive T-Lymphocytes - cytology | Flow Cytometry - methods | Immune System - physiology | Cytokines - metabolism | Humans | Spleen - cytology | Interferon-gamma - metabolism | Viral Proteins - metabolism | Histocompatibility Antigens Class I - metabolism | Animals | Spleen - metabolism | T-Lymphocytes - cytology | Adenoviridae - genetics | Female | HIV - metabolism | Immunologic Memory | Lysosomal-Associated Membrane Protein 1 - biosynthesis | Mice | Mice, Inbred BALB C | Immunity, Cellular | Usage | Immune response | Cytokines | Vaccination | Physiological aspects | Research | Vaccines | T cells | HIV (Viruses) | CD8 antigen | Effector cells | Staining | Homology | Lymphocytes T | Immunity | Proteins | Interleukin 2 | Acquired immune deficiency syndrome--AIDS | Lymphocytes | Human immunodeficiency virus--HIV | Inserts | Enzyme-linked immunosorbent assay | Recombinant | Immune system | Immunological memory | Immunization | Memory cells | Immune response (cell-mediated) | Tumor necrosis factor-α | Studies | Infectious diseases | Nef protein | Adenoviruses | γ-Interferon | Phenotyping | Interferon | Laboratory animals | Acquired immune deficiency syndrome | AIDS | HIV | Human immunodeficiency virus
Journal Article