American Journal of Physiology - Renal Physiology, ISSN 0363-6127, 05/2019, Volume 316, Issue 5, pp. F986 - F992
Isoform 3 of the Na+/H+ exchanger (NHE3) is responsible for the majority of the reabsorption of NaCl, NaHCO3, and. consequently, water in the renal proximal...
Myosin VI | Extracellular volume homeostasis | Sodium reabsorption | Myosin IIA | myosin IIA | myosin VI | PHYSIOLOGY | KINASE-A | HEAVY-CHAIN IIA | SODIUM TRANSPORTERS | ANGIOTENSIN-II | NEPHRON FUNCTION | BLOOD-PRESSURE | MICE LACKING | extracellular volume homeostasis | sodium reabsorption | UROLOGY & NEPHROLOGY | NA+/H+ EXCHANGER NHE3 | APICAL MEMBRANE | GENDER-DIFFERENCES
Myosin VI | Extracellular volume homeostasis | Sodium reabsorption | Myosin IIA | myosin IIA | myosin VI | PHYSIOLOGY | KINASE-A | HEAVY-CHAIN IIA | SODIUM TRANSPORTERS | ANGIOTENSIN-II | NEPHRON FUNCTION | BLOOD-PRESSURE | MICE LACKING | extracellular volume homeostasis | sodium reabsorption | UROLOGY & NEPHROLOGY | NA+/H+ EXCHANGER NHE3 | APICAL MEMBRANE | GENDER-DIFFERENCES
Journal Article
American Journal of Physiology, ISSN 0363-6143, 11/2016, Volume 311, Issue 5, p. C768
 Binding of angiotensin II (ANG II) to the AT^sub 1^ receptor (AT^sub 1^R) in the proximal tubule stimulates Na+/H+ exchanger isoform 3 (NHE3) activity...
Hypothesis testing | Proteins | Phosphorylation | Physiology | ACE inhibitors | Cells
Hypothesis testing | Proteins | Phosphorylation | Physiology | ACE inhibitors | Cells
Journal Article
American Journal of Physiology: Cell Physiology, ISSN 0363-6143, 11/2016, Volume 311, Issue 5, pp. C768 - C768
Binding of angiotensin II (ANG II) to the AT sub( 1) receptor (AT sub( 1)R) in the proximal tubule stimulates Na+/H+ exchanger isoform 3 (NHE3) activity...
Journal Article
American Journal of Physiology, ISSN 0363-6143, 09/2014, Volume 206, Issue 6, p. C532
 Cumulative evidence suggests that guanylin peptides play an important role on electrolyte homeostasis. We have previously reported that uroguanylin (UGN)...
Peptides | Homeostasis | Enzyme kinetics | Gene expression | Adenosine triphosphatase | Cells
Peptides | Homeostasis | Enzyme kinetics | Gene expression | Adenosine triphosphatase | Cells
Journal Article
American Journal of Physiology - Renal Physiology, ISSN 0363-6127, 2011, Volume 301, Issue 2, pp. F355 - F363
Crajoinas RO, Oricchio FT, Pessoa TD, Pacheco BP, Lessa LM, Malnic G, Girardi AC. Mechanisms mediating the diuretic and natriuretic actions of the incretin...
Protein kinase A | Proximal tubule | Renal hemodynamics | CELLS | PHYSIOLOGY | RAT | PHOSPHORYLATION | RECEPTOR | Na+/H+ exchanger isoform 3 | RENAL PROXIMAL TUBULE | DIABETES-MELLITUS | renal hemodynamics | UROLOGY & NEPHROLOGY | proximal tubule | protein kinase A | EXCHANGER ISOFORM NHE3 | HYPERTENSION | BINDING | Cyclic AMP-Dependent Protein Kinases - metabolism | Kidney - drug effects | Glucagon-Like Peptide 1 - administration & dosage | Glucagon-Like Peptide 1 - metabolism | Rats, Wistar | Rats | Receptors, Glucagon - metabolism | Hypoglycemic Agents - pharmacology | Natriuretic Agents - metabolism | Sodium-Hydrogen Exchangers - metabolism | Peptides - drug effects | Kidney - metabolism | Animals | Glucagon-Like Peptide-1 Receptor | Venoms | Natriuretic Agents - administration & dosage | Pentanoic Acids - pharmacology | Phosphorylation - drug effects | Thiazolidines - pharmacology | Cyclic AMP - urine | Sodium-Hydrogen Exchanger 3 | Biomechanics | Kidneys | Peptides | Physiological aspects | Research | Gastrointestinal hormones | Health aspects
Protein kinase A | Proximal tubule | Renal hemodynamics | CELLS | PHYSIOLOGY | RAT | PHOSPHORYLATION | RECEPTOR | Na+/H+ exchanger isoform 3 | RENAL PROXIMAL TUBULE | DIABETES-MELLITUS | renal hemodynamics | UROLOGY & NEPHROLOGY | proximal tubule | protein kinase A | EXCHANGER ISOFORM NHE3 | HYPERTENSION | BINDING | Cyclic AMP-Dependent Protein Kinases - metabolism | Kidney - drug effects | Glucagon-Like Peptide 1 - administration & dosage | Glucagon-Like Peptide 1 - metabolism | Rats, Wistar | Rats | Receptors, Glucagon - metabolism | Hypoglycemic Agents - pharmacology | Natriuretic Agents - metabolism | Sodium-Hydrogen Exchangers - metabolism | Peptides - drug effects | Kidney - metabolism | Animals | Glucagon-Like Peptide-1 Receptor | Venoms | Natriuretic Agents - administration & dosage | Pentanoic Acids - pharmacology | Phosphorylation - drug effects | Thiazolidines - pharmacology | Cyclic AMP - urine | Sodium-Hydrogen Exchanger 3 | Biomechanics | Kidneys | Peptides | Physiological aspects | Research | Gastrointestinal hormones | Health aspects
Journal Article
Journal of Hypertension, ISSN 0263-6352, 03/2011, Volume 29, Issue 3, pp. 520 - 528
OBJECTIVESThe present study aimed to assess the effect of the specific dipeptidyl peptidase IV (DPPIV) inhibitor sitagliptin on blood pressure and renal...
sodium reabsorption | kidney | proximal tubule | hypertension | exchanger isoform 3 | SITAGLIPTIN | TUBULES | MECHANISMS | Na+/H+ exchanger isoform 3 | KIDNEYS | GLUCAGON-LIKE PEPTIDE-1 | PERIPHERAL VASCULAR DISEASE | MICE | EXCHANGER ISOFORM NHE3 | EXPRESSION | GLUCOSE-TOLERANCE | Rats, Inbred SHR | Dipeptidyl Peptidase 4 - metabolism | Kidney - drug effects | Sodium-Hydrogen Exchangers - physiology | Dipeptidyl-Peptidase IV Inhibitors - therapeutic use | Rats | Rats, Inbred WKY | Hypertension - drug therapy | Male | Pyrazines - therapeutic use | Hypertension - physiopathology | Animals | Kidney Tubules, Proximal - metabolism | Aging | Blood Pressure - drug effects | Sitagliptin Phosphate | Kidney Tubules, Proximal - drug effects | Sodium-Hydrogen Exchanger 3 | Triazoles - therapeutic use
sodium reabsorption | kidney | proximal tubule | hypertension | exchanger isoform 3 | SITAGLIPTIN | TUBULES | MECHANISMS | Na+/H+ exchanger isoform 3 | KIDNEYS | GLUCAGON-LIKE PEPTIDE-1 | PERIPHERAL VASCULAR DISEASE | MICE | EXCHANGER ISOFORM NHE3 | EXPRESSION | GLUCOSE-TOLERANCE | Rats, Inbred SHR | Dipeptidyl Peptidase 4 - metabolism | Kidney - drug effects | Sodium-Hydrogen Exchangers - physiology | Dipeptidyl-Peptidase IV Inhibitors - therapeutic use | Rats | Rats, Inbred WKY | Hypertension - drug therapy | Male | Pyrazines - therapeutic use | Hypertension - physiopathology | Animals | Kidney Tubules, Proximal - metabolism | Aging | Blood Pressure - drug effects | Sitagliptin Phosphate | Kidney Tubules, Proximal - drug effects | Sodium-Hydrogen Exchanger 3 | Triazoles - therapeutic use
Journal Article
American Journal of Physiology - Renal Physiology, ISSN 0363-6127, 2015, Volume 308, Issue 8, pp. 848 - 856
Renal nerve stimulation at a low frequency (below 2 Hz) causes water and sodium reabsorption via alpha(1)-adrenoreceptor tubular activation, a process...
ANG II | receptor and NHE3 | Sympathetic nervous system | NEURAL-CONTROL | PHYSIOLOGY | PROTEIN | SYMPATHETIC-NERVES | RAT | RENIN | SODIUM-TRANSPORT | PHOSPHORYLATION | sympathetic nervous system | NHE3 | PROXIMAL BICARBONATE | AT receptor and NHE3 | UROLOGY & NEPHROLOGY | HYPERTENSION | Phosphorylation | Electric Stimulation | Sodium-Hydrogen Exchangers - drug effects | Rats, Wistar | Kidney Tubules, Proximal - innervation | Male | Sodium - metabolism | Angiotensin II Type 1 Receptor Blockers - pharmacology | Sodium-Hydrogen Exchangers - metabolism | Renal Reabsorption - drug effects | Sympathetic Nervous System - physiology | Time Factors | Receptor, Angiotensin, Type 1 - drug effects | Cyclic AMP - metabolism | Cyclic AMP-Dependent Protein Kinases - metabolism | Angiotensin II - metabolism | Signal Transduction | Angiotensinogen - metabolism | Urodynamics | Animals | Receptor, Angiotensin, Type 1 - metabolism | Kidney Tubules, Proximal - metabolism | Renin-Angiotensin System - drug effects | Natriuresis | Hydrogen-Ion Concentration | Kidney Tubules, Proximal - drug effects | Sodium-Hydrogen Exchanger 3
ANG II | receptor and NHE3 | Sympathetic nervous system | NEURAL-CONTROL | PHYSIOLOGY | PROTEIN | SYMPATHETIC-NERVES | RAT | RENIN | SODIUM-TRANSPORT | PHOSPHORYLATION | sympathetic nervous system | NHE3 | PROXIMAL BICARBONATE | AT receptor and NHE3 | UROLOGY & NEPHROLOGY | HYPERTENSION | Phosphorylation | Electric Stimulation | Sodium-Hydrogen Exchangers - drug effects | Rats, Wistar | Kidney Tubules, Proximal - innervation | Male | Sodium - metabolism | Angiotensin II Type 1 Receptor Blockers - pharmacology | Sodium-Hydrogen Exchangers - metabolism | Renal Reabsorption - drug effects | Sympathetic Nervous System - physiology | Time Factors | Receptor, Angiotensin, Type 1 - drug effects | Cyclic AMP - metabolism | Cyclic AMP-Dependent Protein Kinases - metabolism | Angiotensin II - metabolism | Signal Transduction | Angiotensinogen - metabolism | Urodynamics | Animals | Receptor, Angiotensin, Type 1 - metabolism | Kidney Tubules, Proximal - metabolism | Renin-Angiotensin System - drug effects | Natriuresis | Hydrogen-Ion Concentration | Kidney Tubules, Proximal - drug effects | Sodium-Hydrogen Exchanger 3
Journal Article
American Journal of Physiology (Consolidated), ISSN 0002-9513, 04/2015, Volume 308, Issue 4, p. F848
Renal nerve stimulation at a low frequency (below 2 Hz) causes water and sodium reabsorption via [[alpha].sub.i]-adrenoreceptor tubular activation, a process...
Neural stimulation | Kidneys | Health aspects | Angiotensin
Neural stimulation | Kidneys | Health aspects | Angiotensin
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 09/2017, Volume 811, pp. 38 - 47
Accumulating evidence from clinical and experimental studies indicates that the incretin glucagon-like peptide-1 (GLP-1) elicits blood-pressure lowering...
Hypertension | Incretin | Renal function | Renal artery | Renal vascular resistance | ACTIVATION | SENSITIVE K+ CHANNELS | NHE3 | BLOOD-PRESSURE | EXENDIN-4 | GLUCOSE | PHARMACOLOGY & PHARMACY | GLP-1 RECEPTOR | INHIBITOR | KIDNEY | ATP | Natriuresis - drug effects | Glucagon-Like Peptide 1 - pharmacology | Rats | Male | Hypertension - pathology | Hypertension - physiopathology | Hypertension - metabolism | Gene Expression Regulation - drug effects | Glucagon-Like Peptide-1 Receptor - genetics | Renal Artery - physiopathology | Animals | Signal Transduction - drug effects | Renal Artery - metabolism | Renal Artery - drug effects | Hypertension - genetics | Cyclic AMP - metabolism | Medical colleges | Enzymes | Glucagon | Vasodilators | Diuretics | Cyclic adenylic acid
Hypertension | Incretin | Renal function | Renal artery | Renal vascular resistance | ACTIVATION | SENSITIVE K+ CHANNELS | NHE3 | BLOOD-PRESSURE | EXENDIN-4 | GLUCOSE | PHARMACOLOGY & PHARMACY | GLP-1 RECEPTOR | INHIBITOR | KIDNEY | ATP | Natriuresis - drug effects | Glucagon-Like Peptide 1 - pharmacology | Rats | Male | Hypertension - pathology | Hypertension - physiopathology | Hypertension - metabolism | Gene Expression Regulation - drug effects | Glucagon-Like Peptide-1 Receptor - genetics | Renal Artery - physiopathology | Animals | Signal Transduction - drug effects | Renal Artery - metabolism | Renal Artery - drug effects | Hypertension - genetics | Cyclic AMP - metabolism | Medical colleges | Enzymes | Glucagon | Vasodilators | Diuretics | Cyclic adenylic acid
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 01/2013, Volume 698, Issue 1-3, pp. 74 - 86
The purpose of the current study was to test the hypothesis that the dipeptidyl peptidase IV (DPPIV) inhibitor sitagliptin, which exerts anti-hyperglycemic and...
Hypertension | Heart | Glucagon-like peptide-1 | Dipeptidyl peptidase IV | Skeletal muscle | Glucose transporter type 4 | PHYSIOLOGY | ADIPOCYTES | TOLERANCE | SITAGLIPTIN | MECHANISMS | BLOOD-PRESSURE | ENZYME | GLUCOSE-TRANSPORTER | INSULIN-RESISTANCE | PHARMACOLOGY & PHARMACY | TISSUES | Dipeptidyl Peptidase 4 - metabolism | Glucose Transporter Type 4 - metabolism | Body Weight - drug effects | Dipeptidyl Peptidase 4 - blood | Glucagon-Like Peptide 1 - blood | Male | Muscle, Skeletal - metabolism | Protein Transport - drug effects | RNA, Messenger - metabolism | Dipeptidyl-Peptidase IV Inhibitors - pharmacology | Muscle, Skeletal - drug effects | Blood Pressure - drug effects | Homeostasis - drug effects | Phosphorylation - drug effects | Sitagliptin Phosphate | Cyclic AMP - metabolism | Cyclic AMP-Dependent Protein Kinases - metabolism | Rats, Inbred SHR | Intracellular Space - drug effects | Glucose Transporter Type 4 - genetics | RNA, Messenger - genetics | Rats | Triazoles - pharmacology | Up-Regulation - drug effects | Animals | Myocytes, Cardiac - drug effects | Signal Transduction - drug effects | Intracellular Space - metabolism | Glucose - metabolism | Heart - drug effects | Myocytes, Cardiac - metabolism | Muscle, Skeletal - pathology | Pyrazines - pharmacology | Messenger RNA | Peptides | Physiological aspects | Muscles | Glucose | Dextrose
Hypertension | Heart | Glucagon-like peptide-1 | Dipeptidyl peptidase IV | Skeletal muscle | Glucose transporter type 4 | PHYSIOLOGY | ADIPOCYTES | TOLERANCE | SITAGLIPTIN | MECHANISMS | BLOOD-PRESSURE | ENZYME | GLUCOSE-TRANSPORTER | INSULIN-RESISTANCE | PHARMACOLOGY & PHARMACY | TISSUES | Dipeptidyl Peptidase 4 - metabolism | Glucose Transporter Type 4 - metabolism | Body Weight - drug effects | Dipeptidyl Peptidase 4 - blood | Glucagon-Like Peptide 1 - blood | Male | Muscle, Skeletal - metabolism | Protein Transport - drug effects | RNA, Messenger - metabolism | Dipeptidyl-Peptidase IV Inhibitors - pharmacology | Muscle, Skeletal - drug effects | Blood Pressure - drug effects | Homeostasis - drug effects | Phosphorylation - drug effects | Sitagliptin Phosphate | Cyclic AMP - metabolism | Cyclic AMP-Dependent Protein Kinases - metabolism | Rats, Inbred SHR | Intracellular Space - drug effects | Glucose Transporter Type 4 - genetics | RNA, Messenger - genetics | Rats | Triazoles - pharmacology | Up-Regulation - drug effects | Animals | Myocytes, Cardiac - drug effects | Signal Transduction - drug effects | Intracellular Space - metabolism | Glucose - metabolism | Heart - drug effects | Myocytes, Cardiac - metabolism | Muscle, Skeletal - pathology | Pyrazines - pharmacology | Messenger RNA | Peptides | Physiological aspects | Muscles | Glucose | Dextrose
Journal Article
American Journal of Physiology - Cell Physiology, ISSN 0363-6143, 2016, Volume 311, Issue 5, pp. C768 - C776
Binding of angiotensin II (ANG II) to the AT(1) receptor (AT(1)R) in the proximal tubule stimulates Na+/H+ exchanger isoform 3 (NHE3) activity through multiple...
Inhibitory G protein | Sodium transport | receptor | exchanger isoform 3 | Pertussis toxin | PROTEIN-KINASE-A | PHYSIOLOGY | SPONTANEOUSLY HYPERTENSIVE-RATS | HEART-FAILURE | sodium transport | RENAL BRUSH-BORDER | PHOSPHO-SPECIFIC ANTIBODIES | Na+/H+ exchanger isoform 3 | NEPHRON FUNCTION | AT receptor | CELL BIOLOGY | GLUCAGON-LIKE PEPTIDE-1 | pertussis toxin | inhibitory G protein | NA+/H+ EXCHANGER NHE3 | ADENYLATE-CYCLASE | RECEPTOR-BINDING PROTEIN | Cyclic AMP-Dependent Protein Kinases - metabolism | Phosphorylation - physiology | Cell Line | Angiotensin II - metabolism | Rats, Wistar | Opossums | Losartan - pharmacology | Rats | Male | Angiotensin II Type 1 Receptor Blockers - pharmacology | Sodium-Hydrogen Exchangers - metabolism | Kidney - metabolism | Animals | Colforsin - metabolism | Receptor, Angiotensin, Type 1 - metabolism | Up-Regulation - physiology | Kidney Tubules, Proximal - metabolism | Signal Transduction - physiology | Cyclic AMP - metabolism | Phosphorylation | Angiotensin | Physiological aspects | Physiological research | Cyclic adenylic acid | Research | Kidney tubules
Inhibitory G protein | Sodium transport | receptor | exchanger isoform 3 | Pertussis toxin | PROTEIN-KINASE-A | PHYSIOLOGY | SPONTANEOUSLY HYPERTENSIVE-RATS | HEART-FAILURE | sodium transport | RENAL BRUSH-BORDER | PHOSPHO-SPECIFIC ANTIBODIES | Na+/H+ exchanger isoform 3 | NEPHRON FUNCTION | AT receptor | CELL BIOLOGY | GLUCAGON-LIKE PEPTIDE-1 | pertussis toxin | inhibitory G protein | NA+/H+ EXCHANGER NHE3 | ADENYLATE-CYCLASE | RECEPTOR-BINDING PROTEIN | Cyclic AMP-Dependent Protein Kinases - metabolism | Phosphorylation - physiology | Cell Line | Angiotensin II - metabolism | Rats, Wistar | Opossums | Losartan - pharmacology | Rats | Male | Angiotensin II Type 1 Receptor Blockers - pharmacology | Sodium-Hydrogen Exchangers - metabolism | Kidney - metabolism | Animals | Colforsin - metabolism | Receptor, Angiotensin, Type 1 - metabolism | Up-Regulation - physiology | Kidney Tubules, Proximal - metabolism | Signal Transduction - physiology | Cyclic AMP - metabolism | Phosphorylation | Angiotensin | Physiological aspects | Physiological research | Cyclic adenylic acid | Research | Kidney tubules
Journal Article
American Journal of Physiology - Renal Physiology, ISSN 0363-6127, 11/2012, Volume 303, Issue 10, pp. F1399 - F1408
Lessa LM, Carraro-Lacroix LR, Crajoinas RO, Bezerra CN, Dariolli R, Girardi AC, Fonteles MC, Malnic G. Mechanisms underlying the inhibitory effects of...
cGMP | Bicarbonate reabsorption | Renal microperfusion | Uroguanylin | cAMP | NHE3 | uroguanylin | PHYSIOLOGY | HEAT-STABLE ENTEROTOXIN | MESSENGER-RNA EXPRESSION | SODIUM-TRANSPORT | INTESTINAL GUANYLATE-CYCLASE | PROTEIN-KINASE | renal microperfusion | MICE LACKING | NATRIURETIC RESPONSE | NITRIC-OXIDE | UROLOGY & NEPHROLOGY | DIETARY SALT | NA+/H+ EXCHANGER ISOFORM | bicarbonate reabsorption | Cell Line | Kidney Tubules, Proximal - cytology | Rats, Wistar | Cells, Cultured | Rats | Male | Sulfonamides - pharmacology | Natriuretic Peptides - pharmacology | Sodium-Hydrogen Exchangers - metabolism | Animals | Cyclic GMP-Dependent Protein Kinases - antagonists & inhibitors | Isoquinolines - pharmacology | Cyclic GMP - metabolism | Kidney Tubules, Proximal - metabolism | Bicarbonates - metabolism | Protein Kinase Inhibitors - pharmacology | Cyclic AMP-Dependent Protein Kinases - antagonists & inhibitors | Carbazoles - pharmacology | Cyclic AMP - metabolism | Kidney Tubules, Proximal - drug effects | Sodium-Hydrogen Exchanger 3
cGMP | Bicarbonate reabsorption | Renal microperfusion | Uroguanylin | cAMP | NHE3 | uroguanylin | PHYSIOLOGY | HEAT-STABLE ENTEROTOXIN | MESSENGER-RNA EXPRESSION | SODIUM-TRANSPORT | INTESTINAL GUANYLATE-CYCLASE | PROTEIN-KINASE | renal microperfusion | MICE LACKING | NATRIURETIC RESPONSE | NITRIC-OXIDE | UROLOGY & NEPHROLOGY | DIETARY SALT | NA+/H+ EXCHANGER ISOFORM | bicarbonate reabsorption | Cell Line | Kidney Tubules, Proximal - cytology | Rats, Wistar | Cells, Cultured | Rats | Male | Sulfonamides - pharmacology | Natriuretic Peptides - pharmacology | Sodium-Hydrogen Exchangers - metabolism | Animals | Cyclic GMP-Dependent Protein Kinases - antagonists & inhibitors | Isoquinolines - pharmacology | Cyclic GMP - metabolism | Kidney Tubules, Proximal - metabolism | Bicarbonates - metabolism | Protein Kinase Inhibitors - pharmacology | Cyclic AMP-Dependent Protein Kinases - antagonists & inhibitors | Carbazoles - pharmacology | Cyclic AMP - metabolism | Kidney Tubules, Proximal - drug effects | Sodium-Hydrogen Exchanger 3
Journal Article
American Journal of Physiology - Renal Physiology, ISSN 0363-6127, 10/2010, Volume 299, Issue 4, pp. F872 - F881
Crajoinas RO, Lessa LMA, Carraro-Lacroix LR, Davel APC, Pacheco BPM, Rossoni LV, Malnic G, Girardi ACC. Posttranslational mechanisms associated with reduced...
Proximal tubule | Phosphorylation | Sodium transport | Blood pressure | Dipeptidyl peptidase IV | blood pressure | CAMP-MEDIATED INHIBITION | PHYSIOLOGY | SUBCELLULAR-DISTRIBUTION | sodium transport | SPONTANEOUSLY HYPERTENSIVE RAT | NEPHRON FUNCTION | RENAL PROXIMAL TUBULE | BRUSH-BORDER | GLUCAGON-LIKE PEPTIDE-1 | MEMBRANE-VESICLES | UROLOGY & NEPHROLOGY | dipeptidyl peptidase IV | REGULATORY PROTEIN | NA+/H+ EXCHANGER ISOFORM | proximal tubule | phosphorylation | Rats, Inbred SHR | Dipeptidyl Peptidase 4 - metabolism | Rats | Rats, Inbred WKY | Male | Hypertension - physiopathology | Protein Processing, Post-Translational - physiology | Hypertension - metabolism | Sodium-Hydrogen Exchangers - metabolism | Absorption | Animals | Microvilli - metabolism | Kidney Tubules, Proximal - metabolism | Bicarbonates - metabolism | Blood Pressure - physiology | Aging - metabolism | Disease Models, Animal | Sodium-Hydrogen Exchanger 3 | Physiological aspects | Research | Renal tubular transport | Kidney tubules | Biological transport | Membrane proteins
Proximal tubule | Phosphorylation | Sodium transport | Blood pressure | Dipeptidyl peptidase IV | blood pressure | CAMP-MEDIATED INHIBITION | PHYSIOLOGY | SUBCELLULAR-DISTRIBUTION | sodium transport | SPONTANEOUSLY HYPERTENSIVE RAT | NEPHRON FUNCTION | RENAL PROXIMAL TUBULE | BRUSH-BORDER | GLUCAGON-LIKE PEPTIDE-1 | MEMBRANE-VESICLES | UROLOGY & NEPHROLOGY | dipeptidyl peptidase IV | REGULATORY PROTEIN | NA+/H+ EXCHANGER ISOFORM | proximal tubule | phosphorylation | Rats, Inbred SHR | Dipeptidyl Peptidase 4 - metabolism | Rats | Rats, Inbred WKY | Male | Hypertension - physiopathology | Protein Processing, Post-Translational - physiology | Hypertension - metabolism | Sodium-Hydrogen Exchangers - metabolism | Absorption | Animals | Microvilli - metabolism | Kidney Tubules, Proximal - metabolism | Bicarbonates - metabolism | Blood Pressure - physiology | Aging - metabolism | Disease Models, Animal | Sodium-Hydrogen Exchanger 3 | Physiological aspects | Research | Renal tubular transport | Kidney tubules | Biological transport | Membrane proteins
Journal Article
Kidney and Blood Pressure Research, ISSN 1420-4096, 02/2013, Volume 36, Issue 1, pp. 320 - 334
Background/Aims: Fructose causes a sodium-sensitive hypertension and acutely reduces the urinary Na+ excretion, suggesting that it may regulate the activity of...
Original Paper | In situ microperfusion | LLC-PK1 cells | CAMP | Fructose | Sodium hydrogen exchangers | PROTEIN-KINASE-A | LOCALIZATION | METABOLIC SYNDROME | PHYSIOLOGY | PHOSPHORYLATION | cAMP | BLOOD-PRESSURE | DIETARY FRUCTOSE | PH REGULATION | INSULIN-RESISTANCE | UROLOGY & NEPHROLOGY | PERIPHERAL VASCULAR DISEASE | NA+/H+ EXCHANGER NHE3 | HYPERTENSION | Cyclic AMP-Dependent Protein Kinases - metabolism | Cell Line | Kidney Tubules, Proximal - cytology | Glucose Transporter Type 5 - metabolism | Rats, Wistar | Cells, Cultured | Rats | Male | Fructokinases - metabolism | Glucose Transporter Type 2 - metabolism | Sodium-Hydrogen Exchangers - metabolism | LLC-PK1 Cells | Animals | Signal Transduction - drug effects | Fructose - pharmacology | Swine | Kidney Tubules, Proximal - metabolism | Models, Animal | Signal Transduction - physiology | Cyclic AMP - metabolism | Kidney Tubules, Proximal - drug effects | Sodium-Hydrogen Exchanger 3
Original Paper | In situ microperfusion | LLC-PK1 cells | CAMP | Fructose | Sodium hydrogen exchangers | PROTEIN-KINASE-A | LOCALIZATION | METABOLIC SYNDROME | PHYSIOLOGY | PHOSPHORYLATION | cAMP | BLOOD-PRESSURE | DIETARY FRUCTOSE | PH REGULATION | INSULIN-RESISTANCE | UROLOGY & NEPHROLOGY | PERIPHERAL VASCULAR DISEASE | NA+/H+ EXCHANGER NHE3 | HYPERTENSION | Cyclic AMP-Dependent Protein Kinases - metabolism | Cell Line | Kidney Tubules, Proximal - cytology | Glucose Transporter Type 5 - metabolism | Rats, Wistar | Cells, Cultured | Rats | Male | Fructokinases - metabolism | Glucose Transporter Type 2 - metabolism | Sodium-Hydrogen Exchangers - metabolism | LLC-PK1 Cells | Animals | Signal Transduction - drug effects | Fructose - pharmacology | Swine | Kidney Tubules, Proximal - metabolism | Models, Animal | Signal Transduction - physiology | Cyclic AMP - metabolism | Kidney Tubules, Proximal - drug effects | Sodium-Hydrogen Exchanger 3
Journal Article
American Journal of Physiology - Cell Physiology, ISSN 0363-6143, 09/2014, Volume 307, Issue 6, pp. C532 - C541
Cumulative evidence suggests that guanylin peptides play an important role on electrolyte homeostasis. We have previously reported that uroguanylin (UGN)...
cGMP | Renal microperfusion | H + -ATPase | Uroguanylin | PKG | Distal tubule | uroguanylin | ACID-BASE TRANSPORT | PHYSIOLOGY | RAT | distal tubule | renal microperfusion | ANGIOTENSIN-II | CELL BIOLOGY | SYSTEMIC ACIDOSIS | CORTICAL COLLECTING DUCT | SUSTAINED CORRECTION | H+-ATPase | INTERCALATED CELLS | SECRETION | PROXIMAL TUBULE | GUANYLATE-CYCLASE-C | Kidney Tubules, Distal - enzymology | Rats, Wistar | Male | Cyclic GMP-Dependent Protein Kinases - metabolism | Receptors, Guanylate Cyclase-Coupled - metabolism | Proton-Translocating ATPases - metabolism | Cyclic GMP-Dependent Protein Kinases - antagonists & inhibitors | Time Factors | Madin Darby Canine Kidney Cells | Receptors, Guanylate Cyclase-Coupled - drug effects | Receptors, Guanylate Cyclase-Coupled - genetics | Cell Membrane - drug effects | Rats | Natriuretic Peptides - pharmacology | Protein Transport | Cell Membrane - enzymology | Animals | Kidney Tubules, Distal - drug effects | Cyclic GMP - metabolism | Signal Transduction - drug effects | Perfusion | Dogs | Bicarbonates - metabolism | Protein Kinase Inhibitors - pharmacology | Hydrogen-Ion Concentration
cGMP | Renal microperfusion | H + -ATPase | Uroguanylin | PKG | Distal tubule | uroguanylin | ACID-BASE TRANSPORT | PHYSIOLOGY | RAT | distal tubule | renal microperfusion | ANGIOTENSIN-II | CELL BIOLOGY | SYSTEMIC ACIDOSIS | CORTICAL COLLECTING DUCT | SUSTAINED CORRECTION | H+-ATPase | INTERCALATED CELLS | SECRETION | PROXIMAL TUBULE | GUANYLATE-CYCLASE-C | Kidney Tubules, Distal - enzymology | Rats, Wistar | Male | Cyclic GMP-Dependent Protein Kinases - metabolism | Receptors, Guanylate Cyclase-Coupled - metabolism | Proton-Translocating ATPases - metabolism | Cyclic GMP-Dependent Protein Kinases - antagonists & inhibitors | Time Factors | Madin Darby Canine Kidney Cells | Receptors, Guanylate Cyclase-Coupled - drug effects | Receptors, Guanylate Cyclase-Coupled - genetics | Cell Membrane - drug effects | Rats | Natriuretic Peptides - pharmacology | Protein Transport | Cell Membrane - enzymology | Animals | Kidney Tubules, Distal - drug effects | Cyclic GMP - metabolism | Signal Transduction - drug effects | Perfusion | Dogs | Bicarbonates - metabolism | Protein Kinase Inhibitors - pharmacology | Hydrogen-Ion Concentration
Journal Article
American Journal of Physiology (Consolidated), ISSN 0002-9513, 09/2014, Volume 307, Issue 3, p. C532
Cumulative evidence suggests that guanylin peptides play an important role on electrolyte homeostasis. We have previously reported that uroguanylin (UGN)...
Physiological aspects | Research | Kidney tubules | Protein kinases | Adenosine triphosphatase | Protein-protein interactions
Physiological aspects | Research | Kidney tubules | Protein kinases | Adenosine triphosphatase | Protein-protein interactions
Journal Article
American Journal of Physiology (Consolidated), ISSN 0002-9513, 11/2012, Volume 303, Issue 5, p. F1399
Lessa LM, Carraro-Lacroix LR, Crajoinas RO, Bezerra CN, Dariolli R, Girardi AC, Fonteles MC, Malnic G. Mechanisms underlying the inhibitory effects of...
Peptides | Physiological aspects | Bicarbonates | Amino acids | Health aspects | Protein kinases
Peptides | Physiological aspects | Bicarbonates | Amino acids | Health aspects | Protein kinases
Journal Article
The American Journal of Physiology, ISSN 0002-9513, 11/2012, Volume 303, Issue 5, p. F1399
Lessa LM, Carraro-Lacroix LR, Crajoinas RO, Bezerra CN, Dariolli R, Girardi AC, Fonteles MC, Malnic G. Mechanisms underlying the inhibitory effects of...
Peptides | Physiological aspects | Bicarbonates | Amino acids | Health aspects | Protein kinases
Peptides | Physiological aspects | Bicarbonates | Amino acids | Health aspects | Protein kinases
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2014, Volume 9, Issue 7, p. e101270
Low-level laser therapy (LLLT) has been used as an anti-inflammatory treatment in several disease conditions, even when inflammation is a secondary...
INFARCT SIZE | IRRADIATION | ENDOTHELIAL-CELL PROLIFERATION | MESSENGER-RNA | NITRIC-OXIDE SYNTHASE | MULTIDISCIPLINARY SCIENCES | HEART-FAILURE | B2 RECEPTORS | GROWTH-FACTOR | KININ B1 | ANGIOTENSIN-CONVERTING ENZYME | Renin-Angiotensin System - radiation effects | Receptor, Bradykinin B2 - genetics | Rats, Wistar | Receptors, G-Protein-Coupled - metabolism | Vascular Endothelial Growth Factor A - metabolism | Interleukin-1beta - genetics | Peptidyl-Dipeptidase A - genetics | Receptor, Bradykinin B1 - genetics | Heart - radiation effects | Interleukin-1beta - metabolism | Myocardium - metabolism | Peptidyl-Dipeptidase A - metabolism | Female | Myocardial Infarction - physiopathology | Kallikreins - blood | Interleukin-6 - metabolism | Low-Level Light Therapy | Proto-Oncogene Proteins - metabolism | Nitric Oxide - blood | Interleukin-6 - genetics | Myocardial Infarction - radiotherapy | Rats | Proto-Oncogene Proteins - genetics | Myocardial Infarction - metabolism | Kallikrein-Kinin System - radiation effects | Animals | Nitric Oxide Synthase Type II - genetics | Gene Expression Regulation - radiation effects | Receptor, Bradykinin B2 - metabolism | Receptor, Bradykinin B1 - metabolism | Receptors, G-Protein-Coupled - genetics | Nitric Oxide - metabolism | Nitric Oxide Synthase Type II - metabolism | Heart | RNA | Lasers in surgery | Nitric oxide | Angiotensin | Inflammation | Vascular endothelial growth factor | Heart attack | Lasers in medicine | Myocardial infarction | Therapy | Heart attacks | Peptides | Interleukin | Irradiated | Interleukin 6 | Receptors | Cell growth | Beta irradiation | Renin | Metabolites | Lasers | Vasoactive agents | Rodents | Plasma kallikrein | Interleukin 1 | Bradykinin B2 receptors | Capillaries | Heart diseases | Heart failure | Hypertension | Enzymes | Medical treatment | Kallikrein | Gene expression | Low level | Nitric-oxide synthase | Ostomy | Coronary vessels | Myocardium | Nitrogen oxides | Infarction | Ventricle | Laboratory animals
INFARCT SIZE | IRRADIATION | ENDOTHELIAL-CELL PROLIFERATION | MESSENGER-RNA | NITRIC-OXIDE SYNTHASE | MULTIDISCIPLINARY SCIENCES | HEART-FAILURE | B2 RECEPTORS | GROWTH-FACTOR | KININ B1 | ANGIOTENSIN-CONVERTING ENZYME | Renin-Angiotensin System - radiation effects | Receptor, Bradykinin B2 - genetics | Rats, Wistar | Receptors, G-Protein-Coupled - metabolism | Vascular Endothelial Growth Factor A - metabolism | Interleukin-1beta - genetics | Peptidyl-Dipeptidase A - genetics | Receptor, Bradykinin B1 - genetics | Heart - radiation effects | Interleukin-1beta - metabolism | Myocardium - metabolism | Peptidyl-Dipeptidase A - metabolism | Female | Myocardial Infarction - physiopathology | Kallikreins - blood | Interleukin-6 - metabolism | Low-Level Light Therapy | Proto-Oncogene Proteins - metabolism | Nitric Oxide - blood | Interleukin-6 - genetics | Myocardial Infarction - radiotherapy | Rats | Proto-Oncogene Proteins - genetics | Myocardial Infarction - metabolism | Kallikrein-Kinin System - radiation effects | Animals | Nitric Oxide Synthase Type II - genetics | Gene Expression Regulation - radiation effects | Receptor, Bradykinin B2 - metabolism | Receptor, Bradykinin B1 - metabolism | Receptors, G-Protein-Coupled - genetics | Nitric Oxide - metabolism | Nitric Oxide Synthase Type II - metabolism | Heart | RNA | Lasers in surgery | Nitric oxide | Angiotensin | Inflammation | Vascular endothelial growth factor | Heart attack | Lasers in medicine | Myocardial infarction | Therapy | Heart attacks | Peptides | Interleukin | Irradiated | Interleukin 6 | Receptors | Cell growth | Beta irradiation | Renin | Metabolites | Lasers | Vasoactive agents | Rodents | Plasma kallikrein | Interleukin 1 | Bradykinin B2 receptors | Capillaries | Heart diseases | Heart failure | Hypertension | Enzymes | Medical treatment | Kallikrein | Gene expression | Low level | Nitric-oxide synthase | Ostomy | Coronary vessels | Myocardium | Nitrogen oxides | Infarction | Ventricle | Laboratory animals
Journal Article