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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2016, Volume 113, Issue 43, pp. E6639 - E6648
Natural infections expose the immune system to escalating antigen and inflammation over days to weeks, whereas nonlive vaccines are single bolus events. We... 
Vaccination kinetics | Antigen retention | Computational immunology | Humoral response | Germinal center formation | HIV-1 | CENTER B-CELLS | IMMUNE-RESPONSE | antigen retention | computational immunology | vaccination kinetics | PERSISTENCE | MULTIDISCIPLINARY SCIENCES | FOLLICULAR HELPER-CELL | RELEASE | INDUCTION | ADJUVANT | DELIVERY | germinal center formation | MALARIA ANTIGEN | humoral response | Immunogenicity, Vaccine | Osmotic Pressure | Adjuvants, Immunologic - administration & dosage | Cricetulus | Germinal Center - immunology | Humans | Lipid A - analogs & derivatives | Germinal Center - drug effects | Vaccination - methods | HEK293 Cells | Female | Germinal Center - cytology | Recombinant Fusion Proteins - administration & dosage | CHO Cells | Antibodies, Viral - biosynthesis | Recombinant Fusion Proteins - biosynthesis | B-Lymphocytes - cytology | Infusion Pumps, Implantable | Lipid A - administration & dosage | Drug Administration Schedule | Mice, Inbred C57BL | Antibody Affinity | HIV Envelope Protein gp120 - administration & dosage | HIV Envelope Protein gp120 - biosynthesis | B-Lymphocytes - drug effects | Animals | B-Lymphocytes - immunology | Vaccination - instrumentation | Mice | AIDS Vaccines - administration & dosage | Antigen-antibody reactions | Observations | Vaccination | Patient outcomes | Biological Sciences | PNAS Plus
Journal Article
Cell, ISSN 0092-8674, 12/2015, Volume 163, Issue 7, pp. 1702 - 1715
Journal Article
PLOS ONE, ISSN 1932-6203, 05/2016, Volume 11, Issue 5
SAP (SH2D1A) is required intrinsically in CD4 T cells to generate germinal center responses and long-term humoral immunity. SAP binds to SLAM family receptors,... 
ACTIVATION | MEMORY B-CELLS | SPECIFICITY | MULTIDISCIPLINARY SCIENCES | HUMORAL IMMUNITY | LINKED LYMPHOPROLIFERATIVE DISEASE | MICE | GENERATION | DIFFERENTIATION | RECEPTORS | ADAPTER SAP
Journal Article
Journal of virology, ISSN 0022-538X, 2015, Volume 89, Issue 20, pp. 10383 - 10398
Generating neutralizing antibodies (nAbs) is a major goal of many current HIV-1 vaccine efforts. To be of practical value, these nAbs must be both potent and... 
CENTER B-CELLS | MUCOSAL SHIV CHALLENGE | POTENT | VIROLOGY | GLYCOPROTEIN TRIMERS | BROADLY NEUTRALIZING ANTIBODIES | VACCINE | IMMUNODEFICIENCY-VIRUS TYPE-1 | FOLLICULAR HELPER-CELL | GERMINAL CENTER | MONOCLONAL-ANTIBODIES | Antibody Specificity | Epitope Mapping | HIV Infections - prevention & control | env Gene Products, Human Immunodeficiency Virus - immunology | Humans | Protein Multimerization | Epitopes - immunology | HIV Infections - immunology | env Gene Products, Human Immunodeficiency Virus - genetics | Immunoglobulin G - biosynthesis | HIV-1 - chemistry | Receptors, Antigen, B-Cell - chemistry | HEK293 Cells | Protein Engineering | HIV Antibodies - biosynthesis | env Gene Products, Human Immunodeficiency Virus - chemistry | Gene Expression | Immunization | HIV Infections - virology | Immunoglobulin G - chemistry | Solubility | Models, Molecular | Recombinant Proteins - chemistry | Antigens, Viral - chemistry | Recombinant Proteins - genetics | HIV-1 - genetics | HIV Antibodies - chemistry | Receptors, Antigen, B-Cell - immunology | Recombinant Proteins - administration & dosage | Antigens, Viral - immunology | HIV-1 - immunology | Animals | B-Lymphocytes - immunology | Recombinant Proteins - immunology | Antibodies, Neutralizing - biosynthesis | Antibodies, Neutralizing - chemistry | env Gene Products, Human Immunodeficiency Virus - administration & dosage | Protein Binding | Epitopes - chemistry | Mice
Journal Article
Journal of immunology (Baltimore, Md. : 1950), ISSN 0022-1767, 3/2016, Volume 196, Issue 5, pp. 2015 - 2019
Follicular helper T (Tfh) cells provide B cell help in germinal center reactions that support class switching, somatic hypermutation, and the generation of... 
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2016, Volume 113, Issue 43, p. E6639
  Natural infections expose the immune system to escalating antigen and inflammation over days to weeks, whereas nonlive vaccines are single bolus events. We... 
Antigens | Immunoglobulins | Immunization | Infections | Inflammation | Immune system
Journal Article
Proceedings of the National Academy of Sciences, USA, ISSN 0027-8424, 10/2016, Volume 113, Issue 43, pp. E6639 - E6639
Natural infections expose the immune system to escalating antigen and inflammation over days to weeks, whereas nonlive vaccines are single bolus events. We... 
Journal Article
The Times, ISSN 0140-0460, 03/2014, p. 44
  Helen Rumbelow My Name is ... by Alastair Campbell Arrow, 342pp, Pounds 7.99 Pounds 7.59; e-book Pounds 9.99 Alastair Campbell charts the story of Hannah, a... 
Books | Newspapers | E-books | Novels | Fashion designers | Criminal investigations | Fraud | Capital punishment | Sons | Comic books | Post traumatic stress disorder | Girls | Television programs | Diplomatic & consular services | Rape | Scandals
Newspaper Article
The Times (London, England), ISSN 0140-0460, 10/2009, p. 18
Bracing is the word. From getting in the car in East London to getting out of it in west Hull three and a bit hours later, the temperature drops from the... 
Newspaper Article
The Times, ISSN 0140-0460, 05/2002
if you didn't know better, then you might think that Lulu lived in a mock-Tudor in Berkshire or Surrey. But she's cool, is Lulu, and in fact she lives in a... 
Newspaper Article
The Times, ISSN 0140-0460, 01/1995
SUNRISE WITH SEA MONSTER, By Neil Jordan, Chatto & Windus, Pounds 9.99 NEIL Jordan writes about Ireland, men, destiny and betrayal. He takes some risks, and... 
Newspaper Article
International Herald Tribune, ISSN 0294-8052, 10/2002
  Weapons sellers, buyers from Iraq, Libya and Syria and a member of the British royal family got together at the Special Operations Forces Exhibition in... 
Newspaper Article
South China Sunday Morning Post (1985-2000), 06/1989, p. 109
  HIGH SPIRITS (1988, Palace, 92 minutes). Neil Jordan, the Irish director whose Cal and Company Of... 
Newspaper Article
The Times, ISSN 0140-0460, 01/2006
After various disasters over the years, I had pretty much given up on interviewing actresses. "So," said my editor, "you won't want to meet [Kelly Brook],... 
Newspaper Article
The Times, ISSN 0140-0460, 06/2004
As we speak we are hurrying through the corridors of the House of Lords, [GEORGE CAREY]'s tall figure moving quickly, pectoral cross bouncing lightly up and... 
Newspaper Article
01/1981, Volume 4, Issue 1
Growing up with philosophy Matthew Lipman and Ann Margaret Sharp Philadelphia: Temple University Press, 1978 An administrator's handbook on designing programs... 
Book Review
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