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02/2019, ISBN 3030111423, 420
eBook
Angewandte Chemie International Edition, ISSN 1433-7851, 08/2019, Volume 58, Issue 33, pp. 11385 - 11389
Reversible covalency, achieved with, for instance, highly electron‐deficient olefins, offers a compelling strategy to design chemical probes and drugs that... 
α-cyanoacrylamides | activity-based protein profiling | proteomics | reversible covalency | reactive cysteines | Proteins | Cysteine | Thiols | Cystine | Organic chemistry | Residues | Spectrometry | Covalence | Profiling | Alkenes | Gel filtration | Strategy | Kinases | Drug development | Index Medicus
Journal Article
Nature Chemical Biology, ISSN 1552-4450, 07/2019, Volume 15, Issue 7, pp. 737 - 746
Ligand-dependent protein degradation has emerged as a compelling strategy to pharmacologically control the protein content of cells. So far, however, only a... 
TARGET | DESIGN | DESTRUCTION | THERAPEUTIC STRATEGY | RECOGNITION | SELECTIVE DEGRADATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | LENALIDOMIDE | CEREBLON | PROTEOLYSIS | DISCOVERY | Proteins | Degradation | Ubiquitin | Organic chemistry | Proteolysis | Ligands | Pharmacology | Chimeras | Substrates | Ubiquitin-protein ligase | Index Medicus
Journal Article
Cell, ISSN 0092-8674, 05/2018, Volume 173, Issue 4, pp. 815 - 817
Matching genetically defined cancer states to drugs that specifically target these states is a principal goal of personalized oncology medicine. In this issue,... 
BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL BIOLOGY | Lung cancer | Cancer | Index Medicus
Journal Article
Current Topics in Microbiology and Immunology, ISSN 0070-217X, 2019, Volume 420, pp. v - vii
Journal Article
Biochemistry, ISSN 0006-2960, 10/2018, Volume 57, Issue 39, pp. 5759 - 5767
Deleterious mutations in the serine hydrolase DDHD domain containing 1 (DDHD1) cause the SPG28 subtype of the neurological disease hereditary spastic... 
ACYLTRANSFERASE | ACID | CLONING | FORM | BIOCHEMISTRY & MOLECULAR BIOLOGY | METABOLIZING ENZYMES | MUTATIONS | LYSOPHOSPHATIDYLINOSITOL | PHOSPHOINOSITIDES | PARAPARESIS | Index Medicus
Journal Article
Chemical Science, ISSN 2041-6520, 2018, Volume 9, Issue 8, pp. 2290 - 2294
The opportunistic human pathogen Pseudomonas aeruginosa secretes 2-heptyl-3-hydroxy-4-quinolone (PQS), a quorum sensing (QS) signal that regulates the... 
CELLS | BACTERIA | QUORUM | SYSTEMS | LIGAND | BINDING | CHEMISTRY, MULTIDISCIPLINARY | DISCOVERY | PROBES | Proteins | Pseudomonas aeruginosa | Gene expression | Virulence
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 05/2015, Volume 353, Issue 2, pp. 424 - 432
Journal Article
Cell Metabolism, ISSN 1550-4131, 09/2019, Volume 30, Issue 3, pp. 525 - 538.e8
Advances in DNA sequencing technologies have reshaped our understanding of the molecular basis of cancer, providing a precise genomic view of tumors.... 
Medical colleges | Genetic aspects | Phospholipids | Nucleotide sequencing | Cancer | DNA sequencing | Index Medicus
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 02/2019, Volume 62, Issue 3, pp. 1643 - 1656
ABHD12 is a membrane-bound hydrolytic enzyme that acts on the lysophosphatidylserine (lyso-PS) and lysophosphatidylinositol (lyso-PI) classes of... 
CELLS | CHEMISTRY, MEDICINAL | LYSOPHOSPHOLIPIDS | POTENCY | REVERSIBLE INHIBITORS | MODEL | RECEPTORS
Journal Article
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 02/2019, Volume 63, Issue 2, p. e01253-18
Journal Article
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