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science & technology (132) 132
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oncology (111) 111
colorectal cancer (78) 78
humans (75) 75
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male (52) 52
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proto-oncogene proteins b-raf - genetics (15) 15
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aged, 80 and over (13) 13
genetic aspects (13) 13
kaplan-meier estimate (13) 13
antineoplastic combined chemotherapy protocols - administration & dosage (12) 12
antineoplastic combined chemotherapy protocols - adverse effects (12) 12
receptor, epidermal growth factor - antagonists & inhibitors (12) 12
single-nucleotide polymorphism (12) 12
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hematology, oncology and palliative medicine (11) 11
liver neoplasms - secondary (11) 11
organoplatinum compounds - administration & dosage (11) 11
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medical prognosis (10) 10
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antibodies, monoclonal, humanized - administration & dosage (9) 9
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biomarkers, tumor - genetics (9) 9
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cancer patients (7) 7
cetuximab - administration & dosage (7) 7
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1. Full Text FOLFOXIRI plus bevacizumab versus FOLFIRI plus bevacizumab as first-line treatment of patients with metastatic colorectal cancer: updated overall survival and molecular subgroup analyses of the open-label, phase 3 TRIBE study
by Cremolini, Chiara, MD and Loupakis, Fotios, PhD and Antoniotti, Carlotta, MD and Lupi, Cristiana, BSc and Sensi, Elisa, PhD and Lonardi, Sara, MD and Mezi, Silvia, MD and Tomasello, Gianluca, MD and Ronzoni, Monica, MD and Zaniboni, Alberto, MD and Tonini, Giuseppe, Prof and Carlomagno, Chiara, PhD and Allegrini, Giacomo, MD and Chiara, Silvana, MD and D'Amico, Mauro, MD and Granetto, Cristina, MD and Cazzaniga, Marina, MD and Boni, Luca, MD and Fontanini, Gabriella, Prof and Falcone, Alfredo, Prof
The lancet oncology, ISSN 1470-2045, 2015, Volume 16, Issue 13, pp. 1306 - 1315
Hematology, Oncology and Palliative Medicine | Life Sciences & Biomedicine | Oncology | Science & Technology | Leucovorin - administration & dosage | ras Proteins - genetics | Proto-Oncogene Proteins p21(ras) | Bevacizumab - therapeutic use | Bevacizumab - adverse effects | Colorectal Neoplasms - genetics | Humans | Middle Aged | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Male | Angiogenesis Inhibitors - administration & dosage | Neoplasm Metastasis | Organoplatinum Compounds - administration & dosage | Fluorouracil - administration & dosage | Time Factors | DNA Mutational Analysis | Colorectal Neoplasms - drug therapy | Angiogenesis Inhibitors - therapeutic use | Camptothecin - administration & dosage | Female | Angiogenesis Inhibitors - adverse effects | Camptothecin - analogs & derivatives | Colorectal Neoplasms - mortality | Bevacizumab - administration & dosage | Drug Administration Schedule | Kaplan-Meier Estimate | Proportional Hazards Models | Proto-Oncogene Proteins - genetics | Treatment Outcome | Disease-Free Survival | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Proto-Oncogene Proteins B-raf - genetics | Intention to Treat Analysis | Italy | Aged | Infusions, Intravenous | Mutation | Colorectal Neoplasms - pathology | Antimitotic agents | Cancer patients | Care and treatment | Patient outcomes | Analysis | Colorectal cancer | Leucovorin | Metastasis | Antineoplastic agents | Index Medicus
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2. Full Text Initial Therapy with FOLFOXIRI and Bevacizumab for Metastatic Colorectal Cancer
by Loupakis, Fotios and Cremolini, Chiara and Masi, Gianluca and Lonardi, Sara and Zagonel, Vittorina and Salvatore, Lisa and Cortesi, Enrico and Tomasello, Gianluca and Ronzoni, Monica and Spadi, Rosella and Zaniboni, Alberto and Tonini, Giuseppe and Buonadonna, Angela and Amoroso, Domenico and Chiara, Silvana and Carlomagno, Chiara and Boni, Luca and Boni, Corrado and Allegrini, Giacomo and Falcone, Alfredo
The New England journal of medicine, ISSN 0028-4793, 10/2014, Volume 371, Issue 17, pp. 1609 - 1618
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Gastroenterology. Liver. Pancreas. Abdomen | Stomach. Duodenum. Small intestine. Colon. Rectum. Anus | General aspects | Pharmacology. Drug treatments | Biological and medical sciences | Medical sciences | Immunomodulators | Tumors | Follow-Up Studies | Humans | Middle Aged | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Male | Bevacizumab | Fluorouracil - therapeutic use | Antibodies, Monoclonal, Humanized - administration & dosage | Leucovorin - adverse effects | Fluorouracil - adverse effects | Neoplasm Metastasis - drug therapy | Colorectal Neoplasms - drug therapy | Adult | Female | Leucovorin - therapeutic use | Liver Neoplasms - secondary | Camptothecin - analogs & derivatives | Colorectal Neoplasms - mortality | Antibodies, Monoclonal, Humanized - adverse effects | Camptothecin - adverse effects | Camptothecin - therapeutic use | Kaplan-Meier Estimate | Liver Neoplasms - drug therapy | Disease-Free Survival | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Aged | Colorectal Neoplasms - pathology | Organoplatinum Compounds - therapeutic use | Organoplatinum Compounds - adverse effects | Treatment outcome | Care and treatment | Analysis | Colorectal cancer | Dosage and administration | Leucovorin | Fluorouracil | Colorectal carcinoma | Diarrhea | Metastasis | Survival | Patients | Clinical outcomes | Metastases | Irinotecan | Stomatitis | Chemotherapy | Neurotoxicity | Oxaliplatin | Monoclonal antibodies | Vascular endothelial growth factor | Neutropenia | Index Medicus | Abridged Index Medicus
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3. Full Text Heterogeneity of acquired resistance to anti-EGFR monoclonal antibodies in patients with metastatic colorectal cancer
by Pietrantonio, Filippo and Vernieri, Claudio and Siravegna, Giulia and Mennitto, Alessia and Berenato, Rosa and Perrone, Federica and Gloghini, Annunziata and Tamborini, Elena and Lonardi, Sara and Morano, Federica and Picciani, Benedetta and Busico, Adele and Volpi, Chiara Costanza and Martinetti, Antonia and Battaglin, Francesca and Bossi, Ilaria and Pellegrinelli, Alessio and Milione, Massimo and Cremolini, Chiara and Di Bartolomeo, Maria and Bardelli, Alberto and De Braud, Filippo
Clinical cancer research, ISSN 1078-0432, 05/2017, Volume 23, Issue 10, pp. 2414 - 2422
Life Sciences & Biomedicine | Oncology | Science & Technology | Receptor, Epidermal Growth Factor - genetics | Receptor, ErbB-2 - genetics | Proto-Oncogene Proteins p21(ras) - genetics | Colorectal Neoplasms - genetics | Humans | Middle Aged | Male | Neoplasm Metastasis | Antibodies, Monoclonal, Humanized - administration & dosage | Colorectal Neoplasms - drug therapy | Adult | Female | Colorectal Neoplasms - blood | Membrane Proteins - genetics | Proto-Oncogene Proteins c-met - genetics | Biomarkers, Tumor - blood | Disease-Free Survival | Drug Resistance, Neoplasm - genetics | GTP Phosphohydrolases - genetics | Proto-Oncogene Proteins B-raf - genetics | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Aged | Circulating Tumor DNA - blood | Mutation | Colorectal Neoplasms - pathology | Epidermal growth factor receptors | Colorectal carcinoma | Colorectal cancer | Tissue analysis | Metastasis | Patients | ErbB-2 protein | Blood | K-Ras protein | Metastases | Complexity | Amplification | Silver | Heterogeneity | Experimental design | Emergence | Monoclonal antibodies | Evolution | Tumors | Cancer | Index Medicus
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4. Full Text Serum LDH predicts benefit from bevacizumab beyond progression in metastatic colorectal cancer
by Marmorino, Federica and Salvatore, Lisa and Barbara, Cecilia and Allegrini, Giacomo and Antonuzzo, Lorenzo and Masi, Gianluca and Loupakis, Fotios and Borelli, Beatrice and Chiara, Silvana and Banzi, Maria Chiara and Miraglio, Emanuela and Amoroso, Domenico and Dargenio, Francesco and Bonetti, Andrea and Martignetti, Angelo and Paris, Myriam and Tomcikova, Daniela and Boni, Luca and Falcone, Alfredo and Cremolini, Chiara
British journal of cancer, ISSN 0007-0920, 01/2017, Volume 116, Issue 3, pp. 318 - 323
LDH | bevacizumab beyond progression | predictive marker | Life Sciences & Biomedicine | Oncology | Science & Technology | Adenocarcinoma - pathology | Bevacizumab - therapeutic use | Prognosis | Humans | Middle Aged | Male | Treatment Outcome | Adenocarcinoma - drug therapy | Disease Progression | Biomarkers, Tumor - blood | Neoplasm Metastasis | L-Lactate Dehydrogenase - blood | Colorectal Neoplasms - drug therapy | Angiogenesis Inhibitors - therapeutic use | Adult | Female | Aged | Chemotherapy, Adjuvant | Colorectal Neoplasms - pathology | Index Medicus | Translational Therapeutics
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5. Full Text Upfront FOLFOXIRI plus bevacizumab and reintroduction after progression versus mFOLFOX6 plus bevacizumab followed by FOLFIRI plus bevacizumab in the treatment of patients with metastatic colorectal cancer (TRIBE2): a multicentre, open-label, phase 3, randomised, controlled trial
by Cremolini, Chiara and Antoniotti, Carlotta and Rossini, Daniele and Lonardi, Sara and Loupakis, Fotios and Pietrantonio, Filippo and Bordonaro, Roberto and Latiano, Tiziana Pia and Tamburini, Emiliano and Santini, Daniele and Passardi, Alessandro and Marmorino, Federica and Grande, Roberta and Aprile, Giuseppe and Zaniboni, Alberto and Murgioni, Sabina and Granetto, Cristina and Buonadonna, Angela and Moretto, Roberto and Corallo, Salvatore and Cordio, Stefano and Antonuzzo, Lorenzo and Tomasello, Gianluca and Masi, Gianluca and Ronzoni, Monica and Di Donato, Samantha and Carlomagno, Chiara and Clavarezza, Matteo and Ritorto, Giuliana and Mambrini, Andrea and Roselli, Mario and Cupini, Samanta and Mammoliti, Serafina and Fenocchio, Elisabetta and Corgna, Enrichetta and Zagonel, Vittorina and Fontanini, Gabriella and Ugolini, Clara and Boni, Luca and Falcone, Alfredo and Falcone, Alfredo and Lonardi, Sara and De Braud, Filippo Guglielmo Maria and Bordonaro, Roberto and Maiello, Evaristo and Tamburini, Emiliano and Santini, Daniele and Frassineti, Giovanni Luca and Gamucci, Teresa and Aprile, Giuseppe and Zaniboni, Alberto and Granetto, Cristina and Buonadonna, Angela and Di Costanzo, Francesco and Tomasello, Gianluca and Gianni, Luca and Di Donato, Samantha and Carlomagno, Chiara and Clavarezza, Matteo and Racca, Patrizia and Mambrini, Andrea and Roselli, Mario and Allegrini, Giacomo and Sobrero, Alberto and Aglietta, Massimo and Corgna, Enrichetta and Cortesi, Enrico and Corsi, Domenico Cristiano and Ballestrero, Alberto and Bonetti, Andrea and Di Clemente, Francesco and Ruggeri, Enzo and Ciardiello, Fortunato and Benasso, Marco and Vitello, Stefano and Cinieri, Saverio and Mosconi, Stefania and Silvestris, Nicola and Frassoldati, Antonio and Cupini, Samantha and Bertolini, Alessandro and Tortora, Giampaolo and Bengala, Carmelo and Ferrari, Daris and Ardizzoia, Antonia and Milandri, Carlo and Chiara, Silvana and Romano, Gianpiero and Miraglia, Stefania and Scaltriti, Laura and Pucci, Francesca and Blasi, Livio and Brugnatelli, Silvia and Fioretto, Luisa and Ribecco, Angela Stefania and Longarini, Raffaella and Frisinghelli, Michela and Banzi, Maria and GONO Foundation Investigators and GONO Fdn Investigators
The lancet oncology, ISSN 1470-2045, 04/2020, Volume 21, Issue 4, pp. 497 - 507
Life Sciences & Biomedicine | Oncology | Science & Technology | Index Medicus
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6. Full Text The landscape of d16HER2 splice variant expression across HER2-positive cancers
by Volpi, Chiara Costanza and Pietrantonio, Filippo and Gloghini, Annunziata and Fucà, Giovanni and Giordano, Silvia and Corso, Simona and Pruneri, Giancarlo and Antista, Maria and Cremolini, Chiara and Fasano, Elena and Saggio, Serena and Faraci, Simona and Di Bartolomeo, Maria and de Braud, Filippo and Di Nicola, Massimo and Tagliabue, Elda and Pupa, Serenella Maria and Castagnoli, Lorenzo
Scientific reports, ISSN 2045-2322, 12/2019, Volume 9, Issue 1, pp. 3545 - 3545
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Alternative splicing | Colorectal carcinoma | Xenografts | Breast cancer | mRNA | Hybridization | Exosomes | Gastric cancer | ErbB-2 protein | Trastuzumab | Cancer | Index Medicus
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7. When to use triplet chemotherapy as first-line treatment in metastatic colorectal cancer
by Cremolini, Chiara
Clinical advances in hematology & oncology, ISSN 1543-0790, 08/2019, Volume 17, Issue 8, p. 433
Colorectal Neoplasms - pathology | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Colorectal Neoplasms - drug therapy | Humans | Colorectal Neoplasms - diagnosis | Colorectal Neoplasms - metabolism
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8. Full Text Author Correction: The landscape of d16HER2 splice variant expression across HER2-positive cancers
by Volpi, Chiara Costanza and Pietrantonio, Filippo and Gloghini, Annunziata and Fucà, Giovanni and Giordano, Silvia and Corso, Simona and Pruneri, Giancarlo and Antista, Maria and Cremolini, Chiara and Fasano, Elena and Saggio, Serena and Faraci, Simona and Di Bartolomeo, Maria and de Braud, Filippo and Di Nicola, Massimo and Tagliabue, Elda and Pupa, Serenella Maria and Castagnoli, Lorenzo
Scientific reports, ISSN 2045-2322, 04/2020, Volume 10, Issue 1, pp. 7210 - 7210
Alternative splicing | ErbB-2 protein | Index Medicus
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9. Full Text Biomarkers of primary resistance to trastuzumab in HER2-positive metastatic gastric cancer patients: The AMNESIA case-control study
by Pietrantonio, Filippo and Fuca, Giovanni and Morano, Federica and Gloghini, Annunziata and Corso, Simona and Aprile, Giuseppe and Perrone, Federica and De Vita, Ferdinando and Tamborini, Elena and Tomasello, Gianluca and Gualeni, Ambra Vittoria and Ongaro, Elena and Busico, Adele and Giommoni, Elisa and Volpi, Chiara Costanza and Laterza, Maria Maddalena and Corallo, Salvatore and Prisciandaro, Michele and Antista, Maria and Pellegrinelli, Alessandro and Castagnoli, Lorenzo and Pupa, Serenella M and Pruneri, Giancarlo and de Braud, Filippo and Giordano, Silvia and Cremolini, Chiara and Bartolomeo, Maria Di
Clinical cancer research, ISSN 1078-0432, 03/2018, Volume 24, Issue 5, pp. 1082 - 1089
Life Sciences & Biomedicine | Oncology | Science & Technology | Impact prediction | Metastasis | Stomach cancer | Metastases | c-Met protein | Confidence intervals | Receptors | Alterations | Amnesia | Protein-tyrosine kinase | Gastric cancer | Predictive control | Tyrosine | Epidermal growth factor receptors | Patients | ErbB-2 protein | 1-Phosphatidylinositol 3-kinase | Signaling | Experimental design | Biomarkers | Mutation | PTEN protein | Trastuzumab | Tumors | Cancer | Index Medicus
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10. Full Text Duration of oxaliplatin‐based adjuvant chemotherapy in patients with Stage III or high‐risk Stage II resected colon cancer
by Moretto, Roberto and Falcone, Alfredo and Cremolini, Chiara
International journal of cancer, ISSN 0020-7136, 05/2020, Volume 146, Issue 9, pp. 2652 - 2654
Life Sciences & Biomedicine | Oncology | Science & Technology | Chemotherapy | Oxaliplatin | Colon cancer | Index Medicus
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11. Full Text TRIBE2 results and toxicity – Authors' reply
by Antoniotti, Carlotta and Cremolini, Chiara and Rossini, Daniele and Falcone, Alfredo
The lancet oncology, ISSN 1470-2045, 06/2020, Volume 21, Issue 6, pp. e300 - e301
Index Medicus
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12. Full Text Bevacizumab with FOLFOXIRI (irinotecan, oxaliplatin, fluorouracil, and folinate) as first-line treatment for metastatic colorectal cancer: a phase 2 trial
by Masi, Gianluca, Dr and Loupakis, Fotios, MD and Salvatore, Lisa, MD and Fornaro, Lorenzo, MD and Cremolini, Chiara, MD and Cupini, Samanta, MD and Ciarlo, Andrea, MD and Del Monte, Francesca, PhD and Cortesi, Enrico, MD and Amoroso, Domenico, MD and Granetto, Cristina, MD and Fontanini, Gabriella, Prof and Sensi, Elisa, MD and Lupi, Cristiana, MD and Andreuccetti, Michele, CTA and Falcone, Alfredo, MD
The lancet oncology, ISSN 1470-2045, 2010, Volume 11, Issue 9, pp. 845 - 852
Hematology, Oncology and Palliative Medicine | Life Sciences & Biomedicine | Oncology | Science & Technology | Leucovorin - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - administration & dosage | Humans | Middle Aged | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Male | Bevacizumab | Antibodies, Monoclonal, Humanized | Organoplatinum Compounds - administration & dosage | Fluorouracil - administration & dosage | Leucovorin - adverse effects | Fluorouracil - adverse effects | Colorectal Neoplasms - drug therapy | Adult | Camptothecin - administration & dosage | Female | Camptothecin - analogs & derivatives | Colorectal Neoplasms - mortality | Camptothecin - adverse effects | Kaplan-Meier Estimate | Adenocarcinoma - drug therapy | Disease-Free Survival | Antibodies, Monoclonal - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Aged | Organoplatinum Compounds - adverse effects | Adenocarcinoma - mortality | Chemotherapy | Oncology, Experimental | Colorectal cancer | Clinical trials | Metastasis | Research | Angiogenesis inhibitors | Drug therapy | Cancer | Medical research | Analysis | Medicine, Experimental | Index Medicus
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13. Full Text Clonal evolution and resistance to EGFR blockade in the blood of colorectal cancer patients
by Siravegna, Giulia and Mussolin, Benedetta and Buscarino, Michela and Corti, Giorgio and Cassingena, Andrea and Crisafulli, Giovanni and Ponzetti, Agostino and Cremolini, Chiara and Amatu, Alessio and Lauricella, Calogero and Lamba, Simona and Hobor, Sebastijan and Avallone, Antonio and Valtorta, Emanuele and Rospo, Giuseppe and Medico, Enzo and Motta, Valentina and Antoniotti, Carlotta and Tatangelo, Fabiana and Bellosillo, Beatriz and Veronese, Silvio and Budillon, Alfredo and Montagut, Clara and Racca, Patrizia and Marsoni, Silvia and Falcone, Alfredo and Corcoran, Ryan B and Di Nicolantonio, Federica and Loupakis, Fotios and Siena, Salvatore and Sartore-Bianchi, Andrea and Bardelli, Alberto
Nature medicine, ISSN 1078-8956, 07/2015, Volume 21, Issue 7, pp. 795 - 801
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Cell Biology | Research & Experimental Medicine | Antibodies - therapeutic use | Receptor, Epidermal Growth Factor - genetics | Receptor, Epidermal Growth Factor - immunology | ras Proteins - genetics | Proto-Oncogene Proteins p21(ras) | Colorectal Neoplasms - blood | Antibodies, Neoplasm - blood | Colorectal Neoplasms - genetics | Humans | Proto-Oncogene Proteins - genetics | Antineoplastic Agents - therapeutic use | Mutation - genetics | Antibodies - pharmacology | Drug Resistance, Neoplasm - genetics | DNA, Neoplasm - blood | Colorectal Neoplasms - drug therapy | Alleles | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Antineoplastic Agents - pharmacology | Clone Cells | Colorectal Neoplasms - pathology | Clonal Evolution | Index Medicus
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