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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 6/2016, Volume 113, Issue 26, pp. 7124 - 7129
Journal Article
Leukemia, ISSN 0887-6924, 09/2017, Volume 31, Issue 9, pp. 1951 - 1961
The PROTAC (proteolysis-targeting chimera) ARV-825 recruits bromodomain and extraterminal (BET) proteins to the E3 ubiquitin ligase cereblon, leading to... 
TRANSFORMATION | PATHOGENESIS | JAK2 INHIBITOR | ONCOLOGY | ACUTE MYELOGENOUS LEUKEMIA | KINASE | DEGRADATION | ACUTE MYELOID-LEUKEMIA | OVERCOMES RESISTANCE | HEMATOLOGY | CANCER | BRD4 | Antigens, CD34 | Apoptosis - drug effects | Leukemia, Myeloid, Acute - pathology | Humans | Leukemia | Ubiquitin-Protein Ligases - metabolism | Nuclear Proteins - metabolism | Myeloproliferative Disorders - pathology | Thalidomide - pharmacology | Azepines - therapeutic use | Azepines - pharmacology | Transcription Factors - metabolism | Thalidomide - analogs & derivatives | Animals | Tumor Burden - drug effects | Proteolysis | Cell Line, Tumor | Leukemia, Myeloid, Acute - drug therapy | Mice | Thalidomide - therapeutic use | Chimera | Pyrazoles - pharmacology | Care and treatment | Usage | Messenger RNA | Chimeras (Organisms) | Research | Mass spectrometry | Myeloproliferative disorders | Ubiquitin | Surgical implants | c-Myc protein | In vitro testing | mRNA | Myc protein | Cyclin-dependent kinase 4 | Degradation | Proteins | Biomedical materials | Bcl-x protein | Janus kinase 2 | Biocompatibility | Ubiquitin-protein ligase | CD34 antigen | Cell survival | Stat3 protein | Hemopoiesis | Cytometry | Protein arrays | Depletion | Inhibitors | Ribonucleic acids | Cells (biology) | Bcl protein | Bet protein | In vivo methods and tests | Acute myeloid leukemia | Apoptosis | Secondary AML | PROTAC | protein degradation
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 08/2011, Volume 10, Issue 8, pp. 1394 - 1406
Journal Article
Current Opinion in Investigational Drugs, ISSN 1472-4472, 06/2010, Volume 11, Issue 6, pp. 638 - 645
The PI3K/Akt/mTOR pathway is frequently activated in human cancers, and mTOR is a clinically validated target for therapeutic intervention in this pathway. The... 
MTORC1 | MTORC2 | Rapalog | Inhibitor | MTOR complex 2 | Rapamycin | MTOR complex 1 | MTOR | rapalog | MAMMALIAN TARGET | MESSENGER-RNA TRANSLATION | mTOR complex 2 | mTOR complex 1 | UPSTREAM | CELL-GROWTH | CANCER | TYROSINE | PATHWAY | SIGNALING NETWORK | mTOR | PHARMACOLOGY & PHARMACY | mTORC2 | mTORC1 | rapamycin | KINASES
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 03/2019, Volume 37, Issue 7_suppl, pp. 259 - 259
Journal Article
Cancer Research, ISSN 0008-5472, 07/2018, Volume 78, Issue 13 Supplement, pp. 5236 - 5236
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 08/2013, Volume 23, Issue 16, pp. 4511 - 4516
Journal Article
Cancer Research, ISSN 0008-5472, 07/2017, Volume 77, Issue 13 Supplement, pp. 5637 - 5637
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 02/2017, Volume 35, Issue 6_suppl, pp. 273 - 273
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 05/2015, Volume 33, Issue 15_suppl, pp. 8557 - 8557
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 02/2018, Volume 36, Issue 6_suppl, pp. 381 - 381
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 06/2016, Volume 113, Issue 26, p. 7124
  Prostate cancer has the second highest incidence among cancers in men worldwide and is the second leading cause of cancer deaths of men in the United States.... 
Proteins | Molecules | Medical prognosis | Rodents | Medical treatment | Prostate cancer
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 01/2016, Volume 34, Issue 2_suppl, pp. 267 - 267
Journal Article
Cancer Research, ISSN 0008-5472, 08/2015, Volume 75, Issue 15 Supplement, pp. LB-097 - LB-097
Journal Article
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