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Nature, ISSN 0028-0836, 02/2018, Volume 554, Issue 7690, pp. 34 - 35
Journal Article
Nature, ISSN 0028-0836, 02/2018, Volume 554, Issue 7690, pp. 34 - 35
The assembly of genome sequences for the flatworm Schmidtea mediterranea and the salamander Ambystoma mexicanum will provide insights into the remarkable... 
Regeneration | Genome | Urodela | Platyhelminths | Genetic aspects | Genomes | Regeneration (Biology) | Observations | Reports | Genomics | Studies | Cell division | Genetic engineering | Research | Gene expression | Reptiles & amphibians | Deoxyribonucleic acid--DNA | Worms | Index Medicus
Journal Article
Cancer Research, ISSN 0008-5472, 01/2019, Volume 79, Issue 1, pp. 251 - 262
Although the number of proteins effectively targeted for posttranslational degradation by PROTAC has grown steadily, the number of E3 ligases successfully... 
BET | UBIQUITINATION | DESIGN | ACTIVATION | CHIMERIC MOLECULES | INHIBITION | ONCOLOGY | INDUCE DEGRADATION | TARGETED PROTEIN-DEGRADATION | KNOCKDOWN | BROMODOMAIN
Journal Article
Biochemistry, ISSN 0006-2960, 02/2019, Volume 58, Issue 7, pp. 861 - 864
Journal Article
Cancer Research, ISSN 0008-5472, 07/2019, p. canres.1236.2019
While the use of ATP-competitive tyrosine kinase inhibitors of oncoprotein BCR-ABL1 has enabled durable responses in patients with chronic myeloid leukemia... 
Journal Article
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 06/2016, Volume 59, Issue 11, pp. 5129 - 5130
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 01/2018, Volume 61, Issue 2, pp. 403 - 404
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 6/2016, Volume 113, Issue 26, pp. 7124 - 7129
Journal Article
Angewandte Chemie International Edition, ISSN 1433-7851, 01/2016, Volume 55, Issue 2, pp. 807 - 810
Journal Article
Molecular biology of the cell, 06/2019, p. mbcE19010069
In eukaryotic cells, organelle-specific protein quality control is critical for maintaining cellular homeostasis. Despite the Golgi apparatus being the major... 
Journal Article
Angewandte Chemie, ISSN 0044-8249, 02/2016, Volume 128, Issue 6, pp. 2002 - 2010
Die heutigen, auf Inhibitoren basierenden Therapieansätze sind zwangsläufig eingeschränkt durch 1) die Notwendigkeit von hoher systemischer Exposition, um... 
Wirkstoffentwicklung | PROTAC | E3-Ligase | Proteinabbau | Inhibitoren | Proteins
Journal Article
Angewandte Chemie, ISSN 0044-8249, 02/2016, Volume 128, Issue 6, p. 2002
  Die heutigen, auf Inhibitoren basierenden Therapieansätze sind zwangsläufig eingeschränkt durch 1)die Notwendigkeit von hoher systemischer Exposition, um... 
Proteins | Proteolysis | Chimeras
Journal Article
Nature Chemical Biology, ISSN 1552-4450, 08/2015, Volume 11, Issue 8, pp. 611 - 617
The current predominant therapeutic paradigm is based on maximizing drug-receptor occupancy to achieve clinical benefit. This strategy, however, generally... 
CHIMERIC MOLECULES | CHEMICAL PROTEOMICS | STRUCTURAL BASIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESTROGEN-RECEPTOR-ALPHA | KINASE INHIBITORS | CARD15 MUTATIONS | BLAU-SYNDROME | ABSOLUTE QUANTIFICATION | LIGASE COMPLEX | CELL-DEATH | Neoplasm Transplantation | Small Molecule Libraries - pharmacology | Receptors, Estrogen - metabolism | Humans | Ubiquitin - metabolism | Neoplasm Proteins - antagonists & inhibitors | Molecular Targeted Therapy | Neoplasm Proteins - metabolism | Receptor-Interacting Protein Serine-Threonine Kinase 2 - genetics | Breast Neoplasms - metabolism | Receptor-Interacting Protein Serine-Threonine Kinase 2 - metabolism | Ubiquitination | MCF-7 Cells | Proteolysis | Female | Antineoplastic Agents - pharmacology | Von Hippel-Lindau Tumor Suppressor Protein - genetics | Neoplasm Proteins - genetics | Binding Sites | Von Hippel-Lindau Tumor Suppressor Protein - metabolism | Receptor-Interacting Protein Serine-Threonine Kinase 2 - antagonists & inhibitors | Biocatalysis | Receptors, Estrogen - genetics | Models, Molecular | Receptors, Estrogen - antagonists & inhibitors | Ubiquitin - genetics | Breast Neoplasms - drug therapy | Animals | Breast Neoplasms - genetics | Breast Neoplasms - pathology | Protein Binding | Mice | Proteasome Endopeptidase Complex - metabolism | Proteins | Molecular biology | Biocatalysts | Index Medicus
Journal Article
Journal Article
Nature Communications, ISSN 2041-1723, 12/2019, Volume 10, Issue 1, pp. 131 - 13
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 12/2018, Volume 140, Issue 48, pp. 16428 - 16432
The receptor tyrosine kinase FLT-3 is frequently mutated in acute myeloid leukemia; however, current small molecule inhibitors suffer from limited efficacy in... 
UBIQUITINATION | INDUCED PROTEIN-DEGRADATION | MEDIATED DEGRADATION | ACUTE MYELOID-LEUKEMIA | INDUCE DEGRADATION | MUTATIONS | KNOCKDOWN | PROTAC DESIGN | CHEMISTRY, MULTIDISCIPLINARY | MODULATION | MOLECULES
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 5/2013, Volume 110, Issue 22, pp. 8942 - 8947
Posttranslational knockdown of a specific protein is an attractive approach for examining its function within a system. Here we introduce phospho-dependent... 
Molecules | Receptors | Phosphorylation | Cell growth | Nerves | Cell lines | Growth factor receptors | Viability | PC12 cells | Tumors | Signal transduction | Protein degradation | SH2 domain | signal transduction | MULTIDISCIPLINARY SCIENCES | PROLIFERATION | IDENTIFICATION | CANCER | BREAST | NERVE GROWTH-FACTOR | MOLECULES | DELIVERY | UBIQUITINATION | DEGRADATION | PC12 CELLS | protein degradation | Receptor, ErbB-3 - metabolism | Receptor, Fibroblast Growth Factor, Type 2 - metabolism | Humans | Protein Processing, Post-Translational - genetics | Receptor, trkA - antagonists & inhibitors | Molecular Sequence Data | Immunoblotting | Phosphatidylinositol 3-Kinases - metabolism | Chromatography, High Pressure Liquid | PC12 Cells | Gene Knockdown Techniques | MCF-7 Cells | Proteolysis | Streptavidin | Female | Molecular Structure | Von Hippel-Lindau Tumor Suppressor Protein - metabolism | Amino Acid Sequence | Rats | Receptor Protein-Tyrosine Kinases - metabolism | Protein Processing, Post-Translational - physiology | Animals | Analysis of Variance | Receptor, trkA - metabolism | Signal Transduction - physiology | Mice | Enzyme Activation - physiology | Receptor, Fibroblast Growth Factor, Type 2 - genetics | Post-translational modification | Tyrosine | Physiological aspects | Research | Health aspects | Phosphotransferases | Proteins | Peptides | Ribonucleic acid--RNA | Index Medicus | Biological Sciences
Journal Article
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