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Journal of Clinical Investigation, ISSN 0021-9738, 01/2013, Volume 123, Issue 1, pp. 340 - 347
Neurofibromatosis type 1 (NF1) patients develop benign neurofibromas and malignant peripheral nerve sheath tumors (MPNST). These incurable peripheral nerve... 
MEDICINE, RESEARCH & EXPERIMENTAL | SIGNALING PATHWAYS | PLEXIFORM NEUROFIBROMAS | GENOMIC ANALYSES | THERAPEUTIC TARGET | NF1 | SCHWANN-CELLS | HYPERACTIVE RAS | CANCER | NERVE SHEATH TUMORS | PREVIOUSLY TREATED PATIENTS | Neoplasm Transplantation | Mitogen-Activated Protein Kinase Kinases - genetics | Diphenylamine - pharmacology | Humans | Child, Preschool | Male | Transplantation, Heterologous | Extracellular Signal-Regulated MAP Kinases - metabolism | raf Kinases - metabolism | Extracellular Signal-Regulated MAP Kinases - genetics | Oncogene Protein p21(ras) - metabolism | Diphenylamine - analogs & derivatives | Mitogen-Activated Protein Kinase Kinases - metabolism | Peripheral Nervous System Neoplasms - enzymology | Mice, Mutant Strains | Female | Benzamides - pharmacology | Neurofibromatosis 1 - genetics | Peripheral Nervous System Neoplasms - pathology | raf Kinases - genetics | Child | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | Peripheral Nervous System Neoplasms - drug therapy | Transcriptome - drug effects | Transcriptome - genetics | Xenograft Model Antitumor Assays | Neurofibromatosis 1 - enzymology | Neurofibromatosis 1 - pathology | Animals | Neurofibromatosis 1 - drug therapy | Mice | Peripheral Nervous System Neoplasms - genetics | Oncogene Protein p21(ras) - genetics | Physiological aspects | Causes of | Neural stimulation | Enzyme inhibitors | Properties | Neurofibromatosis
Journal Article
Journal Article
2015, 2015, Pediatric Oncology, ISBN 9783319180984, 313
This book describes in detail current best practice in the diagnosis and treatment of malignant pediatric bone tumors and also discusses other important... 
Clinical & internal medicine | Rehabilitation | Pediatrics | Oncology | Medicine & Public Health | Surgery
eBook
Journal Article
PEDIATRICS, ISSN 0031-4005, 06/2019, Volume 143, Issue 6, p. e20182495
Cardiac rhabdomyoma is the most common neonatal cardiac tumor and is typically associated with tuberous sclerosis complex (TSC). Although these tumors may... 
REGRESSION | PEDIATRICS | TUBEROUS SCLEROSIS COMPLEX | NEWBORN | INFANTS | Heart | TOR protein | Neonates | Cardiac arrhythmia | Therapy | Echocardiography | Stability | Arrhythmia | Dimensional measurement | Case reports | Tuberous sclerosis | Rapamycin | Anticancer properties | Magnetic resonance imaging | Antitumor activity | Hemodynamics | Monitoring | Tumors
Journal Article
Pediatric Blood & Cancer, ISSN 1545-5009, 09/2018, Volume 65, Issue 9, pp. e27227 - n/a
Osteosarcoma is the most common bone tumor in children and young adults, with few advances in survival and treatment, especially for metastatic disease, in the... 
osteosarcoma | sarcoma | immunotherapy | PD-L1 EXPRESSION | PHASE-II | COMBINATION | MHC CLASS-I | T-CELL INFILTRATION | AUTOLOGOUS TUMOR LYSATE | ONCOLOGY | CANCER REGRESSION | PEDIATRIC-PATIENTS | PEDIATRICS | REFRACTORY SOLID TUMORS | BLOCKADE | HEMATOLOGY | Osteosarcoma | Immunotherapy | Medical research | Bone cancer | Young adults | Medical treatment | Clinical trials | Biocompatibility | Adults | Bone tumors | Children | Metastases
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2017, Volume 7, Issue 1, pp. 2396 - 10
Oncolytic virotherapy is an effective immunotherapeutic approach for cancer treatment via a multistep process including direct tumor cell lysis, induction of... 
RESPONSES | IMMUNITY | VIRUS | THERAPY | IMMUNOTHERAPY | MULTIDISCIPLINARY SCIENCES | SENSITIVITY | TUMORS | CHECKPOINT BLOCKADE | Simplexvirus - physiology | Dendritic Cells - immunology | Programmed Cell Death 1 Receptor - antagonists & inhibitors | T-Lymphocytes, Regulatory - immunology | Injections, Intralesional | Neoplasms, Experimental | Dendritic Cells - drug effects | Female | Cytokines - genetics | Rhabdomyosarcoma - mortality | Rhabdomyosarcoma - immunology | Cytokines - immunology | Gene Expression | Antibodies, Monoclonal - pharmacology | Mice, Inbred C57BL | Injections, Intraperitoneal | Oncolytic Virotherapy - methods | T-Lymphocytes, Regulatory - drug effects | Animals | CD8-Positive T-Lymphocytes - drug effects | Survival Analysis | Combined Modality Therapy - methods | Mice | Rhabdomyosarcoma - genetics | Programmed Cell Death 1 Receptor - immunology | CD8-Positive T-Lymphocytes - immunology | Programmed Cell Death 1 Receptor - genetics | Rhabdomyosarcoma - therapy | Animal models | PD-1 protein | CD8 antigen | Rhabdomyosarcoma | Herpes simplex | Cytotoxicity | Lymphocytes T | Lymphocytes | Immunotherapy | Oncolysis | CD25 antigen | Foxp3 protein | Children | Cytokines | Soft tissue sarcoma | CD4 antigen | Immunosuppression | Major histocompatibility complex | Cell death | PD-L1 protein | Lysis | Antitumor activity | Ligands | Solid tumors | Apoptosis | Tumors
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 11/2015, Volume 125, Issue 11, pp. 4269 - 4280
Oncolytic viral (OV) therapy, which uses genetically engineered tumor-targeting viruses, is being increasingly used in cancer clinical trials due to the direct... 
NUCLEAR-LOCALIZATION | MEDICINE, RESEARCH & EXPERIMENTAL | HERPES-SIMPLEX-VIRUS | STEM-CELLS | TEGUMENT PROTEIN | INNATE ANTIVIRAL RESPONSE | COMBINATION THERAPY | GENE-EXPRESSION | MICROTUBULE REORGANIZATION | TYPE-1 INFECTION | MAMMALIAN-CELLS | RNA, Small Interfering - genetics | Humans | Brain Neoplasms - pathology | Neoplasm Proteins - antagonists & inhibitors | Tubulin - genetics | Protein Transport - drug effects | Acetyltransferases - genetics | Valproic Acid - pharmacology | Glioma - genetics | Herpesvirus 1, Human - physiology | Microtubules - metabolism | Tubulin - metabolism | RNA, Viral - genetics | RNA Interference | Glioma - pathology | Cell Nucleus - virology | Acetylation | Capsid - metabolism | Spheroids, Cellular | Hydroxamic Acids - pharmacology | Virus Replication - drug effects | Histone Deacetylases - genetics | Histone Deacetylase 6 | Endocytosis - drug effects | RNA, Messenger - genetics | Brain Neoplasms - genetics | Interferon-beta - antagonists & inhibitors | Oncolytic Virotherapy - methods | Interferon-beta - pharmacology | Anilides - pharmacology | Oncolytic Viruses - physiology | Cell Line, Tumor | RNA, Neoplasm - genetics | Histone Deacetylase Inhibitors - pharmacology | Lysosomes - virology | Protein Processing, Post-Translational | Histone Deacetylases - physiology | Brain Neoplasms - virology | In Vitro Techniques | Glioma - virology | Enzymes | Care and treatment | Biological products | Gliomas | Regulation | Health aspects | Methods | Genetic engineering | Analysis | Genetically modified organisms | Microscopy | Immunotherapy | Medical prognosis | Colleges & universities | Infections | Experiments | Viral infections | Tumors
Journal Article
Cancer, ISSN 0008-543X, 06/2017, Volume 123, Issue 12, pp. 2368 - 2375
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 07/2017, Volume 23, Issue 14, pp. 3566 - 3574
Journal Article