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1. Full Text The interplay between microbes and the immune response in inflammatory bowel disease
: Interplay between NOD2, microbiota and immune response in IBD
by Goethel, Ashleigh and Croitoru, Kenneth and Philpott, Dana J
The Journal of Physiology, ISSN 0022-3751, 09/2018, Volume 596, Issue 17, pp. 3869 - 3882
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2. Full Text The interplay between microbes and the immune response in inflammatory bowel disease
by Goethel, Ashleigh and Croitoru, Kenneth and Philpott, Dana J
The Journal of Physiology, ISSN 0022-3751, 09/2018, Volume 596, Issue 17, pp. 3869 - 3882
The aetiology and pathogenesis of inflammatory bowel disease (IBD) remains unclear but involves a complex interplay between genetic risk, environmental... 
inflammatory bowel diseases | innate immunity | Nod2 | NLRs | gut microbiota | adaptive immunity | immune‐microbe interactions | immune-microbe interactions | PHYSIOLOGY | CROHNS-DISEASE | EARLY-LIFE | COMMENSAL BACTERIA | HUMAN GUT MICROBIOTA | ULCERATIVE-COLITIS | CD4(+) T-CELLS | INTERLEUKIN-10-DEFICIENT MICE | NEUROSCIENCES | INTESTINAL EPITHELIAL-CELLS | NOD-LIKE RECEPTORS | CITROBACTER-RODENTIUM INFECTION | Disease susceptibility | Immune response | Microbiota (Symbiotic organisms) | Gastrointestinal diseases | Inflammatory bowel diseases | Mucosal immunity | Digestive system | Pathogenesis | Microbiomes | Homeostasis | Crohn's disease | Inflammatory bowel disease | Microbiota | Intestine | Digestive tract | NOD2 protein | Immune system | Index Medicus | Symposium Review | Symposium section reviews | New frontiers in gastrointestinal physiology and pathophysiology
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3. Full Text Bacterial biogeography of the human digestive tract
by Stearns, Jennifer C and Lynch, Michael D. J and Senadheera, Dilani B and Tenenbaum, Howard C and Goldberg, Michael B and Cvitkovitch, Dennis G and Croitoru, Kenneth and Moreno-Hagelsieb, Gabriel and Neufeld, Josh D
Scientific Reports, ISSN 2045-2322, 2011, Volume 1, Issue 1, pp. 170 - 170
We present bacterial biogeography as sampled from the human gastrointestinal tract of four healthy subjects. This study generated > 32 million paired-end... 
PROFILES | BEHAVIOR | MULTIDISCIPLINARY SCIENCES | DISEASE | POPULATIONS | DIVERSITY | WRINKLES | GUT MICROBIOTA | RARE BIOSPHERE | BODY HABITATS | MOLECULAR ANALYSIS | Humans | Gastrointestinal Tract - microbiology | Male | Phylogeny | Biodiversity | Organ Specificity | Bacteria - genetics | Bacteria - isolation & purification | Metagenome - genetics | Bacteria - classification | RNA, Bacterial - genetics | RNA, Ribosomal, 16S - genetics | Adult | Female | Stomach | rRNA 16S | Duodenum | Biopsy | Biogeography | Microflora | Gastrointestinal tract | Colon | Digestive tract | Index Medicus
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4. Full Text Association of host genome with intestinal microbial composition in a large healthy cohort
by Turpin, Williams and Espin-Garcia, Osvaldo and Xu, Wei and Silverberg, Mark S and Kevans, David and Smith, Michelle I and Guttman, David S and Griffiths, Anne and Panaccione, Remo and Otley, Anthony and Xu, Lizhen and Shestopaloff, Konstantin and Moreno-Hagelsieb, Gabriel and Paterson, Andrew D and Croitoru, Kenneth and GEM Project Res Consortium and GEM Project Research Consortium
Nature Genetics, ISSN 1061-4036, 11/2016, Volume 48, Issue 11, pp. 1413 - 1417
Intestinal microbiota is known to be important in health and disease. Its composition is influenced by both environmental and host factors. Few large-scale... 
CROHNS-DISEASE | METAGENOME | GENOTYPE | GENETICS & HEREDITY | IBD | GUT MICROBIOTA | WIDE ASSOCIATION | Young Adult | Humans | Adolescent | Gastrointestinal Microbiome | Bacteria - classification | Female | Genotype | Male | Polymorphism, Single Nucleotide | Genome, Human | Cohort Studies | Host-bacteria relationships | Microbiota (Symbiotic organisms) | Genetic variation | Disease susceptibility | Genetic aspects | Identification and classification | Health aspects | Studies | Inflammatory bowel disease | Consortia | Ribosomal DNA | Genomes | Age | Crohns disease | Index Medicus
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5. Full Text A finite mixture model for X‐chromosome association with an emphasis on microbiome data analysis
by Espin‐Garcia, Osvaldo and Croitoru, Kenneth and Xu, Wei
Genetic Epidemiology, ISSN 0741-0395, 06/2019, Volume 43, Issue 4, pp. 427 - 439
Analysis of the X chromosome has been largely neglected in genetic studies mainly because of complex underlying biological mechanisms. On the other hand, the... 
random/escape/skewed X‐chromosome inactivation | X‐chromosome association | finite mixture models | microbiome data | random/escape/skewed X-chromosome inactivation | X-chromosome association | INACTIVATION | random | METAGENOMICS | GENETICS & HEREDITY | MATHEMATICAL & COMPUTATIONAL BIOLOGY | MULTINOMIAL REGRESSION | escape | skewed X-chromosome inactivation | ABUNDANCE | Genetic variance | Chromosomes | X Chromosomes | Genotypes | Microbiomes | Index Medicus
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6. Full Text Preoperative biological therapy and short-term outcomes of abdominal surgery in patients with inflammatory bowel disease
by Waterman, Matti and Xu, Wei and Dinani, Amreen and Steinhart, A Hillary and Croitoru, Kenneth and Nguyen, Geoffrey C and McLeod, Robin S and Greenberg, Gordon R and Cohen, Zane and Silverberg, Mark S
Gut, ISSN 0017-5749, 03/2013, Volume 62, Issue 3, pp. 387 - 394
Objective Previous investigations of short-term outcomes after preoperative exposure to biological therapy in inflammatory bowel disease (IBD) were... 
METAANALYSIS | CROHNS-DISEASE | EFFICACY | POSTOPERATIVE COMPLICATIONS | SAFETY | ULCERATIVE-COLITIS | RISK | IBD | INFLIXIMAB | CORTICOSTEROIDS | GASTROENTEROLOGY & HEPATOLOGY | Inflammatory Bowel Diseases - drug therapy | Length of Stay | Antibodies, Monoclonal, Humanized - therapeutic use | Humans | Antibodies, Monoclonal - therapeutic use | Male | Treatment Outcome | Case-Control Studies | Wound Infection - epidemiology | Young Adult | Urinary Tract Infections - epidemiology | Infliximab | Gastrointestinal Agents - therapeutic use | Inflammatory Bowel Diseases - surgery | Adult | Female | Retrospective Studies | Adalimumab | Drug Therapy, Combination | Postoperative Complications | Tumor Necrosis Factor-alpha - antagonists & inhibitors | Preoperative Period | Abdominal surgery | Inflammatory bowel diseases | Care and treatment | Usage | Biological products | Patient outcomes | Research | Preoperative care | Methods | Surgical outcomes | Short term | Postoperative period | Mortality | Infections | Multivariate analysis | Data bases | Abdomen | Urinary tract diseases | Inflammatory bowel disease | Studies | Antibiotics | Surgery | Immunotherapy | Tumor necrosis factor-TNF | Urogenital system | Age | Index Medicus | Abridged Index Medicus
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7. Full Text A rare presentation of hypovolemic shock secondary to Whipple’s disease
by Tandon, Parul and Huang, Vivian and Jaffer, Nasir and Kirsch, Richard and Croitoru, Kenneth
European Journal of Gastroenterology & Hepatology, ISSN 0954-691X, 05/2019, Volume 31, Issue 5, pp. 642 - 645
Whipple’s disease is a rare, multisystem infection caused by the Gram-positive Tropheryma whippelii organism. In addition to neurological and rheumatological... 
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8. Full Text Comparison of Co-housing and Littermate Methods for Microbiota Standardization in Mouse Models
by Robertson, Susan J and Lemire, Paul and Maughan, Heather and Goethel, Ashleigh and Turpin, Williams and Bedrani, Larbi and Guttman, David S and Croitoru, Kenneth and Girardin, Stephen E and Philpott, Dana J
Cell Reports, ISSN 2211-1247, 05/2019, Volume 27, Issue 6, pp. 1910 - 1919.e2
The intestinal microbiota is a fundamental factor that broadly influences physiology. Thus, studies using transgenic animals should be designed to limit the... 
microbiota | intestinal | mouse | co-housing | littermates | microbiota standardization | PATHOGENESIS | IMMUNE | TRANSMISSION | BACTERIA | OBESITY | INTESTINAL MICROBIOTA | SHAPES | INFLAMMATION | AKKERMANSIA-MUCINIPHILA | GUT MICROBIOTA | CELL BIOLOGY
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9. Generational patterns of asthma incidence among immigrants to Canada over two decades: A population-based cohort study
by Radhakrishnan, Dhenuka and Guttmann, Astrid and To, Teresa and Reisman, John Joseph and Knight, Braden D and Mojaverian, Nassim and Manuel, Douglas G and Gommerman, Jennifer L and Croitoru, Kenneth and Benchimol, Eric I
Annals of the American Thoracic Society, ISSN 2325-6621, 02/2019, Volume 16, Issue 2, pp. 248 - 257
Rationale: Canada, an industrialized country with high endemic asthma rates, is characterized by a large immigrant population. Objectives: We sought to provide... 
Immigrant | Risk factors | Asthma | Incidence | risk factors | asthma | SYMPTOMS | PREVALENCE | TRENDS | CHILDHOOD ASTHMA | CHILDREN | PREGNANCY | RESPIRATORY SYSTEM | immigrant | ALLERGIC DISEASE | BIRTH COHORT | incidence | ASSOCIATION | ATOPY
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10. Full Text Asthma, type 1 and type 2 diabetes mellitus, and inflammatory bowel disease amongst South Asian immigrants to Canada and their children: A population-based cohort study
by Benchimol, Eric I and Manuel, Douglas G and To, Teresa and Mack, David R and Nguyen, Geoffrey C and Gommerman, Jennifer L and Croitoru, Kenneth and Mojaverian, Nassim and Wang, Xuesong and Quach, Pauline and Guttmann, Astrid
PLoS ONE, ISSN 1932-6203, 04/2015, Volume 10, Issue 4, pp. e0123599 - e0123599
BACKGROUND There is a high and rising rate of immune-mediated diseases in the Western world. Immigrants from South Asia have been reported to be at higher risk... 
WHITE | ADMINISTRATIVE DATA ALGORITHM | BRITISH-COLUMBIA | MULTIDISCIPLINARY SCIENCES | ULCERATIVE-COLITIS | ONTARIO | VALIDATION | RISK | PREVALENCE | LEICESTERSHIRE | Diabetes Mellitus, Type 1 - epidemiology | Humans | Middle Aged | Risk Factors | Male | Emigrants and Immigrants - statistics & numerical data | Diabetes Mellitus, Type 2 - epidemiology | Incidence | Young Adult | Asia - epidemiology | Asian Continental Ancestry Group | Inflammatory Bowel Diseases - epidemiology | Adolescent | Ontario - epidemiology | Adult | Female | Retrospective Studies | Asthma - epidemiology | Type 2 diabetes | Asthma in children | Immigrants | Analysis | Gastrointestinal diseases | Pediatrics | Inflammatory bowel diseases | Country of birth | Personal health | Risk | Population studies | Diabetes mellitus (insulin dependent) | Epidemiology | Data bases | Immunology | Intestine | Hepatology | Gastroenterology | Population | Children | Diabetes mellitus (non-insulin dependent) | Public health | Chronic illnesses | Aliens | Nutrition | Diabetes mellitus | Health risks | Westernization | Patients | Asthma | Diseases | Medicine | Inflammatory bowel disease | Hospitals | Algorithms | Surveillance | Immigration | Adults | Diabetes | Index Medicus
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11. Full Text Nod2 activates NF-kB in CD4+ T cells but its expression is dispensable for T cell-induced colitis
by Zanello, Galliano and Goethel, Ashleigh and Forster, Katharina and Geddes, Kaoru and Philpott, Dana J and Croitoru, Kenneth
PLoS ONE, ISSN 1932-6203, 12/2013, Volume 8, Issue 12, pp. e82623 - e82623
Although the etiology of Crohn's disease (CD) remains elusive this disease is characterized by T cell activation that leads to chronic inflammation and mucosal... 
INFLAMMATORY-BOWEL-DISEASE | CROHNS-DISEASE | IMMUNE-RESPONSES | MULTIDISCIPLINARY SCIENCES | SUSCEPTIBILITY | HOST-DEFENSE | TOXOPLASMA-GONDII | KAPPA-B | RECEPTORS | LYMPHOCYTES | RIP2 | T-Lymphocyte Subsets - immunology | Receptors, Antigen, T-Cell - metabolism | Colitis - genetics | CD4-Positive T-Lymphocytes - metabolism | Cytokines - secretion | Gene Expression Regulation | NF-kappa B - metabolism | Nod2 Signaling Adaptor Protein - genetics | Adoptive Transfer | Mice, Knockout | Acetylmuramyl-Alanyl-Isoglutamine - pharmacology | CD4-Positive T-Lymphocytes - immunology | Immunosuppression | Animals | Nod2 Signaling Adaptor Protein - metabolism | T-Lymphocyte Subsets - drug effects | T-Lymphocyte Subsets - metabolism | Gene Deletion | Colitis - metabolism | Mice | Colitis - immunology | CD4-Positive T-Lymphocytes - drug effects | Disease Models, Animal | Cell proliferation | Biotechnology | Mucosal immunity | Muramyl dipeptide | Disease | Transgenic | Stimulation | Lymphocytes T | Kinases | Immunity | Experiments | Immunity (cell-mediated) | Risk factors | T-cell receptor | Cell activation | Microbiota | Immunology | Clonal deletion | Lymphocytes | Etiology | Intestine | Rodents | Gastroenterology | Deletion | CD25 antigen | Foxp3 protein | Intestinal microflora | NOD2 protein | Spleen | NF-κB protein | Immunoglobulins | Immunological memory | Memory cells | Immune response | Secretion | Inflammation | Pattern recognition | RNA polymerase | Gene expression | Cell differentiation | CD4 antigen | Immune systems | Medicine | Inflammatory bowel disease | Crohn's Disease | Colitis | Mutation | Index Medicus
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12. Full Text Tu1831 – Use of Drug-Tolerant Assays in Inflammatory Bowel Disease; What Does It Tell Us?
by Walshe, Margaret and Borowski, Krzysztof and Kabakchiev, Boyko and Milgrom, Raquel and Stempak, Joanne M and Steinhart, A. Hillary and Croitoru, Kenneth and Silverberg, Mark S
Gastroenterology, ISSN 0016-5085, 05/2019, Volume 156, Issue 6, pp. S-1142 - S-1142
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13. Full Text A rare presentation of hypovolemic shock secondary to Whipple's disease
by Tandon, P and Huang, V and Jaffer, N and Kirsch, R and Croitoru, K
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, ISSN 0954-691X, 05/2019, Volume 31, Issue 5, pp. 642 - 645
Whipple's disease is a rare, multisystem infection caused by the Gram-positive Tropheryma whippelii organism. In addition to neurological and rheumatological... 
TROPHERYMA-WHIPPLEI | protein-losing enteropathy | GASTROENTEROLOGY & HEPATOLOGY | duodenitis | CEFTRIAXONE | Whipple's disease
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14. Full Text Su1892 - Factors Associated with Intestinal Resection in Crohn's Disease Patients with Bowel Damage Progression as Assessed by Lemann Index
by Zezos, Petros and Chawla, Tanya P and Weizman, Adam and Nguyen, Geoffrey C and Milgrom, Raquel and Croitoru, Kenneth and Steinhart, A. Hillary and Silverberg, Mark S
Gastroenterology, ISSN 0016-5085, 05/2018, Volume 154, Issue 6, pp. S-622 - S-623
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15. Full Text Su1893 - Patients with Persistently Clinically Silent Crohn's Disease can have Insidious, but Uneventful, Progression of Bowel Damage Due to small Bowel Stricturing as Assessed by Lemann Index
by Zezos, Petros and Chawla, Tanya P and Weizman, Adam and Nguyen, Geoffrey C and Milgrom, Raquel and Croitoru, Kenneth and Steinhart, A. Hillary and Silverberg, Mark S
Gastroenterology, ISSN 0016-5085, 05/2018, Volume 154, Issue 6, pp. S-623 - S-623
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16. Full Text Mo1957 - Characterizing Microbiota Composition and Function that Precede Development of Clinically Relevant Inflammation in UC Patients
by Bermudez-Brito, Miriam and Galipeau, Heather J and Fernandez, Alberto Caminero and Turpin, Williams and Bedrani, Larbi and Croitoru, Kenneth and Verdu, Elena F
Gastroenterology, ISSN 0016-5085, 05/2018, Volume 154, Issue 6, pp. S-864 - S-864
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17. Full Text 108 – The Prevalence and Use of Cannabis by Patients with Inflammatory Bowel Disease
by Du, Lillian and Deshpande, Amol and Yang, Laura and Boguslavsky, Shlomit and Croitoru, Kenneth and Gallinger, Zane and Huang, Vivian and Silverberg, Mark S and Weizman, Adam V and Nguyen, Geoffrey C and Steinhart, A. Hillary
Gastroenterology, ISSN 0016-5085, 05/2019, Volume 156, Issue 6, pp. S-27 - S-28
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18. Full Text Tu1827 – Maintenance Levels of Vedolizumab Do Not Correlate with Clinical Remission in IBD Patients
by Tessolini, Jenna M and Bajaj, Girish and Zezos, Petros and O'Connell, Jim W and Huang, Vivian and Croitoru, Kenneth and Steinhart, A. Hillary and Kelly, Orlaith and O'Toole, Aoibhlinn and Kevans, David and Silverberg, Mark S
Gastroenterology, ISSN 0016-5085, 05/2019, Volume 156, Issue 6, pp. S-1140 - S-1140
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19. Full Text 89 Ileal Pouch Symptoms Are Associated With Changes in Microbial Composition and Diversity Not Necessarily Related to Endoscopic Inflammation
by Turpin, Williams and Kelly, Orlaith and Tyler, Andrea and Borowski, Krzysztof and Croitoru, Kenneth and Silverberg, Mark S
Gastroenterology, ISSN 0016-5085, 2016, Volume 150, Issue 4, pp. S22 - S23
Gastroenterology and Hepatology
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