X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
index medicus (11) 11
humans (7) 7
biochemistry & molecular biology (6) 6
proteins (6) 6
chemistry, multidisciplinary (4) 4
inhibitors (4) 4
models, molecular (4) 4
molecular structure (4) 4
peptides - chemistry (4) 4
protein (4) 4
protein binding (4) 4
protein-protein interactions (4) 4
alpha-helical peptides (3) 3
amino acid sequence (3) 3
cancer (3) 3
chemistry (3) 3
chemistry, medicinal (3) 3
crystal-structure (3) 3
drug design (3) 3
drug discovery (3) 3
e3 ubiquitin ligase (3) 3
molecular sequence data (3) 3
peptides (3) 3
rab gtp-binding proteins - metabolism (3) 3
small molecule libraries - chemistry (3) 3
stapled peptides (3) 3
structural basis (3) 3
activation (2) 2
affinity (2) 2
article (2) 2
asterisk-asterisk (2) 2
cell line (2) 2
cellular (2) 2
closing olefin metathesis (2) 2
cyclic-peptides (2) 2
diseases (2) 2
drugs (2) 2
effector interactions (2) 2
g proteins (2) 2
gross domestic product (2) 2
heterocyclic compounds (2) 2
human cancer-cells (2) 2
human necessities (2) 2
hygiene (2) 2
in-vitro (2) 2
inhibitor (2) 2
inhibitoren (2) 2
inhibitors:material (2) 2
krebs (2) 2
kristallstruktur (2) 2
macrocyclization (2) 2
medical or veterinary science (2) 2
metallurgy (2) 2
modulation (2) 2
monomeric gtp-binding proteins - metabolism (2) 2
multiple-myeloma (2) 2
organic chemistry (2) 2
peptides - pharmacology (2) 2
protacs (2) 2
protein conformation (2) 2
protein degradation (2) 2
protein-degradation (2) 2
protein–protein interactions (2) 2
proteolysis (2) 2
rab gtp-binding proteins - chemistry (2) 2
ras-effector interactions (2) 2
selective degradation (2) 2
small molecule libraries - pharmacology (2) 2
specific therapeutic activity of chemical compounds ormedicinal preparations (2) 2
strategy (2) 2
target (2) 2
ubiquitin-protein ligases - metabolism (2) 2
ubiquitination - drug effects (2) 2
14-3-3 proteins - chemistry (1) 1
20s proteasome (1) 1
abstracts (1) 1
activated (1) 1
acute lymphoblastic-leukemia (1) 1
adhesion (1) 1
adhäsion (1) 1
affinität (1) 1
alkenes - chemical synthesis (1) 1
alkenes - chemistry (1) 1
alkenes - metabolism (1) 1
alkine (1) 1
alkynes (1) 1
alkynes - chemistry (1) 1
alpha-melanotropin (1) 1
amino-acids (1) 1
analogs (1) 1
androgen receptor (1) 1
animals (1) 1
antigenic determinants (1) 1
antimalarials - chemical synthesis (1) 1
antimalarials - chemistry (1) 1
antimalarials - pharmacology (1) 1
antimitotic agent (1) 1
antineoplastic agents - chemical synthesis (1) 1
antineoplastic agents - chemistry (1) 1
antineoplastic agents - pharmacology (1) 1
more...
Language Language
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


ACS Chemical Biology, ISSN 1554-8929, 10/2017, Volume 12, Issue 10, pp. 2570 - 2578
Proteolysis targeting chimera (PROTAC) technology, the recruitment of E3 ubiquitin ligases to induce the degradation of a protein target, is rapidly impacting... 
PARKIN | ACTIVATION | SPECIFICITY | STRATEGY | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROTACS | MITOPHAGY | KINASE INHIBITOR | CHAINS | CANCER | PROTEOMICS | Cell Line | Ubiquitination - drug effects | Proteolysis | Humans | Cloning, Molecular | Ubiquitin-Protein Ligases - metabolism | Models, Molecular | Protein Conformation | Molecular Structure | Ubiquitin-Protein Ligases - genetics | Index Medicus
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 12/2018, Volume 140, Issue 49, pp. 17019 - 17026
Enzymatic inhibition has proven to be a successful modality for the development of many small-molecule drugs. In recent years, small-molecule-induced protein... 
TARGET | DESIGN | SELECTIVE DEGRADATION | PROTEIN-DEGRADATION | FOCAL ADHESION KINASE | SMALL-MOLECULE MODULATION | INHIBITORS | KNOCKDOWN | CANCER | CHEMISTRY, MULTIDISCIPLINARY | E3 UBIQUITIN LIGASE | Index Medicus
Journal Article
Angewandte Chemie, ISSN 0044-8249, 11/2015, Volume 127, Issue 46, p. 13718
  Kleine GTPasen bilden eine Familie von GDP-/GTP-bindenden Proteinen, die als biomolekulare Schalter innerhalb von Zellen wirken. Fehlfunktionen oder... 
Journal Article
Acs chemical biology, ISSN 1554-8929, 2016, Volume 11, Issue 8, pp. 2375 - 2382
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 04/2018, Volume 61, Issue 8, pp. 3674 - 3684
Ultrastable cyclic peptide frameworks offer great potential for drug design due to their improved bioavailability compared to their linear analogues. Using the... 
POTENT | CHEMISTRY, MEDICINAL | DISEASES | ALPHA-MELANOTROPIN | ANALOGS | LEADS | MULTIPLE N-METHYLATION | SELECTIVITY | PROGRAM | SUBSTRATE-GUIDED DESIGN | SCAFFOLD | Index Medicus
Journal Article
Angewandte Chemie, ISSN 0044-8249, 11/2015, Volume 127, Issue 46, pp. 13718 - 13741
Kleine GTPasen bilden eine Familie von GDP‐/GTP‐bindenden Proteinen, die als biomolekulare Schalter innerhalb von Zellen wirken. Fehlfunktionen oder... 
Krebs | Proteine | Wirkstoffentwicklung | Kleine GTPasen | Inhibitoren | Gross domestic product
Journal Article
Angewandte Chemie, ISSN 0044-8249, 02/2014, Volume 126, Issue 9, pp. 2531 - 2536
Kleine GTPasen fungieren als molekulare Schalter bei der Kontrolle zahlreicher essenzieller zellulärer Prozesse. Während eine fehlerhafte Funktion oder... 
Verbrückte Peptide | Protein‐Protein‐Wechselwirkung | Rab‐Protein | Kleine GTPase | Inhibitoren
Journal Article
Angewandte Chemie, ISSN 0044-8249, 02/2014, Volume 126, Issue 9, p. 2531
  Kleine GTPasen fungieren als molekulare Schalter bei der Kontrolle zahlreicher essenzieller zellulärer Prozesse. Während eine fehlerhafte Funktion oder... 
Journal Article
Angewandte Chemie, ISSN 0044-8249, 02/2014, Volume 126, Issue 9, p. 2531
Kleine GTPasen fungieren als molekulare Schalter bei der Kontrolle zahlreicher essenzieller zellularer Prozesse. Wahrend eine fehlerhafte Funktion oder... 
Peptides
Journal Article
by Deng, Zixin and Deshaies, Ray and Strieter, Eric and Guenette, Robert and Anderson, Larry and Pham, HongNgoc “Grace” and Schenone, Monica and Krönke, Jan and Narla, Anupama and Grauman, Peter and Hurst, Slater N and McConkey, Marie and Svinkina, Tanya and Heckl, Dirk and Hartman, Emily and Udeshi, Namrata D and Schreiber, Stuart L and Carr, Steven A and Ebert, Benjamin L and Gestwicki, Jason and Kelly, Jeff and Konze, Kyle and Jin, Jian and Wang, Greg and Pattenden, Samantha and Grembecka, Jolanta and Borkin, Dmitry and He, Shihan and Miao, Hongzhi and Purohit, Trupta and Hess, Jay and Maillard, Ivan and Chase, Jennifer and Sun, Duxin and Cierpicki, Tomasz and Arrowsmith, Cheryl and Zhang, Xin and Liu, Yu and Kelly, Jeffery W and Chupakhin, Vladimir and Wegner, Jörg and Ceulemans, Hugo and Peeters, Pieter and Cravatt, Benjamin and Wandless, Tom and Shokat, Kevan and Andolina, Gloria and Sugiyama, Hiroshi and McCombs, Janet and Kohler, Jennifer J and Lawrence, David and Ding, Sheng and Hartley, Richard and Matsuda, Michiyuki and Chen, Peng and Cox, Liam and Jervis, Peter J and Salio, Mariolina and Wojno, Justyna and Ghadbane, Hemza and Jukes, John-Paul and Cerundolo, Vincenzo and Besra, Gurdyal S and Gautier, Arnaud and Plamont, Marie-Aude and Billon-Denis, Emmanuelle and Maurin, Sylvie and Jullien, Ludovic and Hanaoka, Kenjiro and Egawa, Takahiro and Hirabayashi, Kazuhisa and Nagano, Tetsuo and Urano, Yasuteru and Uno, Shin-nosuke and Kamiya, Mako and Yoshihara, Toshitada and Sugawara, Ko and Okabe, Kohki and Tarhan, Mehmet C and Fujita, Hiroyuki and Funatsu, Takashi and Okada, Yasushi and Tobita, Seiji and Urano, Yasuteru and Sternson, Scott and Vial, Marie-Laure and Lafanechère, Laurence and Prunier, Chloé and Prudent, Renaud and Martinez, Anne and Nguyen, Chi-Hung and Viallet, Jean and Di Pietro, Attilio and Bernard, Ora and Knapp, Stefan and Varney, Michael and Bertran-Vicente, Jordi and Schümann, Michael and Krause, Eberhard and Hackenberger, Christian P. R and ...
ASSAY and Drug Development Technologies, ISSN 1540-658X, 03/2015, Volume 13, Issue 2, pp. 12 - 141
Journal Article
08/2019
The description relates to imide-based compounds, including bifunctional compounds comprising the same, which find utility as modulators of targeted... 
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS | METALLURGY | HYGIENE | ORGANIC CHEMISTRY | CHEMISTRY | HETEROCYCLIC COMPOUNDS | MEDICAL OR VETERINARY SCIENCE | HUMAN NECESSITIES
Patent
Acs chemical biology, ISSN 1554-8929, 06/2015, Volume 10, Issue 6, pp. 1362 - 1375
Peptide-based drug discovery has experienced a significant upturn within the past decade since the introduction of chemical modifications and :unnatural amino... 
ALPHA-HELICAL PEPTIDES | CLOSING OLEFIN METATHESIS | FACTOR-RECEPTOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | EPIDERMAL-GROWTH-FACTOR | ACUTE LYMPHOBLASTIC-LEUKEMIA | PROTEIN-PROTEIN INTERACTIONS | CELL-PENETRATING PEPTIDES | HYDROGEN-BOND SURROGATE | C-TERMINAL-DOMAIN | HIV-1 INTEGRASE INHIBITORS | Hepatitis C - drug therapy | Antineoplastic Agents - chemical synthesis | Humans | Malaria, Falciparum - pathology | Receptors, Cell Surface - antagonists & inhibitors | Neoplasms - chemistry | Peptides - chemical synthesis | HIV Infections - pathology | Neoplasms - genetics | Antiviral Agents - chemistry | Antineoplastic Agents - pharmacology | Antimalarials - chemical synthesis | Protein Structure, Tertiary | Malaria, Falciparum - drug therapy | Antiviral Agents - pharmacology | Peptides - chemistry | Protein Structure, Secondary | Signal Transduction | HIV Infections - virology | Gene Expression Regulation | Receptors, Cell Surface - agonists | Models, Molecular | Receptors, Cell Surface - metabolism | Antineoplastic Agents - chemistry | Drug Discovery | Antimalarials - pharmacology | Neoplasms - drug therapy | Peptides - pharmacology | Malaria, Falciparum - parasitology | Antimalarials - chemistry | Hepatitis C - virology | Antiviral Agents - chemical synthesis | HIV Infections - drug therapy | Hepatitis C - pathology | Neoplasms - pathology | Receptors, Cell Surface - genetics | Index Medicus
Journal Article