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1. Full Text Shane Crotty: Exploring immune memory
by Crotty, Shane
Journal of Experimental Medicine, ISSN 0022-1007, 05/2009, Volume 206, Issue 5, pp. 974 - 975
Virologist and published author Shane Crotty sees immune memory as the key to making a better vaccine. 
HELP | MEDICINE, RESEARCH & EXPERIMENTAL | HUMORAL IMMUNITY | SAP | IMMUNOLOGY | ANTIBODY-RESPONSES | People & Ideas
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2. Full Text Shane Crotty: exploring immune memory. Interview by Kira Heller
by Crotty, Shane
The Journal of experimental medicine, 05/2009, Volume 206, Issue 5, pp. 974 - 975
Laboratories - standards | Humans | Vaccines - immunology | Immunologic Memory | T-Lymphocytes - immunology | Vaccines - therapeutic use | Research - standards | Index Medicus
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3. Immune memory and vaccines
: great debates
by Crotty, Shane, 1974- editor and Ahmed, Rafi editor
2018, Cold Spring Harbor perspectives in biology, ISBN 1621821544, ix, 418 pages
B cells | Vaccines | Immunologic memory | T cells
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4. Full Text Editorial overview: Vaccine immunology: what is seen and not seen
by Crotty, Shane
Current Opinion in Immunology, ISSN 0952-7915, 2019
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5. Full Text RAGING EVOLUTION OF A B CELL RESPONSE TO A VIRAL INFECTION
by Crotty, S
NATURE REVIEWS IMMUNOLOGY, ISSN 1474-1733, 02/2018, Volume 18, Issue 2, pp. 79 - 79
IMMUNOLOGY | Virus diseases | Care and treatment | Immune response | Development and progression | B cells | Observations | Health aspects | Lymphocytes B
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6. Full Text Dances with cytokines, featuring TFH cells, IL-21, IL-4 and B cells
by Bélanger, Simon and Crotty, Shane
Nature Immunology, ISSN 1529-2908, 09/2016, Volume 17, Issue 10, pp. 1135 - 1136
B-Lymphocytes | T-Lymphocytes, Helper-Inducer | Interleukin-4 | Cytokines | Interleukins | Humans | Physiological aspects | Genetic aspects | B cells | Research | Index Medicus
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7. Full Text Dances with cytokines, featuring T sub(FH) cells, IL-21, IL-4 and B cells
by Belanger, Simon and Crotty, Shane
Nature Immunology, ISSN 1529-2908, 10/2016, Volume 17, Issue 10, pp. 1135 - 1136
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8. Full Text Germinal center enhancement by extended antigen availability
by Cirelli, Kimberly M and Crotty, Shane
Current Opinion in Immunology, ISSN 0952-7915, 08/2017, Volume 47, p. 64
* Extended antigen delivery immunization results in stronger humoral immune responses. * Germinal centers are enhanced by extended antigen delivery. * Slow... 
Antigens
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9. Full Text Bcl6 and Blimp-1 Are Reciprocal and Antagonistic Regulators of T Follicular Helper Cell Differentiation
by Robert J. Johnston and Amanda C. Poholek and Daniel DiToro and Isharat Yusuf and Danelle Eto and Burton Barnett and Alexander L. Dent and Joe Craft and Shane Crotty
Science, ISSN 0036-8075, 8/2009, Volume 325, Issue 5943, pp. 1006 - 1010
Effective B cell--mediated immunity and antibody responses often require help from CD4⁺ T cells. It is thought that a distinct CD4⁺ effector T cell subset,... 
T lymphocytes | Up regulation | Transcription factors | Messenger RNA | B lymphocytes | Reports | Mice | Lymphoid tissue | Cellular differentiation | Immunity | Cells | B-CELLS | SAP | GERMINAL-CENTER FORMATION | IMMUNE-RESPONSES | INFLAMMATION | FOLLICLES | MULTIDISCIPLINARY SCIENCES | IN-VIVO | GENE-EXPRESSION | TRANSCRIPTIONAL REPRESSOR BLIMP-1 | PROVIDE HELP | Lymphocytic choriomeningitis virus - immunology | T-Lymphocyte Subsets - immunology | T-Lymphocyte Subsets - cytology | Germinal Center - immunology | RNA, Messenger - metabolism | CD4-Positive T-Lymphocytes - immunology | DNA-Binding Proteins - metabolism | T-Lymphocytes, Helper-Inducer - immunology | T-Lymphocytes, Helper-Inducer - cytology | Cell Differentiation | Germinal Center - cytology | Arenaviridae Infections - immunology | Cytokines - metabolism | Signal Transduction | Lymphocyte Activation | CD4-Positive T-Lymphocytes - cytology | Mice, Inbred C57BL | RNA, Messenger - genetics | Gene Expression Regulation | Mice, Transgenic | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Transcription Factors - metabolism | Cell Lineage | Animals | B-Lymphocytes - immunology | Antibody Formation | Positive Regulatory Domain I-Binding Factor 1 | Proto-Oncogene Proteins c-bcl-6 | Physiological aspects | T cells | Properties | Cellular biology | Molecular biology | Gene expression | Lymphocytes | Immune system | Index Medicus
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10. Full Text IL-21 and IL-6 are critical for different aspects of B cell immunity and redundantly induce optimal follicular helper CD4 T cell (Tfh) differentiation
by Eto, Danelle and Lao, Christopher and DiToro, Daniel and Barnett, Burton and Escobar, Tania C and Kageyama, Robin and Yusuf, Isharat and Crotty, Shane
PLoS ONE, ISSN 1932-6203, 2011, Volume 6, Issue 3, pp. e17739 - e17739
Cytokines are important modulators of lymphocytes, and both interleukin-21 (IL-21) and IL-6 have proposed roles in T follicular helper (Tfh) differentiation,... 
CXC CHEMOKINE RECEPTOR-5 | MULTIPLE-MYELOMA | ANTIBODY-PRODUCTION | MULTIDISCIPLINARY SCIENCES | IMMUNOGLOBULIN PRODUCTION | HUMORAL IMMUNITY | BCL-6 EXPRESSION | DOWN-REGULATION | GROWTH-FACTOR | CHRONIC VIRAL-INFECTION | PLASMA-CELLS | B-Lymphocytes - cytology | Germinal Center - immunology | Humans | Immunity - immunology | Interleukin-6 - deficiency | Interleukins - metabolism | Cell Differentiation - immunology | Lymphocyte Activation - immunology | Animals | B-Lymphocytes - immunology | T-Lymphocytes, Helper-Inducer - immunology | T-Lymphocytes, Helper-Inducer - cytology | Interleukins - deficiency | Mice | Interleukins - biosynthesis | Germinal Center - cytology | Interleukin-6 - metabolism | Plasma Cells - cytology | Plasma Cells - immunology | Infection | Antiviral agents | Interleukins | Immunoglobulin G | Monoclonal antibodies | B cells | T cells | Cell differentiation | Health aspects | Immunity | Interleukin | Differentiation (biology) | Viruses | Lymphocytes T | Kinases | Modulators | Antibody response | Interleukin 6 | T-cell receptor | Immunology | Germinal centers | CXCR5 protein | Lymphocytes | Interleukin 21 | Antigen presentation | Lymphatic system | Cytokines | T cell receptors | CD4 antigen | Lymphocytes B | Synergistic effect | Laboratory animals | Bcl-6 protein | Index Medicus
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11. Full Text Human Circulating PD-1+CXCR3−CXCR5+ Memory Tfh Cells Are Highly Functional and Correlate with Broadly Neutralizing HIV Antibody Responses
by Locci, Michela and Havenar-Daughton, Colin and Landais, Elise and Wu, Jennifer and Kroenke, Mark A and Arlehamn, Cecilia L and Su, Laura F and Cubas, Rafael and Davis, Mark M and Sette, Alessandro and Haddad, Elias K and Poignard, Pascal and Crotty, Shane and Int AIDS Vaccine Initiative Protoc and International AIDS Vaccine Initiative Protocol C Principal Investigators
Immunity, ISSN 1074-7613, 10/2013, Volume 39, Issue 4, pp. 758 - 769
The vast majority of currently licensed human vaccines work on the basis of long-term protective antibody responses. It is now conceivable that an... 
B-CELLS | T-FOLLICULAR HELPER | COMMITMENT | BCL6 | PROTECTION | DYNAMICS | REGULATORS | IMMUNOLOGY | EXPRESSION | PROGRAM | LYMPHOCYTES | Germinal Center - immunology | Humans | Molecular Sequence Data | Gene Expression Profiling | T-Lymphocytes, Helper-Inducer - virology | HIV Infections - immunology | HIV Infections - pathology | Immunity, Humoral | T-Lymphocytes, Helper-Inducer - immunology | B-Lymphocytes - virology | HIV Antibodies - biosynthesis | T-Lymphocytes, Helper-Inducer - pathology | B-Lymphocytes - pathology | Amino Acid Sequence | Gene Expression | Receptors, CXCR5 - genetics | Signal Transduction | HIV Infections - virology | Germinal Center - pathology | Receptors, CXCR5 - immunology | HIV-1 - immunology | B-Lymphocytes - immunology | Antibodies, Neutralizing - biosynthesis | Germinal Center - virology | Receptors, CXCR3 - genetics | Receptors, CXCR3 - immunology | Immunologic Memory | Programmed Cell Death 1 Receptor - immunology | Programmed Cell Death 1 Receptor - genetics | Antigens | Hypotheses | Acquired immune deficiency syndrome--AIDS | Lymphocytes | Infections | Vaccines | Mutation | Gene expression | Viral infections | Immune system | Index Medicus
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12. Full Text The aerial dragnet: a drone-ing need for Fourth Amendment change
by Crotty, Shane
Valparaiso University Law Review, ISSN 0042-2363, 09/2014, Volume 49, Issue 1, p. 219
Drone aircraft | Electronic surveillance | Laws, regulations and rules | Privacy, Right of | Searches and seizures
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13. Full Text LEF-1 and TCF-1 orchestrate TFH differentiation by regulating differentiation circuits upstream of the transcriptional repressor Bcl6
by Choi, Youn Soo and Gullicksrud, Jodi A and Xing, Shaojun and Zeng, Zhouhao and Shan, Qiang and Li, Fengyin and Love, Paul E and Peng, Weiqun and Xue, Hai-Hui and Crotty, Shane
Nature Immunology, ISSN 1529-2908, 08/2015, Volume 16, Issue 9, pp. 980 - 990
  Follicular helper T cells (TFH cells) are specialized effector CD4+ T cells that help B cells develop germinal centers (GCs) and memory. However, the... 
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14. Full Text Runx3 programs CD8+ T cell residency in non-lymphoid tissues and tumours
by Milner, J. Justin and Toma, Clara and Yu, Bingfei and Zhang, Kai and Omilusik, Kyla and Phan, Anthony T and Wang, Dapeng and Getzler, Adam J and Nguyen, Toan and Crotty, Shane and Wang, Wei and Pipkin, Matthew E and Goldrath, Ananda W
Nature, ISSN 0028-0836, 12/2017, Volume 552, Issue 7684, pp. 253 - 257
Tissue-resident memory CD8(+) T (T-RM) cells are found at common sites of pathogen exposure, where they elicit rapid and robust protective immune... 
TRANSCRIPTION FACTORS | LUNG-CANCER | POPULATION | MEMORY | RNA-SEQ | INFILTRATING LYMPHOCYTES | MULTIDISCIPLINARY SCIENCES | CD4(+) | INFECTION | DIFFERENTIATION | EXPRESSION | T-Lymphocyte Subsets - immunology | CD8-Positive T-Lymphocytes - cytology | Chromatin - metabolism | Core Binding Factor Alpha 3 Subunit - metabolism | Cell Proliferation | T-Lymphocyte Subsets - cytology | Humans | Homeostasis | Male | Adoptive Transfer | Organ Specificity - immunology | Organ Specificity - genetics | Melanoma - genetics | CD8-Positive T-Lymphocytes - metabolism | Female | Lymphocytes, Tumor-Infiltrating - metabolism | Cell Differentiation | Disease Models, Animal | Gene Expression Regulation | Melanoma - pathology | Animals | Core Binding Factor Alpha 3 Subunit - deficiency | Lymphocytes, Tumor-Infiltrating - pathology | Melanoma - immunology | T-Lymphocyte Subsets - metabolism | Survival Analysis | Core Binding Factor Alpha 3 Subunit - genetics | Immunologic Memory | Mice | CD8-Positive T-Lymphocytes - immunology | Melanoma - therapy | Chromatin - genetics | Physiological aspects | T cells | Tumors | Chromatin | Transcription factors | CD8 antigen | Genes | Lung cancer | Cytotoxicity | Systematic review | Lymphocytes T | Tissues | Lymphocytes | Immunological memory | Cell survival | Immune response | RNA-mediated interference | Melanoma | Principal components analysis | T cell receptors | Lymphoid tissue | Cell differentiation | Gene expression | Ribonucleic acids | Runx3 protein | Cancer | Index Medicus
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15. Full Text Dengue virus infection elicits highly polarized CX3CR1⁺ cytotoxic CD4⁺ T cells associated with protective immunity
by Daniela Weiskopf and Derek J. Bangs and John Sidney and Ravi V. Kolla and Aruna D. De Silva and Aravinda M. de Silva and Shane Crotty and Bjoern Peters and Alessandro Sette
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2015, Volume 112, Issue 31, pp. E4256 - E4263
Dengue virus (DENV) is a rapidly spreading pathogen with unusual pathogenesis, and correlates of protection from severe dengue disease and vaccine efficacy... 
HLA DR | CD4 | Cytotoxic | Dengue virus | T cell memory | FREQUENCIES | MULTIDISCIPLINARY SCIENCES | dengue virus | IDENTIFICATION | ANTIBODY-DEPENDENT ENHANCEMENT | EFFECTOR | HETEROGENEITY | RESPONSES | HLA-DR | MEMORY | DISEASE | CORRELATE | cytotoxic | Cell Polarity | Cell Proliferation | Species Specificity | Humans | Receptors, Chemokine - metabolism | Male | Dengue - virology | Immunity | Lymphocyte Subsets - immunology | CD4-Positive T-Lymphocytes - immunology | Phenotype | Histocompatibility Antigens Class II - immunology | Peptides - metabolism | Dengue Virus - immunology | Alleles | Protein Binding | Adult | Female | Immunologic Memory | Dengue - immunology | CX3C Chemokine Receptor 1 | Cytotoxicity, Immunologic | Genotype & phenotype | Cytotoxicity | T cell receptors | Dengue fever | Viral infections | Index Medicus | Biological Sciences | PNAS Plus
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16. Full Text The Transcription Factor NFAT Promotes Exhaustion of Activated CD8+ T Cells
by Martinez, Gustavo J and Pereira, Renata M and Äijö, Tarmo and Kim, Edward Y and Marangoni, Francesco and Pipkin, Matthew E and Togher, Susan and Heissmeyer, Vigo and Zhang, Yi Chen and Crotty, Shane and Lamperti, Edward D and Ansel, K. Mark and Mempel, Thorsten R and Lähdesmäki, Harri and Hogan, Patrick G and Rao, Anjana
Immunity, ISSN 1074-7613, 02/2015, Volume 42, Issue 2, pp. 265 - 278
During persistent antigen stimulation, CD8 T cells show a gradual decrease in effector function, referred to as exhaustion, which impairs responses in the... 
MEMORY | TOLERANCE | DNA | CALCIUM | CALCINEURIN | REGULATES PD-1 EXPRESSION | IMMUNOLOGY | CHRONIC VIRAL-INFECTION | TIM-3 | PROTEINS | MOLECULAR-MECHANISMS | Gene Expression Regulation - genetics | Cells, Cultured | NFATC Transcription Factors - physiology | Mice, Transgenic | Recombinant Proteins - genetics | Listeria monocytogenes - immunology | Recombinant Proteins - pharmacology | Promoter Regions, Genetic - genetics | Transcription Factor AP-1 - metabolism | Lymphocyte Activation - immunology | Animals | Clonal Anergy - drug effects | Neoplasms - immunology | Clonal Anergy - genetics | Listeriosis - immunology | Listeriosis - microbiology | Receptors, Antigen, T-Cell - immunology | Mice | CD8-Positive T-Lymphocytes - immunology | NFATC Transcription Factors - genetics | T cell receptors | Cytokines | Kinases | Immune system | Index Medicus
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17. Full Text IL-2 Mediates Generalized Tfh Downregulation during Allergen-Specific Immunotherapy
by Schulten, Véronique M., PhD and Crotty, Shane, PhD and Sette, Alessandro, Dr. Biol. Sci and Peters, Bjoern, PhD
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2016, Volume 137, Issue 2, pp. AB95 - AB95
  Elucidating the exact mechanism by which IL-2 is involved in CXCR5 down-modulation and to what extend Tfh cell mobility and functionality is affected could... 
Allergy and Immunology | Allergens | Allergy | Allergic reaction | Immunotherapy | T cell receptors | Allergies
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18. Full Text S-4
by Crotty, Shane and Discovery, Vaccine
Cytokine, ISSN 1043-4666, 09/2013, Volume 63, Issue 3, p. 241
T cell help to B cells is a fundamental aspect of adaptive immunity and the generation of B cell memory. The development of virtually all neutralizing... 
B cells
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19. Full Text S-4: Differentiation and function of follicular helper T cells (Tfh)
by Crotty, Shane and Discovery, Vaccine
Cytokine, ISSN 1043-4666, 09/2013, Volume 63, Issue 3, pp. 241 - 241
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20. Full Text Allergen-specific immunotherapy modulates the balance of circulating Tfh and Tfr cells
by Schulten, Veronique, PhD and Tripple, Victoria, BSc and Seumois, Grégory, PhD and Qian, Yu, PhD and Scheuermann, Richard H., PhD and Fu, Zheng, PhD and Locci, Michela, PhD and Rosales, Sandy, BSc and Vijayanand, Pandurangan, MD and Sette, Alessandro, PhD and Alam, Rafeul, MD and Crotty, Shane, PhD and Peters, Bjoern, PhD
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2017, Volume 141, Issue 2, pp. 775 - 777.e6
Capsule summary Follicular helper T cells (Tfh cells) are a CD4 T cell subset essential for germinal center formation and B cell responses, although their role... 
Allergy and Immunology | RESPONSES | IMMUNOLOGY | ALLERGY | T-FH | Proteins | Allergens | Phenotypes | Cytokines | Lymphocytes | Immunotherapy | T cell receptors | Gene expression | Allergies | Index Medicus | Abridged Index Medicus | Allergy | Interleukin-2 | Allergen-specific immunotherapy | regulatory T follicular helper cell | T follicular helper cell
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