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1. Disease modification in rheumatic diseases
by Paget, Stephen A and Crow, Mary K
2006, Rheumatic disease clinics of North America, ISBN 9781416035466, Volume 32, no. 1., xvii, 254
Rheumatism | Treatment
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2. Full Text IgG reactive with the p40 protein encoded by the LINE-1 retroelement
by Crow, Mary K
Arthritis & rheumatology (Hoboken, N.J.), ISSN 2326-5191, 09/2019
The nature and specificity of the self-antigens targeted by autoantibodies characteristic of systemic autoimmune diseases can suggest clues to mechanisms... 
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3. Full Text Type I interferon in the pathogenesis of lupus
by Crow, Mary K
Journal of Immunology, ISSN 0022-1767, 06/2014, Volume 192, Issue 12, pp. 5459 - 5468
Investigations of patients with systemic lupus erythematosus have applied insights from studies of the innate immune response to define IFN-I, with IFN-alpha... 
PLASMACYTOID DENDRITIC CELLS | ALPHA MONOCLONAL-ANTIBODY | PERIPHERAL-BLOOD CELLS | INDUCIBLE GENE-EXPRESSION | AICARDI-GOUTIERES SYNDROME | CYTOSOLIC DNA SENSOR | PERSISTENT LCMV INFECTION | TOLL-LIKE RECEPTORS | IMMUNOLOGY | DISEASE RISK VARIANT | AUTOIMMUNE-DISEASE | Animals | Gene Expression Regulation - immunology | Humans | Toll-Like Receptors - immunology | Lupus Erythematosus, Systemic - immunology | Lupus Erythematosus, Systemic - blood | Immunity, Innate | Interferon Type I - immunology
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4. Full Text In Memoriam
by Crow, Mary K and Gibofsky, Allan and Sergent, John S
Arthritis & Rheumatology, ISSN 2326-5191, 09/2019
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5. Full Text Autoimmunity: Interferon α or β: Which is the culprit in autoimmune disease?
by Crow, Mary K
Nature Reviews Rheumatology, ISSN 1759-4790, 08/2016, Volume 12, Issue 8, pp. 439 - 440
Interferon Type I - immunology | Autoimmunity - immunology | Humans | Autoimmune Diseases - immunology
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6. Full Text Activation of the type I interferon pathway in primary Sjogren's syndrome
by Mavragani, Clio P and Crow, Mary K
Journal of Autoimmunity, ISSN 0896-8411, 11/2010, Volume 35, Issue 3, pp. 225 - 231
Sjogren's syndrome (SS), a chronic autoimmune systemic disease affecting middle aged women, is characterized by lymphocytic infiltration of the salivary and... 
Type I interferon | Pathogenesis | Sjogren's syndrome | SYSTEMIC-LUPUS-ERYTHEMATOSUS | GLAND EPITHELIAL-CELLS | IMMUNOLOGY | PLASMACYTOID DENDRITIC CELLS | DNA METHYLTRANSFERASES | TOLL-LIKE RECEPTORS | IRF5 | EXPRESSION | ASSOCIATION | IFN-ALPHA | Salivary Glands - immunology | Genetic Predisposition to Disease | Signal Transduction | Gene Expression Regulation - immunology | Humans | Long Interspersed Nucleotide Elements - genetics | Middle Aged | Interferon Regulatory Factors - genetics | Sjogren's Syndrome - immunology | Interferon Type I - immunology | Polymorphism, Genetic | Epigenesis, Genetic - immunology | Interferon Type I - genetics | Interferon Type I - metabolism | Female | STAT4 Transcription Factor - genetics | Sjogren's Syndrome - genetics | Physiological aspects | Interferon | Biological response modifiers | Methylation
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7. Full Text Autoimmunity: Interferon [alpha] or [beta]: which is the culprit in autoimmune disease?
by Mary K Crow
Nature Reviews. Rheumatology, ISSN 1759-4790, 08/2016, Volume 12, Issue 8, p. 439
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8. Full Text Interferon [alpha] or [beta]: which is the culprit in autoimmune disease?
by Crow, Mary K
Nature Reviews Rheumatology, ISSN 1759-4790, 08/2016, Volume 12, Issue 8, p. 439
Autoimmunity | Complications and side effects | Care and treatment | Systemic lupus erythematosus | Analysis | Interferon alpha | Influence | Research
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9. Full Text Dubois' Lupus Erythematosus and Related Syndromes
by Wallace, Daniel
01/2019, 9, ISBN 0323479278
For more than 50 years, Dubois' Lupus Erythematosus and Related Syndromes has been recognized internationally as the go-to clinical reference on lupus and... 
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10. Full Text Advances in understanding the role of type I interferons in systemic lupus erythematosus
by Crow, Mary K
Current Opinion in Rheumatology, ISSN 1040-8711, 09/2014, Volume 26, Issue 5, pp. 467 - 474
PURPOSE OF REVIEWAdvances in understanding the genetic and molecular basis of innate immune system activation and function have supported the hypothesis that... 
systemic lupus erythematosus | autoimmunity | interferon-α | cytoplasmic sensors | Toll-like receptors | long interspersed nuclear elements | type I interferons | ALPHA MONOCLONAL-ANTIBODY | DNA SENSOR | CYCLIC GMP-AMP | REGULATED GENES | AICARDI-GOUTIERES SYNDROME | TREX1 | RHEUMATOLOGY | ENDOGENOUS RETROELEMENTS | PLASMACYTOID DENDRITIC CELLS | DOUBLE-BLIND | interferon-alpha | PHASE-I | Genetic Association Studies | Humans | Toll-Like Receptors - immunology | Neutrophils - immunology | Autoimmunity - genetics | Lupus Erythematosus, Systemic - etiology | Immunity, Innate | Lupus Erythematosus, Systemic - therapy | Receptor, Interferon alpha-beta - antagonists & inhibitors | Models, Immunological | Animals | Lupus Erythematosus, Systemic - immunology | Toll-Like Receptors - antagonists & inhibitors | Interferon Type I - genetics | Interferon Type I - metabolism | Mice | Interferon Type I - antagonists & inhibitors
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11. Full Text In Memoriam
by Crow, Mary K and Gibofsky, Allan and Sergent, John S
Arthritis & rheumatology (Hoboken, N.J.), 09/2019
Charles L. Christian, MD, a beloved mentor and revered icon in academic medicine died Sunday morning, August 11 in Fernandina Beach, Florida, surrounded by his... 
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12. Full Text Interferon alpha or beta: which is the culprit in autoimmune disease?
by Crow, MK
NATURE REVIEWS RHEUMATOLOGY, ISSN 1759-4790, 08/2016, Volume 12, Issue 8, pp. 439 - 440
Type I interferons contribute to the pathogenesis of several autoimmune diseases, with each interferon being preferentially produced in different settings by... 
SYSTEMIC-LUPUS-ERYTHEMATOSUS | RHEUMATOLOGY | I INTERFERON
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13. Full Text Advances in Understanding the Role of Type I Interferons in SLE
by Crow, Mary K
Current opinion in rheumatology, ISSN 1040-8711, 9/2014, Volume 26, Issue 5, pp. 467 - 474
Systemic lupus erythematosus | interferon-α | autoimmunity | cytoplasmic sensors | Toll-like receptors | long interspersed nuclear elements | type I interferons
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14. Full Text Collaboration, Genetic Associations, and Lupus Erythematosus
by Crow, Mary K
The New England Journal of Medicine, ISSN 0028-4793, 02/2008, Volume 358, Issue 9, pp. 956 - 961
Systemic lupus erythematosus (SLE), a disease that preferentially targets women during the reproductive years, is considered by many clinicians and... 
MEDICINE, GENERAL & INTERNAL | ACTIVATION | INTEGRIN | DNA EXONUCLEASE TREX1 | MAC-1 | RISK | RECEPTOR | ALPHA | CD11b Antigen - genetics | Autoantibodies - physiology | Humans | Lupus Erythematosus, Systemic - genetics | Lupus Erythematosus, Systemic - immunology | Genotype | Polymorphism, Single Nucleotide | src-Family Kinases - genetics | Immune response | Systemic lupus erythematosus | Development and progression | Genetic aspects | Research | Single nucleotide polymorphisms | Health aspects | Lupus | Proteins | Autoimmune diseases | Immune system
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15. Full Text CD8 T cells and mTOR: new concepts and targets for systemic lupus erythematous
by Fernandez, David R and Crow, Mary K
Lancet (London, England), 03/2018
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16. Full Text CD8 T cells and mTOR: new concepts and targets for systemic lupus erythematosus
by Fernandez, David R and Crow, Mary K
The Lancet, ISSN 0140-6736, 03/2018, Volume 391, Issue 10126, pp. 1126 - 1127
Sirolimus results in immediate inhibition of mTORC1 signalling and delayed inhibition of mTORC2 signalling, which has a marked effect on the immune system,... 
MEDICINE, GENERAL & INTERNAL | ANTIBODY | INTERFERON | DIFFERENTIATION | METABOLISM | DISEASE | TOR protein | Lupus | CD8 antigen | Cell division | Arthritis | Lymphocytes T | Metabolism | Kinases | Studies | Genotype & phenotype | Chronic conditions | Systemic lupus erythematosus | Lymphocytes | Interferon | Autoimmune diseases | Immune system
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17. Full Text Long interspersed nuclear elements (LINE-1): Potential triggers of systemic autoimmune disease
by Crow, Mary K
Autoimmunity, ISSN 0891-6934, 02/2010, Volume 43, Issue 1, pp. 7 - 16
Recent advances have identified immune complexes containing nucleic acids as stimuli for toll-like receptors and inducers of type I interferon (IFN). While a... 
LINE-1 | Systemic lupus erythematosus | retrotransposons | interferon | innate immune response | Retrotransposons | Interferon | Innate immune response | CELLS | OPEN READING FRAME | LUPUS-ERYTHEMATOSUS | IMMUNOLOGY | HUMAN L1 RETROTRANSPOSON | ENDOGENOUS RETROVIRUSES | MAMMARY-TUMOR VIRUS | INTERFERON-ALPHA | HUMAN GENOME | ORF1 PROTEIN | GENE-EXPRESSION | Humans | Long Interspersed Nucleotide Elements - genetics | Toll-Like Receptors - immunology | Autoimmune Diseases - immunology | DNA Transposable Elements - immunology | Interferon-alpha - immunology | Autoimmune Diseases - genetics | Immunity, Innate - immunology | Animals | Lupus Erythematosus, Systemic - genetics | Lupus Erythematosus, Systemic - immunology | Long Interspersed Nucleotide Elements - immunology | Transcription, Genetic - immunology
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18. Full Text Imatinib mesylate (Gleevec) in the treatment of diffuse cutaneous systemic sclerosis: results of a 1-year, phase IIa, single-arm, open-label clinical trial
by Spiera, Robert F and Gordon, Jessica K and Mersten, Jamie N and Magro, Cynthia M and Mehta, Mansi and Wildman, Horatio F and Kloiber, Stacey and Kirou, Kyriakos A and Lyman, Stephen and Crow, Mary K
Annals of the Rheumatic Diseases, ISSN 0003-4967, 06/2011, Volume 70, Issue 6, pp. 1003 - 1009
Objective To assess the safety and effectiveness of imatinib mesylate in the treatment of diffuse cutaneous systemic sclerosis (dcSSc). Methods In this phase... 
TGF-BETA | FIBROTIC DISEASES | STIMULATORY AUTOANTIBODIES | DOUBLE-BLIND | PLACEBO-CONTROLLED TRIAL | RHEUMATOLOGY | VERSUS-HOST-DISEASE | D-PENICILLAMINE | PULMONARY-FIBROSIS | DERMAL FIBROSIS | PDGF RECEPTOR | Humans | Middle Aged | Male | Dermatologic Agents - therapeutic use | Protein Kinase Inhibitors - adverse effects | Dermatologic Agents - adverse effects | Vital Capacity - drug effects | Young Adult | Scleroderma, Diffuse - pathology | Pulmonary Fibrosis - diagnostic imaging | Ultrasonography | Adult | Female | Skin - pathology | Severity of Illness Index | Treatment Outcome | Piperazines - therapeutic use | Imatinib Mesylate | Piperazines - adverse effects | Radiography | Biopsy | Protein Kinase Inhibitors - therapeutic use | Pulmonary Diffusing Capacity - drug effects | Pyrimidines - therapeutic use | Adolescent | Pulmonary Fibrosis - physiopathology | Pyrimidines - adverse effects | Scleroderma, Diffuse - drug therapy | Aged | Benzamides | Research | Systemic scleroderma | Drug therapy | Scleroderma (Disease) | Studies | Statistical analysis | Pulmonary fibrosis | Mortality | Clinical trials | Scleroderma | Growth factors
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19. Full Text Expression of Long Interspersed Nuclear Element 1 Retroelements and Induction of Type I Interferon in Patients With Systemic Autoimmune Disease
by Mavragani, Clio P and Sagalovskiy, Irina and Guo, Qiu and Nezos, Adrianos and Kapsogeorgou, Efstathia K and Lu, Pin and Liang Zhou, Jun and Kirou, Kyriakos A and Seshan, Surya V and Moutsopoulos, Haralampos M and Crow, Mary K
Arthritis & Rheumatology, ISSN 2326-5191, 11/2016, Volume 68, Issue 11, pp. 2686 - 2696
ObjectiveIncreased expression of type I interferon (IFN) and a broad signature of type I IFN-induced gene transcripts are observed in patients with systemic... 
PATHOGENESIS | HUMAN TISSUES | ACTIVATION | PRIMARY SJOGRENS-SYNDROME | PERIPHERAL-BLOOD CELLS | AICARDI-GOUTIERES SYNDROME | TREX1 | GENE-EXPRESSION | LUPUS-ERYTHEMATOSUS | RHEUMATOLOGY | IFN-ALPHA | Immunohistochemistry | Interferon-alpha - drug effects | Interferon-beta - immunology | Toll-Like Receptor 7 - antagonists & inhibitors | Dendritic Cells - immunology | Humans | Long Interspersed Nucleotide Elements - genetics | Middle Aged | Lupus Erythematosus, Systemic - metabolism | Sjogren's Syndrome - immunology | Male | Monocytes - immunology | Sjogren's Syndrome - metabolism | Interferon Type I - immunology | Interferon-beta - drug effects | Autoimmune Diseases - genetics | DNA Methylation | Kidney - metabolism | Toll-Like Receptor 8 - antagonists & inhibitors | I-kappa B Kinase - antagonists & inhibitors | Leukocytes, Mononuclear - immunology | Lupus Erythematosus, Systemic - immunology | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Interferon Type I - metabolism | Long Interspersed Nucleotide Elements - immunology | Adult | Female | Lupus Nephritis - metabolism | Interferon Type I - drug effects | Sjogren's Syndrome - genetics | Interferon-alpha - metabolism | Leukocytes, Mononuclear - drug effects | Salivary Glands, Minor - metabolism | Toll-Like Receptor 9 - antagonists & inhibitors | Autoimmune Diseases - immunology | Lupus Nephritis - immunology | Blotting, Western | Interferon-alpha - immunology | Immunity, Innate - immunology | Interferon-beta - metabolism | Lupus Erythematosus, Systemic - genetics | Aged
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20. Full Text Targeting of type I interferon in systemic autoimmune diseases
by Crow, Mary K and Olferiev, Mikhail and Kirou, Kyriakos A
Translational Research, ISSN 1931-5244, 2015, Volume 165, Issue 2, pp. 296 - 305
Increased blood levels of type I interferon (IFN-I) and expression of a broad signature of gene transcripts that reflect induction by IFN-I are observed in... 
Internal Medicine | MEDICINE, RESEARCH & EXPERIMENTAL | ALPHA MONOCLONAL-ANTIBODY | AICARDI-GOUTIERES SYNDROME | PERSISTENT LCMV INFECTION | AFRICAN-GREEN MONKEYS | PLASMACYTOID DENDRITIC CELLS | MEDICINE, GENERAL & INTERNAL | LUPUS-ERYTHEMATOSUS PATIENTS | GENE-EXPRESSION | DOUBLE-BLIND | MEDICAL LABORATORY TECHNOLOGY | PHASE-I | SIV INFECTION | Virus Diseases - immunology | Signal Transduction | Humans | Risk Factors | Translational Medical Research | Autoimmune Diseases - immunology | Lupus Nephritis - immunology | Lupus Erythematosus, Systemic - therapy | Autoimmune Diseases - genetics | Lupus Nephritis - etiology | Animals | Lupus Erythematosus, Systemic - immunology | Autoimmune Diseases - therapy | Interferon Type I - genetics | Mutation | Disease Models, Animal | Interferon Type I - antagonists & inhibitors | Virus diseases | Lupus | Systemic lupus erythematosus | Analysis | Therapeutics | Interferon | Biological response modifiers | Health aspects | Homeopathy | Materia medica and therapeutics
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