X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
animals (29) 29
humans (24) 24
renin - antagonists & inhibitors (17) 17
male (15) 15
rats (14) 14
index medicus (13) 13
chemistry, medicinal (12) 12
renin - blood (10) 10
administration, oral (9) 9
blood-pressure (9) 9
female (9) 9
hypertension (9) 9
structure-activity relationship (9) 9
blood pressure (8) 8
blood pressure - drug effects (8) 8
protease inhibitors - chemistry (8) 8
protein binding (8) 8
renin (8) 8
renin - metabolism (8) 8
discovery (7) 7
drug design (7) 7
kinetics (7) 7
models, molecular (7) 7
renin-angiotensin system (7) 7
angiotensin ii (6) 6
expression (6) 6
potent (6) 6
aliskiren (5) 5
biochemistry & molecular biology (5) 5
crystallography, x-ray (5) 5
heart rate - drug effects (5) 5
human necessities (5) 5
hygiene (5) 5
medical or veterinary science (5) 5
molecular structure (5) 5
oligopeptides - pharmacology (5) 5
plasma (5) 5
preparations for medical, dental, or toilet purposes (5) 5
protease inhibitors - pharmacology (5) 5
renin - chemistry (5) 5
renin - genetics (5) 5
specific therapeutic activity of chemical compounds ormedicinal preparations (5) 5
tetrazoles - pharmacology (5) 5
activation (4) 4
angiotensin (4) 4
antihypertensive agents - pharmacology (4) 4
base sequence (4) 4
binding, competitive (4) 4
callithrix (4) 4
chemistry, organic (4) 4
drug discovery (4) 4
imidazoles - pharmacology (4) 4
molecular sequence data (4) 4
peripheral vascular disease (4) 4
pharmacology & pharmacy (4) 4
structure-based design (4) 4
therapy (4) 4
time factors (4) 4
active renin (3) 3
adult (3) 3
amides - chemistry (3) 3
angiotensin ii - antagonists & inhibitors (3) 3
angiotensin receptor antagonists (3) 3
angiotensin-converting enzyme inhibitors - pharmacology (3) 3
angiotensin-ii (3) 3
angiotensinogen - blood (3) 3
angiotensinogen - genetics (3) 3
antihypertensive agents - chemical synthesis (3) 3
antihypertensive agents - chemistry (3) 3
benzazepines - pharmacology (3) 3
binding sites (3) 3
biological availability (3) 3
biphenyl compounds - pharmacology (3) 3
cardiovascular system (3) 3
converting enzyme-inhibition (3) 3
dose-response relationship, drug (3) 3
enzymes (3) 3
fumarates - chemistry (3) 3
fumarates - pharmacology (3) 3
heart (3) 3
heart-failure (3) 3
hydrogen-ion concentration (3) 3
hypertension - drug therapy (3) 3
hypertension - genetics (3) 3
inhibitory concentration 50 (3) 3
liver - metabolism (3) 3
losartan (3) 3
messenger-rna (3) 3
mice (3) 3
oligopeptides - metabolism (3) 3
paroxysmal-nocturnal hemoglobinuria (3) 3
peptides - chemistry (3) 3
peptidyl-dipeptidase a - metabolism (3) 3
protease (3) 3
protease inhibitors (3) 3
protease inhibitors - administration & dosage (3) 3
protease inhibitors - pharmacokinetics (3) 3
proteases (3) 3
protein conformation (3) 3
pyrrolidines - chemistry (3) 3
more...
Library Location Library Location
Language Language
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Scientific Reports, ISSN 2045-2322, 06/2016, Volume 6, Issue 1, p. 27909
Sacubitril is an ethyl ester prodrug of LBQ657, the active neprilysin (NEP) inhibitor, and a component of LCZ696 (sacubitril/valsartan). We report herein the... 
REFINEMENT | POTENT | PHOSPHORAMIDON | MULTIDISCIPLINARY SCIENCES | HEART-FAILURE | NEUTRAL ENDOPEPTIDASE INHIBITORS | LCZ696
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2014, Volume 135, Issue 4, pp. 1031 - 1043.e6
Journal Article
Nature Chemical Biology, ISSN 1552-4450, 12/2016, Volume 12, Issue 12, pp. 1105 - 1110
Journal Article
Current Pharmaceutical Design, ISSN 1381-6128, 01/2007, Volume 13, Issue 3, pp. 271 - 285
Journal Article
2011, 2e éd. revue et augmentée., Références. Mondes, ISBN 2724612167, 519
Book
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 04/2019, Volume 116, Issue 16, pp. 7926 - 7931
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 05/2017, Volume 323, pp. 53 - 65
Sacubitril/valsartan (LCZ696) is the first angiotensin receptor neprilysin inhibitor approved to reduce cardiovascular mortality and hospitalization in... 
SILK-Aβ | Angiotensin receptor neprilysin inhibitor | Sacubitril/valsartan | LCZ696 | Amyloid beta | Alzheimer's disease | LOCALIZATION | A-BETA-42 | ALZHEIMERS-DISEASE | HEART-FAILURE | ENDOPEPTIDASE-24.11 | ENKEPHALINASE | IDENTIFICATION | SILK-A beta | PHARMACOLOGY & PHARMACY | CHOROID-PLEXUS | TOXICOLOGY | BRAIN | Immunohistochemistry | Up-Regulation | Angiotensin Receptor Antagonists - pharmacokinetics | Protease Inhibitors - pharmacokinetics | Humans | Brain - enzymology | Macaca fascicularis | Aminobutyrates - toxicity | Aminobutyrates - pharmacokinetics | Tetrazoles - administration & dosage | Biotransformation | Protease Inhibitors - toxicity | Amyloid beta-Peptides - metabolism | Angiotensin Receptor Antagonists - toxicity | Isotope Labeling | Protease Inhibitors - administration & dosage | Female | Aminobutyrates - administration & dosage | Recombinant Proteins - metabolism | Risk Assessment | Administration, Oral | Neprilysin - metabolism | Brain - drug effects | Animals | Protein Isoforms | Neprilysin - antagonists & inhibitors | Tetrazoles - toxicity | Tetrazoles - pharmacokinetics | Angiotensin Receptor Antagonists - administration & dosage | Index Medicus | CLEARANCE | CEREBROSPINAL FLUID | STABLE ISOTOPES | 60 APPLIED LIFE SCIENCES | ANGIOTENSIN | CONCENTRATION RATIO | ABUNDANCE | HEART | PARAFFIN | FLUORESCENCE | ENZYMES | ENDOTHELINS | MONKEYS | RECEPTORS | FORMALDEHYDE
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 05/2017, Volume 323, p. 53
Sacubitril/valsartan (LCZ696) is the first angiotensin receptor neprilysin inhibitor approved to reduce cardiovascular mortality and hospitalization in... 
Heart failure | Immunohistochemistry | Proteases | Cardiac patients | Angiotensin | Central nervous system | Medical research | Amyloid beta-protein | Medicine, Experimental
Journal Article
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 2003, Volume 308, Issue 4, pp. 698 - 705
Journal Article
International journal of cancer, ISSN 0020-7136, 07/2019
The treatment landscape in metastatic renal cell carcinoma has changed fundamentally over the last decade by the development of anti-angiogenic agents, mTOR... 
Journal Article
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 05/2019, Volume 62, Issue 9, pp. 4656 - 4668
Complement factor D (FD), a highly specific S1 serine protease, plays a central role in the amplification of the alternative complement pathway (AP) of the... 
POTENT | CHEMISTRY, MEDICINAL | DISCOVERY
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 02/2017, Volume 35, Issue 6_suppl, pp. 451 - 451
451 Background: Sequential targeted therapy is standard in patients (pts) with clear-cell renal carcinoma (CCRCC). Clinical Practice Guidelines exists only for... 
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 07/2017, Volume 60, Issue 13, pp. 5717 - 5735
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 05/2018, Volume 9, Issue 5, pp. 490 - 495
Complement Factor D, a serine protease of the S1 family and key component of the alternative pathway amplification loop, represents a promising target for the... 
fragment-based drug discovery | Alternative complement pathway | structure-based design | factor D inhibitors | POTENT | CHEMISTRY, MEDICINAL | ALTERNATIVE PATHWAY | PAROXYSMAL-NOCTURNAL HEMOGLOBINURIA | INHIBITORS | DERIVATIVES | PROTEASE | UROKINASE
Journal Article