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1. Full Text Survival outcomes by high‐risk human papillomavirus status in nonoropharyngeal head and neck squamous cell carcinomas: A propensity‐scored analysis of the National Cancer Data Base
by Tian, Sibo and Switchenko, Jeffrey M and Jhaveri, Jaymin and Cassidy, Richard J and Ferris, Matthew J and Press, Robert H and Pfister, Neil T and Patel, Mihir R and Saba, Nabil F and McDonald, Mark W and Higgins, Kristin A and Yu, David S and Curran, Walter J and Gillespie, Theresa W and Beitler, Jonathan J
Cancer, ISSN 0008-543X, 08/2019, Volume 125, Issue 16, pp. 2782 - 2793
Background The prognostic relevance of human papillomavirus (HPV) status in patients with nonoropharyngeal (OPX) squamous cell cancer (SCC) of the head and... 
human papillomavirus (HPV) | larynx | head and neck cancer | p16 | National Cancer Data Base | oral cavity | hypopharynx | biomarker | OROPHARYNGEAL | POSITIVE HEAD | HPV DNA | ONCOLOGY | EXPRESSION | PROGNOSTIC ROLE | Squamous cell carcinoma | Populations | Identification methods | Risk | Hepatocellular carcinoma | Survival | Patients | Data bases | Rank tests | Hypopharynx | Oral cavity | Human papillomavirus | Databases | Human papilloma viruses | Head and neck cancer | Larynx | Head and neck carcinoma | Cancer | Index Medicus | Abridged Index Medicus
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2. Full Text Small Molecule KRAS Agonist for Mutant KRAS Cancer Therapy
by Xu, Ke and Park, Dongkyoo and Magis, Andrew T and Zhang, Jun and Zhou, Wei and Sica, Gabriel L and Ramalingam, Suresh S and Curran, Walter J and Deng, Xingming
Molecular Cancer, ISSN 1476-4598, 04/2019, Volume 18, Issue 1, pp. 85 - 16
Background: Lung cancer patients with KRAS mutation(s) have a poor prognosis due in part to the development of resistance to currently available therapeutic... 
Therapy | Agonist | KRAS | NSCLC | Autophagy | Apoptosis | GENE-MUTATIONS | PATHWAYS | BCL-XL | BIOCHEMISTRY & MOLECULAR BIOLOGY | DEATH | SOMATIC MUTATIONS | CELL LUNG-CANCER | K-RAS MUTATIONS | ONCOLOGY | ACTIVATED RAS | INHIBITORS | MODULATION | Care and treatment | Prognosis | Cell death | Hydrogen | Analysis | Genetically modified organisms | Respiratory agents | Genetic aspects | Lung cancer, Non-small cell | Health aspects | Cancer | Biotechnology | GTP | Toxicity | Lung cancer | Xenotransplantation | Colorectal cancer | Amino acids | Cancer therapies | Anticancer properties | Proteins | Signal transduction | GDP | Cell growth | Antitumor agents | Hydrogen bonds | Xenografts | Binding | Therapeutic applications | Tumor cell lines | Cell lines | New classes | Agonists | Genetic engineering | Mutation | Binding sites | Tumors
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3. Full Text Acetylation regulates ribonucleotide reductase activity and cancer cell growth
by Chen, G and Luo, Y and Warncke, K and Sun, YW and Yu, DS and Fu, HA and Behera, M and Ramalingam, SS and Doetsch, PW and Duong, DM and Lammers, M and Curran, WJ and Deng, XM
NATURE COMMUNICATIONS, ISSN 2041-1723, 07/2019, Volume 10, Issue 1, pp. 3213 - 16
Ribonucleotide reductase (RNR) catalyzes the de novo synthesis of deoxyribonucleoside diphosphates (dNDPs) to provide dNTP precursors for DNA synthesis. Here,... 
DEACETYLATION | PHOSPHORYLATION | MULTIDISCIPLINARY SCIENCES | GENOME INTEGRITY | DEGRADATION | CHECKPOINT | REPLICATION STRESS | DAMAGE | DNA-REPLICATION | ATR | P53 | Molecular machines | Reductases | Camptothecin | DNA damage | Radiation | DNA biosynthesis | Cell growth | Ribonucleotide reductase | Deacetylation | S phase | Regulatory mechanisms (biology) | Replication | In vivo methods and tests | Acetylation | Disruption | Diphosphates | Chemical synthesis | Stalling | Deoxyribonucleic acid--DNA | Radiation damage | Reductase | Index Medicus
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4. Full Text Targeted sequencing and intracranial outcomes of patients with lung adenocarcinoma brain metastases treated with radiotherapy
by Press, Robert H and Zhang, Chao and Cassidy, Richard J and Ferris, Matthew J and Zhong, Jim and Steuer, Conor E and Pillai, Rathi N and Owonikoko, Taofeek K and Kahn, Shannon and Ramalingam, Suresh S and Patel, Pretesh R and Curran, Walter J and Shu, Hui‐Kuo G and Sica, Gabriel L and Higgins, Kristin A
Cancer, ISSN 0008-543X, 09/2018, Volume 124, Issue 17, pp. 3586 - 3595
BACKGROUND Treatment for advanced lung adenocarcinoma (AC) has become increasingly personalized based on molecular results. However, for patients with AC brain... 
intracranial failure | whole‐brain radiotherapy | DNA sequence analysis | brain metastases | distant brain failure | adenocarcinoma | neoplasm metastases | next‐generation sequencing | non‐small cell lung cancer | stereotactic radiosurgery | non-small cell lung cancer | next-generation sequencing | whole-brain radiotherapy | 1ST-LINE TREATMENT | CANCER MUTATION STATUS | SELUMETINIB PLUS DOCETAXEL | OPEN-LABEL | PRIMARY RESISTANCE | EGFR | CHEMOTHERAPY | GROWTH-FACTOR RECEPTOR | NONSMALL CELL LUNG | ONCOLOGY | KRAS | Adenocarcinoma | Brain | p53 Protein | Homology | Metastasis | K-Ras protein | Metastases | Proteins | Epidermal growth factor | Salvage | Surgery | Growth factors | Protein-tyrosine kinase | Tensin | Epidermal growth factor receptors | Health risks | Radiation therapy | Risk analysis | Patients | Lymphoma | Lungs | Radiology | Mutation | Aberration | PTEN protein
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5. Full Text Current Activities of the Coalition of Cancer Cooperative Groups
by Bertagnolli, Monica M and Blaney, Susan M and Blanke, Charles D and Curran, Walter J and Dancey, Janet and Mannel, Robert S and O’Dwyer, Peter J and Schnall, Mitchell D and Wolmark, Norman and Coalition Canc Cooperative Grp and Coalition of Cancer Cooperative Groups
JNCI: Journal of the National Cancer Institute, ISSN 0027-8874, 01/2019, Volume 111, Issue 1, pp. 11 - 18
Abstract The Coalition of Cancer Cooperative Groups is an organization representing the interests of patients and researchers who conduct research through the... 
ADJUVANT CHEMOTHERAPY | TRIALS | THERAPIES | ONCOLOGY | Leadership | Clinical trials | Pharmacology | Research | Chemical compounds | Private sector | Cancer
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6. Full Text Prognostic value of radiographically defined extranodal extension in human papillomavirus‐associated locally advanced oropharyngeal carcinoma
by Tian, Sibo and Ferris, Matthew J and Switchenko, Jeffrey M and Magliocca, Kelly R and Cassidy, Richard J and Jhaveri, Jaymin and Aiken, Ashley H and Baugnon, Kristen L and Hudgins, Patricia A and Kendi, Ayse T. K and Patel, Mihir R and Saba, Nabil F and Curran, Walter J and Beitler, Jonathan J
Head & Neck, ISSN 1043-3074, 09/2019, Volume 41, Issue 9, pp. 3056 - 3063
Background Pathologic extranodal extension (ENE) has traditionally guided the management of head and neck cancers. The prognostic value of radiographic ENE... 
p16 | oropharynx cancer | ENE | extranodal extension | HPV | SURGERY | EXTRACAPSULAR SPREAD | RISK | ADVANCED HEAD | COMPUTED-TOMOGRAPHY | NECK-CANCER | CHEMOTHERAPY | ACCURACY | OTORHINOLARYNGOLOGY | SQUAMOUS-CELL CARCINOMA | RADIOTHERAPY | LIKELIHOOD | Head and neck | Squamous cell carcinoma | Human papillomavirus | Cell survival | Health risk assessment | Metastases | Index Medicus
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7. Full Text A Randomized Trial of Bevacizumab for Newly Diagnosed Glioblastoma
by Gilbert, Mark R and Dignam, James J and Armstrong, Terri S and Wefel, Jeffrey S and Blumenthal, Deborah T and Vogelbaum, Michael A and Colman, Howard and Chakravarti, Arnab and Pugh, Stephanie and Won, Minhee and Jeraj, Robert and Brown, Paul D and Jaeckle, Kurt A and Schiff, David and Stieber, Volker W and Brachman, David G and Werner-Wasik, Maria and Tremont-Lukats, Ivo W and Sulman, Erik P and Aldape, Kenneth D and Curran, Walter J and Mehta, Minesh P
The New England Journal of Medicine, ISSN 0028-4793, 02/2014, Volume 370, Issue 8, pp. 699 - 708
The addition of bevacizumab to temozolomide and radiotherapy did not improve overall survival in patients with glioblastoma. Patients receiving bevacizumab had... 
MEDICINE, GENERAL & INTERNAL | RESPONSE CRITERIA | GLIOMA | RECURRENT GLIOBLASTOMA | PHASE-III | CLINICAL-TRIALS | VALIDATION | COMBINATION | MULTIFORME | ADJUVANT TEMOZOLOMIDE | RADIATION-THERAPY | Antibodies, Monoclonal, Humanized - adverse effects | Dacarbazine - adverse effects | Antibodies, Monoclonal, Humanized - therapeutic use | Double-Blind Method | Dacarbazine - therapeutic use | Humans | Proportional Hazards Models | Combined Modality Therapy | Brain Neoplasms - drug therapy | Glioblastoma - radiotherapy | Bevacizumab | Disease-Free Survival | Dacarbazine - analogs & derivatives | Survival Analysis | Angiogenesis Inhibitors - therapeutic use | Adult | Brain Neoplasms - mortality | Brain Neoplasms - radiotherapy | Glioblastoma - drug therapy | Angiogenesis Inhibitors - adverse effects | Glioblastoma - mortality | Drug therapy | Glioblastoma multiforme | Research | Nuclear magnetic resonance--NMR | Medical imaging | Glioblastoma | Cognition | Radiation therapy | Cancer therapies | Survival | Patients | Quality of life | Angiogenesis | Chemotherapy | Intestine | Monoclonal antibodies | Ligands | Death | Temozolomide | Thromboembolism | Vascular endothelial growth factor | Neutropenia
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8. Full Text A learning-based automatic segmentation and quantification method on left ventricle in gated myocardial perfusion SPECT imaging: A feasibility study
by Wang, Tonghe and Lei, Yang and Tang, Haipeng and He, Zhuo and Castillo, Richard and Wang, Cheng and Li, Dianfu and Higgins, Kristin and Liu, Tian and Curran, Walter J and Zhou, Weihua and Yang, Xiaofeng
Journal of Nuclear Cardiology, ISSN 1071-3581, 2019
The performance of left ventricular (LV) functional assessment using gated myocardial perfusion SPECT (MPS) relies on the accuracy of segmentation. Current... 
segmentation | machine learning | Myocardial perfusion | SPECT
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9. Full Text Lung cancer: current therapies and new targeted treatments
by Hirsch, Fred R, Prof and Scagliotti, Giorgio V, Prof and Mulshine, James L, Prof and Kwon, Regina, BA and Curran, Walter J, Prof and Wu, Yi-Long, Prof and Paz-Ares, Luis, Prof
Lancet, The, ISSN 0140-6736, 2016, Volume 389, Issue 10066, pp. 299 - 311
Summary Lung cancer is the most frequent cause of cancer-related deaths worldwide. Every year, 1·8 million people are diagnosed with lung cancer, and 1·6... 
Internal Medicine | ANAPLASTIC LYMPHOMA KINASE | MEDICINE, GENERAL & INTERNAL | MULTICENTER PHASE-II | 1ST-LINE CHEMOTHERAPY | ADULT PATIENTS PTS | DOUBLE-BLIND | BODY RADIATION-THERAPY | OPEN-LABEL | EGFR MUTATIONS | SINGLE-ARM | MAINTENANCE THERAPY | Lung Neoplasms - genetics | Carcinoma, Non-Small-Cell Lung - genetics | Early Detection of Cancer | Lung Neoplasms - mortality | Humans | Survival Rate | Antineoplastic Agents - therapeutic use | Carcinoma, Non-Small-Cell Lung - diagnosis | Combined Modality Therapy | Lung Neoplasms - therapy | Carcinoma, Non-Small-Cell Lung - mortality | Carcinoma, Non-Small-Cell Lung - therapy | Immunotherapy | Mutation | Lung Neoplasms - diagnosis | Medical colleges | Care and treatment | Lung cancer | Analysis | Oncology, Experimental | Research | Diagnosis | Health aspects | Cancer | Oncology | Medical screening | Cancer therapies
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10. Full Text Reduced‐volume tumor‐bed boost is not associated with inferior local control and survival outcomes in high‐risk medulloblastoma
by Tian, Sibo and Sudmeier, Lisa J and Zhang, Chao and Madden, Nicholas A and Buchwald, Zachary S and Shu, Hui‐Kuo G and Curran, Walter J and Eaton, Bree R and Esiashvili, Natia
Pediatric Blood & Cancer, ISSN 1545-5009, 01/2020, Volume 67, Issue 1, pp. e28027 - n/a
Background Radiotherapy boost to the entire posterior fossa (PF) is standard of care for high‐risk (H‐R) medulloblastoma patients; the utility of tumor bed... 
craniospinal irradiation | tumor bed | medulloblastoma | posterior fossa | high risk | Radiation | Risk reduction | Risk | Radiation therapy | Survival | Radiation dosage | Medulloblastoma | Health hazards | Irradiation | Hazard assessment | Failure | Tumors | Ototoxicity | Index Medicus
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11. Full Text Sequential vs Concurrent Chemoradiation for Stage III Non-Small Cell Lung Cancer: Randomized Phase III Trial RTOG 9410
by Curran, Walter J and Paulus, Rebecca and Langer, Corey J and Komaki, Ritsuko and Lee, Jin S and Hauser, Stephen and Movsas, Benjamin and Wasserman, Todd and Rosenthal, Seth A and Gore, Elizabeth and Machtay, Mitchell and Sause, William and Cox, James D
Journal of the National Cancer Institute, ISSN 0027-8874, 10/2011, Volume 103, Issue 19, pp. 1452 - 1460
Background The combination of chemotherapy with thoracic radiotherapy (TRT) compared with TRT alone has been shown to confer a survival advantage for good... 
IRRADIATION | CARBOPLATIN | CISPLATIN | VINORELBINE | ONCOLOGY | THERAPY-ONCOLOGY-GROUP | CHEMORADIOTHERAPY | RADIOTHERAPY | CHEMOTHERAPY | RADIATION-THERAPY | PACLITAXEL | Carcinoma, Non-Small-Cell Lung - radiotherapy | Lung Neoplasms - drug therapy | Multivariate Analysis | Antineoplastic Combined Chemotherapy Protocols - administration & dosage | Follow-Up Studies | United States | Humans | Middle Aged | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Lung Neoplasms - radiotherapy | Lung Neoplasms - pathology | Male | Vinblastine - administration & dosage | Cisplatin - administration & dosage | Time Factors | Vinblastine - adverse effects | Aged, 80 and over | Adult | Dose Fractionation | Chemotherapy, Adjuvant | Odds Ratio | Radiotherapy, Adjuvant | Carcinoma, Non-Small-Cell Lung - pathology | Radiotherapy Dosage | Etoposide - adverse effects | Drug Administration Schedule | Kaplan-Meier Estimate | Etoposide - administration & dosage | Treatment Outcome | Disease Progression | Canada | Confounding Factors (Epidemiology) | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Cisplatin - adverse effects | Aged | Carcinoma, Non-Small-Cell Lung - drug therapy | Neoplasm Staging | Etoposide | Research | Lung cancer, Non-small cell | Drug therapy | Radiotherapy | Health aspects | Index Medicus
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