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Journal Article
Journal Article
Journal of medicinal chemistry, ISSN 0022-2623, 07/2019
Small molecule JAK inhibitors have emerged as a major therapeutic advancement in treating autoimmune diseases. The discovery of isoform selective JAK... 
Journal Article
Journal of medicinal chemistry, ISSN 0022-2623, 07/2019
As a member of the Janus (JAK) family of nonreceptor tyrosine kinases, TYK2 plays an important role in mediating the signaling of pro-inflammatory cytokines... 
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 01/2018, Volume 28, Issue 2, pp. 85 - 93
We disclose the optimization of a high throughput screening hit to yield benzothiazine and tetrahydroquinoline sulfonamides as potent RORγt inverse agonists.... 
POTENT | AUTOIMMUNE | CHEMISTRY, MEDICINAL | INHIBITION | INTERLEUKIN-17 | NUCLEAR RECEPTORS | MODULATORS | DISEASE | GENE-EXPRESSION | CHEMISTRY, ORGANIC | DISCOVERY | PSORIASIS | Rheumatoid factor | Multiple sclerosis | Sulfonamides | Analysis | Gastrointestinal diseases | Liver | Arthritis
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 07/2016, Volume 59, Issue 13, pp. 6248 - 6264
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 03/2008, Volume 51, Issue 6, pp. 1976 - 1980
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 03/2016, Volume 59, Issue 6, pp. 2820 - 2840
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 02/2013, Volume 56, Issue 4, pp. 1656 - 1669
Journal Article
SCIENCE TRANSLATIONAL MEDICINE, ISSN 1946-6234, 07/2019, Volume 11, Issue 502, p. eaaw1736
TYK2 is a nonreceptor tyrosine kinase involved in adaptive and innate immune responses. A deactivating coding variant has previously been shown to prevent... 
MEDICINE, RESEARCH & EXPERIMENTAL | SYSTEMIC-LUPUS-ERYTHEMATOSUS | INTERFERON | ACTIVATION | INHIBITION | GENE-EXPRESSION | SCLEROSIS | CELL-DIFFERENTIATION | IL-12 | TYROSINE KINASE 2 | IFN-ALPHA | CELL BIOLOGY
Journal Article
Bioanalysis, ISSN 1757-6180, 01/2012, Volume 4, Issue 1, pp. 29 - 40
Background: There is considerable interest in the pharmaceutical industry today in both development of therapeutic proteins as viable biopharmaceutical agents... 
ANTIBODIES | CHEMISTRY, MEDICINAL | PLASMA | DBS | PHARMACOKINETICS | QUANTIFICATION | BIOCHEMICAL RESEARCH METHODS | MS/MS | MASS-SPECTROMETRY | Index Medicus
Journal Article
Journal Article
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 2007, Volume 17, Issue 4, pp. 895 - 901
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 11/2016, Volume 59, Issue 21, pp. 9837 - 9854
Journal Article
Bioanalysis, ISSN 1757-6180, 08/2010, Volume 2, Issue 8, pp. 1415 - 1422
Background: Prodrugs that exhibit ex vivo instability owing to high levels of esterases in rodent blood, plasma and serum present challenges in the accurate... 
CHEMISTRY, MEDICINAL | BIOCHEMICAL RESEARCH METHODS | SUPPRESSION | MS/MS | DRIED BLOOD SPOTS | ELECTROSPRAY-IONIZATION | MOLECULES
Journal Article
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