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1. Full Text Associations between Genetic Polymorphisms in IL-33, IL1R1 and Risk for Inflammatory Bowel Disease
by Latiano, Anna and Palmieri, Orazio and Pastorelli, Luca and Vecchi, Maurizio and Pizarro, Theresa T and Bossa, Fabrizio and Merla, Giuseppe and Augello, Bartolomeo and Latiano, Tiziana and Corritore, Giuseppe and Settesoldi, Alessia and Valvano, Maria Rosa and D'Incà, Renata and Stronati, Laura and Annese, Vito and Andriulli, Angelo
PLoS ONE, ISSN 1932-6203, 04/2013, Volume 8, Issue 4, pp. e62144 - e62144
Background: Recent evidence suggests that the IL-33/IL1RL1 axis plays a critical role in several autoimmune and inflammatory disorders; however, its... 
COMMON VARIANTS | CROHNS-DISEASE | MULTIDISCIPLINARY SCIENCES | ULCERATIVE-COLITIS | MAST-CELLS | SUSCEPTIBILITY LOCI | INTERLEUKIN-18 GENE | SEQUENCE VARIANTS | ALLERGIC AIRWAY INFLAMMATION | GENOME-WIDE ASSOCIATION | CELIAC-DISEASE | Crohn Disease - epidemiology | Haplotypes | Crohn Disease - genetics | Humans | Middle Aged | Colitis, Ulcerative - genetics | Child, Preschool | Infant | Male | Colitis, Ulcerative - epidemiology | Case-Control Studies | Young Adult | Interleukins - genetics | Aged, 80 and over | Adult | Female | Child | Genetic Predisposition to Disease - genetics | Interleukin-33 | Gene Expression Regulation | Phenotype | Adolescent | Age of Onset | Receptors, Interleukin-1 Type I - genetics | Aged | Polymorphism, Single Nucleotide | Cohort Studies | Pediatrics | Medical research | RNA | Genes | Medicine, Experimental | Genetic aspects | Research | Children | Health aspects | Risk factors | Genetic polymorphisms | Ulcerative colitis | Inflammatory bowel diseases | Health risks | Risk | Single-nucleotide polymorphism | Gene expression | Disease control | Patients | Inflammatory diseases | Studies | Inflammatory bowel disease | Intestine | Biopsy | Rodents | Interleukin 1 | Alleles | Colon | Index Medicus
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2. Full Text Detection of a fluorescent-labeled avidin-nucleic acid nanoassembly by confocal laser endomicroscopy in the microvasculature of chronically inflamed intestinal mucosa
by Buda, Andrea and Facchin, Sonia and Dassie, Elisa and Casarin, Elisabetta and Jepson, Mark A and Neumann, Helmut and Hatem, Giorgia and Realdon, Stefano and D’Incà, Renata and Sturniolo, Giacomo Carlo and Morpurgo, Margherita
International Journal of Nanomedicine, ISSN 1176-9114, 01/2015, Volume 10, pp. 399 - 408
Inflammatory bowel diseases are chronic gastrointestinal pathologies causing great discomfort in both children and adults. The pathogenesis of inflammatory... 
Fluorescent nanoparticles | Inflammatory bowel disease | Dextran sodium sulfate | Diagnostics | Avidin-nucleic acid nanoassembly | Confocal laser endomicroscopy | Ulcerative colitis | diagnostics | confocal laser endomicroscopy | NANOSCIENCE & NANOTECHNOLOGY | PHARMACOLOGY & PHARMACY | dextran sodium sulfate | fluorescent nanoparticles | ulcerative colitis | avidin-nucleic acid nanoassembly | inflammatory bowel disease | Fluorescent Dyes - chemistry | Nanoparticles - analysis | Nanoparticles - chemistry | Fluorescent Dyes - analysis | Intestinal Mucosa - chemistry | Inflammatory Bowel Diseases - metabolism | Microscopy, Confocal - methods | Drug Delivery Systems | Animals | Nucleic Acids - analysis | Nucleic Acids - chemistry | Avidin - analysis | Avidin - chemistry | Mice | Disease Models, Animal | Microvessels - chemistry | Nanoparticles | Inflammatory bowel diseases | Usage | Diagnosis | Research | Laser scanning microscopy | Visualization | Acids | Lasers | Colon | Endoscopy | Medical diagnosis | Laboratory animals | Cancer | Chronic illnesses | Crohns disease | Index Medicus
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3. Full Text Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci
by Franke, Ane and McGovern, Dermot P. B and Barrett, Jeffrey C and Wang, Kai and Radford-Smith, Graham L and Ahmad, Tariq and Lees, Charlie W and Balschun, Tobias and Lee, James and Roberts, Rebecca and Anderson, Carl A and Bis, Joshua C and Bumpstead, Suzanne and Ellinghaus, David and Festen, Eleonora M and Georges, Michel and Green, Todd and Haritunians, Talin and Jostins, Luke and Latiano, Anna and Mathew, Christopher G and Montgomery, Grant W and Prescott, Natalie J and Raychaudhuri, Soumya and Rotter, Jerome I and Schumm, Philip and Sharma, Yashoda and Simms, Lisa A and Taylor, Kent D and Whiteman, David and Wijmenga, Cisca and Baldassano, Robert N and Barclay, Murray and Bayless, Theodore M and Brand, Stephan and Büning, Carsten and Cohen, Albert and Colombel, Jean-Frederick and Cottone, Mario and Stronati, Laura and Denson, Ted and de Vos, Martine and D'Inca, Renata and Dubinsky, Marla and Edwards, Cathryn and Florin, Tim and Franchimont, Denis and Gearry, Richard and Glas, Jürgen and van Gossum, Ane and Guthery, Stephen L and Halfvarson, Jonas and Verspaget, Hein W and Hugot, Jean-Pierre and Karban, Amir and Laukens, Debby and Lawrance, Ian and Lemann, Marc and Levine, Arie and Libioulle, Cecile and Louis, Edouard and Mowat, Craig and Newman, William and Panés, Julián and Phillips, Anne and Proctor, Deborah D and Regueiro, Miguel and Russell, Richard and Rutgeerts, Paul and Sanderson, Jeremy and Sans, Miquel and Seibold, Frank and Steinhart, A. Hillary and Stokkers, Pieter C. F and Torkvist, Leif and Kullak-Ublick, Gerd and Wilson, David and Walters, Thomas and Targan, Stephan R and Brant, Steven R and Rioux, John D and D'Amato, Mauro and Weersma, Rinse K and Kugathasan, Subra and Griffiths, Anne M and Mansfield, John C and Vermeire, Severine and Duerr, Richard H and Silverberg, Mark S and Satsangi, Jack and Schreiber, Stefan and Cho, Judy H and Annese, Vito and Hakonarson, Hakon and Daly, Mark J and Parkes, Miles and Hälsoakademin and Örebro universitet
Nature genetics, ISSN 1061-4036, 2010, Volume 42, Issue 12, pp. 1118 - 1125
We undertook a meta-analysis of six Crohn's disease genome-wide association studies (GWAS) comprising 6,333 affected individuals (cases) and 15,056 controls... 
COMMON VARIANTS | ACTIVATION | INFLAMMATORY-BOWEL-DISEASE | PROTEIN | NEDD4 FAMILY | GENE | GENETICS & HEREDITY | SEQUENCE VARIANTS | RECEPTOR | IDENTIFICATION | ASSOCIATION | Genetic Variation | Crohn Disease - genetics | Genetic Predisposition to Disease | Genome-Wide Association Study | Reproducibility of Results | Humans | Computational Biology | Genetic Loci - genetics | Crohn Disease - etiology | Genome, Human - genetics | Genetic Linkage | Care and treatment | Methyltransferases | Physiological aspects | Disease susceptibility | Genetic aspects | Crohn's disease | Research | Risk factors | Inflammatory bowel disease | Genetics | Genomics | Meta-analysis | Index Medicus | Medicine | Medicin | Clinical Medicine | Medical and Health Sciences | Klinisk medicin | Medicin och hälsovetenskap
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4. Full Text Calprotectin and lactoferrin in the assessment of intestinal inflammation and organic disease
by D’Incà, Renata and Dal Pont, Elisabetta and Di Leo, Vincenza and Ferronato, Antonio and Fries, Walter and Vettorato, Maria Grazia and Martines, Diego and Sturniolo, Giacomo Carlo
International Journal of Colorectal Disease, ISSN 0179-1958, 4/2007, Volume 22, Issue 4, pp. 429 - 437
Calprotectin and lactoferrin are specific neutrophil-derived proteins, which can be measured in the feces because they are released by cells in inflammatory... 
Lactoferrin | Colon cancer | Medicine & Public Health | Hepatology | Surgery | Gastroenterology | Internal Medicine | Calprotectin | Proctology | Crohn’s disease | Ulcerative colitis | Crohn's disease | SURGERY | DIAGNOSIS | CROHNS-DISEASE | CHRONIC DIARRHEA | colon cancer | EXCRETION | FECAL OCCULT BLOOD | calprotectin | NEUTROPHIL-DERIVED PROTEINS | COLORECTAL-CANCER | lactoferrin | ulcerative colitis | ACTIVE ULCERATIVE-COLITIS | GRANULOCYTE MARKER PROTEIN | GASTROENTEROLOGY & HEPATOLOGY | IRRITABLE-BOWEL-SYNDROME | Predictive Value of Tests | Leukocyte L1 Antigen Complex - analysis | Humans | Middle Aged | Inflammatory Bowel Diseases - diagnosis | Gastroenteritis - diagnosis | Male | Feces - chemistry | Colitis, Ulcerative - diagnosis | Lactoferrin - analysis | Colonoscopy | Sensitivity and Specificity | Adolescent | Crohn Disease - diagnosis | Aged, 80 and over | Adult | Female | Aged | Analysis | Inflammation | Index Medicus
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5. Full Text Crohn's disease localization displays different predisposing genetic variants
by Palmieri, Orazio and Bossa, Fabrizio and Valvano, Maria Rosa and Corritore, Giuseppe and Latiano, Tiziana and Martino, Giuseppina and D'Incà, Renata and Cucchiara, Salvatore and Pastore, Maria and D'Altilia, Mario and Scimeca, Daniela and Biscaglia, Giuseppe and Andriulli, Angelo and Latiano, Anna
PLoS ONE, ISSN 1932-6203, 01/2017, Volume 12, Issue 1, pp. e0168821 - e0168821
Background Crohn's disease (CD) is a pathologic condition with different clinical expressions that may reflect an interplay between genetics and environmental... 
POPULATION | INFLAMMATORY-BOWEL-DISEASE | METAANALYSIS | MULTIDISCIPLINARY SCIENCES | SUSCEPTIBILITY LOCI | RISK | CLASSIFICATION | WORKING PARTY | EPIDEMIOLOGY | GENOME-WIDE ASSOCIATION | GASTROENTEROLOGY | Crohn Disease - genetics | Genetic Predisposition to Disease - genetics | Humans | Ileum - metabolism | Genotype | Male | Young Adult | Genetic Markers - genetics | Adolescent | Polymorphism, Single Nucleotide - genetics | Adult | Female | ROC Curve | Genetic Variation - genetics | Care and treatment | Gastrointestinal diseases | Reports | Crohn's disease | Research | Diagnosis | Health aspects | Index Medicus
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6. Full Text Glycosylation of Immunoglobulin G Associates With Clinical Features of Inflammatory Bowel Diseases
by Šimurina, Mirna and de Haan, Noortje and Vučković, Frano and Kennedy, Nicholas A and Štambuk, Jerko and Falck, David and Trbojević-Akmačić, Irena and Clerc, Florent and Razdorov, Genadij and Khon, Anna and Latiano, Anna and D'Incà, Renata and Danese, Silvio and Targan, Stephan and Landers, Carol and Dubinsky, Marla and Campbell, Harry and Zoldoš, Vlatka and Permberton, Iain K and Kolarich, Daniel and Fernandes, Daryl L and Theorodorou, Evropi and Merrick, Victoria and Spencer, Daniel I and Gardner, Richard A and Doran, Ray and Shubhakar, Archana and Boyapati, Ray and Rudan, Igor and Lionetti, Paolo and Krištić, Jasminka and Novokmet, Mislav and Pučić-Baković, Maja and Gornik, Olga and Andriulli, Angelo and Cantoro, Laura and Sturniolo, Giancarlo and Fiorino, Gionata and Manetti, Natalia and Arnott, Ian D and Noble, Colin L and Lees, Charlie W and Shand, Alan G and Ho, Gwo-Tzer and Dunlop, Malcolm G and Murphy, Lee and Gibson, Jude and Evenden, Louise and Wrobel, Nicola and Gilchrist, Tamara and Fawkes, Angie and Kammeijer, Guinevere S.M and Vojta, Aleksandar and Samaržija, Ivana and Markulin, Dora and Klasić, Marija and Dobrinić, Paula and Aulchenko, Yurii and van den Heuve, Tim and Jonkers, Daisy and Pierik, Marieke and McGovern, Dermot P.B and Annese, Vito and Wuhrer, Manfred and Lauc, Gordan and Inflammatory Bowel Dis Biomarkers and Inflammatory Bowel Disease Biomarkers Consortium
Gastroenterology, ISSN 0016-5085, 04/2018, Volume 154, Issue 5, pp. 1320 - 1333.e10
Causes of inflammatory bowel diseases are not well understood and the most prominent forms, Crohn’s disease (CD) and ulcerative colitis (UC), are sometimes... 
Biomarker | IBD | Glycans | Glycopeptides | RHEUMATOID-ARTHRITIS | ANTIINFLAMMATORY ACTIVITY | EFFECTOR FUNCTIONS | CROHNS-DISEASE | ULCERATIVE-COLITIS | N-GLYCOSYLATION | MASS-SPECTROMETRY | DEPENDENT CELLULAR CYTOTOXICITY | FC-GALACTOSYLATION | GASTROENTEROLOGY & HEPATOLOGY | IBD PATIENTS | Predictive Value of Tests | Prognosis | Immunoglobulin G - blood | Area Under Curve | United States | Humans | Middle Aged | Male | Colitis, Ulcerative - immunology | Case-Control Studies | Crohn Disease - diagnosis | Colitis, Ulcerative - therapy | Adult | Female | Odds Ratio | Immunoglobulin Fc Fragments - blood | Severity of Illness Index | Risk Factors | Logistic Models | Glycosylation | Colitis, Ulcerative - blood | Crohn Disease - immunology | Crohn Disease - therapy | Colitis, Ulcerative - diagnosis | Crohn Disease - blood | Italy | ROC Curve | Protein Processing, Post-Translational | Inflammatory bowel diseases | Immunoglobulin G | Index Medicus | Abridged Index Medicus | glycopeptides | glycans | biomarker
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7. Full Text Can Calprotectin Predict Relapse Risk in Inflammatory Bowel Disease
by D'Inca, Renata and Dal Pont, Elisabetta and Di Leo, Vincenza and Benazzato, Luca and Martinato, Matteo and Lamboglia, Francesca and Oliva, Lydia and Carlo Sturniolo, Giacomo
The American Journal of Gastroenterology, ISSN 0002-9270, 08/2008, Volume 103, Issue 8, pp. 2007 - 2014
OBJECTIVE: Assessing the clinical course of inflammatory bowel disease (IBD) patients consists of periodical clinical evaluations and laboratory tests. We... 
INTESTINAL INFLAMMATION | PROTEIN | THERAPY | CROHNS-DISEASE | PERMEABILITY | MARKER | LACTOFERRIN | ULCERATIVE-COLITIS | EXCRETION | GASTROENTEROLOGY & HEPATOLOGY | FECAL CALPROTECTIN | Predictive Value of Tests | Recurrence | Prospective Studies | Follow-Up Studies | Colitis, Ulcerative - metabolism | Humans | Leukocyte L1 Antigen Complex - metabolism | Middle Aged | Crohn Disease - metabolism | Male | Crohn Disease - therapy | Disease-Free Survival | Feces - chemistry | Colitis, Ulcerative - diagnosis | Adolescent | Crohn Disease - diagnosis | Aged, 80 and over | Colitis, Ulcerative - therapy | Adult | Female | ROC Curve | Aged | Medicine, Experimental | Medical research | Gastrointestinal diseases | Risk factors | Index Medicus
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8. Full Text Fecal HMGB1 reveals microscopic inflammation in adult and pediatric patients with inflammatory bowel disease in clinical and endoscopic remission
by Palone, Francesca and Vitali, Roberta and Cucchiara, Salvatore and Mennini, Maurizio and Armuzzi, Alessandro and Pugliese, Daniela and D'incà, Renata and Barberio, Brigida and Stronati, Laura
Inflammatory Bowel Diseases, ISSN 1078-0998, 12/2016, Volume 22, Issue 12, pp. 2886 - 2893
Background: Fecal high mobility group box 1 (HMGB1) has been suggested to be a novel noninvasive biomarker of gut inflammation. We aimed to assess the... 
fecal HMGB1 | endoscopic remission | histologic inflammation | biomarkers | C-REACTIVE PROTEIN | CROHNS-DISEASE | LACTOFERRIN | ULCERATIVE-COLITIS | VALIDATION | CALPROTECTIN | MECHANISMS | GROUP BOX 1 | LOW-GRADE INFLAMMATION | GASTROENTEROLOGY & HEPATOLOGY | Leukocyte L1 Antigen Complex - analysis | Humans | Middle Aged | Crohn Disease - surgery | Crohn Disease - metabolism | Male | Case-Control Studies | Young Adult | Colonoscopy | Aged, 80 and over | Adult | Colitis, Ulcerative - surgery | Female | Child | Severity of Illness Index | Reproducibility of Results | Enzyme-Linked Immunosorbent Assay | HMGB1 Protein - analysis | Colitis, Ulcerative - metabolism | Biomarkers - analysis | Postoperative Period | Colitis, Ulcerative - pathology | Remission Induction | Blotting, Western | Feces - chemistry | Crohn Disease - pathology | Adolescent | Aged | Intestinal Mucosa - pathology | Index Medicus
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9. Full Text Aberrant gene methylation in non-neoplastic mucosa as a predictive marker of ulcerative colitis-associated CRC
by Scarpa, Marco and Scarpa, Melania and Castagliuolo, Ignazio and Erroi, Francesca and Kotsafti, Andromachi and Basato, Silvia and Brun, Paola and D'Incà, Renata and Rugge, Massimo and Angriman, Imerio and Castoro, Carlo
Oncotarget, ISSN 1949-2553, 2016, Volume 7, Issue 9, pp. 10322 - 10331
BACKGROUND PROMOTER: hypermethylation plays a major role in cancer through transcriptional silencing of critical genes. The aim of our study is to evaluate the... 
Promoter methylation | Biomarker | APC | Colorectal cancer | Ulcerative colitis | Colonic Neoplasms - genetics | Adenocarcinoma - pathology | Humans | Middle Aged | Colitis, Ulcerative - genetics | DNA Repair Enzymes - genetics | Male | Promoter Regions, Genetic - genetics | Young Adult | RNA, Messenger - biosynthesis | Tumor Suppressor Proteins - genetics | Adult | Female | Adenocarcinoma - genetics | Cadherins - genetics | DNA (Cytosine-5-)-Methyltransferases - biosynthesis | Adenomatous Polyposis Coli Protein - genetics | Colon - pathology | DNA (Cytosine-5-)-Methyltransferase 1 | Carcinogenesis - genetics | Colitis, Ulcerative - pathology | DNA Methylation - genetics | DNA (Cytosine-5-)-Methyltransferases - genetics | DNA Modification Methylases - genetics | Colonic Neoplasms - pathology | MutL Protein Homolog 1 - genetics | Adolescent | Core Binding Factor Alpha 3 Subunit - genetics | Aged | Biomarkers, Tumor - genetics | Intestinal Mucosa - pathology | Index Medicus
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10. Full Text Rectal Administration of Lactobacillus casei DG Modifies Flora Composition and Toll-Like Receptor Expression in Colonic Mucosa of Patients with Mild Ulcerative Colitis
by D’Incà, Renata and Barollo, Michela and Scarpa, Marco and Grillo, Alessia Rosaria and Brun, Paola and Vettorato, Maria Grazia and Castagliuolo, Ignazio and Sturniolo, Giacomo Carlo
Digestive Diseases and Sciences, ISSN 0163-2116, 4/2011, Volume 56, Issue 4, pp. 1178 - 1187
An imbalance in gut microbiota seems to contribute to the development of chronic inflammatory disorders of the gastrointestinal tract, such as ulcerative... 
Biochemistry, general | Medicine & Public Health | Hepatology | Lactobacilli | Gastroenterology | Oncology | Toll-like receptor | Transplant Surgery | Enema | Ulcerative colitis | INTESTINAL-MUCOSA | CROHNS-DISEASE | CONJUGATED LINOLEIC-ACID | PROTEIN-KINASE | INFLAMMATORY-BOWEL-DISEASE | IN-VIVO | PPAR-GAMMA | PROBIOTIC THERAPY | MAINTAINING REMISSION | GASTROENTEROLOGY & HEPATOLOGY | GUT BACTERIA | Probiotics - administration & dosage | Toll-Like Receptor 4 - biosynthesis | Lactobacillus casei | Humans | Administration, Rectal | Treatment Outcome | Intestinal Mucosa - microbiology | Intestinal Mucosa - chemistry | Anti-Inflammatory Agents, Non-Steroidal - therapeutic use | Colitis, Ulcerative - therapy | Mesalamine - therapeutic use | Interleukin-10 - biosynthesis | Colon - microbiology | Interleukin-1beta - biosynthesis | Colitis, Ulcerative - drug therapy | Mesalamine | Messenger RNA | Index Medicus | Abridged Index Medicus
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11. Full Text Investigation of multiple susceptibility loci for inflammatory bowel disease in an Italian cohort of patients
by Latiano, Anna and Palmieri, Orazio and Latiano, Tiziana and Corritore, Giuseppe and Bossa, Fabrizio and Martino, Giuseppina and Biscaglia, Giuseppe and Scimeca, Daniela and Valvano, Maria Rosa and Pastore, Maria and Marseglia, Antonio and D'Incà, Renata and Andriulli, Angelo and Annese, Vito
PLoS ONE, ISSN 1932-6203, 2011, Volume 6, Issue 7, pp. e22688 - e22688
Background: Recent GWAs and meta-analyses have outlined about 100 susceptibility genes/loci for inflammatory bowel diseases (IBD). In this study we aimed to... 
POPULATION | CANADIAN CHILDREN | RISK LOCI | POLYMORPHISMS | GENE | TNFSF15 | BIOLOGY | SEQUENCE VARIANTS | ULCERATIVE-COLITIS SUSCEPTIBILITY | ONSET CROHNS-DISEASE | GENOME-WIDE ASSOCIATION | Crohn Disease - genetics | Multivariate Analysis | Demography | Humans | Middle Aged | Colitis, Ulcerative - genetics | Genetic Loci - genetics | Child, Preschool | Infant | Male | Case-Control Studies | Young Adult | Inflammatory Bowel Diseases - genetics | Aged, 80 and over | Adult | Female | Child | Genetic Predisposition to Disease | Phenotype | Epistasis, Genetic | Adolescent | Alleles | Polymorphism, Single Nucleotide - genetics | Italy | Aged | Cohort Studies | Pediatrics | Medical research | Analysis | Medicine, Experimental | Disease susceptibility | Genetic aspects | Single nucleotide polymorphisms | Ulcerative colitis | Inflammatory bowel diseases | Genes | Nkx2.3 protein | Crohn's disease | Single-nucleotide polymorphism | Marking | Patients | Loci | Inflammatory bowel disease | Intestine | Surgery | Tagging | Tumor necrosis factor-TNF | Histocompatibility antigen HLA | Colon | Chromosomes | NOD2 protein | PTPN2 protein | Index Medicus
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