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1. Full Text Functional detection of botulinum neurotoxin serotypes A to F by monoclonal neoepitope-specific antibodies and suspension array technology
by von Berg, L and Stern, D and Pauly, D and Mahrhold, S and Weisemann, J and Jentsch, L and Hansbauer, EM and Muller, C and Avondet, MA and Rummel, A and Dorner, MB and Dorner, BG
SCIENTIFIC REPORTS, ISSN 2045-2322, 04/2019, Volume 9, Issue 1, pp. 5531 - 14
Botulinum neurotoxins (BoNTs) are the most potent toxins known and cause the life threatening disease botulism. Sensitive and broad detection is extremely... 
TOXIN TYPES | ENDOPEPTIDASE IMMUNOASSAYS | IN-VITRO DETECTION | MOUSE BIOASSAY | ASSAY | CATALYTIC-PROPERTIES | MULTIDISCIPLINARY SCIENCES | RECEPTOR | IDENTIFICATION | BINDING | COMPLEX MATRICES | Firing pattern | Neurotransmitter release | Neurotoxins | Botulism | Toxicity | Bioassays | Serotypes | Monoclonal antibodies | Biological assays | Botulinum toxin
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2. Full Text Real-time cytotoxicity assay for rapid and sensitive detection of ricin from complex matrices
by Pauly, Diana and Worbs, Sylvia and Kirchner, Sebastian and Shatohina, Olena and Dorner, Martin B and Dorner, Brigitte G
PLoS ONE, ISSN 1932-6203, 04/2012, Volume 7, Issue 4, p. e35360
Background: In the context of a potential bioterrorist attack sensitive and fast detection of functionally active toxins such as ricin from complex matrices is... 
LECTINS ABRIN | A-CHAIN | MULTIDISCIPLINARY SCIENCES | BIOLOGICAL-ACTIVITY | TOXINS | FOOD MATRICES | ANTIBODY | TOXICITY | TANDEM MASS-SPECTROMETRY | RIBOSOME-INACTIVATING PROTEINS | AGGLUTININ | Toxins, Biological - analysis | Ricin - analysis | Animals | Sensitivity and Specificity | Cercopithecus aethiops | Toxicity Tests - methods | Biological Assay - methods | Vero Cells | Organic fertilizers | Lectins | Toxicity | Blocking antibodies | Antibodies | Cytotoxicity | Assaying | Veterinary medicine | Environmental engineering | Poisons | Impedance measurement | Petroleum production | Immunoglobulins | Incubation | Ricin | Biological assays | Bioterrorism | Real time | Biological activity | Fertilizers | Cytotoxins | Toxins | Environmental monitoring | Impedance | Viability | Vero cells | Apoptosis
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3. Full Text Development of a genus-specific antigen capture ELISA for orthopoxviruses - Target selection and optimized screening
by Stern, Daniel and Pauly, Diana and Zydek, Martin and Miller, Lilija and Piesker, Janett and Laue, Michael and Lisdat, Fred and Dorner, Martin B and Dorner, Brigitte G and Nitsche, Andreas
PLoS ONE, ISSN 1932-6203, 03/2016, Volume 11, Issue 3, p. e0150110
Orthopoxvirus species like cowpox, vaccinia and monkeypox virus cause zoonotic infections in humans worldwide. Infections often occur in rural areas lacking... 
NEUTRALIZING MONOCLONAL-ANTIBODIES | CELL-SURFACES | OUTER-MEMBRANE PROTEINS | 14-KILODALTON ENVELOPE PROTEIN | MULTIDISCIPLINARY SCIENCES | 2 INFECTIOUS FORMS | VACCINATION | A27L | VACCINIA VIRUS | IDENTIFICATION | SMALLPOX | Enzyme-Linked Immunosorbent Assay - methods | Epitopes - immunology | Orthopoxvirus - immunology | Orthopoxvirus - genetics | Antibodies, Viral - immunology | Orthopoxvirus - metabolism | Antibodies, Monoclonal - immunology | Usage | Physiological aspects | Genetic aspects | Research | DNA viruses | Enzyme-linked immunosorbent assay | Antigenic determinants | Laboratories | Monkeypox | Antibodies | Viruses | Infections | Genomes | Morphogenesis | Proteins | Epitope mapping | Life sciences | Fusion protein | Smallpox | Antigens | Immunoglobulins | Rural areas | Cowpox | Particulates | Medical screening | Peptide mapping | Virology | Animals | Immunogenicity | Microscopy | Monoclonal antibodies | Surface plasmon resonance | Diagnostic systems | Heparin | Gene mapping | Binding sites
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4. Full Text A lipid-binding loop of botulinum neurotoxin serotypes B, DC and G is an essential feature to confer their exquisite potency
by Stern, Daniel and Weisemann, Jasmin and Le Blanc, Alexander and von Berg, Laura and Mahrhold, Stefan and Piesker, Janett and Laue, Michael and Luppa, Peter B and Dorner, Martin Bernhard and Dorner, Brigitte Gertrud and Rummel, Andreas
PLoS Pathogens, ISSN 1553-7366, 05/2018, Volume 14, Issue 5, pp. e1007048 - e1007048
The exceptional toxicity of botulinum neurotoxins (BoNTs) is mediated by high avidity binding to complex polysialogangliosides and intraluminal segments of... 
SITE | DOMAIN | PROTEIN-RECEPTOR | RECOGNITION | TOXIN | MICROBIOLOGY | HIGH-AFFINITY BINDING | IDENTIFICATION | SV2 | SYNAPTOTAGMIN-II | VIROLOGY | PARASITOLOGY | UNIQUE GANGLIOSIDE BINDING | Proteins | Lipids | Protein binding | Research | Binding proteins | Botulinum toxin | Gangliosides | Protein-protein interactions | Neurotoxins | Food contamination & poisoning | Toxicity | Hydrophobicity | Mutants | Critical components | Neurotoxicity | Receptors | Microscopy | Serotypes | Avidity | Toxins | Surface plasmon resonance | Synaptotagmin | Supervision | Binding sites | Index Medicus
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5. Full Text Pentaplexed Quantitative Real-Time PCR Assay for the Simultaneous Detection and Quantification of Botulinum Neurotoxin-Producing Clostridia in Food and Clinical Samples
by Sebastian Kirchner and K. Melanie Krämer and Martin Schulze and Diana Pauly and Daniela Jacob and Frank Gessler and Andreas Nitsche and Brigitte G. Dorner and Martin B. Dorner
Applied and Environmental Microbiology, ISSN 0099-2240, 07/2010, Volume 76, Issue 13, pp. 4387 - 4395
Classifications Services AEM Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit... 
SUBTYPE | STRAINS | POLYMERASE-CHAIN-REACTION | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | MICROBIOLOGY | TOXIGENIC CLOSTRIDIA | TOXIN GENES | ENVIRONMENTAL-SAMPLES | IDENTIFICATION | DIAGNOSTICS | Taq Polymerase | Clostridium botulinum - classification | Food Contamination - analysis | Humans | Infant | Bird Diseases - diagnosis | Botulism - microbiology | Food Microbiology | Polymerase Chain Reaction - methods | Feces - microbiology | Clostridium botulinum - pathogenicity | Cattle | Clostridium botulinum - isolation & purification | Sensitivity and Specificity | Botulism - diagnosis | Ducks - microbiology | Serotyping | Clostridium botulinum - genetics | Cattle Diseases - microbiology | Botulinum Toxins - analysis | Neurotoxins - analysis | Animals | Botulism - veterinary | Cattle Diseases - diagnosis | Bird Diseases - microbiology | Polymerase chain reaction | Control | Usage | Clostridium botulinum | Microbial contamination | Physiological aspects | Genetic aspects | Research | Health aspects | Neurotoxic agents | Index Medicus | Botulinum toxin | Methods
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6. Are microbial indicators and pathogens correlated? A statistical analysis of 40 years of research
by Wu, J and Long, S.C and Das, D and Dorner, S.M
Journal of Water and Health, ISSN 1477-8920, 2011, Volume 9, Issue 2, pp. 265 - 278
Indicator organisms are used to assess public health risk in recreational waters, to highlight periods of challenge to drinking water treatment plants, and to... 
Water | Logistic regression | Pathogens | Correlation | Sample size | Indicators | COMPARATIVE SURVIVAL | BACTERIA | COLIPHAGES | ESCHERICHIA-COLI | MICROBIOLOGY | indicators | water | CRYPTOSPORIDIUM-PARVUM OOCYSTS | INACTIVATION | ENVIRONMENTAL SCIENCES | correlation | pathogens | WASTE-WATER | logistic regression | CLOSTRIDIUM-PERFRINGENS | WATER SAMPLES | sample size | CAMPYLOBACTER | Feces - microbiology | Animals | Sewage | Recreation | Humans | Environmental Monitoring - methods | Indicators and Reagents | Logistic Models | Waste Disposal, Fluid | Water Supply | Water Microbiology | Water treatment | Drinking water | Statistical analysis | Identification methods | Health risks | Fecal coliforms | Data processing | Statistical methods | Regression analysis | Statistics | Regression models | Microorganisms | Water treatment plants | Correlation analysis | Samples | Water quality | Recreational waters | Public health
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7. Full Text Bioluminescence assay for the highly sensitive detection of botulinum neurotoxin A activity
by Stevens, G.B and Silver, D.A and Zgaga-Griesz, A and Bessler, W.G and Vashist, S.K and Patel, P and Achazi, K and Strotmeier, J and Worbs, S and Dorner, M.B and Dorner, B.G and Pauly, D and Rummel, A and Urban, G.A and Krueger, M
Analyst, ISSN 0003-2654, 10/2013, Volume 138, Issue 20, pp. 6154 - 6162
This article describes a novel bioluminescence assay for detecting the proteolytic activity of Botulinum NeuroToxins (BoNT) in complex matrices. The assay is... 
CHEMISTRY, ANALYTICAL | DOMAIN | CLOSTRIDIUM-BOTULINUM | TOXIN | SNARE MOTIF | PROTEOLYSIS | SAMPLES | TETANUS NEUROTOXINS | SEROTYPE-A | SNAP-25 | FOOD | Animals | Protein Structure, Secondary | Humans | Botulinum Toxins, Type A - chemistry | Botulinum Toxins, Type A - analysis | Mice | Mice, Inbred BALB C | Clostridium botulinum - chemistry | Luminescent Measurements - methods | Index Medicus | Clostridium | Bioluminescence | Mathematical analysis | Drinks | Toxins | Assaying | Blood
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8. Full Text Simultaneous quantification of five bacterial and plant toxins from complex matrices using a multiplexed fluorescent magnetic suspension assay
by Pauly, Diana and Kirchner, Sebastian and Stoermann, Britta and Schreiber, Tanja and Kaulfuss, Stefan and Schade, Rüdiger and Zbinden, Reto and Avondet, Marc-André and Dorner, Martin B and Dorner, Brigitte G
Analyst, ISSN 0003-2654, 2009, Volume 134, Issue 10, pp. 2028 - 2039
Proteotoxins such as ricin, abrin, botulinum neurotoxins type A and B (BoNT/A, BoNT/B) and staphylococcal enterotoxin B (SEB) are regarded as potential... 
CHEMISTRY, ANALYTICAL | LINKED-IMMUNOSORBENT-ASSAY | ARRAY BIOSENSOR | BIOLOGICAL WARFARE AGENTS | CLASS-I | AUTONOMOUS DETECTION | MONOCLONAL-ANTIBODY | NEUROTOXIN TYPE-A | SENSITIVE DETECTION | BOTULINUM TOXIN | PARTICULATE ANTIGENS | Antibody Specificity | Immunization | Limit of Detection | Reproducibility of Results | Toxins, Biological - immunology | Bacterial Toxins - analysis | Enzyme-Linked Immunosorbent Assay | Bacterial Toxins - immunology | Spectrometry, Fluorescence | Magnetics | Toxins, Biological - analysis | Food Analysis | Animals | Time Factors | Mice | Mice, Inbred BALB C | Plants - chemistry | Antibodies, Monoclonal - immunology | Suspensions | Index Medicus
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9. Full Text The Case of Botulinum Toxin in Milk: Experimental Data
by Oliver G. Weingart and Tanja Schreiber and Conny Mascher and Diana Pauly and Martin B. Dorner and Thomas F. H. Berger and Charlotte Egger and Frank Gessler and Martin J. Loessner and Marc-Andre Avondet and Brigitte G. Dorner
Applied and Environmental Microbiology, ISSN 0099-2240, 05/2010, Volume 76, Issue 10, pp. 3293 - 3300
Classifications Services AEM Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit... 
CLOSTRIDIUM-BOTULINUM | HEMAGGLUTININ | NEUROTOXINS | PASTEURIZATION | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | HA PROTEINS | MICROBIOLOGY | FOODS | IDENTIFICATION | BINDING | THERMAL INACTIVATION | Milk - chemistry | Enzyme-Linked Immunosorbent Assay | Food Contamination - analysis | Alkaline Phosphatase - metabolism | Botulinum Toxins - analysis | Male | Toxicity Tests, Acute | Hot Temperature | Clostridium botulinum - physiology | Botulinum Toxins - toxicity | Food Contamination - prevention & control | Animals | Botulinum Toxins - chemistry | Sensitivity and Specificity | Mice | Prevention | Evaluation | Pasteurization | Research | Botulinum toxin | Milk contamination | Milk | Alkaline phosphatase
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10. Full Text 5-year results of accelerated partial breast irradiation using sole interstitial multicatheter brachytherapy versus whole-breast irradiation with boost after breast-conserving surgery for low-risk invasive and in-situ carcinoma of the female breast: a randomised, phase 3, non-inferiority trial
by Strnad, Vratislav, Prof and Ott, Oliver J, MD and Hildebrandt, Guido, Prof and Kauer-Dorner, Daniela, MD and Knauerhase, Hellen, MD and Major, Tibor, PhD and Lyczek, Jaroslaw, MD and Guinot, Jose Luis, MD and Dunst, Jürgen, Prof and Miguelez, Cristina Gutierrez, MD and Slampa, Pavel, Prof and Allgäuer, Michael, MD and Lössl, Kristina, MD and Polat, Bülent, MD and Kovács, György, Prof and Fischedick, Arnt-René, Prof and Wendt, Thomas G, Prof and Fietkau, Rainer, Prof and Hindemith, Marion, MD and Resch, Alexandra, MD and Kulik, Anna, MD and Arribas, Leo, Prof and Niehoff, Peter, Prof and Guedea, Fernando, Prof and Schlamann, Annika, MD and Pötter, Richard, Prof and Gall, Christine, DSc and Malzer, Martina, MDO and Uter, Wolfgang, Prof and Polgár, Csaba, Prof and GEC ESTRO and Groupe Européen de Curiethérapie of European Society for Radiotherapy and Oncology (GEC-ESTRO)
Lancet, The, ISSN 0140-6736, 2016, Volume 387, Issue 10015, pp. 229 - 238
Summary Background In a phase 3, randomised, non-inferiority trial, accelerated partial breast irradiation (APBI) for patients with stage 0, I, and IIA breast... 
Internal Medicine | SURVIVAL | WOMEN | MEDICINE, GENERAL & INTERNAL | MANAGEMENT | LUMPECTOMY PLUS TAMOXIFEN | OLDER | INTRAOPERATIVE RADIOTHERAPY | FOLLOW-UP | TOXICITY | CANCER | RADIATION-THERAPY | Radiotherapy Dosage | Breast Neoplasms - surgery | Carcinoma, Ductal, Breast - surgery | Humans | Middle Aged | Brachytherapy - methods | Treatment Outcome | Combined Modality Therapy | Carcinoma in Situ - radiotherapy | Carcinoma in Situ - therapy | Breast Neoplasms - therapy | Carcinoma, Ductal, Breast - therapy | Breast Neoplasms - radiotherapy | Carcinoma in Situ - surgery | Carcinoma, Ductal, Breast - radiotherapy | Adult | Female | Aged | Mastectomy, Segmental - methods | Catheters, Indwelling | Lumpectomy | Radioisotope brachytherapy | Breast cancer | Mastectomy | Clinical trials | Radiation therapy | Breasts
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