Lancet, The, ISSN 0140-6736, 2015, Volume 386, Issue 9991, pp. 369 - 375
Summary Background Although studies have provided estimates of premature deaths attributable to either heat or cold in selected countries, none has so far...
Internal Medicine | MEDICINE, GENERAL & INTERNAL | RED-CELL COUNTS | IMPACT | WEATHER | METAANALYSIS | EPIDEMIOLOGIC EVIDENCE | WINTER | BLOOD-VISCOSITY | COLD | CEREBRAL THROMBOSIS | HEAT WAVES | Risk Assessment - methods | Climate | Hot Temperature - adverse effects | Humans | Mortality | Global Health - statistics & numerical data | Cold Temperature - adverse effects | Brazil | Australia | Health aspects | Environmental health | Studies | Outdoor air quality | Climate change | Temperature | Heat | Sensitivity analysis | Cold | Research | Health risk assessment | Hälsovetenskaper | Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi | Medical and Health Sciences | Medicin och hälsovetenskap | Public Health, Global Health, Social Medicine and Epidemiology | Health Sciences
Internal Medicine | MEDICINE, GENERAL & INTERNAL | RED-CELL COUNTS | IMPACT | WEATHER | METAANALYSIS | EPIDEMIOLOGIC EVIDENCE | WINTER | BLOOD-VISCOSITY | COLD | CEREBRAL THROMBOSIS | HEAT WAVES | Risk Assessment - methods | Climate | Hot Temperature - adverse effects | Humans | Mortality | Global Health - statistics & numerical data | Cold Temperature - adverse effects | Brazil | Australia | Health aspects | Environmental health | Studies | Outdoor air quality | Climate change | Temperature | Heat | Sensitivity analysis | Cold | Research | Health risk assessment | Hälsovetenskaper | Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi | Medical and Health Sciences | Medicin och hälsovetenskap | Public Health, Global Health, Social Medicine and Epidemiology | Health Sciences
Journal Article
JAMA Internal Medicine, ISSN 2168-6106, 01/2017, Volume 177, Issue 1, pp. 44 - 50
IMPORTANCE In 2005, Florida amended its self-defense laws to provide legal immunity to individuals using lethal force in self-defense. The enactment of "stand...
REGRESSION | MEDICINE, GENERAL & INTERNAL | CRIME | RACE
REGRESSION | MEDICINE, GENERAL & INTERNAL | CRIME | RACE
Journal Article
ENVIRONMENTAL HEALTH PERSPECTIVES, ISSN 0091-6765, 07/2019, Volume 127, Issue 7, pp. 77006 - 77006
BACKGROUND: Climate change has marked implications for the burden of infectious diseases. However, no studies have estimated future projections of climate...
SYSTEMATIC ANALYSIS | GLOBAL BURDEN | MORTALITY | METAANALYSIS | TIME-SERIES ANALYSIS | WEATHER VARIABILITY | AMBIENT-TEMPERATURE | DIARRHEAL DISEASES | SEASONALITY | ENVIRONMENTAL SCIENCES | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | TOXICOLOGY | DEVELOPING-COUNTRIES | Disease | General circulation models | Time series analysis | Gastroenteritis | Mortality | Time series | Variations | Diarrhea | Viruses | Systematic review | Epidemiology | Empirical analysis | Morbidity | Emissions | Confidence intervals | Studies | Climate change | Heterogeneity | Infectious diseases | Surveillance | Temperature effects | Spatial heterogeneity | Public health | Low temperature | Index Medicus
SYSTEMATIC ANALYSIS | GLOBAL BURDEN | MORTALITY | METAANALYSIS | TIME-SERIES ANALYSIS | WEATHER VARIABILITY | AMBIENT-TEMPERATURE | DIARRHEAL DISEASES | SEASONALITY | ENVIRONMENTAL SCIENCES | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | TOXICOLOGY | DEVELOPING-COUNTRIES | Disease | General circulation models | Time series analysis | Gastroenteritis | Mortality | Time series | Variations | Diarrhea | Viruses | Systematic review | Epidemiology | Empirical analysis | Morbidity | Emissions | Confidence intervals | Studies | Climate change | Heterogeneity | Infectious diseases | Surveillance | Temperature effects | Spatial heterogeneity | Public health | Low temperature | Index Medicus
Journal Article
Environmental Health Perspectives, ISSN 0091-6765, 01/2017, Volume 125, Issue 1, pp. 47 - 55
BACKGROUND: High temperatures have substantial impacts on mortality and, with growing concerns about climate change, numerous studies have developed...
PUBLIC-HEALTH | CITIES | PART II | COUPLED MODEL | SIMULATION | FORMULATION | VARIABILITY | ENVIRONMENTAL SCIENCES | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | TEMPERATURE | EARTH SYSTEM MODEL | TOXICOLOGY | IMPACTS | Adaptation, Physiological | Models, Theoretical | Climate Change | Risk Assessment | Extreme Heat | Humans | Acclimatization | New York City - epidemiology | Mortality - trends | Environmental Exposure - statistics & numerical data | Forecasting | New York | Forecasts and trends | Atmospheric temperature | Health aspects | Mortality | Urban health | Climate | Temperature | Demography | Cold | General circulation models | Global climate models | Climate models | Studies | Climate change | Demographics | Heat | Census of Population | Temperature effects | Fatalities | Cities | Parks & recreation areas | Adaptation | Vital statistics | Index Medicus | Research
PUBLIC-HEALTH | CITIES | PART II | COUPLED MODEL | SIMULATION | FORMULATION | VARIABILITY | ENVIRONMENTAL SCIENCES | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | TEMPERATURE | EARTH SYSTEM MODEL | TOXICOLOGY | IMPACTS | Adaptation, Physiological | Models, Theoretical | Climate Change | Risk Assessment | Extreme Heat | Humans | Acclimatization | New York City - epidemiology | Mortality - trends | Environmental Exposure - statistics & numerical data | Forecasting | New York | Forecasts and trends | Atmospheric temperature | Health aspects | Mortality | Urban health | Climate | Temperature | Demography | Cold | General circulation models | Global climate models | Climate models | Studies | Climate change | Demographics | Heat | Census of Population | Temperature effects | Fatalities | Cities | Parks & recreation areas | Adaptation | Vital statistics | Index Medicus | Research
Journal Article
Annals of the New York Academy of Sciences, ISSN 0077-8923, 01/2017, Volume 1388, Issue 1, pp. 42 - 58
Microbial communities contain diverse bacteria that play important roles in every environment. Advances in sequencing and computational methodologies over the...
antimicrobials | antimicrobial resistance | microbiome | metagenomics | NATURAL-PRODUCTS | MULTIDISCIPLINARY SCIENCES | ANTIBIOTIC-RESISTANCE | BACTERIAL | DISCOVERY | METAGENOMIC INVESTIGATIONS | DNA | EFFLUX PUMPS | BETA-LACTAMASES | TETRACYCLINE | MOLECULAR-MECHANISMS | Drug Resistance - genetics | Genomics - methods | Microbiota - genetics | Anti-Infective Agents | Genetic research | Drug resistance in microorganisms | Phylogeny | Genes | Methods | Public health | Drug resistance | Antimicrobial agents | Biosynthesis
antimicrobials | antimicrobial resistance | microbiome | metagenomics | NATURAL-PRODUCTS | MULTIDISCIPLINARY SCIENCES | ANTIBIOTIC-RESISTANCE | BACTERIAL | DISCOVERY | METAGENOMIC INVESTIGATIONS | DNA | EFFLUX PUMPS | BETA-LACTAMASES | TETRACYCLINE | MOLECULAR-MECHANISMS | Drug Resistance - genetics | Genomics - methods | Microbiota - genetics | Anti-Infective Agents | Genetic research | Drug resistance in microorganisms | Phylogeny | Genes | Methods | Public health | Drug resistance | Antimicrobial agents | Biosynthesis
Journal Article
The EMBO Journal, ISSN 0261-4189, 02/2016, Volume 35, Issue 3, pp. 258 - 280
Receptor organization and dynamics at the cell membrane are important factors of signal transduction regulation. Using super‐resolution microscopy and...
B‐cell receptor signalling | siglec CD22 | glycoprotein CD45 | super‐resolution microscopy | membrane dynamics | B-cell receptor signalling | super-resolution microscopy | LIGAND-BINDING | BIOCHEMISTRY & MOLECULAR BIOLOGY | CIS LIGANDS | TRANSLATIONAL DIFFUSION | UNMASKED CD22 | NEGATIVE REGULATOR | CELL BIOLOGY | TYROSINE-PHOSPHATASE 1C | IN-VIVO | B-CELL ACTIVATION | CLASS-II | MEMBRANE-RECEPTORS | B-Lymphocytes - cytology | Animals | Sialic Acid Binding Ig-like Lectin 2 - metabolism | Signal Transduction | Mice, Inbred C57BL | B-Lymphocytes - physiology | Cytoskeleton - metabolism | Mice, Inbred BALB C | Receptors, Antigen, B-Cell - metabolism | Microscopy, Fluorescence | Immunology
B‐cell receptor signalling | siglec CD22 | glycoprotein CD45 | super‐resolution microscopy | membrane dynamics | B-cell receptor signalling | super-resolution microscopy | LIGAND-BINDING | BIOCHEMISTRY & MOLECULAR BIOLOGY | CIS LIGANDS | TRANSLATIONAL DIFFUSION | UNMASKED CD22 | NEGATIVE REGULATOR | CELL BIOLOGY | TYROSINE-PHOSPHATASE 1C | IN-VIVO | B-CELL ACTIVATION | CLASS-II | MEMBRANE-RECEPTORS | B-Lymphocytes - cytology | Animals | Sialic Acid Binding Ig-like Lectin 2 - metabolism | Signal Transduction | Mice, Inbred C57BL | B-Lymphocytes - physiology | Cytoskeleton - metabolism | Mice, Inbred BALB C | Receptors, Antigen, B-Cell - metabolism | Microscopy, Fluorescence | Immunology
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/2013, Volume 110, Issue 8, pp. 2916 - 2921
Uterine serous carcinoma (USC) is a biologically aggressive subtype of endometrial cancer. We analyzed the mutational landscape of USC by whole-exome...
Somatic mutation | Exome | Phenotypes | Genes | DNA | Genetic mutation | Chromosomes | Sequencing | Tumors | Cancer | Endometrial carcinoma | Uterine serous papillary cancer | Cancer genomics | ACTIVATION | CYCLIN D1 | MULTIDISCIPLINARY SCIENCES | TRANSCRIPTION | endometrial carcinoma | IDENTIFICATION | GENOME | uterine serous papillary cancer | UBIQUITIN LIGASE COMPLEX | cancer genomics | TUMOR-SUPPRESSOR | OVARIAN | HUMAN CANCERS | ABERRATIONS | Sequence Homology, Amino Acid | Uterine Neoplasms - genetics | Amino Acid Sequence | Animals | Humans | Molecular Sequence Data | Female | Base Pair Mismatch | Mutation | DNA Copy Number Variations | Carcinoma | Physiological aspects | Development and progression | Genetic aspects | Single nucleotide polymorphisms | Research | Uterine tumors | DNA repair | Biological Sciences
Somatic mutation | Exome | Phenotypes | Genes | DNA | Genetic mutation | Chromosomes | Sequencing | Tumors | Cancer | Endometrial carcinoma | Uterine serous papillary cancer | Cancer genomics | ACTIVATION | CYCLIN D1 | MULTIDISCIPLINARY SCIENCES | TRANSCRIPTION | endometrial carcinoma | IDENTIFICATION | GENOME | uterine serous papillary cancer | UBIQUITIN LIGASE COMPLEX | cancer genomics | TUMOR-SUPPRESSOR | OVARIAN | HUMAN CANCERS | ABERRATIONS | Sequence Homology, Amino Acid | Uterine Neoplasms - genetics | Amino Acid Sequence | Animals | Humans | Molecular Sequence Data | Female | Base Pair Mismatch | Mutation | DNA Copy Number Variations | Carcinoma | Physiological aspects | Development and progression | Genetic aspects | Single nucleotide polymorphisms | Research | Uterine tumors | DNA repair | Biological Sciences
Journal Article
Antioxidants & Redox Signaling, ISSN 1523-0864, 02/2019, Volume 30, Issue 4, pp. 577 - 634
Significance: In eukaryotes, autophagy represents a highly evolutionary conserved process, through which macromolecules and cytoplasmic material are degraded...
Comprehensive Invited Review | epigenetic modification | autophagy | disease prevention | natural bioactive compounds | molecular targets | FED C57BL/6J MICE | REDUCING OXIDATIVE STRESS | INDUCED RENAL DAMAGE | ACTIVATED PROTEIN-KINASE | CHAPERONE-MEDIATED AUTOPHAGY | BIOCHEMISTRY & MOLECULAR BIOLOGY | BETA (A-BETA(1-42))-INDUCED PARALYSIS | NECROSIS-FACTOR-ALPHA | BREAST-CANCER CELLS | TRAUMATIC BRAIN-INJURY | ENDOCRINOLOGY & METABOLISM | HYPOXIA-INDUCED AUTOPHAGY
Comprehensive Invited Review | epigenetic modification | autophagy | disease prevention | natural bioactive compounds | molecular targets | FED C57BL/6J MICE | REDUCING OXIDATIVE STRESS | INDUCED RENAL DAMAGE | ACTIVATED PROTEIN-KINASE | CHAPERONE-MEDIATED AUTOPHAGY | BIOCHEMISTRY & MOLECULAR BIOLOGY | BETA (A-BETA(1-42))-INDUCED PARALYSIS | NECROSIS-FACTOR-ALPHA | BREAST-CANCER CELLS | TRAUMATIC BRAIN-INJURY | ENDOCRINOLOGY & METABOLISM | HYPOXIA-INDUCED AUTOPHAGY
Journal Article
Environmental Health Perspectives, ISSN 0091-6765, 10/2016, Volume 124, Issue 10, pp. 1554 - 1559
BACKGROUND: The evidence and method are limited for the associations between mortality and temperature variability (TV) within or between days. OBJECTIVES: We...
ADMISSIONS | ASSOCIATIONS | OUTDOOR TEMPERATURE | CHINA | AMBIENT-TEMPERATURE | LAG NONLINEAR MODELS | ENVIRONMENTAL SCIENCES | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | HEAT ACCLIMATION | EPIDEMIOLOGIC EVIDENCE | TIME-SERIES | TOXICOLOGY | RANGE | Canada | Analysis | Mortality | Japan | Climatic changes | Thailand | Health aspects | Risk factors | Outdoor air quality | Temperature | Statistical analysis | Cold | Time series | Estimates | Studies | Weather | Datasets | Climate change | Data collection | Standard deviation | Seasons | Cities | Health risk assessment | Research
ADMISSIONS | ASSOCIATIONS | OUTDOOR TEMPERATURE | CHINA | AMBIENT-TEMPERATURE | LAG NONLINEAR MODELS | ENVIRONMENTAL SCIENCES | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | HEAT ACCLIMATION | EPIDEMIOLOGIC EVIDENCE | TIME-SERIES | TOXICOLOGY | RANGE | Canada | Analysis | Mortality | Japan | Climatic changes | Thailand | Health aspects | Risk factors | Outdoor air quality | Temperature | Statistical analysis | Cold | Time series | Estimates | Studies | Weather | Datasets | Climate change | Data collection | Standard deviation | Seasons | Cities | Health risk assessment | Research
Journal Article
Environment International, ISSN 0160-4120, 10/2017, Volume 107, pp. 196 - 204
There is an established U-shaped association between daily temperature and mortality. Temperature changes projected through the end of century are expected to...
Climate change | Health impacts | Ambient temperature | United States | COLD-RELATED MORTALITY | WAVE | ENVIRONMENTAL SCIENCES | IMPACT | ACCLIMATIZATION | MORBIDITY | HEAT-RELATED MORTALITY | HEALTH | Models, Theoretical | Temperature | Climate Change | Humans | Mortality | Cities | Global temperature changes | Analysis | Environmental health | Environmental aspects | Metropolitan areas | Air pollution | Greenhouse gases | ambient temperature | climate change | health impacts
Climate change | Health impacts | Ambient temperature | United States | COLD-RELATED MORTALITY | WAVE | ENVIRONMENTAL SCIENCES | IMPACT | ACCLIMATIZATION | MORBIDITY | HEAT-RELATED MORTALITY | HEALTH | Models, Theoretical | Temperature | Climate Change | Humans | Mortality | Cities | Global temperature changes | Analysis | Environmental health | Environmental aspects | Metropolitan areas | Air pollution | Greenhouse gases | ambient temperature | climate change | health impacts
Journal Article
Environmental Health Perspectives, ISSN 0091-6765, 11/2015, Volume 123, Issue 11, pp. 1200 - 1207
Recent investigations have reported a decline in the heat-related mortality risk during the last decades. However, these studies are frequently based on...
UNITED-STATES | PUBLIC-HEALTH | SUMMER TEMPERATURE | AMBIENT-TEMPERATURE | CLIMATE-CHANGE | VULNERABILITY | ENVIRONMENTAL SCIENCES | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | NEW-YORK-CITY | UNCERTAINTY ANALYSIS | TIME-SERIES | TOXICOLOGY | IMPACTS | Models, Theoretical | Seasons | Hot Temperature - adverse effects | Time Factors | Humans | Mortality | Environmental aspects | Health aspects | Hot weather | Index Medicus | Research
UNITED-STATES | PUBLIC-HEALTH | SUMMER TEMPERATURE | AMBIENT-TEMPERATURE | CLIMATE-CHANGE | VULNERABILITY | ENVIRONMENTAL SCIENCES | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | NEW-YORK-CITY | UNCERTAINTY ANALYSIS | TIME-SERIES | TOXICOLOGY | IMPACTS | Models, Theoretical | Seasons | Hot Temperature - adverse effects | Time Factors | Humans | Mortality | Environmental aspects | Health aspects | Hot weather | Index Medicus | Research
Journal Article