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1. Full Text Antiretroviral Therapy for the Prevention of HIV-1 Transmission
by Cohen, Myron S and Chen, Ying Q and McCauley, Marybeth and Gamble, Theresa and Hosseinipour, Mina C and Kumarasamy, Nagalingeswaran and Hakim, James G and Kumwenda, Johnstone and Grinsztejn, Beatriz and Pilotto, Jose H.S and Godbole, Sheela V and Chariyalertsak, Suwat and Santos, Breno R and Mayer, Kenneth H and Hoffman, Irving F and Eshleman, Susan H and Piwowar-Manning, Estelle and Cottle, Leslie and Zhang, Xinyi C and Makhema, Joseph and Mills, Lisa A and Panchia, Ravindre and Faesen, Sharlaa and Eron, Joseph and Gallant, Joel and Havlir, Diane and Swindells, Susan and Elharrar, Vanessa and Burns, David and Taha, Taha E and Nielsen-Saines, Karin and Celentano, David D and Essex, Max and Hudelson, Sarah E and Redd, Andrew D and Fleming, Thomas R and HPTN 052 Study Team
The New England Journal of Medicine, ISSN 0028-4793, 09/2016, Volume 375, Issue 9, pp. 830 - 839
In this report involving 1763 HIV-1 serodiscordant couples, the suppression of HIV-1 in the infected partner significantly decreased the transmission of... 
VIRAL LOAD | POPULATION | MEDICINE, GENERAL & INTERNAL | INITIATION | HPTN 052 | RANDOMIZED-TRIAL | INFECTION | SERODISCORDANT COUPLES | CHALLENGES | HIV Infections - prevention & control | Anti-Retroviral Agents - therapeutic use | Follow-Up Studies | HIV Seropositivity | Humans | Middle Aged | Kaplan-Meier Estimate | Male | Risk | HIV-1 - genetics | Disease Transmission, Infectious - prevention & control | Young Adult | Intention to Treat Analysis | Adult | Female | HIV Infections - transmission | Sexual Partners | Prevention | Antiviral agents | Usage | Care and treatment | HIV (Viruses) | Antiretroviral drugs | Hypersensitivity | Clinical trials | Data processing | Antiretroviral therapy | CD4 antigen | Disease prevention | Disease transmission | Infectious diseases | Motivation | Acquired immune deficiency syndrome--AIDS | Human immunodeficiency virus--HIV | Drug therapy | Sexual partners
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2. Full Text Effects of early versus delayed initiation of antiretroviral treatment on clinical outcomes of HIV-1 infection: results from the phase 3 HPTN 052 randomised controlled trial
by Grinsztejn, Beatriz, MD and Hosseinipour, Mina C, MD and Ribaudo, Heather J, PhD and Swindells, Susan, MBBS and Eron, Joseph, MD and Chen, Ying Q, PhD and Wang, Lei, PhD and Ou, San-San, MS and Anderson, Maija, MN and McCauley, Marybeth, MPH and Gamble, Theresa, PhD and Kumarasamy, Nagalingeshwaran, MB and Hakim, James G, MD and Kumwenda, Johnstone, FRCP and Pilotto, Jose H S, MD and Godbole, Sheela V, MD and Chariyalertsak, Suwat, MD and de Melo, Marineide Gonçalves, MD and Mayer, Kenneth H, MD and Eshleman, Susan H, MD and Piwowar-Manning, Estelle, MT and Makhema, Joseph, FRCP and Mills, Lisa A, MD and Panchia, Ravindre, MBBCh and Sanne, Ian, MBBCh and Gallant, Joel, MD and Hoffman, Irving, PA and Taha, Taha E, MBBS and Nielsen-Saines, Karin, MD and Celentano, David, ScD and Essex, Max, DVM and Havlir, Diane, MD and Cohen, Myron S, Dr and HPTN 052-ACTG Study Team
Lancet Infectious Diseases, The, ISSN 1473-3099, 2014, Volume 14, Issue 4, pp. 281 - 290
Summary Background Use of antiretroviral treatment for HIV-1 infection has decreased AIDS-related morbidity and mortality and prevents sexual transmission of... 
Infectious Disease | MORTALITY | INFECTIOUS DISEASES | THERAPY | EVENTS | ADULTS | AIDS | HIV-1-INFECTED PATIENTS | HIV-1 | Humans | Male | Young Adult | Acquired Immunodeficiency Syndrome - immunology | Neoplasms - complications | Cardiovascular Diseases - complications | Time Factors | Liver Diseases - complications | Adult | Female | Diabetes Mellitus, Type 2 - complications | Drug Administration Schedule | AIDS-Related Opportunistic Infections - immunology | AIDS-Related Opportunistic Infections - drug therapy | Kaplan-Meier Estimate | Proportional Hazards Models | CD4 Lymphocyte Count | Acquired Immunodeficiency Syndrome - drug therapy | Disease Progression | Tuberculosis, Pulmonary - diagnosis | Anti-Retroviral Agents - administration & dosage | Intention to Treat Analysis | Kidney Failure, Chronic - complications | Acquired Immunodeficiency Syndrome - complications | Antiviral agents | Mortality | Public health | Bacterial infections | Acquired immune deficiency syndrome--AIDS | Drug therapy | Human immunodeficiency virus--HIV
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3. Full Text An Extremely Luminous Panchromatic Outburst from the Nucleus of a Distant Galaxy
by A. J. Levan and N. R. Tanvir and S. B. Cenko and D. A. Perley and K. Wiersema and J. S. Bloom and A. S. Fruchter and A. de Ugarte Postigo and P. T. O'Brien and N. Butler and A. J. van der Horst and G. Leloudas and A. N. Morgan and K. Misra and G. C. Bower and J. Farihi and R. L. Tunnicliffe and M. Modjaz and J. M. Silverman and J. Hjorth and C. Thöne and A. Cucchiara and J. M. Castro Cerón and A. J. Castro-Tirado and J. A. Arnold and M. Bremer and J. P. Brodie and T. Carroll and M. C. Cooper and P. A. Curran and R. M. Cutri and J. Ehle and D. Forbes and J. Fynbo and J. Gorosabel and J. Graham and D. I. Hoffman and S. Guziy and P. Jakobsson and A. Kamble and T. Kerr and M. M. Kasliwal and C. Kouveliotou and D. Kocevski and N. M. Law and P. E. Nugent and E. O. Ofek and D. Poznanski and R. M. Quimby and E. Rol and A. J. Romanowsky and R. Sánchez-Ramírez and S. Schulze and N. Singh and L. van Spaandonk and R. L. C. Starling and R. G. Strom and J. C. Tello and O. Vaduvescu and P. J. Wheatley and R. A. M. J. Wijers and J. M. Winters and D. Xu
Science, ISSN 0036-8075, 7/2011, Volume 333, Issue 6039, pp. 199 - 202
Variable x-ray and γ-ray emission is characteristic of the most extreme physical processes in the universe. We present multiwavelength observations of a unique... 
Observational research | Astrophysics | Galaxies | Black holes | REPORTS | Optical bursts | Infrared radiation | Astronomical cosmology | Astronomical research | Grants | Astronomical magnitude | GAMMA-RAY BURST | MULTIDISCIPLINARY SCIENCES | SWIFT-ERA | Observations | Spectra | Galactic nuclei | Luminosity | Space telescopes | Stars & galaxies | Gamma ray astronomy | Physics - High Energy Astrophysical Phenomena | Physics
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4. Full Text A Panel to Predict Long-term Outcome of Infliximab Therapy for Patients With Ulcerative Colitis
by Arias, Maria Theresa and Vande Casteele, Niels and Vermeire, Séverine and de Buck van Overstraeten, Anthony and Billiet, Thomas and Baert, Filip and Wolthuis, Albert and Van Assche, Gert and Noman, Maja and Hoffman, Ilse and D’Hoore, Andre and Gils, Ann and Rutgeerts, Paul and Ferrante, Marc
Clinical Gastroenterology and Hepatology, ISSN 1542-3565, 2015, Volume 13, Issue 3, pp. 531 - 538
Background & Aims Infliximab is effective for patients with refractory ulcerative colitis (UC), but few factors have been identified that predict long-term... 
Gastroenterology and Hepatology | Drug | Biomarker | Response To Therapy | Prognostic Factor | Prognostic factor | Response to therapy | COLECTOMY | EARLY RESPONSE | DISEASE | OPTIMIZATION | GASTROENTEROLOGY & HEPATOLOGY | RESCUE THERAPY | Prognosis | Humans | Middle Aged | Biomarkers - analysis | Antibodies, Monoclonal - pharmacokinetics | Antibodies, Monoclonal - therapeutic use | Male | Treatment Outcome | Colitis, Ulcerative - pathology | Immunologic Factors - pharmacokinetics | Belgium | Infliximab | Adult | Female | Colitis, Ulcerative - drug therapy | Immunologic Factors - therapeutic use | Intestinal Mucosa - pathology | Serum - chemistry | Medicine, Experimental | Medical research | Patient outcomes | Ulcerative colitis
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5. Full Text Immunogenicity of the RTS,S/AS01 malaria vaccine and implications for duration of vaccine efficacy: secondary analysis of data from a phase 3 randomised controlled trial
by White, Michael T, Dr and Verity, Robert, PhD and Griffin, Jamie T, PhD and Asante, Kwaku Poku, MD and Owusu-Agyei, Seth, PhD and Greenwood, Brian, Prof and Drakeley, Chris, Prof and Gesase, Samwel, MD and Lusingu, John, MD and Ansong, Daniel, MBChB and Adjei, Samuel, MBChB and Agbenyega, Tsiri, PhD and Ogutu, Bernhards, MD and Otieno, Lucas, MD and Otieno, Walter, MD and Agnandji, Selidji T, MD and Lell, Bertrand, MD and Kremsner, Peter, Prof and Hoffman, Irving, Prof and Martinson, Francis, PhD and Kamthunzu, Portia, MD and Tinto, Halidou, PhD and Valea, Innocent, PhD and Sorgho, Hermann, PhD and Oneko, Martina, MD and Otieno, Kephas, MD and Hamel, Mary J, MD and Salim, Nahya, PhD and Mtoro, Ali, MD and Abdulla, Salim, MD and Aide, Pedro, PhD and Sacarlal, Jahit, PhD and Aponte, John J, PhD and Njuguna, Patricia, MMed and Marsh, Kevin, Prof and Bejon, Philip, Prof and Riley, Eleanor M, Prof and Ghani, Azra C, Prof
Lancet Infectious Diseases, The, ISSN 1473-3099, 2015, Volume 15, Issue 12, pp. 1450 - 1458
Summary Background The RTS,S/AS01 malaria vaccine targets the circumsporozoite protein, inducing antibodies associated with the prevention of Plasmodium... 
Infectious Disease | BLIND | IMMUNIZATION | IMMUNITY | INFECTIOUS DISEASES | PROTECTION | PLASMODIUM-FALCIPARUM INFECTION | DISEASE | ANTIBODY | MECHANISMS | Malaria, Falciparum - prevention & control | Protozoan Proteins - antagonists & inhibitors | Humans | Vaccination | Infant | Male | Plasmodium falciparum - drug effects | Plasmodium falciparum - immunology | Incidence | Malaria Vaccines - chemistry | Malaria, Falciparum - blood | Antibodies, Protozoan - blood | Immunization, Secondary | Malaria Vaccines - immunology | Female | Protozoan Proteins - chemistry | Plasmodium falciparum - chemistry | Vaccines, Subunit | Tanzania | Treatment Outcome | Ghana | Kenya | Malaria, Falciparum - parasitology | Malaria Vaccines - administration & dosage | Malaria, Falciparum - immunology | Protozoan Proteins - immunology | Malaria | Parasitic diseases | Analysis | Malaria vaccine | Clinical trials | Product development | Vaccines | Health aspects | Studies | Antigens | Hepatitis | Animal vaccines | Immunoglobulins | Population | Infections | Regression analysis | Estimates | Age | Assaigs clínics | Plasmodium falciparum | Vacuna de la malària | Malària
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6. Full Text High-resolution modeling of the western North American power system demonstrates low-cost and low-carbon futures
by Nelson, James and Johnston, Josiah and Mileva, Ana and Fripp, Matthias and Hoffman, Ian and Petros-Good, Autumn and Blanco, Christian and Kammen, Daniel M
Energy Policy, ISSN 0301-4215, 04/2012, Volume 43, pp. 436 - 447
Decarbonizing electricity production is central to reducing greenhouse gas emissions. Exploiting intermittent renewable energy resources demands power system... 
Renewable energy | Energy modeling | Carbon emissions | ENVIRONMENTAL SCIENCES | ENVIRONMENTAL STUDIES | ENERGY & FUELS | Usage | Control | Alternative energy sources | Models | Research | Electric power systems | Greenhouse gases | North America | Integer programming | Studies | Emissions control | Energy policy | Electricity generation
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7. Full Text Genetic Diversity and Protective Efficacy of the RTS,S/AS01 Malaria Vaccine
by Neafsey, Daniel E and Juraska, Michal and Bedford, Trevor and Benkeser, David and Valim, Clarissa and Griggs, Allison and Lievens, Marc and Abdulla, Salim and Adjei, Samuel and Agbenyega, Tsiri and Agnandji, Selidji T and Aide, Pedro and Anderson, Scott and Ansong, Daniel and Aponte, John J and Asante, Kwaku Poku and Bejon, Philip and Birkett, Ashley J and Bruls, Myriam and Connolly, Kristen M and D’Alessandro, Umberto and Dobaño, Carlota and Gesase, Samwel and Greenwood, Brian and Grimsby, Jonna and Tinto, Halidou and Hamel, Mary J and Hoffman, Irving and Kamthunzi, Portia and Kariuki, Simon and Kremsner, Peter G and Leach, Amanda and Lell, Bertrand and Lennon, Niall J and Lusingu, John and Marsh, Kevin and Martinson, Francis and Molel, Jackson T and Moss, Eli L and Njuguna, Patricia and Ockenhouse, Christian F and Ogutu, Bernhards Ragama and Otieno, Lucas and Otieno, Walter and Otieno, Kephas and Owusu-Agyei, Seth and Park, Daniel J and Pellé, Karell and Robbins, Dana and Russ, Carsten and Ryan, Elizabeth M and Sacarlal, Jahit and Sogoloff, Brian and Sorgho, Hermann and Tanner, Marcel and Theander, Thor and Valea, Innocent and Volkman, Sarah K and Yu, Qing and Lapierre, Didier and Birren, Bruce W and Gilbert, Peter B and Wirth, Dyann F
The New England Journal of Medicine, ISSN 0028-4793, 11/2015, Volume 373, Issue 21, pp. 2025 - 2037
There is a tremendous need for a malaria vaccine. By means of a sieve analysis, the RTS,S/AS01 candidate vaccine, which is in advanced clinical development,... 
MEDICINE, GENERAL & INTERNAL | IMMUNOGENICITY | SAFETY | PLASMODIUM-FALCIPARUM INFECTION | CIRCUMSPOROZOITE PROTEIN | RTS,S/AS02A | DOUBLE-BLIND | EXPANDED-PROGRAM | ENDEMIC AREA | SELECTION | CHILDREN | Genetic Variation | Malaria, Falciparum - parasitology | Malaria, Falciparum - prevention & control | Humans | Plasmodium falciparum - genetics | Africa | Malaria Vaccines - immunology | Malaria, Falciparum - immunology | Female | Infant | Male | Treatment Outcome | Care and treatment | Usage | Malaria | Antimalarials | Clinical trials | Dosage and administration | Children | Health aspects | Antigens | Vaccination | Amino acids | Protein C | Infants | Genetic diversity | Vaccines | Parasites | Population genetics | Polymerase chain reaction | Proteins | Alleles | Circumsporozoite protein | DNA sequencing
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